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公开(公告)号：US20240160043A1
公开(公告)日：2024-05-16
申请号：US18278669
申请日：2022-02-04
发明人： Rumiko KITAGAWA , Masataka NAKAMURA
CPC分类号： G02C7/04 , A61L29/085 , A61L2300/404 , A61L2420/02
摘要： An object of the present invention is to provide a simple method for manufacturing a coated medical device allowed to have not only properties such as sufficient hydrophilicity but also a bacteria adhesion inhibiting capability. The present invention provides a method for manufacturing a coated medical device, including: (A) a contacting step of housing a medical device in a container, and bringing the medical device into contact with a solution a containing a hydrophilic polymer A; and (C) a heating step of heating the container; wherein the hydrophilic polymer A is a polymer containing, as a monomer unit, a compound having a quaternary ammonium cation group; and wherein the pH of the solution a after the heating step is 6.1 to 8.0.
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公开(公告)号：US20220008630A1
公开(公告)日：2022-01-13
申请号：US17289117
申请日：2019-09-13
摘要： Disclosed is a medical device including a substrate and a polymer layer, wherein the polymer layer is provided on at least a part of a surface of the substrate and satisfies the following requirements: (a) a water content of the medical device in hydrated state is in a range of 28% by mass or more and 50% by mass or less; (b) the substrate has a 2-alkoxyethyl group; and (c) the polymer layer contains one type of a carboxylic acid group-containing polymer and one type of a copolymer having an amide structure. The present invention provides a medical device capable of maintaining surface wettability for a long time.
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公开(公告)号：US20240157027A1
公开(公告)日：2024-05-16
申请号：US18278677
申请日：2022-02-04
发明人： Rumiko KITAGAWA , Masataka NAKAMURA
CPC分类号： A61L27/34 , A61L27/52 , A61L29/085 , A61L29/145 , A61L2400/18 , G02B1/043 , G02C7/04
摘要： An object of the present invention is to provide a coated medical device allowed to have not only properties such as sufficient hydrophilicity but also a bacteria adhesion inhibiting capability, and to provide a simple method of manufacturing the device. The present invention provides a coated medical device and a method of manufacturing the same, the coated medical device including a medical device and a hydrophilic polymer layer coating the surface of the medical device; wherein the hydrophilic polymer layer contains a hydrophilic polymer A, the hydrophilic polymer A containing, as monomer units, a compound a1 having a quaternary ammonium cation group and a compound a2 having a specific structure; and wherein the copolymerization ratio of the compound a1 to the compound a2 is 6/94 to 94/6.
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公开(公告)号：US20220184908A1
公开(公告)日：2022-06-16
申请号：US17442231
申请日：2020-04-16
发明人： Rumiko KITAGAWA , Masataka NAKAMURA
摘要： An objective of the present invention is to provide a method for easily manufacturing a hydrophilized medical device of superior durability. In order to achieve the abovementioned objective, a method for manufacturing a medical device according to the present invention comprises a step for heating an aqueous package fluid, wherein, in the heating step, the aqueous package fluid contains one or more types of hydrophilic polymer, heating is performed with a substrate of the medical device at least partially is contact with the aqueous package fluid, and the following conditions (a) through (c) are all met. (a) The hydrophilic polymer is a (meth)acrylamide (co)polymer comprising two substituents comprising two or more carbon atoms on a nitrogen atom. (b) The mass % concentration of the hydrophilic polymer in the aqueous package fluid is in a range of 0.0001-30 mass %. (c) The pH of the aqueous package fluid after the heating step is in a range of 6.1-8.0.
