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1.发明申请Substituted 4h-chromens, 2h-chromenes, chromans and analogs as activators of caspases and inducers of apoptosis and the use thereof 失效作为胱天蛋白酶的活化剂和细胞凋亡诱导剂的取代的4h-色调，2h-色烯，着色剂和类似物及其用途公开(公告)号：US20050176750A1
公开(公告)日：2005-08-11
申请号：US10514426
申请日：2003-05-16
申请人： Sui Cai , Songchun Jiang , Giorgio Attardo , Real Denis , Richard Storer , Rabindra Rej
发明人： Sui Cai , Songchun Jiang , Giorgio Attardo , Real Denis , Richard Storer , Rabindra Rej
IPC分类号： A61K31/353 , A61K31/407 , A61K31/4188 , A61K31/4741 , C07D311/04 , C07D311/74 , C07D311/76
CPC分类号： C07D311/04 , C07D311/74 , C07D311/76
摘要： The present invention is directed to substituted 4H-chromenes, 2H-chromenes, chromans and analogs thereof, represented by the general Formula (I) wherein R5, A, B, X, Y, Z and dotted lines are defined herein. The present invention also relates to the discovery that compounds having Formula (I) are activators of caspases and inducers of apoptosis. Therefore, the activators of caspases and inducers of apoptosis of this invention can be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.
摘要翻译： 本发明涉及由通式（I）表示的取代的4H-色烯，2H-色烯，着色剂及其类似物，其中R 5，A，B，X，Y，Z和虚线 线条在本文中定义。 本发明还涉及具有式（I）的化合物是胱天蛋白酶的激活剂和凋亡诱导剂的发现。 因此，本发明的胱天蛋白酶和细胞凋亡诱导剂的激活剂可用于诱导异常细胞发生不受控制的生长和扩散的各种临床病症中的细胞死亡。
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![Substituted 4-aryl-4h-pyrrolo[2,3-h]chromenes and analogs as activators of caspases and inducers of apoptosis and the use thereof](/abs-image/US/2006/05/18/US20060104998A1/abs.jpg.150x150.jpg)
2.发明申请Substituted 4-aryl-4h-pyrrolo[2,3-h]chromenes and analogs as activators of caspases and inducers of apoptosis and the use thereof 失效取代的4-芳基-4H-吡咯并[2,3-h]色烯和类似物作为胱天蛋白酶的激活剂和凋亡诱导剂及其用途公开(公告)号：US20060104998A1
公开(公告)日：2006-05-18
申请号：US10514427
申请日：2003-05-16
申请人： Sui Cai , Songchun Jiang , William Kemnitzer , Hong Zhang , Giorgio Attardo , Real Denis
发明人： Sui Cai , Songchun Jiang , William Kemnitzer , Hong Zhang , Giorgio Attardo , Real Denis
IPC分类号： A61K31/724 , A61K31/498 , A61K31/497 , A61K31/4439 , A61K31/407 , C07D491/02
CPC分类号： C07D491/04
摘要： The present invention is directed to substituted 4H-chromenes and analogs thereof, represented by the Formula (I): wherein R1, R3-R5, A, D, Y and Z are defined herein. The present invention also relates to the discovery that compounds having Formula (I) are activators of caspases and inducers of apoptosis. Therefore, the activators of caspases and inducers of apoptosis of this invention can be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.
摘要翻译： 本发明涉及由式（I）表示的取代的4H-色烯及其类似物：其中R 1，R 3，R 5， SUP，A，D，Y和Z在本文中定义。 本发明还涉及具有式（I）的化合物是胱天蛋白酶的激活剂和凋亡诱导剂的发现。 因此，本发明的胱天蛋白酶和细胞凋亡诱导剂的激活剂可用于诱导异常细胞发生不受控制的生长和扩散的各种临床病症中的细胞死亡。
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公开(公告)号：US20050256034A1
公开(公告)日：2005-11-17
申请号：US11149193
申请日：2005-06-10
申请人： Giorgio Attardo , Boulos Zacharie , Rabindra Rej , Jean-Francois Lavallee , Louis Vaillancourt , Real Denis , Sophie Levesque
发明人： Giorgio Attardo , Boulos Zacharie , Rabindra Rej , Jean-Francois Lavallee , Louis Vaillancourt , Real Denis , Sophie Levesque
IPC分类号： A61K31/513 , A61K31/675 , A61K31/7068 , A61K38/00 , A61P35/00 , A61P35/02 , A61P43/00 , C07D405/04 , C07D405/14 , C07D473/18 , C07F9/655 , C07F9/6558 , C07F9/6561 , C07K5/06 , C07K5/08 , C07K5/10 , C07K7/06 , A61K38/16
CPC分类号： C07D405/04 , C07D473/18 , C07F9/65515 , C07F9/65586 , C07F9/65616
摘要： Dioxolane analogs of the following formula: wherein R1 and R2 are defined herein, are useful in the treatment of cancer. For example, the compounds can be used to treat patients with cancer in which the cancer cells are deficient in nucleoside or nucleoside base transporters.
