公开(公告)号：US08637667B2

公开(公告)日：2014-01-28

申请号：US13382265

申请日：2010-07-07

Applicant: Young Lag Cho ,  Jong Un Cho ,  Sung Yoon Baek ,  Ho Young Song ,  Tae Kyo Park ,  Sung Ho Woo ,  Yong Zu Kim

Inventor： Young Lag Cho ,  Jong Un Cho ,  Sung Yoon Baek ,  Ho Young Song ,  Tae Kyo Park ,  Sung Ho Woo ,  Yong Zu Kim

IPC: C07D413/02 ,  C07D413/04 ,  C07D273/04

CPC classification number: C07D413/14 ,  C07D413/12

Abstract: Provided is a method for preparing (S)-5-chloro-N-((3-(4-(5,6-dihydro-4H-1,2,4-oxadiazin-3-yl)phenyl)-2-oxooxazolidin-5-yl)methyl)thiophene-2-carboxamide derivatives of Formula (I) which are useful as blood coagulation factor Xa inhibitors, and said method using 1-fluoro-4-nitrobenzen as a starting material. According to the method of the present invention, (S)-5-chloro-N-((3-(4-(5,6-dihydro-4H-1,2,4-oxadiazin-3-yl)phenyl)-2-oxooxazolidin-5-yl)methyl)thiophene-2-carboxamide derivatives of Formula (I) which are useful as blood coagulation factor Xa inhibitors can be prepared in a high purity and a high yield.

Abstract translation: 提供制备（S）-5-氯-N - （（3-（4-（5,6-二氢-4H-1,2,4-恶二嗪-3-基）苯基）-2-氧代恶唑烷 -5-基）甲基）噻吩-2-甲酰胺衍生物，所述方法使用1-氟-4-硝基苯作为原料，所述方法可用作凝血因子Xa抑制剂。 根据本发明的方法，（S）-5-氯-N - （（3-（4-（5,6-二氢-4H-1,2,4-恶二嗪-3-基）苯基） - 可用作凝血因子Xa抑制剂的式（I）的噻吩-2-甲酰胺衍生物可以以高纯度和高产率制备。

公开(公告)号：US08178525B2

公开(公告)日：2012-05-15

申请号：US13002271

申请日：2009-06-05

Applicant: Ho Young Song ,  Young Lag Cho ,  Dae Yon Lee ,  Hee Sock Park ,  Sung Yoon Baek ,  Sang Eun Chae ,  Sang Hui Jo ,  Yeon Ok Kim ,  Hyang Sook Lee ,  Ju Hyun Park ,  Tae Kyo Park ,  Sung Ho Woo ,  Yong Zu Kim

Inventor： Ho Young Song ,  Young Lag Cho ,  Dae Yon Lee ,  Hee Sock Park ,  Sung Yoon Baek ,  Sang Eun Chae ,  Sang Hui Jo ,  Yeon Ok Kim ,  Hyang Sook Lee ,  Ju Hyun Park ,  Tae Kyo Park ,  Sung Ho Woo ,  Yong Zu Kim

IPC: C07D413/12 ,  C07D413/14 ,  C07D487/04 ,  A61K31/5395 ,  A61K31/53

CPC classification number: C07D413/14 ,  C07D487/04

Abstract: Disclosed are novel oxazolidinone derivatives with cyclic amidoxime or cyclic amidrazone group, pharmaceutically acceptable salts thereof, methods for preparing the same and pharmaceutical compositions containing the same. The oxazolidinone derivatives with cyclic amidoxime or cyclic amidrazone group or the pharmaceutically acceptable salts thereof can be effectively used for the treatment of thromboembolism and tumor as an anticoagulant based on the inhibition of factor Xa.

Abstract translation: 公开了具有环状偕胺肟或环状氨基腙基团的新型恶唑烷酮衍生物，其药学上可接受的盐，其制备方法和含有它们的药物组合物。 具有环偕胺肟或环状氨基腙基的恶唑烷酮衍生物或其药学上可接受的盐可以有效地用于基于对因子Xa的抑制作为抗凝血剂治疗血栓栓塞和肿瘤。

公开(公告)号：US07920073B2

公开(公告)日：2011-04-05

申请号：US11782485

申请日：2007-07-24

Applicant: Sung Ho Woo ,  Jun Jeong Lee ,  Seon Hui Kim

Inventor： Sung Ho Woo ,  Jun Jeong Lee ,  Seon Hui Kim

IPC: G08G1/123

CPC classification number: G08G1/092 ,  G08G1/093

Abstract: A method and terminal for receiving and processing traffic information and a method and apparatus for providing the traffic information, where the method for receiving traffic information includes reading region information included in received traffic information, determining whether a first region indicated by the region information overlaps with a second region corresponding to location information on which traffic information is desired, and decoding the traffic information including the region information indicating the first region if the determination result indicates that the first and second regions overlap.

