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公开(公告)号：US20090035793A1
公开(公告)日：2009-02-05
申请号：US11988731
申请日：2006-08-31
CPC分类号： B01L3/502761 , B01L3/5025 , B01L2200/0668 , B01L2300/0825 , B01L2400/0487 , C12M23/34
摘要： In a microchip which enables cell cultivation and accurate cell count measurement, fine particles affixed with cells are trapped within a passage by making the minimum width of a solution and fine particle inlet into a cell culture portion larger than the maximum diameter of the fine particles, and making the width of an outlet smaller than the maximum diameter of the fine particles.
摘要翻译： 在能够进行细胞培养和精确细胞计数测定的微芯片中，通过使溶液和细颗粒入口的最小宽度进入细胞培养部分的最小宽度大于微粒的最大直径，将细胞附着的细小颗粒捕获在通道内， 并使出口的宽度小于微粒的最大直径。
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2.发明授权公开(公告)号：US07402439B2
公开(公告)日：2008-07-22
申请号：US10483233
申请日：2002-07-10
CPC分类号： B01F13/0062 , B01F13/0059 , B01F13/0066 , B01F13/0093 , B01J19/0093 , B01J2219/00783 , B01J2219/00788 , B01J2219/00831 , B01J2219/0086 , B01J2219/00889 , B01L3/502776 , B01L2200/0636 , B01L2200/10 , B01L2300/0816 , B01L2300/0874 , B01L2300/0887 , G01N1/40 , G01N35/00029 , G01N35/08 , G01N2001/4061 , G01N2035/00158 , G01N2035/00514 , Y10T436/2575
摘要： An integrated structure of multilayer flow microchannel, which comprises a plurality of microchannels in which parallel multilayer flow that involves the interface of fluids is formed, arranged on various positions of a substrate, wherein each of the multilayer flow microchannels is communicated with another multilayer flow microchannel. A plurality of unit operations can be carried out continuously with high efficiency on a microchip, enabling high-degree microanalysis or precise chemical synthesis using the highly integrated structure of multilayer flow microchannel.
摘要翻译： 多层流微通道的集成结构，其包括多个微通道，其中形成有涉及流体界面的平行多层流，布置在基板的各个位置上，其中每个多层流微通道与另一多层流微通道连通 。 可以在微芯片上以高效率连续进行多个单元操作，能够使用高度集成的多层流微通道结构实现高度微量分析或精确的化学合成。
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公开(公告)号：US20070202557A1
公开(公告)日：2007-08-30
申请号：US11710508
申请日：2007-02-26
申请人： Takehiko Kitamori , Manabu Tokeshi , Kiichi Sato
发明人： Takehiko Kitamori , Manabu Tokeshi , Kiichi Sato
CPC分类号： G01N33/54346 , B01L3/502753 , B01L2200/0668 , B01L2300/0816 , B01L2300/0867 , G01N33/54366 , G01N33/54386
摘要： An enzyme immunoassay chip having, as micro channels, a reaction liquid leading-in flow passage part, a reaction flow passage part, and detection flow passage part sequentially disposed on a substrate continuously to each other, comprising an installed part for bead-bodies supporting antibodies and the bead-body flow stopping part formed in the micro channel of the reaction flow passage part, wherein enzyme reactive product flowing beyond the flow stopping part can be analyzed by using the chip.
