专利检索 ap:("Steve A. Kay" OR "Ewa Lis" OR "Susan Golden" OR "Michael Melnick" OR "Dawn M. Adin" OR "James W. Golden") AND inv:"Michael Melnick" 第 1 页

1.

发明申请
METHODS AND COMPOSITIONS FOR THE PRODUCTION OF FATTY ACIDS IN PHOTOSYNTHETIC PROKARYOTIC MICROORGANISMS 有权
标题翻译：光合原生质体微生物中脂肪酸生产的方法和组合物

公开(公告)号：US20120184004A1

公开(公告)日：2012-07-19

申请号：US13383409

申请日：2010-07-22

申请人： Steve A. Kay , Ewa Lis , Susan Golden , Michael Melnick , Dawn M. Adin , James W. Golden

发明人： Steve A. Kay , Ewa Lis , Susan Golden , Michael Melnick , Dawn M. Adin , James W. Golden

IPC分类号： C12P7/64 , C12N1/13 , C12N1/00 , C12N15/63

CPC分类号： C12P7/6409 , C12N9/16 , C12N9/88 , G01N33/92 , Y02P20/52

摘要： Provided herein are methods and compositions for the production of renewable fatty acids from photosynthetic prokaryotic microorganisms, such as a blue green algae, any specie of the phylum Cyanophyta, a chloroplast of a green algae and/or a Cyanobacterium. Engineered or natural strains of these organisms or organelles can be used to produce both saturated and unsaturated fatty acids with variable chain length specificity from 8-18 carbons. The fatty acids can then be secreted into the culture medium, allowing for rapid, continuous and efficient separation of fatty acid product without harvesting of cell mass.

摘要翻译： 本文提供了用于从光合原核微生物生产可再生脂肪酸的方法和组合物，例如蓝绿色藻类，蓝藻属的任何物种，绿藻和/或蓝细菌的叶绿体。这些生物或细胞器的工程化或天然菌株可用于产生具有8-18个碳的可变链长特异性的饱和和不饱和脂肪酸。然后可以将脂肪酸分泌到培养基中，允许快速，连续和有效地分离脂肪酸产物而不收获细胞团。

2.

发明授权
Methods and compositions for the production of fatty acids in photosynthetic prokaryotic microorganisms 有权
标题翻译：在光合原核生物微生物中生产脂肪酸的方法和组合物

公开(公告)号：US09359623B2

公开(公告)日：2016-06-07

申请号：US13383409

申请日：2010-07-22

申请人： Steve A. Kay , Ewa Lis , Susan Golden , Michael Melnick , Dawn M. Adin , James W. Golden

发明人： Steve A. Kay , Ewa Lis , Susan Golden , Michael Melnick , Dawn M. Adin , James W. Golden

IPC分类号： C12P7/64 , C12N9/16 , C12N9/88 , G01N33/92

CPC分类号： C12P7/6409 , C12N9/16 , C12N9/88 , G01N33/92 , Y02P20/52

摘要： Provided herein are methods and compositions for the production of renewable fatty acids from photosynthetic prokaryotic microorganisms, such as a blue green algae, any specie of the phylum Cyanophyta, a chloroplast of a green algae and/or a Cyanobacterium. Engineered or natural strains of these organisms or organelles can be used to produce both saturated and unsaturated fatty acids with variable chain length specificity from 8-18 carbons. The fatty acids can then be secreted into the culture medium, allowing for rapid, continuous and efficient separation of fatty acid product without harvesting of cell mass.

摘要翻译： 本文提供了用于从光合原核微生物生产可再生脂肪酸的方法和组合物，例如蓝绿色藻类，蓝藻属的任何物种，绿藻和/或蓝细菌的叶绿体。这些生物或细胞器的工程化或天然菌株可用于产生具有8-18个碳的可变链长特异性的饱和和不饱和脂肪酸。然后可以将脂肪酸分泌到培养基中，允许快速，连续和有效地分离脂肪酸产物而不收获细胞团。

3.

发明授权
HIV protease inhibitors, compositions containing the same, their pharmaceutical uses and materials for their synthesis 失效

公开(公告)号：US07179918B2

公开(公告)日：2007-02-20

申请号：US10166979

申请日：2002-06-11

申请人： Stacie S. Canan Koch , Therese N. Alexander , Benjamin J. Burke , Tanya M. Jewell , David J. Kucera , Maria Angelica Linton , Lennert J. Mitchell, Jr. , Siegfried H. Reich , Donald J. Skalitzky , John H. Tatlock , Michael D. Varney , Scott C. Virgil , Stephen E. Webber , Stephen T. Worland , Mark Barvian , Gary Bolton , Frederick Earl Boyer, Jr. , Jeffrey J. Machak , Tod Holler , Sean T. Murphy , Michael Melnick , Vara Prasad Josyula

发明人： Stacie S. Canan Koch , Therese N. Alexander , Benjamin J. Burke , Tanya M. Jewell , David J. Kucera , Maria Angelica Linton , Lennert J. Mitchell, Jr. , Siegfried H. Reich , Donald J. Skalitzky , John H. Tatlock , Michael D. Varney , Scott C. Virgil , Stephen E. Webber , Stephen T. Worland , Mark Barvian , Gary Bolton , Frederick Earl Boyer, Jr. , Jeffrey J. Machak , Tod Holler , Sean T. Murphy , Michael Melnick , Vara Prasad Josyula

IPC分类号： C07D207/16 , C07D221/02

CPC分类号： C07D231/12 , A61K31/426 , A61K31/427 , C07D207/09 , C07D207/16 , C07D213/38 , C07D217/26 , C07D277/06 , C07D277/60 , C07D295/13 , C07D307/52 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/08

摘要： Compounds of the formula: where the formula variables are as defined herein, are disclosed that advantageously inhibit or block the biological activity of the HIV protease. These compounds, as well as pharmaceutical compositions containing these compounds, are useful for treating patients or hosts infected with the HIV virus. Intermediates and synthetic methods for preparing such compounds are also described.

4.

发明授权
Fluoro-pyridinone derivatives useful as antibacterial agents 有权
标题翻译：用作抗菌剂的氟 - 吡啶酮衍生物

公开(公告)号：US08624034B2

公开(公告)日：2014-01-07

申请号：US13414057

申请日：2012-03-07

申请人： Usa Reilly , Michael Melnick , Matthew F. Brown , Mark S. Plummer , Justin Montgomery , Ye Che , Loren Price

发明人： Usa Reilly , Michael Melnick , Matthew F. Brown , Mark S. Plummer , Justin Montgomery , Ye Che , Loren Price

IPC分类号： A61K31/44 , C07D211/72

CPC分类号： C07D405/04 , C07D213/64 , C07D213/69 , C07D401/04 , C07D401/10 , C07D405/12 , C07D413/10 , C07D417/12

摘要： The present invention is directed to a new class of hydroxamic acid derivatives, their use as LpxC inhibitors and, more specifically, their use to treat bacterial infections.

摘要翻译： 本发明涉及一类新的异羟肟酸衍生物，它们用作LpxC抑制剂，更具体地，其用于治疗细菌感染。