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1.发明授权C-terminal ketone inhibitors of matrix metalloproteinases and TNF.alpha. secretion 失效基质金属蛋白酶的C末端酮抑制剂和TNFα分泌
公开(公告)号：US5985911A
公开(公告)日：1999-11-16
申请号：US992578
申请日：1997-12-17
申请人： Steven K. Davidsen , Alan S. Florjancic , George S. Sheppard , Jamie R. Giesler , Lianhong Xu , Yan Guo , Michael L. Curtin , Michael R. Michaelides , Carol K. Wada , James H. Holms
发明人： Steven K. Davidsen , Alan S. Florjancic , George S. Sheppard , Jamie R. Giesler , Lianhong Xu , Yan Guo , Michael L. Curtin , Michael R. Michaelides , Carol K. Wada , James H. Holms
IPC分类号： C07C233/32 , C07C259/06 , C07D207/32 , C07D207/335 , C07D209/14 , C07D213/50 , C07D235/14 , C07D263/32 , C07D277/28 , C07D333/22 , C07C259/10 , A61K31/165
CPC分类号： C07D207/335 , C07C233/32 , C07C259/06 , C07D209/14 , C07D213/50 , C07D235/14 , C07D263/32 , C07D277/28 , C07D333/22 , C07B2200/07 , C07C2101/14
摘要： C-terminal compounds of formula ##STR1## are potent inhibitors of matrix metalloproteinase and are useful in the treatment of diseases in which matrix metalloproteinase play a role. Also disclosed are matrix metalloproteinase inhibiting compositions and a method of inhibiting matrix metalloproteinase in a mammal.
摘要翻译： C末端化合物是基质金属蛋白酶的有效抑制剂，可用于治疗基质金属蛋白酶发挥作用的疾病。 还公开了抑制哺乳动物的基质金属蛋白酶抑制组合物和抑制基质金属蛋白酶的方法。
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公开(公告)号：US06294573B1
公开(公告)日：2001-09-25
申请号：US09492567
申请日：2000-01-27
申请人： Michael L. Curtin , Yujia Dai , Steven K. Davidsen , Joseph F. Dellaria, Jr. , Alan S. Florjancic , Jianchun Gong , Yan Guo , Howard R. Heyman , James H. Holms , Michael R. Michaelides , Jamie R. Stacey , Douglas H. Steinman , Carol K. Wada , Lianhong Xu
发明人： Michael L. Curtin , Yujia Dai , Steven K. Davidsen , Joseph F. Dellaria, Jr. , Alan S. Florjancic , Jianchun Gong , Yan Guo , Howard R. Heyman , James H. Holms , Michael R. Michaelides , Jamie R. Stacey , Douglas H. Steinman , Carol K. Wada , Lianhong Xu
IPC分类号： C07C25537
CPC分类号： C07D263/04 , C07D207/09 , C07D207/48 , C07D307/14 , C07D317/28
摘要： Compounds having the formula are matrix metalloproteinase inhibitors. Also disclosed are matrix metalloproteinase-inhibiting compositions and methods of inhibiting matrix metalloproteinase in a mammal.
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3.发明授权Macrocyclic inhibitors of matrix metalloproteinases and TNF.alpha. secretion 失效基质金属蛋白酶和TNFα分泌的大环抑制剂
公开(公告)号：US5952320A
公开(公告)日：1999-09-14
申请号：US992668
申请日：1997-12-17
申请人： Steven K. Davidsen , Douglas H. Steinman , George S. Sheppard , Lianhong Xu , James H. Holms , Yan Guo , James B. Summers , Alan S. Florjancic , Michael R. Michaelides
发明人： Steven K. Davidsen , Douglas H. Steinman , George S. Sheppard , Lianhong Xu , James H. Holms , Yan Guo , James B. Summers , Alan S. Florjancic , Michael R. Michaelides
IPC分类号： C07D245/06 , C07D267/00 , C07D413/04 , C07D413/06 , C07D413/12 , C07D417/12 , C07D487/08 , A61K31/33 , C07D225/04 , C07D267/22 , C07D281/18
CPC分类号： C07D413/04 , C07D245/06 , C07D267/00 , C07D413/06 , C07D413/12 , C07D417/12 , C07D487/08
摘要： Macrocyclic compounds of formula ##STR1## are potent inhibitors of matrix metalloproteinase and are useful in the treatment of diseases in which matrix metalloproteinase play a role. Also disclosed are matrix metalloproteinase inhibiting compositions and a method of inhibiting matrix metalloproteinase in a mammal.
