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1.发明授权Quantitative phase microscopy for high-contrast cell imaging using frequency domain phase shift 有权定量相位显微镜用于使用频域相移的高对比度细胞成像公开(公告)号：US09097900B2
公开(公告)日：2015-08-04
申请号：US13523816
申请日：2012-06-14
CPC分类号： G02B21/14 , G01B9/04 , G01B2290/20 , G02B21/0088 , G02B21/361
摘要： Some systems described herein include a frequency dependent phase plate for generating multiple phase-contrast images of a sample, each from a different frequency range of light, each phase-contrast image for frequency range of light formed from light diffracted by the sample interfered with undiffracted light that has a frequency-dependent baseline relative phase shift from the phase plate. In some embodiments, the multiple phase-contrast images may be used to generate a quantitative phase image of a sample. The phase-contrast images or the produced quantitative phase image may have sufficient contrast for label-free auto-segmentation of cell bodies and nuclei.
摘要翻译： 本文描述的一些系统包括频率相关相位板，用于产生每个来自不同频率范围的样品的多个相位对比图像，用于由被样品干涉的未衍射的光形成的光的频率范围的每个相位对比度图像 具有频率相关基准的相对于相位板相对相移的光。 在一些实施例中，多个相位对比图像可用于产生样本的定量相位图像。 相位对比图像或产生的定量相位图像可以具有足够的对比度，用于无标记的细胞体和核的自动分割。
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2.发明申请QUANTITATIVE PHASE MICROSCOPY FOR HIGH-CONTRAST CELL IMAGING USING FREQUENCY DOMAIN PHASE SHIFT 有权使用频域相移的高对比度细胞成像的定量相位显微镜公开(公告)号：US20130335548A1
公开(公告)日：2013-12-19
申请号：US13523816
申请日：2012-06-14
IPC分类号： H04N7/18
CPC分类号： G02B21/14 , G01B9/04 , G01B2290/20 , G02B21/0088 , G02B21/361
摘要： Some systems described herein include a frequency dependent phase plate for generating multiple phase-contrast images of a sample, each from a different frequency range of light, each phase-contrast image for frequency range of light formed from light diffracted by the sample interfered with undiffracted light that has a frequency-dependent baseline relative phase shift from the phase plate. In some embodiments, the multiple phase-contrast images may be used to generate a quantitative phase image of a sample. The phase-contrast images or the produced quantitative phase image may have sufficient contrast for label-free auto-segmentation of cell bodies and nuclei.
摘要翻译： 本文描述的一些系统包括频率相关相位板，用于产生每个来自不同频率范围的样品的多个相位对比图像，用于由被样品干涉的未衍射的光形成的光的频率范围的每个相位对比度图像 具有频率相关基准的相对于相位板相对相移的光。 在一些实施例中，多个相位对比图像可用于产生样本的定量相位图像。 相位对比图像或产生的定量相位图像可以具有足够的对比度，用于无标记的细胞体和核的自动分割。
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3.发明申请公开(公告)号：US20130163002A1
公开(公告)日：2013-06-27
申请号：US13335748
申请日：2011-12-22
IPC分类号： G01B9/02
CPC分类号： G02B21/367 , G02B21/14
摘要： Systems and methods described herein employ multiple phase-contrast images with various relative phase shifts between light diffracted by a sample and light not diffracted by the sample to produce a quantitative phase image. The produced quantitative phase image may have sufficient contrast for label-free auto-segmentation of cell bodies and nuclei.
摘要翻译： 本文描述的系统和方法使用多个相差图像，其在由样品衍射的光和不被样品衍射的光之间具有各种相对相移，以产生定量相位图像。 所产生的定量相图可能具有足够的对比度，用于细胞体和细胞核的无标记自动分割。
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4.发明授权公开(公告)号：US08693000B2
公开(公告)日：2014-04-08
申请号：US13335748
申请日：2011-12-22
CPC分类号： G02B21/367 , G02B21/14
摘要： Systems and methods described herein employ multiple phase-contrast images with various relative phase shifts between light diffracted by a sample and light not diffracted by the sample to produce a quantitative phase image. The produced quantitative phase image may have sufficient contrast for label-free auto-segmentation of cell bodies and nuclei.