摘要翻译： 下式的二氧杂环戊烷类似物：其中R1和R2如本文所定义，可用于治疗癌症。 例如，这些化合物可用于治疗癌细胞中核苷或核苷碱基转运蛋白缺乏的癌症患者。
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![Substituted 4-aryl-4h-pyrrolo[2,3-h]chromenes and analogs as activators of caspases and inducers of apoptosis and the use thereof](/abs-image/US/2009/05/05/US07528164B2/abs.jpg.150x150.jpg)
4.发明授权Substituted 4-aryl-4h-pyrrolo[2,3-h]chromenes and analogs as activators of caspases and inducers of apoptosis and the use thereof 失效取代的4-芳基-4H-吡咯并[2,3-h]色烯和类似物作为胱天蛋白酶的激活剂和凋亡诱导剂及其用途公开(公告)号：US07528164B2
公开(公告)日：2009-05-05
申请号：US10514427
申请日：2003-05-16
申请人： Sui Xiong Cai , Songchun Jiang , William E. Kemnitzer , Hong Zhang , Giorgio Attardo , Real Denis
发明人： Sui Xiong Cai , Songchun Jiang , William E. Kemnitzer , Hong Zhang , Giorgio Attardo , Real Denis
IPC分类号： A61K31/407
CPC分类号： C07D491/04
摘要： The present invention is directed to substituted 4H-chromenes and analogs thereof, represented by the Formula (I): wherein R1, R3-R5, A, D, Y and Z are defined herein. The present invention also relates to the discovery that compounds having Formula (I) are activators of caspases and inducers of apoptosis. Therefore, the activators of caspases and inducers of apoptosis of this invention can be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.
摘要翻译： 本发明涉及由式（I）表示的取代的4H-色烯及其类似物：其中R1，R3-R5，A，D，Y和Z如本文所定义。 本发明还涉及具有式（I）的化合物是胱天蛋白酶的激活剂和凋亡诱导剂的发现。 因此，本发明的胱天蛋白酶和细胞凋亡诱导剂的激活剂可用于诱导异常细胞发生不受控制的生长和扩散的各种临床病症中的细胞死亡。
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5.发明申请Compounds and Methods for the Treatment or Prevention of Flavivirus Infections 失效用于治疗或预防黄病毒感染的化合物和方法公开(公告)号：US20120164103A1
公开(公告)日：2012-06-28
申请号：US13416565
申请日：2012-03-09
申请人： Real Denis , Carl Poisson , Sanjoy Kumar Das , Irina Motorina , Rabindra Rej , Constantin G. Yannopoulos , Laval Chan Chun Kong
发明人： Real Denis , Carl Poisson , Sanjoy Kumar Das , Irina Motorina , Rabindra Rej , Constantin G. Yannopoulos , Laval Chan Chun Kong
IPC分类号： A61K31/381 , C07D413/12 , C07D409/12 , C07D409/14 , A61K31/5377 , A61K31/4196 , A61K31/4535 , A61K31/41 , A61K31/4184 , A61K31/506 , A61K31/4545 , A61K39/00 , A61K31/7088 , A61K38/21 , A61K38/20 , A61K38/13 , A61K31/7056 , A61K38/22 , A61K39/12 , A61P31/14 , C07D409/08 , C07D471/04 , A61K31/437 , A61K36/28 , A61K31/7105 , A61P37/04 , A61P1/16 , A61P37/02 , C07D333/38
CPC分类号： C07D471/04 , C07D333/38 , C07D409/04 , C07D409/12 , C07D409/14
摘要： Compounds represented by formula I: or pharmaceutically acceptable salts and solvates thereof, wherein R1, X, Y, Y1, and Z are as defined herein, are useful for treating flaviviridae viral infections.
摘要翻译： 由式I表示的化合物或其药学上可接受的盐和溶剂化物，其中R 1，X，Y，Y 1和Z如本文所定义，可用于治疗黄病毒科病毒感染。
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6.发明授权Compounds and methods for the treatment or prevention of Flavivirus infections 失效用于治疗或预防黄病毒感染的化合物和方法公开(公告)号：US08158675B2
公开(公告)日：2012-04-17
申请号：US12508893
申请日：2009-07-24
申请人： Real Denis , Carl Poisson , Sanjoy Kumar Das , Irina Motorina , Rabindra Rej , Constantin G. Yannopoulos , Laval Chan Chun Kong
发明人： Real Denis , Carl Poisson , Sanjoy Kumar Das , Irina Motorina , Rabindra Rej , Constantin G. Yannopoulos , Laval Chan Chun Kong
IPC分类号： A61K31/38 , C07D333/42
CPC分类号： C07D471/04 , C07D333/38 , C07D409/04 , C07D409/12 , C07D409/14
摘要： Compounds represented by formula I: or pharmaceutically acceptable salts and solvates thereof, wherein R1, X, Y, Y1, and Z are as defined herein, are useful for treating flaviviridae viral infections.
