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公开(公告)号：US20130224245A1
公开(公告)日：2013-08-29
申请号：US13700436
申请日：2011-06-01
IPC分类号： A61K39/145
CPC分类号： A61K39/145 , A61K39/12 , A61K2039/55566 , A61K2039/70 , C12N7/00 , C12N2760/16134 , C12N2760/16151 , C12N2760/16234 , C12N2760/16251
摘要： An antigen concentration procedure does not involve lyophilisation of a bulk antigen before its final formulation and/or delivery. Thus a process for preparing a vaccine comprises steps of (i) increasing the concentration of an antigen in a liquid composition including that antigen, to provide a concentrated antigen, and (ii) formulating a vaccine from the concentrated antigen. The concentrated antigen is not lyophilised between or during steps (i) and (ii). The invention is particularly useful for preparing solid vaccine forms.
摘要翻译： 抗原浓缩程序不包括在其最终制剂和/或递送之前冻干本体抗原。 因此，制备疫苗的方法包括以下步骤：（i）增加包含该抗原的液体组合物中的抗原浓度，以提供浓缩抗原，和（ii）从浓缩抗原配制疫苗。 浓缩的抗原在步骤（i）和（ii）之间或之间不被冷冻干燥。 本发明特别可用于制备固体疫苗形式。
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公开(公告)号：US20130243841A1
公开(公告)日：2013-09-19
申请号：US13700437
申请日：2011-06-01
申请人： Sushma Kommareddy , Derek O'Hagan , Manmohan Singh , Amanda Scampini Bonificio , Barbara Baudner
发明人： Sushma Kommareddy , Derek O'Hagan , Manmohan Singh , Amanda Scampini Bonificio , Barbara Baudner
IPC分类号： A61K9/00
CPC分类号： A61K9/0087 , A61K9/0019 , A61K9/19 , A61K39/12 , A61K39/145 , A61K47/26 , C12N7/00 , C12N2760/16134 , C12N2760/16151 , C12N2760/16234 , C12N2760/16251
摘要： A process for preparing a lyophilised vaccine antigen, comprising steps of (i) increasing the concentration of an antigen in a liquid composition including that antigen using centrifugal filtration and/or ultrafiltration, to provide a concentrated antigen, and (ii) lyophilising the concentrated antigen, to provide the lyophilised vaccine antigen. The lyophilised material can be reconstituted and used for vaccine formulation. The process is particularly useful with influenza vaccine antigens.
摘要翻译： 一种制备冻干疫苗抗原的方法，包括以下步骤：（i）使用离心过滤和/或超滤提高包含该抗原的液体组合物中的抗原浓度，以提供浓缩的抗原，和（ii）将浓缩的抗原冻干 ，以提供冻干的疫苗抗原。 冻干的材料可以重构并用于疫苗制剂。 该过程对流感疫苗抗原特别有用。
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公开(公告)号：US09517263B2
公开(公告)日：2016-12-13
申请号：US13377511
申请日：2010-06-10
IPC分类号： A61K39/02 , C07D471/00 , A61K39/39 , A61K39/00 , A61K39/12
CPC分类号： A61K39/39 , A61K2039/55511 , A61K2039/6093
摘要： The invention provides, inter alia, immunogenic compositions that comprise (a) a first antigen, (b) polymeric particles and (c) a benzonaphthyridine compound, which compositions elicits an immune response when administered to a vertebrate subject. The invention also provides, inter alia, methods of producing immunogenic compositions and methods for using immunogenic compositions (e.g., for treatment), among other benefits.
摘要翻译： 本发明尤其提供了免疫原性组合物，其包含（a）第一抗原，（b）聚合物颗粒和（c）苯并萘啶化合物，该组合物在施用于脊椎动物受试者时引起免疫应答。 本发明尤其提供产生免疫原性组合物的方法和使用免疫原性组合物（例如用于治疗）的方法以及其它益处。
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公开(公告)号：US20120263753A1
公开(公告)日：2012-10-18
申请号：US13377511
申请日：2010-06-10
CPC分类号： A61K39/39 , A61K2039/55511 , A61K2039/6093
摘要： The invention provides, inter alia, immunogenic compositions that comprise (a) a first antigen, (b) polymeric particles and (c) a benzonaphthyridine compound, which compositions elicits an immune response when administered to a vertebrate subject. The invention also provides, inter alia, methods of producing immunogenic compositions and methods for using immunogenic compositions (e.g., for treatment), among other benefits.