摘要翻译： 一种酶免疫测定芯片，其具有作为微通道的反应液引入流路部分，反应流路部分和检测流路部分，其顺序地彼此连续地设置在基板上，包括用于珠体支撑的安装部分 抗体和形成在反应流路部分的微通道中的珠粒体流动停止部分，其中可以通过使用芯片来分析流过流动停止部分的酶反应产物。
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公开(公告)号：US20050140971A1
公开(公告)日：2005-06-30
申请号：US10944653
申请日：2004-09-17
CPC分类号： G01N21/05 , B01L3/502715 , B01L2300/0654 , B01L2300/0816 , G01N2021/0346
摘要： A microchemical system chip and a microchemical system that can be reduced in size while improving measurement sensitivity. The microchemical system chip 1 is comprised of a plate-shaped glass substrate 10, and the glass substrate 10 has a U-shaped channel 11 therein. The U-shaped channel 11 is comprised of a longitudinal channel 11a, and a pair of transverse channels 11b and 11c that are connected to the two ends of the longitudinal channel 11a. The glass substrate 10 has therein two voids provided coaxially with the longitudinal channel 11a near the two ends of the longitudinal channel 11a, and gradient index rod lenses 14 and 15 are housed respectively in the two voids. An optical fiber 16 that propagates detecting light emitted from a light source is connected to the gradient index rod lens 14, and an optical fiber 17 that leads detecting light received by the gradient index rod lens 15 to a detector is connected to the gradient index rod lens 15.
摘要翻译： 微化学系统芯片和微化学系统，可以减小尺寸，同时提高测量灵敏度。 微化学系统芯片1由板状的玻璃基板10构成，玻璃基板10具有U形的通道11。 U形通道11包括纵向通道11a和连接到纵向通道11a的两端的一对横向通道11b和11c。 玻璃基板10具有在纵向通道11a的两端附近与纵向通道11a同轴设置的两个空隙，梯度分度杆透镜14和15分别容纳在两个空隙中。 将从光源发出的检测光传播的光纤16连接到梯度折射率棒状透镜14，将由梯度折射率棒状透镜15接收的检测光引导到检测器的光纤17连接到梯度折射率棒 镜头15。
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公开(公告)号：US07695684B2
公开(公告)日：2010-04-13
申请号：US11138373
申请日：2005-05-27
IPC分类号： B01L3/02
CPC分类号： G01N35/1097 , G01N2035/00237
摘要： For enlarging the application range of samples capable of being treated, decreasing the amount of samples used, preventing deterioration of samples by a change with the passage of time and preventing mixing of samples by diffusion, a micro fluidics system according to the present invention comprises a sample server which stores plural samples and which has sample efflux portions, a microchip for feeding samples to a treating portion through plural sample introducing portions communicating with the sample efflux portions and further through a microchannel, allowing the samples to be subjected to a predetermined treatment, and a sample feeder for feeding the samples stored in the sample server to the sample introducing portions through the sample efflux portions. The sample feeder comprises valves for opening and closing communication paths between the sample efflux portions of the sample server and the sample introducing portions of the microchip and pressurizing devices for pressurizing the samples stored in the sample server and pushing them out into the sample introducing portions in an open condition of the valves.
摘要翻译： 为了扩大能够处理的样品的应用范围，减少使用的样品量，通过随时间的改变改变样品的劣化并防止样品通过扩散混合，根据本发明的微流体系统包括： 存储多个样品并具有样品外排部分的样品服务器，用于通过与样品排出部分连通的多个样品导入部分进一步将样品供给到处理部分的微芯片，并且进一步通过微通道，允许样品经受预定处理， 以及用于将存储在样品服务器中的样品通过样品排出部分供给到样品引入部分的样品进料器。 样品供给器包括用于打开和关闭样品服务器的样品排出部分和微芯片的样品引入部分之间的连通路径的阀，以及用于对存储在样品服务器中的样品加压并将其推出到样品引入部分中的加压装置 阀的开启状态。
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公开(公告)号：US20100060981A1
公开(公告)日：2010-03-11
申请号：US11815976
申请日：2006-02-10
IPC分类号： G02B21/06
CPC分类号： G01N21/171 , G01N21/19 , G01N2021/1712
摘要： An objective of the present invention is to provide a circular dichroism thermal lens microscope apparatus capable of identifying and quantifying optically active samples in ultra-trace amounts, and which has a higher sensitivity than conventional apparatuses.The objective is achieved by a circular dichroism thermal lens microscope apparatus which beams excitation light and detection light into an optical microscope, where the detection light enters a thermal lens formed by irradiating a sample with the excitation light, and a substance in a sample is detected by determining the diffusion of the detection light by the thermal lens, and where the excitation light is modulated by a phase-modulation element, so as to identify or quantify an optical isomer.