Abstract translation: 一种用于接收和处理交通信息的方法和终端，以及用于提供交通信息的方法和装置，其中用于接收交通信息的方法包括：读取接收到的交通信息中包含的区域信息，确定区域信息指示的第一区域是否与 对应于期望交通信息的位置信息的第二区域，以及如果所述确定结果指示所述第一和第二区域重叠，则解码包括指示所述第一区域的区域信息的交通信息。

公开(公告)号：US20080229377A1

公开(公告)日：2008-09-18

申请号：US11924521

申请日：2007-10-25

Applicant: Sung Ho Woo ,  Jae Do Kwak

Inventor： Sung Ho Woo ,  Jae Do Kwak

IPC: H04N7/00

CPC classification number: H04N5/50 ,  H04N5/64 ,  H04N5/782 ,  H04N21/41407 ,  H04N21/4334 ,  H04N21/44209 ,  H04N21/458 ,  H04N21/47214 ,  H04N21/4882 ,  H04N21/64322 ,  H04N21/84

Abstract: A method for displaying broadcast content in a portable electronic device includes identifying a priority channel to be displayed on a display associated with the electronic device, indicating that the priority channel is no longer available, and displaying content associated with a current channel which differs from the priority channel. The method further includes indicating that the priority channel is available for displaying on the display, and switching a displayed channel of the display from the current channel to the priority channel.

Abstract translation: 一种用于在便携式电子设备中显示广播内容的方法包括：识别要在与电子设备相关联的显示器上显示的优先级信道，指示优先级信道不再可用，并且显示与当前信道不相关的内容 优先渠道。 该方法还包括指示优先级信道可用于在显示器上显示，并将显示的显示频道从当前频道切换到优先级信道。

公开(公告)号：US6162107A

公开(公告)日：2000-12-19

申请号：US475117

申请日：1999-12-30

Applicant: Sung Ho Woo

Inventor： Sung Ho Woo

IPC: H01J9/02 ,  H01J9/20 ,  H01J9/24 ,  H01J11/12 ,  H01J11/22 ,  H01J11/24 ,  H01J11/26 ,  H01J11/34 ,  H01J11/44 ,  H01J9/00

CPC classification number: H01J11/12 ,  H01J9/02 ,  H01J9/241 ,  H01J2211/24 ,  H01J2211/446

Abstract: A process of fabricating a front substrate in a color display panel that is adapted to form transparent electrodes and transparent conductive films in a plasma display panel. In the process, a liquid-state transparent conductive material is entirely formed on both the front side and the rear side of the substrate. Next, any one of the transparent conductive material films formed on the front side and rear side thereof is patterned.

Abstract translation: 在彩色显示面板中制造适于在等离子体显示面板中形成透明电极和透明导电膜的前基板的工艺。 在该过程中，液态透明导电材料完全形成在基板的正面和背面。 接下来，对形成在其前侧和后侧的透明导电材料膜中的任何一个进行图案化。

公开(公告)号：US08809541B2

公开(公告)日：2014-08-19

申请号：US13818355

申请日：2011-08-25

Applicant: Hyung Sub Gwak ,  Yong Zu Kim ,  Uk Il Kim ,  Byeong Deog Park ,  Tae Kyo Park ,  Sung Ho Woo ,  Joung Yul Yun ,  Dae Yon Lee ,  Hyang Sook Lee ,  Jeong Eun Jeon ,  Se Kyoo Jeong ,  Hyung Mook Choi

Inventor： Hyung Sub Gwak ,  Yong Zu Kim ,  Uk Il Kim ,  Byeong Deog Park ,  Tae Kyo Park ,  Sung Ho Woo ,  Joung Yul Yun ,  Dae Yon Lee ,  Hyang Sook Lee ,  Jeong Eun Jeon ,  Se Kyoo Jeong ,  Hyung Mook Choi

IPC: A61K31/497 ,  C07D211/32 ,  A61Q19/00 ,  A61K8/49 ,  C07D471/04 ,  C07D235/08

CPC classification number: C07D235/08 ,  A61K8/4946 ,  A61Q19/00 ,  A61Q19/007 ,  A61Q19/008 ,  C07D471/04

Abstract: Provided are heterocyclic compounds, having effects of treating and preventing inflammatory diseases and treating skin wounds, and particularly, exhibiting effects of recovering disrupted skin barriers, mitigating inflammation, and pruritus. Also, a composition containing the compound as an effective component can be used to mitigate various inflammatory diseases and protease activated receptor-2 (PAR-2)-overexpressed diseases, and can be particularly used as a composition having an anti-inflammatory function in inflammatory skin diseases including atopic dermatitis and the like, by inhibiting PAR-2 activity.

