公开(公告)号：US4647431A

公开(公告)日：1987-03-03

申请号：US725694

申请日：1985-04-22

申请人： Takasi Sekine ,  Kenichiro Yazawa ,  Masao Kitajima

发明人： Takasi Sekine ,  Kenichiro Yazawa ,  Masao Kitajima

IPC分类号： B01L7/00 ,  G01N35/00

CPC分类号： G01N35/00029 ,  B01L7/00 ,  G01N2035/00039 ,  G01N2035/00079 ,  G01N2035/00138 ,  G01N2035/00376 ,  Y10T436/112499

摘要： A device for maintaining a constant temperature for chemical analysis performed with slides having at least one layer adapted to absorb a substance to be analyzed. The slides are conveyed upon a lower conveying belt which may have projections or recesses formed therein for receiving the slides. The upper portions of the slides are sealed by a sealing guide belt which has a surface disposed parallel to and adjacent the conveying belt with the slides passing therebetween. A heater may be provided within the conveying belt and the guide member provided within the sealing guide belt which may itself perform a heating function.

摘要翻译： 用于通过具有适于吸收待分析物质的至少一层的载玻片来进行化学分析的恒定温度的装置。 滑块被输送到下部输送带上，该输送带可以具有形成在其中的突出部或凹部，用于接纳滑块。 滑块的上部由密封引导带密封，密封引导带具有平行于输送带并且与输送带相邻的表面，滑块通过它们之间。 可以在传送带内设置加热器，并且设置在密封导向带内的引导件本身可以执行加热功能。

公开(公告)号：US4981805A

公开(公告)日：1991-01-01

申请号：US682478

申请日：1984-12-17

申请人： Kenichiro Yazawa ,  Masao Kitajima ,  Asaji Kondo

发明人： Kenichiro Yazawa ,  Masao Kitajima ,  Asaji Kondo

IPC分类号： G01N1/28 ,  B01L3/00 ,  G01N21/78 ,  G01N21/86 ,  G01N33/48 ,  G01N33/52 ,  G02B21/34

CPC分类号： B01L3/508 ,  G01N21/8483 ,  G01N33/525 ,  G02B21/34 ,  B01L2200/142 ,  B01L2300/041 ,  B01L2300/048 ,  B01L2300/069 ,  B01L2300/0822 ,  B01L2400/0406

摘要： A method of using a chemical analysis slide comprising a slide frame and a sheet-like or film-like chemical analysis element for colorimetric determination of a specific component in an aqueous liquid sample, which comprisesapplying an aqueous liquid sample to the chemical analysis element, andcovering the upper face of the side of the slide frame to which the sample is applied with a sheet-like, plate-like or block or brick-like cover to thereby ensure a space between the chemical analysis element and the cover and to prevent evaporation of water or to control evaporation rate of water.

摘要翻译： 一种使用包括滑动框架和片状或膜状化学分析元件的化学分析载玻片的方法，用于比色测定水性液体样品中的特定组分，其包括将水性液体样品施加到化学分析元件， 并且将覆盖样品的滑动框架的侧面的上表面覆盖有片状，板状或块状或砖状的盖，​​从而确保化学分析元件与盖之间的空间，并防止 蒸发水或控制水的蒸发速率。

公开(公告)号：US06045699A

公开(公告)日：2000-04-04

申请号：US118633

申请日：1998-07-17

申请人： Kenichiro Yazawa ,  Fumio Sugaya ,  Masao Kitajima

发明人： Kenichiro Yazawa ,  Fumio Sugaya ,  Masao Kitajima

IPC分类号： G01N33/48 ,  B01D39/16 ,  B01D39/20 ,  G01N33/49 ,  B01D61/22

CPC分类号： G01N33/491 ,  B01D39/1692 ,  B01D39/2017 ,  Y10T436/255

摘要： This invention provides a method of filtering blood using a filtering material comprising glass fiber filter, capable of obtaining a desired amount of plasma or serum without hemolysis and leakage of blood cells easily which comprises keeping pressure difference between blood inlet side and filtrate outlet side 50 mmHg or less at least for 5 seconds from contacting the blood to be filtered, and keeping the pressure difference 200 mmHg or less throughout the filtering of the blood.