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公开(公告)号：US20220008631A1
公开(公告)日：2022-01-13
申请号：US17289588
申请日：2019-12-05
发明人： Rumiko KITAGAWA , Masataka NAKAMURA
IPC分类号： A61L31/14 , A61L15/24 , A61L15/44 , A61L27/18 , A61L27/34 , A61L27/52 , A61L27/54 , A61L29/06 , A61L29/08 , A61L29/14 , A61L29/16 , A61L31/10 , A61L31/16 , C08G77/20
摘要： A medical device including a substrate and a hydrophilic polymer layer and satisfying the following conditions: (1) that the hydrophilic polymer layer is on at least a part of the substrate; (2) that the hydrophilic polymer layer contains: a hydrophilic polymer having an acidic group; and a compound having an acidic group and a ring structure; and (3) that a time during which a liquid film is retained on the surface of the medical device (a liquid film retention time) is 10 seconds or more after the medical device is stationarily immersed in a phosphate buffer solution, pulled up from the phosphate buffer solution, and retained in the air. The present invention provides a medical device in which a surface of a substrate is hydrophilized, and a method for manufacturing same by a simple method.
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公开(公告)号：US20210395526A1
公开(公告)日：2021-12-23
申请号：US17289560
申请日：2019-12-05
发明人： Rumiko KITAGAWA , Masataka NAKAMURA
摘要： A medical device including an internal wetting agent and a copolymer of a silicone monomer and satisfying the following conditions: (1) that the internal wetting agent contains a copolymer of an open-chain compound having an acidic group and an open-chain compound having an amide group; (2) that the internal wetting agent is contained in the range of from 0.1 to 10% by mass with respect to the whole medical device; and (3) that the copolymer of a silicone monomer has a hydroxyl group and that the content ratio of the hydroxyl group in the silicone monomer is in the range of from 0.0005 to 0.01 equivalents/g. A medical device containing an internal wetting agent and having excellent transparency and hydrophilicity can be obtained.
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公开(公告)号：US20240139382A1
公开(公告)日：2024-05-02
申请号：US18278738
申请日：2022-02-04
发明人： Rumiko KITAGAWA , Masataka NAKAMURA
CPC分类号： A61L29/085 , A61L26/008 , A61L29/145 , A61L31/10 , A61L31/145 , A61L2300/424 , A61L2400/10 , A61L2420/02
摘要： An object of the present invention is to provide a coated medical device allowed to have not only sufficient hydrophilicity and lubricity but also a lipid adhesion inhibiting capability, and to provide a simple method for manufacturing the device. The present invention provides a coated medical device and a method for manufacturing the same, the coated medical device including a medical device and a hydrophilic polymer layer coating the surface of the medical device; wherein the hydrophilic polymer layer contains a hydrophilic polymer A, the hydrophilic polymer A containing, as monomer units, a compound a1 having a specific structure and a compound a2 having an amide group; and wherein the copolymerization ratio of the compound a1 to the compound a2 is 1/99 to 99/1 by mass.
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公开(公告)号：US20230057266A1
公开(公告)日：2023-02-23
申请号：US17788546
申请日：2021-01-06
发明人： Rumiko KITAGAWA , Masataka NAKAMURA
IPC分类号： B29D11/00
摘要： A method of producing a medical device having a substrate and a hydrophilic polymer layer, including the steps of: pretreating the substrate by placing the substrate in an alkali solution and heating the substrate at a temperature ranging from 50° C. to 100° C.; and heating a solution containing the pretreated substrate, a hydrophilic polymer having an acidic group and a hydroxyalkyl group, and an organic acid at a temperature ranging from 50° C. to 100° C. Provided is a simple method of producing a medical device imparted with hydrophilicity excellent in durability.
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公开(公告)号：US20220249731A1
公开(公告)日：2022-08-11
申请号：US17620197
申请日：2020-08-19
发明人： Rumiko KITAGAWA , Masataka NAKAMURA
IPC分类号： A61L15/24 , A61L29/08 , A61L29/12 , A61L29/14 , A61L31/10 , A61L31/12 , A61L31/14 , G02C7/04
摘要： The present invention provides a method of manufacturing a medical device including a substrate and a hydrophilic polymer layer, including the steps of: placing the substrate in a solution containing a hydrophilic polymer and a normal salt in an amount ranging from 1.0 to 20% by mass; and heating the solution at a temperature ranging from 50° C. to 140° C. The present invention provides a simple method of manufacturing a medical device having excellent durability and imparted with hydrophilicity.
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