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    System and method for temperature control
    1.
    发明授权
    System and method for temperature control 有权
    温度控制系统和方法

    公开(公告)号：US07188001B2

    公开(公告)日：2007-03-06

    申请号：US10353186

    申请日：2003-01-27

    申请人： Steven J. Young ,  Gregory T. A. Kovacs ,  M. Allen Northrup ,  Kurt E. Petersen ,  William A. McMillan ,  Konstantin Othmer ,  Lee A. Christel

    发明人： Steven J. Young ,  Gregory T. A. Kovacs ,  M. Allen Northrup ,  Kurt E. Petersen ,  William A. McMillan ,  Konstantin Othmer ,  Lee A. Christel

    IPC分类号： G05B21/00 ,  G01N25/20 ,  G01N21/00

    CPC分类号： B01L7/52 ,  G05B13/021 ,  G05D23/1913 ,  Y10T436/12

    摘要： A system for controlling the temperature of a reaction mixture comprises at least one heating device for heating the mixture and a power regulator for regulating the amount of power supplied to the heating device. A controller in communication with the power regulator includes program instructions for heating the reaction mixture by setting a variable target temperature that initially exceeds a desired setpoint temperature for the mixture. When the heating device reaches a threshold temperature, the variable target temperature is decreased to the desired setpoint temperature. In another embodiment, the controller includes an adaptive control program for dynamically adjusting the duration or intensity of power pulses provided to the heating device.

    摘要翻译： 用于控制反应混合物的温度的系统包括至少一个用于加热混合物的加热装置和用于调节供应给加热装置的功率量的功率调节器。 与功率调节器通信的控制器包括用于通过设定最初超过混合物的期望设定点温度的可变目标温度来加热反应混合物的程序指令。 当加热装置达到阈值温度时，可变目标温度降低到所需的设定点温度。 在另一个实施例中，控制器包括用于动态调整提供给加热装置的功率脉冲的持续时间或强度的自适应控制程序。

    Device incorporating a microfluidic chip for separating analyte from a sample
    8.
    发明授权
    Device incorporating a microfluidic chip for separating analyte from a sample 有权
    装有微流体芯片以用于从样品中分离分析物的装置

    公开(公告)号：US06664104B2

    公开(公告)日：2003-12-16

    申请号：US10006850

    申请日：2001-11-07

    申请人： Farzad Pourahmadi ,  William A. McMillan ,  Jesus Ching ,  Ronald Chang ,  Lee A. Christel ,  Gregory T. A. Kovacs ,  M. Allen Northrup ,  Kurt E. Petersen

    发明人： Farzad Pourahmadi ,  William A. McMillan ,  Jesus Ching ,  Ronald Chang ,  Lee A. Christel ,  Gregory T. A. Kovacs ,  M. Allen Northrup ,  Kurt E. Petersen

    IPC分类号： C12M134

    CPC分类号： C12M47/06 ,  B01L2400/0622 ,  B01L2400/0644

    摘要： A device for separating an analyte from a fluid sample comprises a cartridge incorporating a flow-through microfluidic chip. The microfluidic chip includes an extraction chamber having an array of microstructures for capturing the analyte and for subsequently releasing the captured analyte into an elution fluid. Each of the microstructures has an aspect ratio of at least 2:1. The cartridge also includes channels and at least one low controller (e.g., one or more valves) for directing the flow of the sample and elution fluid through the microfluidic chip. The cartridge may optionally include a lysing region for lysing sample components (e.g., cells spores, or microorganisms), a waste chamber for storing waste fluid, and reaction or detection chambers for amplifying or detecting the analyte.

    摘要翻译： 用于从流体样品分离分析物的装置包括结合流过微流控芯片的盒。 微流体芯片包括具有用于捕获分析物的微结构阵列并用于随后将捕获的分析物释放到洗脱流体中的提取室。 每个微结构具有至少2:1的纵横比。 墨盒还包括通道和至少一个低控制器（例如，一个或多个阀），用于引导样品流和洗脱流体通过微流体芯片。 筒可任选地包括用于裂解样品组分（例如细胞孢子或微生物）的裂解区，用于储存废液的废物室和用于扩增或检测分析物的反应或检测室。

    Method for separating an analyte from a sample
    10.
    发明授权
    Method for separating an analyte from a sample 有权
    从样品中分离分析物的方法

    公开(公告)号：US08592157B2

    公开(公告)日：2013-11-26

    申请号：US13552950

    申请日：2012-07-19

    申请人： Kurt E. Petersen ,  William A. McMillan ,  Lee A. Christel ,  Ronald Chang ,  Farzad Pourahmadi ,  Jesus Ching ,  Gregory T. A. Kovacs ,  M. Allen Northrup

    发明人： Kurt E. Petersen ,  William A. McMillan ,  Lee A. Christel ,  Ronald Chang ,  Farzad Pourahmadi ,  Jesus Ching ,  Gregory T. A. Kovacs ,  M. Allen Northrup

    IPC分类号： C12Q1/68

    CPC分类号： C12N15/1017 ,  B01D15/00 ,  B01L7/52 ,  B01L2400/0622 ,  B01L2400/0644 ,  C12M47/06 ,  G01N1/34 ,  Y10T436/255

    摘要： An analyte is separated from a fluid sample by introducing the sample into a cartridge having a sample port and a first flow path extending from the sample port. The first flow path includes an extraction chamber containing a solid support for capturing the analyte from the sample. The cartridge has a second flow path for eluting the captured analyte from the extraction chamber, the second flow diverging from the first flow path after passing through the extraction chamber. The sample is forced to flow through the extraction chamber and into a waste chamber, thereby capturing the analyte with the solid support as the sample flows through the extraction chamber. The captured analyte is then eluted from the extraction chamber by forcing an elution fluid to flow through the extraction chamber and along the second flow path.

    摘要翻译： 将样品通过将样品引入具有样品端口和从样品端口延伸的第一流路的盒中而将分析物与流体样品分离。 第一流路包括提取室，其包含用于从样品捕获分析物的固体支持物。 所述筒具有用于从所述提取室洗脱所捕获的分析物的第二流动路径，所述第二流在通过所述提取室之后从所述第一流动路径发散。 样品被迫流过提取室并进入废物室，从而当样品流过提取室时用固体支持物捕获分析物。 然后通过迫使洗脱液体流过提取室并沿着第二流动路径，将捕获的分析物从萃取室洗脱。