摘要翻译： 本发明提供一种使用包含玻璃纤维过滤器的过滤材料过滤血液的方法，其能够容易地获得所需量的血浆或血清而不溶血和泄漏血细胞，其包括保持血液入口侧和滤液出口侧之间的压力差为50mmHg 或更少至少5秒以内接触要过滤的血液，并且在整个血液过滤中保持压力差为200mmHg或更小。

公开(公告)号：US06217540B1

公开(公告)日：2001-04-17

申请号：US09349173

申请日：1999-07-09

申请人： Kenichiro Yazawa ,  Keiichi Ishizaki ,  Takeshi Igarashi ,  Masao Kitajima ,  Shigeru Tezuka ,  Takaki Arai ,  Toshihisa Ito ,  Osamu Seshimoto

发明人： Kenichiro Yazawa ,  Keiichi Ishizaki ,  Takeshi Igarashi ,  Masao Kitajima ,  Shigeru Tezuka ,  Takaki Arai ,  Toshihisa Ito ,  Osamu Seshimoto

IPC分类号： A61M3700

CPC分类号： G01N33/491

摘要： The invention provides a blood filter cartridge which is made so that the filtrate discharged from the filtrate outlet is not drawn back to the inside of the filtering chamber. The blood filter cartridge includes a blood filtering material, a holder containing the blood filtering material and having a blood inlet and a filtrate outlet, and a filtrate receiver which receives the filtrate discharged from the filtrate outlet. The blood filter catridge is provided with a means for preventing the filtrate in the filtrate receiver from returning to inside of the holder upon finishing filtration. Such means include the following: removing opposite faces around the filtrate outlet, making length of lower end of the filtrate outlet 0.8 mm or more, smoothing surface around the filtrate outlet, and forming surface around the filtrate outlet by a material having a small surface energy.

摘要翻译： 本发明提供了一种血液过滤器滤芯，其被制成使得从滤液出口排出的滤液不会被抽回到过滤室的内部。 血液过滤器滤芯包括血液过滤材料，含有血液过滤材料并具有血液入口和滤液出口的保持器和接收从滤​​液出口排出的滤液的滤液接收器。 血液过滤器夹具设置有用于防止滤液接收器中的滤液在完成过滤时返回到保持器内部的装置。 这样的方法包括以下步骤：除去滤液出口周围的相对面，使滤液出口的下端长度为0.8mm以上，使滤液出口周围的表面光滑，并且通过具有小表面能的材料在滤液出口周围形成表面 。

公开(公告)号：US06170671B2

公开(公告)日：2001-01-09

申请号：US09290650

申请日：1999-04-12

申请人： Masao Kitajima ,  Kenichiro Yazawa ,  Shigeru Tezuka ,  Fumio Sugaya ,  Akemi Higo ,  Kiyotaka Fujiwara

发明人： Masao Kitajima ,  Kenichiro Yazawa ,  Shigeru Tezuka ,  Fumio Sugaya ,  Akemi Higo ,  Kiyotaka Fujiwara

IPC分类号： B01D2900

CPC分类号： B01D39/2017 ,  B01D61/18 ,  B01D61/20 ,  B01D69/12 ,  G01N33/491

摘要： The blood filter unit of the invention is composed of a blood filtering material made of glass fiber filter and microporous membrane and a holder having a blood inlet and a filtrate outlet. The holder accommodates the blood filtering material so that the microporous membrane is located on the filtrate outlet side, provides a space between the blood filtering material and the filtrate outlet, and provides a means for preventing adhesion of the blood filtering material on the filtrate outlet side. By using the blood filter unit, a necessary volume of plasma or serum for analysis can be separated surely, irrespective of hematocrit value of the blood.

