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    Process for preparing .alpha., .beta.-unsaturated aldehydes
    5.
    发明授权
    Process for preparing .alpha., .beta.-unsaturated aldehydes 失效
    制备α，β-不饱和醛的方法

    公开(公告)号：US4745229A

    公开(公告)日：1988-05-17

    申请号：US15095

    申请日：1987-02-13

    申请人： Junzo Otera ,  Shigeaki Suzuki ,  Takashi Onishi ,  Yoshiji Fujita

    发明人： Junzo Otera ,  Shigeaki Suzuki ,  Takashi Onishi ,  Yoshiji Fujita

    IPC分类号： C07C45/27 ,  C07C45/28 ,  C07C45/56 ,  C07C47/21 ,  C07C69/145

    CPC分类号： C07C47/21 ,  C07C45/27 ,  C07C45/28 ,  C07C45/56 ,  C07C67/29

    摘要： A process for preparing .alpha.,.beta.-unsaturated aldehydes of the general formula (I) ##STR1## in which R.sup.1, R.sup.2 and R.sup.3 are independently a hydrogen atom, or an alkyl or alkenyl group with or without being substituted with a lower acyloxy group. The aldehyde of the general formula (I) is prepared by reaction between an allylic chloride of the following general formula (IIa) ##STR2## in which R.sup.1, R.sup.2 and R.sup.3 have, respectively, the same meanings as defined above, and an amine oxide selected from the group consisting of tri(lower alkyl)amine N-oxides of the formula,R.sub.3.sup.4 N.sup.+ O.sup.-,in which R.sup.4 represents a lower alkyl group having from 2 to 4 carbon atoms, and N-lower alkylmorpholine N-oxides of the following formula ##STR3## in which R.sup.5 represents a lower alkyl group having from 1 to 4 carbon atoms. Alternatively, the aldehyde of the formula (I) is obtained by reaction between an allylic chloride of the following general formula (IIb) ##STR4## in which R.sup.1, R.sup.2 and R.sup.3 have, respectively, the same meanings as defined above, and an amine oxide selected from the group consisting of tri(lower alkyl)amine N-oxides of the formula,R.sub.3.sup.4 N.sup.+ O.sup.-,in which R.sup.4 has the same meaning as defined above, and N-lower alkylmorpholine N-oxides of the following formula ##STR5## in which R.sup.5 has the same meaning as defined above, in the presence of an alkali metal iodide or a copper halide.

    摘要翻译： 制备通式（I）的α，β-不饱和醛的方法，其中R 1，R 2和R 3独立地为氢原子，或具有或不具有低级烷基或烯基的烷基或烯基 酰氧基。 通式（I）的醛通过以下通式（IIa）的烯丙基氯与其中R 1，R 2和R 3分别具有与上述相同的含义和 选自下列的三（低级烷基）胺N-氧化物的氧化胺，其中R 4表示具有2至4个碳原子的低级烷基的式R 34 N + O-，和N-低级烷基吗啉N- 下式“IMAGE”的氧化物，其中R 5表示具有1至4个碳原子的低级烷基。 或者，式（I）的醛通过以下通式（IIb）的烯丙基氯（IIb）（其中R1，R2和R3分别具有与上述相同的含义） 和选自下式的三（低级烷基）胺N-氧化物的氧化胺，其中R 4具有与上述相同的含义的R 34 N + O-，以及下述的N-低级烷基吗啉N-氧化物 在碱金属碘化物或卤化铜存在下，其中R 5具有与上述相同的含义的式“IMAGE”。

    1,3-Cyclohexanedione derivatives
    7.
    发明授权
    1,3-Cyclohexanedione derivatives 失效
    1,3-环己二酮衍生物

    公开(公告)号：US4336202A

    公开(公告)日：1982-06-22

    申请号：US264463

    申请日：1981-05-18

    申请人： Sigeru Torii ,  Kenji Uneyama ,  Takashi Onishi ,  Yoshiji Fujita ,  Michihiro Ishiguro ,  Takashi Nishida

    发明人： Sigeru Torii ,  Kenji Uneyama ,  Takashi Onishi ,  Yoshiji Fujita ,  Michihiro Ishiguro ,  Takashi Nishida

    IPC分类号： C07C49/517 ,  C07D209/08 ,  C07D307/83 ,  C07C49/403

    CPC分类号： C07D307/83 ,  C07C49/517 ,  C07D209/08

    摘要： Novel cyclohexanone derivatives of general formula: ##STR1## (wherein R.sup.1 is a hydrocarbon group of 1 to 15 carbon atoms) and new cyclohexanone derivatives of general formula: ##STR2## (wherein R.sup.1 and R.sup.2 each is a hydrocarbon group of 1 to 15 carbon atoms) are produced by an electrooxidative coupling of 1,3-cyclohexanedione with a vinyl ether of general formula:CH.sub.2 .dbd.CH-O-R.sup.1(wherein R.sup.1 is as defined above) in the presence or absence of an alcohol of general formula:R.sup.2 OH(wherein R.sup.2 is as defined above). These new cyclohexanone derivatives can be easily converted to N-substituted or unsubstituted-4-oxo-4,5,6,7-tetrahydroindoles, which are of value as intermediates for the production of N-substituted or unsubstituted-4-hydroxyindoles and, thence, to pindolol and its analogs.

    摘要翻译： 新型的通式为：IMA（其中R 1为1至15个碳原子的烃基）的环己酮衍生物和通式为新的环己酮衍生物：其中R1和R2各自为1至15个碳原子的烃基 原子）通过在通式R 2 OH的存在或不存在的情况下，通过1,3-环己二酮与通式为CH 2 = CH-O-R 1（其中R 1如上定义）的乙烯基醚的电氧偶合而产生 （其中R2如上所定义）。 这些新的环己酮衍生物可以容易地转化成N-取代或未取代的-4-氧代-4,5,6,7-四氢吲哚，它们作为制备N-取代或未取代的4-羟基吲哚的中间体， 因此，对吲哚洛尔及其类似物。