Abstract translation: 提供具有治疗和预防炎性疾病和治疗皮肤伤口的作用的杂环化合物，特别是显示恢复破坏的皮肤屏障，减轻炎症和瘙痒的作用。 此外，含有该化合物作为有效成分的组合物可用于缓解各种炎性疾病和蛋白酶活化受体-2（PAR-2） - 去表达疾病，并且可特别用作具有炎性功能的组合物 皮肤病，包括特应性皮炎等，通过抑制PAR-2活性。

公开(公告)号：US20140179691A1

公开(公告)日：2014-06-26

申请号：US14008702

申请日：2012-03-29

Applicant: Young Lag Cho ,  Sung Yoon Baek ,  Sang Eun Chae ,  Sun Young Kim ,  Hong Bum Lee ,  Hyang Sook Lee ,  Kyuman Oh ,  Tae Kyo Park ,  Sung Ho Woo ,  Yong Zu Kim ,  Hye Jin Heo

Inventor： Young Lag Cho ,  Sung Yoon Baek ,  Sang Eun Chae ,  Sun Young Kim ,  Hong Bum Lee ,  Hyang Sook Lee ,  Kyuman Oh ,  Tae Kyo Park ,  Sung Ho Woo ,  Yong Zu Kim ,  Hye Jin Heo

IPC: C07D413/14

CPC classification number: C07D413/14

Abstract: Disclosed is a novel oxazolidinone derivative represented by Formula 1 above, in particular, a novel oxazolidinone compound having a cyclic amidoxime or cyclic amidrazone group.In Formula 1, R and Q are the same as defined in the detailed description.In addition, disclosed is a pharmaceutical composition for an antibiotic which includes the novel oxazolidinone derivative of Formula 1, a prodrug thereof, a hydrate thereof, a solvate thereof, an isomer thereof, or a pharmaceutically acceptable salt thereof as an active ingredient.The novel oxazolidinone derivative, the prodrug thereof, the hydrate thereof, the solvate thereof, the isomer thereof, and the pharmaceutically acceptable salt thereof have broad antibacterial spectrum against resistant bacteria, low toxicity and strong antibacterial effects against Gram-positive and Gram-negative bacteria and thus may be effectively used as antibiotics.

Abstract translation: 公开了上述通式1所示的新型恶唑烷酮衍生物，特别是具有环状偕胺肟或环状氨基腙基的新型恶唑烷酮化合物。 在式1中，R和Q与详细描述中定义相同。 此外，公开了一种抗生素的药物组合物，其包含式1的新型恶唑烷酮衍生物，其前药，其水合物，其溶剂合物，其异构体或其药学上可接受的盐作为活性成分。 新型恶唑烷酮衍生物，其前体药剂，其水合物，其溶剂合物，其异构体及其药学上可接受的盐具有抗抗性细菌的抗菌谱，对革兰氏阳性和革兰氏阴性菌具有低毒性和强抗菌作用 因此可以有效地用作抗生素。

公开(公告)号：US08703939B2

公开(公告)日：2014-04-22

申请号：US13583492

申请日：2011-03-08

Applicant: Young Lag Cho ,  Sung Yoon Baek ,  Sang Eun Chae ,  Hong Bum Lee ,  Tae Kyo Park ,  Sung Ho Woo ,  Yong Zu Kim

Inventor： Young Lag Cho ,  Sung Yoon Baek ,  Sang Eun Chae ,  Hong Bum Lee ,  Tae Kyo Park ,  Sung Ho Woo ,  Yong Zu Kim

IPC: C07D253/065 ,  C07D413/10 ,  C07D413/14

CPC classification number: C07D255/02 ,  C07D253/06 ,  C07D413/10

Abstract: Provided are a method for preparing (R)-3-(3-fluoro-4-(1-methyl-5, 6-dihydro-1,2,4-triazin-4(1H)-yl)phenyl)-5-(substituted methyl) oxazolidin-2-one derivatives, which are oxazolidinone antibiotic compounds having a cyclic amidrazone group, represented by Chemical Formula 1, and intermediates thereof, and uses 3,4-difluoro-4-nitrobenzen as a starting material. According to the preparation method of the present invention, (R)-3-(3-fluoro-4-(1-methyl-5, 6-dihydro-1,2,4-triazin-4(1H)-yl)phenyl)-5-(substituted methyl) oxazolidin-2-one derivatives, which are useful as oxazolidinone antibiotics, can be prepared in high purity and high yield in a simpler manner than conventional methods.