摘要翻译： 本文描述的系统和方法使用多个相差图像，其在由样品衍射的光和不被样品衍射的光之间具有各种相对相移，以产生定量相位图像。 所产生的定量相图可能具有足够的对比度，用于细胞体和细胞核的无标记自动分割。
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公开(公告)号：US20130162948A1
公开(公告)日：2013-06-27
申请号：US13335211
申请日：2011-12-22
申请人： Siavash Yazdanfar , Sora Kim , Chulmin Joo
发明人： Siavash Yazdanfar , Sora Kim , Chulmin Joo
CPC分类号： G01B9/02044 , A61B3/102 , A61B3/12 , G01B9/02048 , G01B9/02063 , G01B9/02064 , G01B9/02091
摘要： A system, in one embodiment, includes an optical coherence tomography (OCT) imaging system having a light source configured to emit light. The OCT imaging system further includes a beam splitter configured to receive the light from the light source, split the light into a first light portion directed along a sample arm comprising a sample and a second light portion directed along a reference arm comprising a reference mirror, receive a first reflected light portion from the sample arm and a second reflected light portion from the reference arm, combine the first and second reflected light portions to obtain an interference signal. Further, the OCT imaging system includes a controller having logic configured to perform an auto-ranging process to match the reference arm with the sample arm.
摘要翻译： 在一个实施例中，系统包括具有被配置为发光的光源的光学相干断层摄影（OCT）成像系统。 OCT成像系统还包括分束器，其被配置为接收来自光源的光，将光分成沿着包括样本的样本臂引导的第一光部分和沿着包括参考反射镜的参考臂引导的第二光部分， 从样品臂接收第一反射光部分和从参考臂的第二反射光部分，组合第一和第二反射光部分以获得干涉信号。 此外，OCT成像系统包括具有被配置为执行自动测距过程以使参考臂与样本臂匹配的逻辑的控制器。
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公开(公告)号：US20130052725A1
公开(公告)日：2013-02-28
申请号：US13285976
申请日：2011-10-31
申请人： Siavash Yazdanfar , Vasile Bogdan Neculaes , Kenneth Roger Conway , Allen Lawrence Garner , Evelina Roxana Loghin , Dmitry Vladimirovich Dylov , Brian Michael Davis , Chulmin Joo
发明人： Siavash Yazdanfar , Vasile Bogdan Neculaes , Kenneth Roger Conway , Allen Lawrence Garner , Evelina Roxana Loghin , Dmitry Vladimirovich Dylov , Brian Michael Davis , Chulmin Joo
IPC分类号： C12M1/42
CPC分类号： C12M35/02
摘要： A system for delivering exogenous molecules comprises a support for containing cells and exogenous molecules; an infra-red (IR) light source that generates an IR optical beam with an average power density at least greater than 105 W/cm2; one or more optical elements; an imaging system to image the cells in a field of view; a processor that generates a signal for localization of cells in the field of view; a light pattern shaper for temporal focusing of optical beam to generate wide field illumination on the cells to permeabilise the cell membrane for delivering the exogenous molecules; and a controller that switches optical beam from wide field illumination to a focused illumination. The processor is operatively coupled to the imaging system and the light pattern shaper and transmits the signal for the localization of cells to ensure the temporal focusing of the optical beam on the cells.
摘要翻译： 用于递送外源分子的系统包括用于含有细胞和外源分子的载体; 红外（IR）光源，其产生平均功率密度至少大于105W / cm2的IR光束; 一个或多个光学元件; 成像系统，用于在视场中对细胞进行成像; 处理器，其在视野中产生用于细胞定位的信号; 用于光束的时间聚焦的光图案整形器以在细胞上产生宽场照明以透过细胞膜以传递外源分子; 以及将光束从宽场照明切换到聚焦照明的控制器。 处理器可操作地耦合到成像系统和光图案整形器，并且传输信号用于细胞的定位，以确保光束在细胞上的时间聚焦。
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公开(公告)号：US08143792B2
公开(公告)日：2012-03-27
申请号：US12543722
申请日：2009-08-19
申请人： Chulmin Joo , Hyunick Shin
发明人： Chulmin Joo , Hyunick Shin
IPC分类号： H05B37/02
CPC分类号： H05B33/0827
摘要： Lighting system embodiments are provided to energize and calibrate strings of light-emitting diodes. These embodiments are particularly useful for calibration of strings of light-emitting diodes that are arranged to provide backlighting of liquid crystal displays. The systems are structured around the use of a single comparator that is multiplexed to facilitate calibration of a plurality of current sources. The systems can be adapted for use in displays in which different techniques (e.g., “analog dimming” and “pulse-width modulation”) are used to vary the brightness of the display. The systems remove the need for special structures (e.g., fuse arrays, special test equipment, and interfaces).
