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1.发明申请Identification of new cd8 epitopes from hiv-1 proteins with therapeutical and vaccinal properties against hiv infections 失效从具有针对HIV感染的治疗和疫苗性质的hiv-1蛋白质鉴定新的cd8表位公开(公告)号：US20050163796A1
公开(公告)日：2005-07-28
申请号：US10491008
申请日：2002-09-27
CPC分类号： C07K14/005 , A61K39/00 , A61K2039/505 , A61K2039/515 , A61K2039/53 , C12N2740/16122 , C12N2740/16222 , C12N2740/16322 , G01N33/56988
摘要： The invention relates to the identification and the selection of CTL epitopes able to induce a protection against an infection. More particularly, the invention is concerned with peptides and nucleic acid sequence coding for these peptides derived from HIV-1 proteins such as GAG, POL, ENV, VIF, TAT, VPU, REV and their applications. Preferably the immunogenic peptides are selected from the group consisting of SEQ ID NOs: 1 to 18 and functional derivatives thereof. The invention also relates to antibodies directed against said peptides.
摘要翻译： 本发明涉及能够诱导针对感染的保护的CTL表位的鉴定和选择。 更具体地说，本发明涉及编码这些衍生自HIV-1蛋白质如GAG，POL，ENV，VIF，TAT，VPU，REV的肽及其应用的肽和核酸序列。 优选地，免疫原性肽选自SEQ ID NO：1至18及其功能衍生物。 本发明还涉及针对所述肽的抗体。
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2.发明申请Identification of new CD8 epitopes from HIV-1 proteins with therapeutical and vaccinal properties against HIV infections 失效鉴定来自HIV-1蛋白质的新CD8表位具有针对HIV感染的治疗和疫苗性质公开(公告)号：US20060115488A1
公开(公告)日：2006-06-01
申请号：US11339605
申请日：2006-01-26
IPC分类号： A61K39/12
CPC分类号： C07K14/005 , A61K39/00 , A61K2039/505 , A61K2039/515 , A61K2039/53 , C12N2740/16122 , C12N2740/16222 , C12N2740/16322 , G01N33/56988
摘要： The invention relates to the identification and the selection of CTL epitopes able to induce a protection against an HIV infection. More particularly, the invention is concerned with peptides and nucleic acid sequence coding for these peptides derived from HIV-1 proteins such as GAG, POL, ENV, VIF, TAT, VPU, REV and their applications. Preferably the immunogenic peptides are selected from the group consisting of SEQ ID NOs:1 to 18 and functional derivatives thereof. The invention also relates to antibodies directed against said peptides.
摘要翻译： 本发明涉及能够诱导针对HIV感染的保护的CTL表位的鉴定和选择。 更具体地，本发明涉及编码这些衍生自HIV-1蛋白质如GAG，POL，ENV，VIF，TAT，VPU，REV的肽及其应用的肽和核酸序列。 优选地，免疫原性肽选自SEQ ID NO：1至18及其功能衍生物。 本发明还涉及针对所述肽的抗体。
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公开(公告)号：US07022325B2
公开(公告)日：2006-04-04
申请号：US10491008
申请日：2002-09-27
IPC分类号： A61K39/21
CPC分类号： C07K14/005 , A61K39/00 , A61K2039/505 , A61K2039/515 , A61K2039/53 , C12N2740/16122 , C12N2740/16222 , C12N2740/16322 , G01N33/56988
摘要： The invention relates to the identification and the selection of CTL epitopes able to induce a protection against an HIV infection. More particularly, the invention is concerned with peptides and nucleic acid sequence coding for these peptides derived from HIV-1 proteins such as GAG, POL, ENV, VIF, TAT, VPU, REV and their applications. Preferably the immunogenic peptides are selected from the group consisting of SEQ ID NOs:1 to 18 and functional derivatives thereof. The invention also relates to antibodies directed against said peptides.