摘要翻译： 本发明的目的是提供一种圆形二色性热透镜显微镜装置，其能够识别和定量超微量的光学活性样品，并且具有比常规装置更高的灵敏度。 目的是通过将激发光和检测光照射到光学显微镜中的圆二色性热透镜显微镜装置来实现，其中检测光进入通过用激发光照射样品而形成的热透镜，并且检测样品中的物质 通过确定通过热透镜的检测光的扩散，并且其中激发光被相位调制元件调制，以便识别或定量光学异构体。
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公开(公告)号：US07604406B2
公开(公告)日：2009-10-20
申请号：US12064456
申请日：2006-08-30
IPC分类号： H05G1/00
CPC分类号： G01N23/223 , B01L3/502715 , B01L3/502792 , B01L2300/0867 , B01L2300/0887 , B01L2300/089 , B01L2300/161 , G01N2223/076
摘要： A plurality of elements can be analyzed simultaneously with high sensitivity using a microchip. The microchip (1) comprises a substrate (30), a channel (23) formed in the substrate (30), and an analyzing part (10) consisting of a part of flat surface of the substrate (30), where the outlet of the channel (23) is formed as an opening (9c) and measurement object liquid overflowed from the opening (9c) stays on the flat surface of the substrate (30) to become a sample of analysis. The measurement object liquid is made to overflow as a sample of analysis to the analyzing part (10) using the microchip (1) and then the sample of analysis is preferably dried before a primary X-ray is made to enter under conditions of total reflection and fluorescent X-rays are detected.
摘要翻译： 可以使用微芯片以高灵敏度同时分析多个元件。 微芯片（1）包括基板（30），形成在基板（30）中的通道（23）和由基板（30）的平坦表面的一部分组成的分析部件（10） 通道（23）形成为开口（9c），并且从开口（9c）溢出的测量对象液体停留在基板（30）的平坦表面上，以成为分析样本。 使用微芯片（1）使测量对象液体作为分析样品溢出作为分析部件（10），然后优选在初步X射线在全反射条件下进入分析样品之前进行干燥 并检测荧光X射线。
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公开(公告)号：US20080123088A1
公开(公告)日：2008-05-29
申请号：US11985823
申请日：2007-11-16
申请人： Masatoshi Nara , Ryo Anraku , Takahiro Asai , Jun Yamaguchi , Akihiko Hattori , Takehiko Kitamori , Manabu Tokeshi , Akihide Hibara , Kazuma Mawatari
发明人： Masatoshi Nara , Ryo Anraku , Takahiro Asai , Jun Yamaguchi , Akihiko Hattori , Takehiko Kitamori , Manabu Tokeshi , Akihide Hibara , Kazuma Mawatari
IPC分类号： G01N21/41
CPC分类号： G01N21/171 , G01N35/08
摘要： There are provided a microchemical system capable of acquiring a highly accurate TLM output value and a method for calculating TLM output thereof. A microchemical system 1 comprises: a microchemical chip having a channel with a depth t in which a sample flows; an exciting light source 13 adapted to irradiate the sample with an exciting light through an objective lens 10 with a numerical aperture NA; a detecting light source 14 adapted to irradiate the sample with a detecting light coaxially with the exciting light through the objective lens 10; and a PD adapted to receive a transmitted light when the detecting light transmits the sample before and after formation of a thermal lens 12. When a TLM output is calculated in the microchemical system 1 on the basis of a received light amount of the PD, the depth t (μm) is set to the range of 75≦t≦300, the numerical aperture NA is set to the range of 0.04≦NA≦0.1 and chromatic aberrations df (nm) for the exciting light and the detecting light of the objective lens 10 is set to the range of 100≦df≦250.