摘要翻译： 本发明的血液过滤器单元由玻璃纤维过滤器和微孔膜制成的血液过滤材料和具有血液入口和滤液出口的保持器构成。 保持器容纳血液过滤材料，使得微孔膜位于滤液出口侧，提供血液过滤材料和滤液出口之间的空间，并提供防止血液过滤材料在滤液出口侧粘附的手段 。 通过使用血液过滤器单元，可以确定地分离所需体积的血浆或血清，而不管血液的血细胞比容值如何。

公开(公告)号：US5876605A

公开(公告)日：1999-03-02

申请号：US784480

申请日：1997-01-17

申请人： Masao Kitajima ,  Kenichiro Yazawa

发明人： Masao Kitajima ,  Kenichiro Yazawa

IPC分类号： G01N33/48 ,  G01N1/28 ,  G01N33/50 ,  B01D61/00

CPC分类号： G01N33/491 ,  G01N33/5002 ,  Y10T436/25375 ,  Y10T436/255

摘要： The method of the invention is for preparing a plasma or serum sample from whole blood and includes mixing an aqueous solution of an inorganic salt or an amino acid or salt thereof with the whole blood in an amount of 20% or less of the whole blood volume so that concentration of the inorganic salt or the amino acid or salt thereof becomes 10 to 200 .mu.mol/1 ml whole blood, and then, filtering the whole blood to remove blood cell components. According to the method of the invention, plasma separation from whole blood can be achieved efficiently, and recovered volume of plasma can be increased. By selecting reagent, good plasma which has no deviation in component viewpoint, and which is possible to measure in the same level accuracy as a plasma obtained by centurifuging, can be obtained through a simple filtration operation.

摘要翻译： 本发明的方法是从全血中制备血浆或血清样品，包括将无机盐或其氨基酸或其盐的水溶液与全血的全血量的20％或更少的量混合 使无机盐或其氨基酸或其盐的浓度成为10〜200μmol/ ml全血，然后过滤全血以除血细胞成分。 根据本发明的方法，能够有效地实现全血的血浆分离，能够提高等离子体的回收体积。 通过选择试剂，可以通过简单的过滤操作获得组分观点没有偏差的良好的等离子体，并且可以以与通过中间脱色获得的等离子体相同的精度测量。

公开(公告)号：US4783315A

公开(公告)日：1988-11-08

申请号：US758562

申请日：1985-07-23

申请人： Fuminori Arai ,  Kenichiro Yazawa ,  Hideaki Takeuchi ,  Masao Kitajima

发明人： Fuminori Arai ,  Kenichiro Yazawa ,  Hideaki Takeuchi ,  Masao Kitajima

IPC分类号： G01N31/22 ,  G01N33/52 ,  G01N33/66

CPC分类号： G01N33/525 ,  Y10T428/31736 ,  Y10T428/3175

摘要： An analysis material sheet is disclosed which is comprised of layers of material with strong adhesion for one another. The sheet includes a water-impermeable support having provided directly or indirectly thereon a layer of fabric. The fabric contains a hydrophobic organic polymer fiber and is physically activated on at least one surface thereof, with the physically activated surface being adhered directly or indirectly to the support. A reagent layer can be provided directly or indirectly on the liquid sample-spreading layer of fabric. By utilizing a fabric containing a hydrophobic organic polymer fiber, body fluids to be analyzed can be quickly and uniformly spread and by utilizing the physically activated surface of the fabric, strong adhesion between the layers can be obtained.

摘要翻译： 公开了一种分析材料片，其由彼此具有强粘合性的材料层组成。 片材包括直接或间接地在其上提供织物层的不透水支撑体。 织物含有疏水性有机聚合物纤维，并在其至少一个表面上物理活化，物理活化表面直接或间接地粘附到载体上。 试剂层可以直接或间接地提供在织物的液体样品铺展层上。 通过使用含有疏水性有机聚合物纤维的织物，可以快速且均匀地分散待分析的体液，并且通过利用织物的物理活化表面，可以获得层间的强粘合性。

公开(公告)号：US5192693A

公开(公告)日：1993-03-09

申请号：US700032

申请日：1991-05-07

申请人： Kenichiro Yazawa ,  Masao Kitajima ,  Asaji Kondo

发明人： Kenichiro Yazawa ,  Masao Kitajima ,  Asaji Kondo

IPC分类号： B01L3/00 ,  G01N21/86 ,  G01N33/52 ,  G02B21/34

CPC分类号： G01N21/8483 ,  B01L3/508 ,  G01N33/525 ,  G02B21/34 ,  B01L2200/142 ,  B01L2300/048 ,  B01L2300/0822 ,  B01L2400/0406

摘要： A method of using a chemical analysis slide which includes a slide frame and a sheet-like or film-like chemical analysis element for colorimetric determination of a specific component in an aqueous liquid sample, which method includesapplying an aqueous liquid sample to the chemical analysis element, andcovering the upper face of the side of the slide frame to which the sample is applied with a sheet-like, plate-like or block or brick-like cover to thereby ensure a space between the chemical analysis element and the cover and to prevent evaporation of water or to control evaporation rate of water.