摘要翻译： 大环化合物是基质金属蛋白酶的有效抑制剂，可用于治疗基质金属蛋白酶发挥作用的疾病。 还公开了抑制哺乳动物的基质金属蛋白酶抑制组合物和抑制基质金属蛋白酶的方法。
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公开(公告)号：US08273736B2
公开(公告)日：2012-09-25
申请号：US12623026
申请日：2009-11-20
申请人： Patrick Betschmann , Andrew F. Burchat , David J. Calderwood , Michael L. Curtin , Steven K. Davidsen , Heather M. Davis , Robin R. Frey , Howard R. Heyman , Gavin C. Hirst , Peter Hrnciar , Michael R. Michaelides , Melanie A. Muckey , Kelly D. Mullen , Paul Rafferty , Carol K. Wada
发明人： Patrick Betschmann , Andrew F. Burchat , David J. Calderwood , Michael L. Curtin , Steven K. Davidsen , Heather M. Davis , Robin R. Frey , Howard R. Heyman , Gavin C. Hirst , Peter Hrnciar , Michael R. Michaelides , Melanie A. Muckey , Kelly D. Mullen , Paul Rafferty , Carol K. Wada
IPC分类号： A61K31/4365 , A61K31/55 , A61K31/5377 , A61K31/496 , C07D495/04
CPC分类号： A61K31/4743 , A61K31/4741 , A61K31/4745 , C07D491/04 , C07D495/04 , Y02A50/401
摘要： Compounds having the formula are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.
摘要翻译： 具有该式的化合物可用于抑制蛋白酪氨酸激酶。 本发明还公开了制备化合物的方法，含有该化合物的组合物和使用该化合物的处理方法。
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公开(公告)号：US07202363B2
公开(公告)日：2007-04-10
申请号：US10899168
申请日：2004-07-26
申请人： Patrick Betschmann , Andrew F. Burchat , David J. Calderwood , Michael L. Curtin , Steven K. Davidsen , Heather M. Davis , Robin R. Frey , Howard R. Heyman , Gavin C. Hirst , Peter Hrnciar , Michael R. Michaelides , Melanie A. Muckey , Kelly D. Mullen , Paul Rafferty , Carol K. Wada
发明人： Patrick Betschmann , Andrew F. Burchat , David J. Calderwood , Michael L. Curtin , Steven K. Davidsen , Heather M. Davis , Robin R. Frey , Howard R. Heyman , Gavin C. Hirst , Peter Hrnciar , Michael R. Michaelides , Melanie A. Muckey , Kelly D. Mullen , Paul Rafferty , Carol K. Wada
IPC分类号： C07D491/04 , C07D421/04
CPC分类号： A61K31/4743 , A61K31/4741 , A61K31/4745 , C07D491/04 , C07D495/04 , Y02A50/401
摘要： Compounds having the formula are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.
摘要翻译： 具有式的化合物
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公开(公告)号：US07737160B2
公开(公告)日：2010-06-15
申请号：US11675183
申请日：2007-02-15
申请人： Patrick Betschmann , Andrew F. Burchat , David J. Calderwood , Michael L. Curtin , Steven K. Davidsen , Heather M. Davis , Robin R. Frey , Howard R. Heyman , Gavin C. Hirst , Peter Hrnciar , Michael R. Michaelides , Melanie A. Muckey , Kelly D. Mullen , Paul Rafferty , Carol K. Wada
发明人： Patrick Betschmann , Andrew F. Burchat , David J. Calderwood , Michael L. Curtin , Steven K. Davidsen , Heather M. Davis , Robin R. Frey , Howard R. Heyman , Gavin C. Hirst , Peter Hrnciar , Michael R. Michaelides , Melanie A. Muckey , Kelly D. Mullen , Paul Rafferty , Carol K. Wada
IPC分类号： A61K31/4745 , A61K31/4743 , A61K31/4741
CPC分类号： A61K31/4743 , A61K31/4741 , A61K31/4745 , C07D491/04 , C07D495/04 , Y02A50/401
摘要： Compounds having the formula are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.