摘要翻译： 本发明涉及能够诱导针对HIV感染的保护的CTL表位的鉴定和选择。 更具体地，本发明涉及编码这些衍生自HIV-1蛋白质如GAG，POL，ENV，VIF，TAT，VPU，REV的肽及其应用的肽和核酸序列。 优选地，免疫原性肽选自SEQ ID NO：1至18及其功能衍生物。 本发明还涉及针对所述肽的抗体。
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4.发明授权Polynucleotides encoding MHC class I-restricted hTERT epitopes, analogues thereof or polyepitopes 有权编码MHC I类限制性hTERT表位的多核苷酸，其类似物或多表位公开(公告)号：US08003773B2
公开(公告)日：2011-08-23
申请号：US11826134
申请日：2007-07-12
申请人： Pierre Langlade-Demoyen , Fransisco Garcia Pons , Olivier Adotevi , Sylvain Cardinaud , Christine Neuveut , Kostas Kosmatopoulos , Stéphanie Graff-Dubois , Jeanne Menez-Jamet
发明人： Pierre Langlade-Demoyen , Fransisco Garcia Pons , Olivier Adotevi , Sylvain Cardinaud , Christine Neuveut , Kostas Kosmatopoulos , Stéphanie Graff-Dubois , Jeanne Menez-Jamet
CPC分类号： C12N9/1276 , A61K38/00 , A61K39/0011 , A61K2039/572 , C12N9/1241
摘要： This invention relates to the field of anticancer therapy, and to the identification of immunogenic peptides derived from the human telomerase reverse transcriptase (hTERT). The present invention relates to polynucleotides encoding hTERT epitopes restricted to MHC class I molecule, analogues thereof and polyepitopes containing such epitopes and/or analogues. Are also included in the present invention, vector and cell comprising such polynucleotides. The present invention also concerns composition comprising hTERT polypeptides, corresponding polynucleotides, vectors and cells, for use in the treatment and/or prevention of cancer.
摘要翻译： 本发明涉及抗癌治疗领域，以及鉴定源自人端粒酶逆转录酶（hTERT）的免疫原性肽。 本发明涉及编码限于MHC I类分子的hTERT表位的多核苷酸，其类似物和含有这些表位和/或类似物的多表位。 也包括在本发明中，包含这种多核苷酸的载体和细胞。 本发明还涉及包含用于治疗和/或预防癌症的hTERT多肽，相应的多核苷酸，载体和细胞的组合物。
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5.发明申请Polynucleotides encoding mhc class i-restricted htert epitopes, analogues thereof or polyepitopes 有权编码mhc类i限制性hTERT表位的多核苷酸，其类似物或多表位公开(公告)号：US20100172878A1
公开(公告)日：2010-07-08
申请号：US11795027
申请日：2006-07-31
申请人： Pierre Langlade-Demoyen , Fransisco Garcia Pons , Olivier Adotevi , Sylvain Cardinaud , Christine Neuveut
发明人： Pierre Langlade-Demoyen , Fransisco Garcia Pons , Olivier Adotevi , Sylvain Cardinaud , Christine Neuveut
IPC分类号： A61K35/12 , C12N15/54 , C12N15/63 , C12N5/07 , C12N9/12 , A61K31/7052 , A61K38/45 , C12N5/0783 , C12Q1/02 , C12N15/00 , A61P35/00 , A61P37/04
CPC分类号： C12N9/1276 , A61K38/00 , A61K39/0011 , A61K2039/572 , C12N9/1241
摘要： This invention relates to the field of anticancer therapy, and to the identification of immunogenic peptides derived from the human telomerase reverse transcriptase (hTERT). The present invention relates to polynucleotides encoding hTERT epitopes restricted to MHC class I molecule, analogues thereof and polyepitopes containing such epitopes and/or analogues. Are also included in the present invention, vector and cell comprising such polynucleotides. The present invention also concerns composition comprising hTERT polypeptides, corresponding polynucleotides, vectors and cells, for use in the treatment and/or prevention of cancer.
