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1.发明申请PYRROLOTRIAZINE DERIVATIVES USEFUL FOR TREATING CANCER THROUGH INHIBITION OF AURORA KINASE 有权用于通过抑制激素激酶治疗癌症的吡咯烷酮衍生物公开(公告)号：US20100273800A1
公开(公告)日：2010-10-28
申请号：US12679787
申请日：2008-09-22
申请人： Steven Magnuson , Philip Wickens , Zhonghua Zhang , Ning Qi , Xin Ma
发明人： Steven Magnuson , Philip Wickens , Zhonghua Zhang , Ning Qi , Xin Ma
IPC分类号： A61K31/53 , C07D253/10 , C12N9/99 , A61P35/00 , A61J1/05
CPC分类号： C07D487/04
摘要： This invention relates to novel compounds and processes for their preparation, methods of treating diseases, particularly Cancer, comprising administering said compounds, and methods of making pharmaceutical compositions for the treatment or prevention of disorders, particularly Cancer.
摘要翻译： 本发明涉及新化合物及其制备方法，治疗疾病，特别是癌症的方法，包括给药所述化合物，以及制备用于治疗或预防病症，特别是癌症的药物组合物的方法。
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2.发明授权公开(公告)号：US08138336B2
公开(公告)日：2012-03-20
申请号：US12679787
申请日：2008-09-22
申请人： Steven Magnuson , Philip Wickens , Zhonghua Zhang , Ning Qi , Xin Ma
发明人： Steven Magnuson , Philip Wickens , Zhonghua Zhang , Ning Qi , Xin Ma
IPC分类号： C07D487/04 , C07D417/02 , C07D413/02 , A61K31/53 , A61P35/00
CPC分类号： C07D487/04
摘要： This invention relates to novel compounds and processes for their preparation, methods of treating diseases, particularly Cancer, comprising administering said compounds, and methods of making pharmaceutical compositions for the treatment or prevention of disorders, particularly Cancer.
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3.发明申请PYRROLOTRIAZINE DERIVATIVES USEFUL FOR TREATING CANCER THROUGH INHIBITION OF AURORA KINASE 有权用于通过抑制激素激酶治疗癌症的吡咯烷酮衍生物公开(公告)号：US20110021518A1
公开(公告)日：2011-01-27
申请号：US12085850
申请日：2006-12-01
申请人： Steven Magnuson , Julie Dixon , Barton Phillips , Uday Khire , Lei Wang , Zhonghua Zhang , Manoj Patel , Ellalahewage Sathyajith Kumarasinghe , Philip Wickens , Alan Olague
发明人： Steven Magnuson , Julie Dixon , Barton Phillips , Uday Khire , Lei Wang , Zhonghua Zhang , Manoj Patel , Ellalahewage Sathyajith Kumarasinghe , Philip Wickens , Alan Olague
IPC分类号： A61K31/5377 , C07D487/04 , A61K31/53 , C07D413/14 , A61P35/00
CPC分类号： C07D487/04 , C07D519/00
摘要： This invention relates to novel compounds and processes for their preparation, methods of treating diseases, particularly Cancer, comprising administering said compounds, and methods of making pharmaceutical compositions for the treatment or prevention of disorders, particularly Cancer.
摘要翻译： 本发明涉及新化合物及其制备方法，治疗疾病，特别是癌症的方法，包括给药所述化合物，以及制备用于治疗或预防病症，特别是癌症的药物组合物的方法。
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4.发明申请公开(公告)号：US20050192294A1
公开(公告)日：2005-09-01
申请号：US11064700
申请日：2005-02-24
申请人： Joachim Rudolph , Philip Wickens , Chih-Yuan Chuang , Libing Chen , Steven Magnuson , Alan Olague , Ning Qi
发明人： Joachim Rudolph , Philip Wickens , Chih-Yuan Chuang , Libing Chen , Steven Magnuson , Alan Olague , Ning Qi
IPC分类号： A61K31/4155 , A61K31/4439 , A61K31/506 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/14 , C07D43/02
CPC分类号： C07D401/12 , C07D403/12 , C07D405/12 , C07D409/14
摘要： The present invention relates to heteroarylaminopyrazole compounds, pharmaceutical compositions, and methods for treating diabetes and related disorders.