摘要翻译： 本发明尤其提供了免疫原性组合物，其包含（a）第一抗原，（b）聚合物颗粒和（c）苯并萘啶化合物，该组合物在施用于脊椎动物受试者时引起免疫应答。 本发明尤其提供产生免疫原性组合物的方法和使用免疫原性组合物（例如用于治疗）的方法以及其它益处。
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公开(公告)号：US20140112950A1
公开(公告)日：2014-04-24
申请号：US14002700
申请日：2012-03-02
申请人： Manmohan Singh , Barbara Baudner , David Skibinski
发明人： Manmohan Singh , Barbara Baudner , David Skibinski
IPC分类号： A61K39/00
CPC分类号： A61K39/0018 , A61K31/4375 , A61K31/66 , A61K33/06 , A61K39/102 , A61K39/116 , A61K39/12 , A61K39/295 , A61K39/39 , A61K2039/545 , A61K2039/55505 , A61K2039/55555 , A61K2039/55566 , A61K2039/70 , C12N2730/10134 , C12N2770/32634 , Y02A50/466 , A61K2300/00
摘要： Combination vaccine compositions as well as methods for their manufacture have a relatively low amount of antigen and/or a relatively low amount of aluminium, but they can nevertheless have immunogenicity which is comparable to combination vaccines with a relatively high amount of antigen and/or a relatively high amount of aluminium. Aluminium-free combination vaccine compositions are also provided e.g. compositions which are adjuvanted with an oil-in-water emulsion adjuvant.
摘要翻译： 组合疫苗组合物及其制备方法具有相对低量的抗原和/或相对低量的铝，但是它们仍可具有免疫原性，其可与具有相对高量抗原和/或 相对较高的铝量。 也提供了无铝组合疫苗组合物，例如， 用水包油乳剂佐剂佐剂化的组合物。
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公开(公告)号：US10286056B2
公开(公告)日：2019-05-14
申请号：US13982042
申请日：2012-01-27
申请人： Luis Brito , Manmohan Singh , Derek O'Hagan
发明人： Luis Brito , Manmohan Singh , Derek O'Hagan
IPC分类号： A61K39/39 , A61K39/095 , A61K9/107 , A61K31/00 , A61K31/4745 , A61K9/00 , A61K31/4375 , A61K47/26 , A61K47/32 , A61K47/44
摘要： High loading of lipophilic pharmacological agents (in particular, lipophilic immunopotentiators) in oil-in-water emulsions can result in crystallisation of the lipophilic agent. To overcome this problem the invention uses an oil-in-water emulsion in combination with a crystallisation inhibitor, and this combination provides emulsions which can be loaded with high levels of lipophilic pharmacological agents.
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公开(公告)号：US09636410B2
公开(公告)日：2017-05-02
申请号：US14130886
申请日：2012-07-06
申请人： Luis Brito , Michelle Chan , Andrew Geall , Derek O'Hagan , Manmohan Singh
发明人： Luis Brito , Michelle Chan , Andrew Geall , Derek O'Hagan , Manmohan Singh
CPC分类号： A61K39/39 , A61K9/1075 , A61K39/12 , A61K39/155 , A61K39/245 , A61K47/02 , A61K47/06 , A61K47/12 , A61K47/22 , A61K47/24 , A61K47/26 , A61K47/34 , A61K2039/5256 , A61K2039/53 , A61K2039/55555 , A61K2039/55566 , A61K2039/575 , C12N7/00 , C12N2710/16134 , C12N2710/16171 , C12N2710/16734 , C12N2710/16771 , C12N2760/18534 , C12N2760/18571 , C12N2770/36134 , C12N2770/36143 , C12N2840/203 , Y02A50/386 , Y02A50/388 , Y02A50/412
摘要： This invention generally relates to cationic oil-in-water emulsions that contain high concentrations of cationic lipids and have a defined oil:lipid ratio. The cationic lipid can interact with the negatively charged molecule thereby anchoring the molecule to the emulsion particles. The cationic emulsions described herein are useful for delivering negatively charged molecules, such as nucleic acid molecules to cells, and for formulating nucleic acid-based vaccines.
