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    METHOD FOR PRODUCING A CHEMICAL PRODUCT AND CONTINUOUS FERMENTATION APPARATUS
    1.
    发明申请
    METHOD FOR PRODUCING A CHEMICAL PRODUCT AND CONTINUOUS FERMENTATION APPARATUS 审中-公开
    生产化学产品和连续发酵装置的方法

    公开(公告)号：US20110177551A1

    公开(公告)日：2011-07-21

    申请号：US13121727

    申请日：2009-09-16

    申请人： Takashi Mimitsuka ,  Kentaro Ishii ,  Ken Morita ,  Masashi Higasa ,  Kenji Sawai ,  Hideki Sawai ,  Katsushige Yamada ,  Shinichi Minegishi

    发明人： Takashi Mimitsuka ,  Kentaro Ishii ,  Ken Morita ,  Masashi Higasa ,  Kenji Sawai ,  Hideki Sawai ,  Katsushige Yamada ,  Shinichi Minegishi

    IPC分类号： C12P1/00 ,  C12M1/12

    CPC分类号： C12P7/56 ,  C12M29/18 ,  C12M47/10 ,  C12N9/00 ,  C12P1/00 ,  C12P7/02 ,  C12P7/40 ,  C12P13/001 ,  C12P13/04 ,  C12P13/08 ,  C12P19/34 ,  C12P21/02

    摘要： To control flow velocity of a culture liquid inside a membrane separation tank without giving influences to culture conditions in the fermentation tank, and also suppress precipitation of microorganisms or culture cells so that the production efficiency of the chemical product can be improved, in a method for producing a chemical product including the steps of: cultivating microorganisms or culture cells in a fermentation tank; transferring a culture liquid from the fermentation tank to a membrane separation tank so as to filter the culture liquid through a separation membrane; and collecting a fermentation product from a filtration liquid as the chemical product while refluxing an unfiltered culture liquid that has not been filtered so as to be joined to the culture liquid on an upstream side of the membrane separation tank, one portion of the culture liquid to be transferred from the fermentation tank is allowed to bypass the membrane separation tank depending on a pressure at the culture liquid flow-in side of the membrane separation tank.

    摘要翻译： 为了控制膜分离槽内的培养液的流速，不影响发酵罐中的培养条件，并且还抑制微生物或培养细胞的沉淀，从而可以提高化学品的生产效率 生产化学产品，包括以下步骤：在发酵罐中培养微生物或培养细胞; 将培养液从发酵罐转移到膜分离罐中，以通过分离膜过滤培养液; 并将来自过滤液的发酵产物作为化学产品收集，同时回流未过滤的未过滤的培养液，以便在膜分离罐的上游侧与培养液接合，将一部分培养液转移至 根据膜分离罐的培养液流入侧的压力，从发酵罐转移允许绕过膜分离罐。

    METHOD FOR PRODUCING LACTIC ACID AND METHOD FOR PRODUCING POLYLACTIC ACID
    2.
    发明申请
    METHOD FOR PRODUCING LACTIC ACID AND METHOD FOR PRODUCING POLYLACTIC ACID 审中-公开
    生产乳酸的方法和生产聚酸的方法

    公开(公告)号：US20110263811A1

    公开(公告)日：2011-10-27

    申请号：US13142062

    申请日：2009-12-25

    申请人： Kenji Sawai ,  Hideki Sawai ,  Takashi Mimitsuka ,  Ito Masateru ,  Katsushige Yamada ,  Kenji Kawamura ,  Shin-ichi Minegishi ,  Izumi Nakagawa ,  Tatsuya Nagano

    发明人： Kenji Sawai ,  Hideki Sawai ,  Takashi Mimitsuka ,  Ito Masateru ,  Katsushige Yamada ,  Kenji Kawamura ,  Shin-ichi Minegishi ,  Izumi Nakagawa ,  Tatsuya Nagano

    IPC分类号： C08G63/78 ,  C07D319/12 ,  C12P7/56

    摘要： Lactic acid is obtained by a method including (A) a step of continuous fermentation wherein a fermentation culture medium of a microorganism having an ability of lactic acid fermentation is filtered through a porous membrane having an average pore size of not less than 0.01 μm and less than 1 μm with a transmembrane pressure difference within the range of 0.1 to 20 kPa, and the permeate is collected, while retaining the non-permeated liquid in or returning the non-permeated liquid to the culture, and adding a fermentation feedstock to the culture; (B) a step of filtering the permeate obtained in Step (A) through a nanofiltration membrane; and (C) a step of distilling the permeate obtained in Step (B) under a pressure of not less than 1 Pa and not more than atmospheric pressure, at 25° C. to 200° C. to recover lactic acid.