摘要翻译： 由式I表示的化合物或其药学上可接受的盐和溶剂合物，其中R1，X，Y，Y1和Z如本文所定义，可用于治疗黄病毒科病毒感染。
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7.发明授权Compounds and methods for the treatment of prevention of Flavivirus infections 失效用于治疗预防黄病毒感染的化合物和方法公开(公告)号：US07569600B2
公开(公告)日：2009-08-04
申请号：US11433749
申请日：2006-05-15
申请人： Real Denis , Carl Poisson , Sanjoy Kumar Das , Irina Motorina , Rabindra Rej , Constantin G. Yannopoulos , Laval Chan Chun Kong
发明人： Real Denis , Carl Poisson , Sanjoy Kumar Das , Irina Motorina , Rabindra Rej , Constantin G. Yannopoulos , Laval Chan Chun Kong
IPC分类号： A61K31/38 , C07D333/42
CPC分类号： C07D471/04 , C07D333/38 , C07D409/04 , C07D409/12 , C07D409/14
摘要： Compounds represented by formula I: or pharmaceutically acceptable salts and solvates thereof, wherein R1, X, Y, Y1, and Z are as defined herein, are useful for treating flaviviridae viral infections.
摘要翻译： 由式I表示的化合物或其药学上可接受的盐和溶剂化物，其中R 1，X，Y，Y 1和Z如本文所定义，可用于治疗黄病毒科病毒感染。
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8.发明申请Compounds and methods for the treatment or prevention of Flavivirus infections 失效用于治疗或预防黄病毒感染的化合物和方法公开(公告)号：US20060276533A1
公开(公告)日：2006-12-07
申请号：US11433749
申请日：2006-05-15
申请人： Real Denis , Carl Poisson , Sanjoy Das , Irina Motorina , Rabindra Rej , Constantin Yannopoulos , Laval Chan Chun Kong
发明人： Real Denis , Carl Poisson , Sanjoy Das , Irina Motorina , Rabindra Rej , Constantin Yannopoulos , Laval Chan Chun Kong
IPC分类号： A61K31/381 , C07D333/42
CPC分类号： C07D471/04 , C07D333/38 , C07D409/04 , C07D409/12 , C07D409/14
摘要： Compounds represented by formula I: or pharmaceutically acceptable salts and solvates thereof, wherein R1, X, Y, Y1, and Z are as defined herein, are useful for treating flaviviridae viral infections.
摘要翻译： 由式I表示的化合物或其药学上可接受的盐和溶剂合物，其中R 1，X，Y，Y 1和Z如本文所定义，可用于治疗 黄病毒感染。
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9.发明授权Compounds and methods for the treatment or prevention of flavivirus infections 失效用于治疗或预防黄病毒感染的化合物和方法公开(公告)号：US08674118B2
公开(公告)日：2014-03-18
申请号：US13416565
申请日：2012-03-09
申请人： Real Denis , Carl Poisson , Sanjoy Kumar Das , Irina Motorina , Rabindra Rej , Constantin G. Yannopoulos , Laval Chan Chun Kong
发明人： Real Denis , Carl Poisson , Sanjoy Kumar Das , Irina Motorina , Rabindra Rej , Constantin G. Yannopoulos , Laval Chan Chun Kong
IPC分类号： C07D409/00
CPC分类号： C07D471/04 , C07D333/38 , C07D409/04 , C07D409/12 , C07D409/14
摘要： Compounds represented by formula I: or pharmaceutically acceptable salts and solvates thereof, wherein R1, X, Y, Y1, and Z are as defined herein, are useful for treating flaviviridae viral infections.
摘要翻译： 由式I表示的化合物或其药学上可接受的盐和溶剂合物，其中R1，X，Y，Y1和Z如本文所定义，可用于治疗黄病毒科病毒感染。
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10.发明授权公开(公告)号：US08658674B2
公开(公告)日：2014-02-25
申请号：US13571659
申请日：2012-08-10
申请人： Laval Chan Chun Kong , Sanjoy Kumar Das , Carl Poisson , Constantin G. Yannopoulos , Guy Falardeau , Louis Vaillancourt , Real Denis
发明人： Laval Chan Chun Kong , Sanjoy Kumar Das , Carl Poisson , Constantin G. Yannopoulos , Guy Falardeau , Louis Vaillancourt , Real Denis
IPC分类号： A61K31/4453 , C07D409/12
CPC分类号： C07F7/0812 , A61K38/005 , A61K38/21 , C07D333/38 , C07D333/40 , C07D409/12 , A61K2300/00
摘要： Compounds represented by formula I: or pharmaceutically acceptable salts and solvates thereof, wherein R1, X, Y, and Z are as defined herein, are useful for treating flaviviridae viral infections.
摘要翻译： 由式I表示的化合物或其药学上可接受的盐和溶剂化物，其中R1，X，Y和Z如本文所定义，可用于治疗黄病毒科病毒感染。
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