摘要翻译： 一种使用化学分析载玻片的方法，其包括滑动框架和片状或膜状化学分析元素，用于比色测定水性液体样品中的特定组分，该方法包括将水性液体样品施加到化学分析 并且将覆盖样品的滑动框架的侧面的上表面覆盖片状，板状或块状或砖状覆盖物，从而确保化学分析元件与盖子之间的空间，以及 以防止水的蒸发或控制水的蒸发速率。

公开(公告)号：US4877579A

公开(公告)日：1989-10-31

申请号：US198590

申请日：1988-05-23

申请人： Kenichiro Yazawa ,  Osamu Seshimoto ,  Masao Kitajima ,  Asaji Kondo

发明人： Kenichiro Yazawa ,  Osamu Seshimoto ,  Masao Kitajima ,  Asaji Kondo

IPC分类号： G01N31/22 ,  G01N33/72

CPC分类号： G01N33/728 ,  Y10T436/146666 ,  Y10T436/255

摘要： A method for quantitative determination of bilirubin is disclosed. The method comprises bringing a bilirubin-containing aqueous liquid sample into contact with a hydrophobic bilirubin extracting composition containing a hydrophobic amine capable of extracting bilirubin. The amine extracts the bilirubin in said aqueous liquid sample. Photometry is then used to determine the concentration of bilirubin extracted with the bilirubin extracting composition. A device for use in this method is also disclosed. The device has a layer containing a hydrophobic bilirubin extracting composition containing a hydrophobic amine capable of extracting bilirubin.

摘要翻译： 公开了一种定量测定胆红素的方法。 该方法包括使含胆红素的含水液体样品与含有能够提取胆红素的疏水性胺的疏水性胆红素提取组合物接触。 胺提取所述含水液体样品中的胆红素。 然后使用光度测定法测定用胆红素提取组合物提取的胆红素的浓度。 还公开了一种用于该方法的装置。 该装置具有包含含有能够提取胆红素的疏水性胺的疏水性胆红素提取组合物的层。

公开(公告)号：US4387990A

公开(公告)日：1983-06-14

申请号：US247677

申请日：1981-03-26

申请人： Kenichiro Yazawa ,  Masao Kitajima ,  Asaji Kondo

发明人： Kenichiro Yazawa ,  Masao Kitajima ,  Asaji Kondo

IPC分类号： G01N21/01 ,  G01N21/03 ,  G01N21/15 ,  G01N21/78 ,  G01N21/86 ,  G01N31/22 ,  G01N33/49 ,  G01N33/52 ,  G01N35/00 ,  G01N21/27

CPC分类号： G01N21/8483 ,  G01N33/525 ,  G01N35/00029 ,  G01N2035/00138 ,  G01N2035/00168

摘要： A chemical analysis slide frame assembly including first and second slide frames each having an opening whose area is smaller than the area of a chemical analysis film inserted therein and a third slide frame disposed between the first and second slide frames. The third slide frame has an opening which is adapted to receive the chemical analysis film and is shaped so as to substantially prevent the displacement of the chemical analysis film. The third slide frame has a thickness which is equal to or larger than the thickness of the chemical analysis film. The side wall of the opening in the first slide frame has a small optical reflection factor, preferably is dark so as to provide a small optical reflection factor.

摘要翻译： 一种化学分析滑动框架组件，包括第一和第二滑动框架，每个滑动框架的开口面积小于插入其中的化学分析薄膜的面积，以及设置在第一和第二滑动框架之间的第三滑动框架。 第三滑动框架具有适于容纳化学分析膜的开口，并且其形状基本上防止化学分析膜的位移。 第三滑动框架的厚度等于或大于化学分析膜的厚度。 第一滑动框架中的开口的侧壁具有小的光学反射系数，优选是暗的，以便提供小的光学反射系数。