    摘要翻译： 乳酸通过以下方法获得：（A）连续发酵步骤，其中具有乳酸发酵能力的微生物的发酵培养基通过平均孔径不小于0.01μm的多孔膜过滤 超过1μm，跨膜压力差在0.1〜20kPa的范围内，并收集渗透物，同时将非渗透液体保留在或将非渗透液体返回到培养物中，并向培养物中加入发酵原料 ; （B）通过纳滤膜对步骤（A）中得到的渗透物进行过滤的工序; 和（C）在25℃至200℃下，在不低于1Pa且不大于大气压的压力下，将步骤（B）中得到的渗透物蒸馏的步骤，以回收乳酸。

    METHOD OF PRODUCING LACTIC ACID BY CONTINUOUS FERMENTATION
    8.
    发明申请
    METHOD OF PRODUCING LACTIC ACID BY CONTINUOUS FERMENTATION 审中-公开
    连续发酵生产酸乳酸的方法

    公开(公告)号：US20140017746A1

    公开(公告)日：2014-01-16

    申请号：US14027754

    申请日：2013-09-16

    申请人： Nanami Sasaki ,  Ken Morita ,  Takashi Mimitsuka ,  Hideki Sawai ,  Katsushige Yamada

    发明人： Nanami Sasaki ,  Ken Morita ,  Takashi Mimitsuka ,  Hideki Sawai ,  Katsushige Yamada

    IPC分类号： C12P7/56

    CPC分类号： C12P7/56

    摘要： A method of producing lactic acid by continuous fermentation includes filtering a culture of polyploidy prototrophic yeast having a capacity to produce lactic acid by introduction of a lactate dehydrogenase gene through a porous membrane having an average pore size of not less than 0.01 μm and less than 1 μm; and recovering the lactic acid from filtrate while the unfiltered liquid is retained in or returned to the culture and a fermentation feedstock is added to the culture.

    摘要翻译： 通过连续发酵生产乳酸的方法包括通过将平均孔径不小于0.01μm和小于1的多孔膜引入乳酸脱氢酶基因来过滤具有产生乳酸能力的多倍体原养酵母的培养物 妈妈 并从滤液中回收乳酸，同时将未过滤的液体保留在培养物中或返回到培养物中，向培养物中加入发酵原料。

    METHOD OF PRODUCING LACTIC ACID BY CONTINUOUS FERMENTATION
    9.
    发明申请
    METHOD OF PRODUCING LACTIC ACID BY CONTINUOUS FERMENTATION 有权
    连续发酵生产酸乳酸的方法

    公开(公告)号：US20110053231A1

    公开(公告)日：2011-03-03

    申请号：US12865934

    申请日：2009-02-03

    申请人： Nanami Sasaki ,  Ken Morita ,  Takashi Mimitsuka ,  Hideki Sawai ,  Katsushige Yamada

    发明人： Nanami Sasaki ,  Ken Morita ,  Takashi Mimitsuka ,  Hideki Sawai ,  Katsushige Yamada

    IPC分类号： C12P7/56

    CPC分类号： C12P7/56

    摘要： A method of producing lactic acid continuous fermentation including filtering a culture of polyploid yeast having a capacity to produce lactic acid through a porous membrane having an average pore size of not less than 0.01 μm and less than 1 μm, and recovering the product from the filtrate while the unfiltered liquid is retained in or returned to the culture and a fermentation feedstock is added to the culture.

    摘要翻译： 一种生产乳酸连续发酵的方法，包括通过平均孔径不小于0.01μm且小于1μm的多孔膜过滤具有生产乳酸能力的多倍体酵母的培养物，并从滤液中回收产物 而未过滤的液体保留在或返回到培养物中，并且向培养物中加入发酵原料。

    Method of producing lactic acid by continuous fermentation
    10.
    发明授权
    Method of producing lactic acid by continuous fermentation 有权
    通过连续发酵生产乳酸的方法

    公开(公告)号：US08551745B2

    公开(公告)日：2013-10-08

    申请号：US12865934

    申请日：2009-02-03

    申请人： Nanami Sasaki ,  Ken Morita ,  Takashi Mimitsuka ,  Hideki Sawai ,  Katsushige Yamada

    发明人： Nanami Sasaki ,  Ken Morita ,  Takashi Mimitsuka ,  Hideki Sawai ,  Katsushige Yamada

    IPC分类号： C12P7/56

    CPC分类号： C12P7/56

    摘要： A method of producing lactic acid continuous fermentation including filtering a culture of polyploid yeast having a capacity to produce lactic acid through a porous membrane having an average pore size of not less than 0.01 μm and less than 1 μm, and recovering the product from the filtrate while the unfiltered liquid is retained in or returned to the culture and a fermentation feedstock is added to the culture.

    摘要翻译： 一种生产乳酸连续发酵的方法，包括通过平均孔径不小于0.01μm和小于1μm的多孔膜过滤具有生产乳酸能力的多倍体酵母的培养物，并从滤液中回收产物 而未过滤的液体保留在或返回到培养物中，并且向培养物中加入发酵原料。