摘要翻译： 提供照明系统实施例以激励和校准发光二极管串。 这些实施例对于校准布置成提供液晶显示器背光的发光二极管串特别有用。 这些系统围绕使用单个比较器进行结构，该比较器被多路复用以便于多个电流源的校准。 该系统可以适用于其中使用不同技术（例如，“模拟调光”和“脉冲宽度调制”）以改变显示器的亮度的显示器。 该系统消除了对特殊结构（例如，熔丝阵列，特殊测试设备和接口）的需要。
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公开(公告)号：US20110122412A1
公开(公告)日：2011-05-26
申请号：US12623714
申请日：2009-11-23
申请人： Chulmin Joo , Anthony John Murray , Masako Yamada
发明人： Chulmin Joo , Anthony John Murray , Masako Yamada
IPC分类号： G01J3/45
CPC分类号： G01N33/6845 , G01N21/0332 , G01N21/05 , G01N21/45 , G01N21/53 , G01N2021/0346
摘要： An optical detection system for sensing one or more samples is provided. The optical detection system comprises a broadband light source that emits a beam comprising a continuous spectrum over a range of wavelengths; a fluidic cell comprising one or more channels that positions the sample so that at least a portion of the beam is directed on the sample to produce a back reflected beam; and a spectrometer that analyzes an interference spectrum of the beam back reflected from the sample.
摘要翻译： 提供了用于感测一个或多个样品的光学检测系统。 光学检测系统包括宽带光源，其发射包括波长范围上的连续光谱的光束; 流体单元包括一个或多个通道，其定位样品，使得至少一部分光束被引导到样品上以产生反射反射光束; 以及分析从样品反射的光束的干涉光谱的光谱仪。
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公开(公告)号：US20110043118A1
公开(公告)日：2011-02-24
申请号：US12543722
申请日：2009-08-19
申请人： Chulmin Joo , Hyunick Shin
发明人： Chulmin Joo , Hyunick Shin
IPC分类号： H05B37/02
CPC分类号： H05B33/0827
摘要： Lighting system embodiments are provided to energize and calibrate strings of light-emitting diodes. These embodiments are particularly useful for calibration of strings of light-emitting diodes that are arranged to provide backlighting of liquid crystal displays. The systems are structured around the use of a single comparator that is multiplexed to facilitate calibration of a plurality of current sources. The systems can be adapted for use in displays in which different techniques (e.g., “analog dimming” and “pulse-width modulation”) are used to vary the brightness of the display. The systems remove the need for special structures (e.g., fuse arrays, special test equipment, and interfaces).
摘要翻译： 提供照明系统实施例以激励和校准发光二极管串。 这些实施例对于校准布置成提供液晶显示器背光的发光二极管串特别有用。 这些系统围绕使用单个比较器进行结构，该比较器被多路复用以便于多个电流源的校准。 该系统可以适用于其中使用不同技术（例如，“模拟调光”和“脉冲宽度调制”）以改变显示器的亮度的显示器。 该系统消除了对特殊结构（例如，熔丝阵列，特殊测试设备和接口）的需要。
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10.发明申请Arrangements, systems and methods capable of providing spectral-domain optical coherence reflectometry for a sensitive detection of chemical and biological sample 审中-公开能够为化学和生物样品的敏感检测提供光谱相干光学相干反射测量的布置，系统和方法公开(公告)号：US20070009935A1
公开(公告)日：2007-01-11
申请号：US11435228
申请日：2006-05-15
申请人： Chulmin Joo , Johannes De Boer
发明人： Chulmin Joo , Johannes De Boer
CPC分类号： G01N21/4795 , A61B5/0066 , G01B9/02025 , G01B9/02044 , G01B9/02057 , G01B9/02091 , G01B11/0625 , G01N21/253 , G01N21/45
摘要： Systems, arrangements and methods for a molecular recognition are provided. For example, a particular radiation having wavelength that varies over time and/or a spectral width that is greater than 10 nm can be provided. For example, at least one first electro-magnetic radiation can be provided to at least one sample, and at least one second electro-magnetic radiation may be provided to a reference, with both the first and second electro-magnetic radiations being part of the particular radiation. Further, the interference between a third electro-magnetic radiation (associated with the first electro-magnetic radiation) and a fourth electro-magnetic radiation (associated with the second electro-magnetic radiation) can be detected. A change in a thickness of at least one portion of the sample based on the interference can be determined.
摘要翻译： 提供了分子识别的系统，布置和方法。 例如，可以提供具有随时间变化的波长和/或大于10nm的光谱宽度的特定辐射。 例如，可以向至少一个样品提供至少一个第一电磁辐射，并且可以将至少一个第二电磁辐射提供给参考，第一和第二电磁辐射都是 特殊辐射。 此外，可以检测第三电磁辐射（与第一电磁辐射相关联）和第四电磁辐射（与第二电磁辐射相关联）之间的干扰。 可以确定基于干涉的至少一部分样品的厚度的变化。
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