摘要翻译： 本发明涉及杂芳基氨基吡唑化合物，药物组合物和治疗糖尿病和相关疾病的方法。
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5.发明授权Pyrrolotriazine derivatives useful for treating cancer through inhibition of aurora kinase 有权用于通过抑制极光激酶治疗癌症的吡咯嗪衍生物公开(公告)号：US08338594B2
公开(公告)日：2012-12-25
申请号：US12085850
申请日：2006-12-01
申请人： Steven Magnuson , Julie Dixon , Barton Phillips , Uday Khire , Lei Wang , Zhonghua Zhang , Manoj Patel , Ellalahewage Sathyajith Kumarasinghe , Philip Wickens , Alan Olague
发明人： Steven Magnuson , Julie Dixon , Barton Phillips , Uday Khire , Lei Wang , Zhonghua Zhang , Manoj Patel , Ellalahewage Sathyajith Kumarasinghe , Philip Wickens , Alan Olague
IPC分类号： C07D487/04 , C07D401/14 , C07D403/14 , A61K31/53 , A61P35/00
CPC分类号： C07D487/04 , C07D519/00
摘要： This invention relates to novel compounds and processes for their preparation, methods of treating diseases, particularly Cancer, comprising administering said compounds, and methods of making pharmaceutical compositions for the treatment or prevention of disorders, particularly Cancer.
摘要翻译： 本发明涉及新化合物及其制备方法，治疗疾病，特别是癌症的方法，包括给药所述化合物，以及制备用于治疗或预防病症，特别是癌症的药物组合物的方法。
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公开(公告)号：US20080064734A1
公开(公告)日：2008-03-13
申请号：US11897620
申请日：2007-08-31
申请人： Joachim Rudolph , Louis-David Cantin , Steven Magnuson , William Bullock , Ann-Marie Bullion , Libing Chen , Chih-Yuan Chuang , Sidney Liang , Dyuti Majumdar , Herbert Ogutu , Alan Olague , Ning Qi , Philip Wickens
发明人： Joachim Rudolph , Louis-David Cantin , Steven Magnuson , William Bullock , Ann-Marie Bullion , Libing Chen , Chih-Yuan Chuang , Sidney Liang , Dyuti Majumdar , Herbert Ogutu , Alan Olague , Ning Qi , Philip Wickens
IPC分类号： A61K31/415 , A61P3/04 , C07D231/10
CPC分类号： C07D231/38 , C07D401/04 , C07D403/12 , C07D413/12 , C07D471/04
摘要： The present invention relates to anilinopyrazole compounds, pharmaceutical compositions, and methods for treating diabetes and related disorders.
摘要翻译： 本发明涉及苯胺基吡唑化合物，药物组合物和治疗糖尿病及相关疾病的方法。
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7.发明授权公开(公告)号：US07517878B2
公开(公告)日：2009-04-14
申请号：US11064700
申请日：2005-02-24
申请人： Joachim Rudolph , Philip Wickens , Chih-Yuan Chuang , Libing Chen , Steven Magnuson , Alan Olague , Ning Qi
发明人： Joachim Rudolph , Philip Wickens , Chih-Yuan Chuang , Libing Chen , Steven Magnuson , Alan Olague , Ning Qi
IPC分类号： C07D403/12 , A61K31/4155
CPC分类号： C07D401/12 , C07D403/12 , C07D405/12 , C07D409/14
摘要： The present invention relates to heteroarylaminopyrazole compounds, pharmaceutical compositions, and methods for treating diabetes and related disorders.
摘要翻译： 本发明涉及杂芳基氨基吡唑化合物，药物组合物和治疗糖尿病和相关疾病的方法。
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公开(公告)号：US20060205723A1
公开(公告)日：2006-09-14
申请号：US11429136
申请日：2006-05-05
申请人： Derek Lowe , Philip Wickens , Xin Ma , Mingbao Zhang , William Bullock , Philip Coish , Ingo Mugge , Andreas Stolle , Ming Wang , Yamin Wang , Chengzhi Zhang , Hai-Jun Zhang , Lei Zhu , Manami Tsutsumi , James Livingston
发明人： Derek Lowe , Philip Wickens , Xin Ma , Mingbao Zhang , William Bullock , Philip Coish , Ingo Mugge , Andreas Stolle , Ming Wang , Yamin Wang , Chengzhi Zhang , Hai-Jun Zhang , Lei Zhu , Manami Tsutsumi , James Livingston
IPC分类号： A61K31/5377 , A61K31/497 , A61K31/496
CPC分类号： C07D277/32 , C07B2200/07 , C07C51/412 , C07C51/44 , C07C59/72 , C07C67/303 , C07C69/732 , C07C69/734 , C07C69/738 , C07C2602/08 , C07D263/32 , C07D277/24 , C07D277/40 , C07D413/04 , C07D413/10 , C07D413/12 , Y02P20/582
摘要： This invention relates to novel indane acetic acid derivatives which are useful in the treatment of diseases such as diabetes, obesity, hyperlipidemia, and atherosclerotic diseases. The invention also relates to intermediates useful in preparation of indane acetic derivatives and to methods of preparation.