摘要翻译： 本发明涉及抗癌治疗领域，以及鉴定源自人端粒酶逆转录酶（hTERT）的免疫原性肽。 本发明涉及编码限于MHC I类分子的hTERT表位的多核苷酸，其类似物和含有这些表位和/或类似物的多表位。 也包括在本发明中，包含这种多核苷酸的载体和细胞。 本发明还涉及包含用于治疗和/或预防癌症的hTERT多肽，相应的多核苷酸，载体和细胞的组合物。
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公开(公告)号：US07431928B2
公开(公告)日：2008-10-07
申请号：US11339605
申请日：2006-01-26
IPC分类号： A61K39/00 , A61K39/12 , A61K39/21 , A61K39/385 , C12Q1/70 , G01N33/53 , G01N33/567 , G01N33/00
CPC分类号： C07K14/005 , A61K39/00 , A61K2039/505 , A61K2039/515 , A61K2039/53 , C12N2740/16122 , C12N2740/16222 , C12N2740/16322 , G01N33/56988
摘要： The invention relates to the identification and the selection of CTL epitopes able to induce a protection against an HIV infection. More particularly, the invention is concerned with peptides and nucleic acid sequence coding for these peptides derived from HIV-1 proteins such as GAG, POL, ENV, VIF, TAT, VPU, REV and their applications. Preferably the immunogenic peptides are selected from the group consisting of SEQ ID NOs:1 to 18 and functional derivatives thereof. The invention also relates to antibodies directed against said peptides.
摘要翻译： 本发明涉及能够诱导针对HIV感染的保护的CTL表位的鉴定和选择。 更具体地，本发明涉及编码这些衍生自HIV-1蛋白质如GAG，POL，ENV，VIF，TAT，VPU，REV的肽及其应用的肽和核酸序列。 优选地，免疫原性肽选自SEQ ID NO：1至18及其功能衍生物。 本发明还涉及针对所述肽的抗体。
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7.发明授权Polynucleotides encoding MHC class I-restricted hTERT epitopes, analogues thereof or polyepitopes 有权编码MHC I类限制性hTERT表位的多核苷酸，其类似物或多表位公开(公告)号：US08858931B2
公开(公告)日：2014-10-14
申请号：US11795027
申请日：2006-07-31
申请人： Pierre Langlade-Demoyen , Fransisco Garcia Pons , Olivier Adotevi , Sylvain Cardinaud , Christine Neuveut
发明人： Pierre Langlade-Demoyen , Fransisco Garcia Pons , Olivier Adotevi , Sylvain Cardinaud , Christine Neuveut
CPC分类号： C12N9/1276 , A61K38/00 , A61K39/0011 , A61K2039/572 , C12N9/1241
摘要： This invention relates to the field of anticancer therapy, and to the identification of immunogenic peptides derived from the human telomerase reverse transcriptase (hTERT). The present invention relates to polynucleotides encoding hTERT epitopes restricted to MHC class I molecule, analogs thereof and polyepitopes containing such epitopes and/or analogs. Are also included in the present invention, vector and cell comprising such polynucleotides. The present invention also concerns composition comprising hTERT polypeptides, corresponding polynucleotides, vectors and cells, for use in the treatment and/or prevention of cancer.
摘要翻译： 本发明涉及抗癌治疗领域，以及鉴定源自人端粒酶逆转录酶（hTERT）的免疫原性肽。 本发明涉及编码限于MHC I类分子的hTERT表位的多核苷酸，其类似物和含有这些表位和/或类似物的多表位。 也包括在本发明中，包含这种多核苷酸的载体和细胞。 本发明还涉及包含用于治疗和/或预防癌症的hTERT多肽，相应的多核苷酸，载体和细胞的组合物。
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