摘要翻译： 具有该式的化合物可用于抑制蛋白酪氨酸激酶。 本发明还公开了制备化合物的方法，含有该化合物的组合物和使用该化合物的处理方法。
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公开(公告)号：US06288261B1
公开(公告)日：2001-09-11
申请号：US09465232
申请日：1999-12-14
申请人： David J. Augeri , David A. Betebenner , Richard Craig , Steven K. Davidsen , Stephen W. Fesik , Jamie R. Giesler-Stacey , Yan Guo , Philip J. Hajduk , Michael R. Michaelides , David G. Nettesheim
发明人： David J. Augeri , David A. Betebenner , Richard Craig , Steven K. Davidsen , Stephen W. Fesik , Jamie R. Giesler-Stacey , Yan Guo , Philip J. Hajduk , Michael R. Michaelides , David G. Nettesheim
IPC分类号： C07C25500
CPC分类号： C07C259/10 , C07C311/29 , C07C317/18 , C07C317/22 , C07C317/44
摘要： Compounds having the formula and pharmaceutically acceptable salts and prodrugs thereof are matrix metalloproteinase inhibitors. Also disclosed are matrix metalloproteinase-inhibiting compositions and methods of inhibiting matrix metalloproteinase in a mammal.
摘要翻译： 具有式及其药学上可接受的盐和前药的化合物是基质金属蛋白酶抑制剂。 还公开了抑制哺乳动物基质金属蛋白酶的基质金属蛋白酶抑制组合物和抑制基质金属蛋白酶的方法。
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公开(公告)号：US20100069371A1
公开(公告)日：2010-03-18
申请号：US12623026
申请日：2009-11-20
申请人： Patrick Betschmann , Andrew F. Burchat , David J. Calderwood , Michael L. Curtin , Steven K. Davidsen , Heather M. Davis , Robin R. Frey , Howard R. Heyman , Gavin C. Hirst , Peter Hrnciar , Michael R. Michaelides , Melanie A. Muckey , Kelly D. Mullen , Paul Rafferty , Carol K. Wada
发明人： Patrick Betschmann , Andrew F. Burchat , David J. Calderwood , Michael L. Curtin , Steven K. Davidsen , Heather M. Davis , Robin R. Frey , Howard R. Heyman , Gavin C. Hirst , Peter Hrnciar , Michael R. Michaelides , Melanie A. Muckey , Kelly D. Mullen , Paul Rafferty , Carol K. Wada
IPC分类号： A61K31/4365 , C07D495/04 , A61K31/55 , A61K31/5377 , A61K31/496
CPC分类号： A61K31/4743 , A61K31/4741 , A61K31/4745 , C07D491/04 , C07D495/04 , Y02A50/401
摘要： Compounds having the formula are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.
摘要翻译： 具有该式的化合物可用于抑制蛋白酪氨酸激酶。 本发明还公开了制备化合物的方法，含有该化合物的组合物和使用该化合物的处理方法。
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公开(公告)号：US07560552B2
公开(公告)日：2009-07-14
申请号：US10392951
申请日：2003-03-20
申请人： Michael R. Michaelides , Lee D. Arnold , Michael L. Curtin , Yujia Dai , Steven K. Davidsen , Robin R. Frey , Yan Guo , Zhiqin Ji , Neil Wishart
发明人： Michael R. Michaelides , Lee D. Arnold , Michael L. Curtin , Yujia Dai , Steven K. Davidsen , Robin R. Frey , Yan Guo , Zhiqin Ji , Neil Wishart
IPC分类号： C07D495/04 , A61K31/519 , A61P35/04 , A61P19/02 , A61P3/10 , A61P37/06
CPC分类号： C07D495/04 , C07D513/04
摘要： Compounds having the formula are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.
摘要翻译： 具有该式的化合物可用于抑制蛋白酪氨酸激酶。 本发明还公开了制备化合物的方法，含有该化合物的组合物和使用该化合物的处理方法。
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公开(公告)号：US06235786B1
公开(公告)日：2001-05-22
申请号：US09492718
申请日：2000-01-27
申请人： Yujia Dai , Steven K. Davidsen , Michael R. Michaelides , Jamie R. Stacey , Douglas H. Steinman , Carol K. Wada
发明人： Yujia Dai , Steven K. Davidsen , Michael R. Michaelides , Jamie R. Stacey , Douglas H. Steinman , Carol K. Wada
IPC分类号： C07C31750
CPC分类号： C07C317/28 , C07C317/40 , C07C2601/14
摘要： Compounds having the formula are matrix metalloproteinase inhibitors. Also disclosed are matrix metalloproteinase-inhibiting compositions and methods of inhibiting matrix metalloproteinase in a mammal.
摘要翻译： 具有式基质金属蛋白酶抑制剂的化合物。 还公开了抑制哺乳动物基质金属蛋白酶的基质金属蛋白酶抑制组合物和抑制基质金属蛋白酶的方法。
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