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9.发明申请Indane acetic acid derivatives and their use as pharmaceutical agents, intermediates, and method of preparation 有权茚基乙酸衍生物及其作为药剂，中间体和制备方法的用途公开(公告)号：US20050075338A1
公开(公告)日：2005-04-07
申请号：US10949119
申请日：2004-09-22
申请人： Derek Lowe , Philip Wickens , Xin Ma , Mingbao Zhang , William Bullock , Philip Coish , Ingo Mugge , Andreas Stolle , Ming Wang , Yamin Wang , Chengzhi Zhang , Hai-Jun Zhang , Lei Zhu , Manami Tsutsumi , James Livingston
发明人： Derek Lowe , Philip Wickens , Xin Ma , Mingbao Zhang , William Bullock , Philip Coish , Ingo Mugge , Andreas Stolle , Ming Wang , Yamin Wang , Chengzhi Zhang , Hai-Jun Zhang , Lei Zhu , Manami Tsutsumi , James Livingston
IPC分类号： C12Q1/02 , A61K31/155 , A61K31/421 , A61K31/422 , A61K31/426 , A61K31/427 , A61K31/4439 , A61K31/454 , A61K31/64 , A61K38/28 , A61K45/00 , A61P3/04 , A61P3/06 , A61P3/10 , A61P5/24 , A61P9/00 , A61P9/10 , A61P9/12 , A61P9/14 , A61P15/00 , A61P17/02 , A61P29/00 , A61P35/00 , A61P37/06 , A61P39/06 , A61P43/00 , C07B57/00 , C07B61/00 , C07C51/41 , C07C51/44 , C07C59/72 , C07C69/732 , C07C69/734 , C07C69/736 , C07C69/738 , C07C237/36 , C07D263/32 , C07D277/20 , C07D277/24 , C07D277/28 , C07D277/30 , C07D277/32 , C07D277/40 , C07D413/04 , C07D413/10 , C07D413/12 , C07D417/04 , C07D417/02 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/541 , C07D413/02
CPC分类号： C07D277/32 , C07B2200/07 , C07C51/412 , C07C51/44 , C07C59/72 , C07C67/303 , C07C69/732 , C07C69/734 , C07C69/738 , C07C2602/08 , C07D263/32 , C07D277/24 , C07D277/40 , C07D413/04 , C07D413/10 , C07D413/12 , Y02P20/582
摘要： This invention relates to novel indane acetic acid derivatives which are useful in the treatment of diseases such as diabetes, obesity, hyperlipidemia, and atherosclerotic diseases. The invention also relates to intermediates useful in preparation of indane acetic derivatives and to methods of preparation.
摘要翻译： 本发明涉及可用于治疗疾病如糖尿病，肥胖症，高脂血症和动脉粥样硬化疾病的新型茚满乙酸衍生物。 本发明还涉及可用于制备茚满乙酸衍生物的中间体及其制备方法。
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公开(公告)号：US20060084680A1
公开(公告)日：2006-04-20
申请号：US10537630
申请日：2003-12-19
申请人： Louis-David Cantin , Soongyu Choi , Roger Clark , Martin Hentemann , Xin Ma , Joachim Rudolph , Sidney Liang , Christiana Akuche , Rico Lavoie , Libing Chen , Dyuti Majumdar , Philip Wickens
发明人： Louis-David Cantin , Soongyu Choi , Roger Clark , Martin Hentemann , Xin Ma , Joachim Rudolph , Sidney Liang , Christiana Akuche , Rico Lavoie , Libing Chen , Dyuti Majumdar , Philip Wickens
IPC分类号： A61K31/445 , A61K31/195 , A61K31/192
CPC分类号： C07D213/30 , C07C59/72 , C07C59/90 , C07C69/734 , C07C211/48 , C07C217/24 , C07C255/54 , C07C327/48 , C07C333/04 , C07C2602/08 , C07D209/08 , C07D213/63 , C07D213/83 , C07D213/84 , C07D215/20 , C07D231/12 , C07D239/26 , C07D239/42 , C07D239/46 , C07D239/47 , C07D239/52 , C07D249/06 , C07D249/08 , C07D261/20 , C07D263/32 , C07D263/56 , C07D277/24 , C07D277/34 , C07D277/56 , C07D277/64 , C07D277/66 , C07D285/08 , C07D307/42 , C07D307/79 , C07D333/16 , C07D405/04 , C07D417/04 , C07D513/04
摘要： This invention relates to novel indane acetic acid derivatives which are useful in the treatment of diseases such as diabetes, obesity, hyperlipidemia, and atherosclerotic diseases. The invention also relates to intermediates useful in preparation of indane acetic derivatives and to methods of preparation.
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