NUCLEOSIDE ANALOG SALTS WITH IMPROVED SOLUBILITY AND METHODS OF FORMING SAME
    10.
    发明申请
    NUCLEOSIDE ANALOG SALTS WITH IMPROVED SOLUBILITY AND METHODS OF FORMING SAME 审中-公开
    具有改进的溶解性的核苷类似物盐和其形成方法

    公开(公告)号:US20160002240A1

    公开(公告)日:2016-01-07

    申请号:US14770655

    申请日:2014-03-17

    发明人: Robin D. Rogers

    摘要: Disclosed are salts of nucleoside analogs and methods of forming the salts. An anion of a nucleoside analog is paired with a permanent counter cation to form a salt that has decreased melting point and increased aqueous solubility compared to the nucleoside compound prior to the salt formation. Also a cation of a nucleoside analog is paired with a permanent counter anion to form a salt that has decreased melting point and increased aqueous solubility compared to the nucleoside compound prior to the salt formation. The nucleoside analog in some embodiments has therapeutic activity such as antiviral. The permanent counter cation or anion in some embodiments has bioactivity such as antibacterial or being a vitamin.

    摘要翻译: 公开了核苷类似物的盐和形成盐的方法。 核苷类似物的阴离子与永久性抗衡阳离子配对以形成与盐形成之前的核苷化合物相比具有降低的熔点和增加的水溶性的盐。 核苷类似物的阳离子与永久性抗衡阴离子配对,以形成与盐形成之前的核苷化合物相比具有降低的熔点和增加的水溶性的盐。 一些实施方案中的核苷类似物具有治疗活性,例如抗病毒药物。 在一些实施方案中,永久性抗衡阳离子或阴离子具有生物活性,例如抗菌剂或维生素。