Abstract translation: 提供制备（R）-3-（3-氟-4-（1-甲基-5,6-二氢-1,2,4-三嗪-4（1H） - 基）苯基）-5- （取代甲基）恶唑烷-2-酮衍生物，它们是由化学式1表示的具有环状氨基腙基的恶唑烷酮类抗生素化合物及其中间体，并以3,4-二氟-4-硝基苯为起始原料。 根据本发明的制备方法，使用（R）-3-（3-氟-4-（1-甲基-5,6-二氢-1,2,4-三嗪-4（1H） - 基）苯基 ）-5-（取代的甲基）恶唑烷-2-酮衍生物可以以比常规方法更简单的方式以高纯度和高产率制备，其可用作恶唑烷酮抗生素。

公开(公告)号：US20110112083A1

公开(公告)日：2011-05-12

申请号：US13002271

申请日：2009-06-05

Applicant: Ho Young Song ,  Young Lag Cho ,  Dae Yon Lee ,  Hee Sock Park ,  Sung Yoon Baek ,  Sang Eun Chae ,  Sang Hui Jo ,  Yeon Ok Kim ,  Hyang Sook Lee ,  Ju Hyun Park ,  Tae Kyo Park ,  Sung Ho Woo ,  Yong Zu Kim

Inventor： Ho Young Song ,  Young Lag Cho ,  Dae Yon Lee ,  Hee Sock Park ,  Sung Yoon Baek ,  Sang Eun Chae ,  Sang Hui Jo ,  Yeon Ok Kim ,  Hyang Sook Lee ,  Ju Hyun Park ,  Tae Kyo Park ,  Sung Ho Woo ,  Yong Zu Kim

IPC: A61K31/5395 ,  C07D413/14 ,  C07D487/04 ,  A61K31/53 ,  A61P7/02 ,  A61P9/10 ,  A61P29/00 ,  A61P25/00 ,  A61P9/00 ,  A61P11/00

CPC classification number: C07D413/14 ,  C07D487/04

Abstract: The present invention relates to novel oxazolidinone derivatives with cyclic amidoxime or cyclic amidrazone group, pharmaceutically acceptable salts thereof, methods for preparing the same and pharmaceutical compositions comprising the same. The oxazolidinone derivatives with cyclic amidoxime or cyclic amidrazone group or the pharmaceutically acceptable salts thereof can be effectively used for the treatment of thromboembolism and tumor as an anticoagulant based on the inhibition of factor Xa.

Abstract translation: 本发明涉及具有环状偕胺肟或环状氨基腙基的新的恶唑烷酮衍生物，其药学上可接受的盐，其制备方法和包含其的药物组合物。 具有环偕胺肟或环状氨基腙基的恶唑烷酮衍生物或其药学上可接受的盐可以有效地用于基于对因子Xa的抑制作为抗凝血剂治疗血栓栓塞和肿瘤。

公开(公告)号：US20130165652A1

公开(公告)日：2013-06-27

申请号：US13818420

申请日：2011-08-25

Applicant: Hyung Sub Gwak ,  Yong Zu Kim ,  Uk Il Kim ,  Byeong Deog Park ,  Tae Kyo Park ,  Sung Ho Woo ,  Joung Yul Yun ,  Dae Yon Lee ,  Hyang Sook Lee ,  Jeong Eun Jeon ,  Se Kyoo Jeong ,  Hyung Mook Choi

Inventor： Hyung Sub Gwak ,  Yong Zu Kim ,  Uk Il Kim ,  Byeong Deog Park ,  Tae Kyo Park ,  Sung Ho Woo ,  Joung Yul Yun ,  Dae Yon Lee ,  Hyang Sook Lee ,  Jeong Eun Jeon ,  Se Kyoo Jeong ,  Hyung Mook Choi

IPC: C07D471/04

CPC classification number: C07D235/08 ,  A61K8/4946 ,  A61Q19/00 ,  A61Q19/007 ,  A61Q19/008 ,  C07D471/04

Abstract: The heterocyclic compound according to the present invention may treat and prevent inflammatory diseases and heal skin wounds, and particularly, have effects of recovering damaged skin barrier, reducing inflammation and pruritus in inflammatory skin diseases. In addition, the composition containing the compound according to the present invention as an active ingredient may be used to alleviate various inflammatory diseases and diseases in which PAR-2 is excessively expressed, and particularly, the composition may inhibit activity of PAR-2 in skin, such that the composition may be used as a composition having anti-inflammatory function in inflammatory skin diseases including atopic dermatitis, or the like.

Abstract translation: 根据本发明的杂环化合物可以治疗和预防炎性疾病并愈合皮肤伤口，特别是具有恢复受损的皮肤屏障，减少炎性皮肤疾病中的炎症和瘙痒的作用。 此外，含有本发明化合物作为活性成分的组合物可以用于缓和各种炎性疾病和PAR-2过度表达的疾病，特别是该组合物可抑制PAR-2在皮肤中的活性 ，使得该组合物可以用作具有抗炎功能的组合物，所述炎性皮肤病包括特应性皮炎等。