摘要翻译： 提供了能够获得高度精确的TLM输出值的微化学系统和用于计算TLM输出的方法。 微化学系统1包括：具有样品流过深度t的通道的微化学芯片; 激光光源13，其适于通过具有数值孔径NA的物镜10照射具有激发光的样品; 检测光源14，适于通过物镜10与激发光同轴地检测具有检测光的样品; 以及适于在检测光在形成热透镜12之前和之后透射样品时接收透射光的PD。当在微量化学系统1中基于PD的接收光量计算TLM输出时， 深度t（母体）设定为75 <= t <= 300的范围，数值孔径NA设定为0.04 <= NA <= 0.1的范围，激发光的色差df（nm） 物镜10的光被设定在100 <= df <= 250的范围内。
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公开(公告)号：US20080030735A1
公开(公告)日：2008-02-07
申请号：US11701875
申请日：2007-02-05
申请人： Takehiko Kitamori , Manabu Tokeshi , Akira Tsunemi
发明人： Takehiko Kitamori , Manabu Tokeshi , Akira Tsunemi
IPC分类号： G01N21/00
CPC分类号： G02B21/0004 , G02B21/06
摘要： A desktop thermal lens microscope apparatus can detect a chemical reaction in a micro spatial region within a glass chip, or the like, more conveniently and at any given place. The desktop thermal lens microscope apparatus has small laser light sources such as semiconductor lasers as an excitation light source and a probe light source. Since an excitation light source system (P), a probe light source (Q), and a thermal lens microscope optical system (R, S, T) are integrally provided in a single housing, the size of the desktop thermal lens microscope is as small as that of a desktop microscope.
摘要翻译： 台式热学透镜显微镜装置可以在任何给定的位置更方便地检测玻璃芯片内的微空间区域中的化学反应等。 台式热学透镜显微镜装置具有小型激光光源，例如作为激发光源的半导体激光器和探针光源。 由于激光源系统（P），探针光源（Q）和热透镜显微镜光学系统（R，S，T）一体地设置在单个壳体中，所以台式热像仪的尺寸为 像桌面显微镜那样小。
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公开(公告)号：US20090147912A1
公开(公告)日：2009-06-11
申请号：US12064456
申请日：2006-08-30
IPC分类号： G01N23/223
CPC分类号： G01N23/223 , B01L3/502715 , B01L3/502792 , B01L2300/0867 , B01L2300/0887 , B01L2300/089 , B01L2300/161 , G01N2223/076
摘要： A plurality of elements can be analyzed simultaneously with high sensitivity using a microchip. The microchip (1) comprises a substrate (30), a channel (23) formed in the substrate (30), and an analyzing part (10) consisting of a part of flat surface of the substrate (30), where the outlet of the channel (23) is formed as an opening (9c) and measurement object liquid overflowed from the opening (9c) stays on the flat surface of the substrate (30) to become a sample of analysis. The measurement object liquid is made to overflow as a sample of analysis to the analyzing part (10) using the microchip (1) and then the sample of analysis is preferably dried before a primary X-ray is made to enter under conditions of total reflection and fluorescent X-rays are detected.
摘要翻译： 可以使用微芯片以高灵敏度同时分析多个元件。 微芯片（1）包括基板（30），形成在基板（30）中的通道（23）和由基板（30）的平坦表面的一部分组成的分析部件（10） 通道（23）形成为开口（9c），并且从开口（9c）溢出的测量对象液体停留在基板（30）的平坦表面上，以成为分析样本。 使用微芯片（1）使测量对象液体作为分析样品溢出作为分析部件（10），然后优选在初步X射线在全反射条件下进入分析样品之前进行干燥 并检测荧光X射线。
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