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8.发明授权公开(公告)号：US09192661B2
公开(公告)日：2015-11-24
申请号：US13808245
申请日：2011-06-07
申请人： Siddhartha Jain , Derek O'Hagan , Manmohan Singh
发明人： Siddhartha Jain , Derek O'Hagan , Manmohan Singh
IPC分类号： A61K39/385 , A61K9/16 , A61K9/51 , A61K39/155 , C12N15/86 , C12N15/88 , A61K39/12 , A61K39/00
CPC分类号： A61K39/385 , A61K9/1617 , A61K9/1647 , A61K9/5123 , A61K9/5153 , A61K39/12 , A61K39/155 , A61K2039/5256 , A61K2039/53 , A61K2039/55555 , A61K2039/622 , A61P31/14 , C12N15/86 , C12N15/88 , C12N2760/18534 , C12N2770/36143
摘要： Particle compositions comprising adsorbed RNA replicons as well as methods of making and using the same are described.
摘要翻译： 描述包含吸附的RNA复制子的颗粒组合物以及其制备和使用方法。
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公开(公告)号：US20130195898A1
公开(公告)日：2013-08-01
申请号：US13621174
申请日：2012-09-15
申请人： Derek O'Hagan , Gary S. Ott , John Donnelly , Jina Kazzaz , Mildred Ugozzoli , Manmohan Singh , John Barackman
发明人： Derek O'Hagan , Gary S. Ott , John Donnelly , Jina Kazzaz , Mildred Ugozzoli , Manmohan Singh , John Barackman
IPC分类号： A61K39/39
CPC分类号： A61K39/39 , A61K9/1075 , A61K9/167 , A61K39/0208 , A61K39/21 , A61K39/245 , A61K39/29 , Y02A50/411 , Y02A50/471
摘要： Microparticles with adsorbent surfaces, methods of making such microparticles, and uses thereof, are disclosed. The microparticles comprise a polymer, such as a poly(α-hydroxy acid), a polyhydroxy butyric acid, a polycaprolactone, a polyorthoester, a polyanhydride, and the like, and are formed using cationic, anionic, or nonionic detergents. The surface of the microparticles efficiently adsorb biologically active macromolecules, such as DNA, polypeptides, antigens, and adjuvants. Also provided are compositions of an oil droplet emulsion having a metabolizable oil and an emulsifying agent. Immunogenic compositions having an immunostimulating amount of an antigenic substance, and an immunostimulating amount of an adjuvant composition are also provided. Methods of stimulating an immune response, methods of immunizing a host animal against a viral, bacterial, or parasitic infection, and methods of increasing a Th1 immune response in a host animal by administering to the animal an immunogenic composition of the microparticles, and/or microemulsions of the invention, are also provided.
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公开(公告)号：US08431160B2
公开(公告)日：2013-04-30
申请号：US11710250
申请日：2007-02-24
申请人： Derek O'Hagan , Manmohan Singh , Janet Wendorf , Jina Kazzaz , Padma Malyala
发明人： Derek O'Hagan , Manmohan Singh , Janet Wendorf , Jina Kazzaz , Padma Malyala
IPC分类号： A61K9/14 , A61K39/00 , A61K39/39 , A61K39/12 , A61K39/02 , A61K39/002 , A61K39/21 , A61K39/29 , A61K39/145 , A61K39/10 , A61K39/05 , A61K39/08 , A61P37/04
CPC分类号： A61K9/1652 , A61K39/095 , A61K39/385 , A61K39/39 , A61K2039/55555 , A61K2039/55561 , A61K2039/6093
摘要： Immunogenic compositions are described herein which comprise microparticles that further comprise a biodegradable polymer. The microparticle compositions also comprise a cationic polysaccharide and an immunological species selected from an antigen, an immunological adjuvant and a combination thereof. Also described are methods of making such compositions and methods of administering such compositions. Methods of modulating the release rate of immunological species from microparticles are also described. These methods comprise varying the ratio of the cationic polysaccharide relative to the biodegradable polymer within the microparticles.
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