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1.发明申请公开(公告)号：US20060115833A1
公开(公告)日：2006-06-01
申请号：US11231998
申请日：2005-09-22
CPC分类号： C12Q1/6872 , C12Q2565/607 , C12Q2537/149 , C12Q2521/319
摘要： Disclosed herein is a method and apparatus for determining the base sequence of a nucleic acid molecule by cleaving a nucleic acid molecule of interest while controlling the cleavage site, measuring the change in mass which occurs in the nucleic acid molecule after the cleavage step, and acquiring the base information of the cleaved nucleic acid molecule from the data about the change in mass. The method and apparatus are based on the principle which is entirely different from that used for the conventional technique.
摘要翻译： 本文公开了一种方法和装置，用于通过在控制切割位点的同时切割感兴趣的核酸分子来测定核酸分子的碱基序列，测量在切割步骤后在核酸分子中发生的质量变化，并获取 从关于质量变化的数据的切割的核酸分子的基础信息。 该方法和装置基于与用于常规技术的原理完全不同的原理。
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2.发明授权公开(公告)号：US07371532B2
公开(公告)日：2008-05-13
申请号：US11231998
申请日：2005-09-22
CPC分类号： C12Q1/6872 , C12Q2565/607 , C12Q2537/149 , C12Q2521/319
摘要： Disclosed herein is a method and apparatus for determining the base sequence of a nucleic acid molecule by cleaving a nucleic acid molecule of interest while controlling the cleavage site, measuring the change in mass which occurs in the nucleic acid molecule after the cleavage step, and acquiring the base information of the cleaved nucleic acid molecule from the data about the change in mass. The method and apparatus are based on the principle which is entirely different from that used for the conventional technique.
摘要翻译： 本文公开了一种方法和装置，用于通过在控制切割位点的同时切割感兴趣的核酸分子来测定核酸分子的碱基序列，测量在切割步骤后在核酸分子中发生的质量变化，并获取 从关于质量变化的数据的切割的核酸分子的基础信息。 该方法和装置基于与用于常规技术的原理完全不同的原理。
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3.发明申请Circadian rhythm control gene cluster, DNA chip, and methods for using the DNA chip 审中-公开昼夜节律控制基因簇，DNA芯片和使用DNA芯片的方法公开(公告)号：US20060154268A1
公开(公告)日：2006-07-13
申请号：US11174992
申请日：2005-07-05
CPC分类号： C07K14/4702
摘要： A circadian rhythm control gee cluster (Bmal1 gene, Npas2 gene, Rev-erbα, Dbp gene, Per3 gene, Per2 gene and Per1 gene) having a given expression timing and expression sequence under normal conditions is provided along with a DNA chip having, at least, the circadian control gene group sequentially arranged. There are also provided a method for predicting modulation in expression timing of the circadian rhythm control gene cluster, a method for detecting a circadian rhythm modulation, a method for selecting a circadian rhythm regulator, a method for screening a circadian rhythm regulator, and screening of a substance involving modulation of a circadian rhythm as a side effect, each using the DNA chip.
摘要翻译： 在正常条件下具有给定表达时间和表达序列的昼夜节律控制gee簇（Bmal1基因，Npas2基因，Rev-erbalpha，Dbp基因，Per3基因，Per2基因和Per1基因）与DNA芯片一起提供， 至少，昼夜节律控制基因组顺序排列。 还提供了一种用于预测昼夜节律控制基因簇的表达定时中的调制的方法，用于检测昼夜节律调节的方法，选择昼夜节律调节剂的方法，筛选昼夜节律调节剂的方法，以及筛选 一种涉及调节昼夜节律作为副作用的物质，每种都使用DNA芯片。
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公开(公告)号：US20120093807A1
公开(公告)日：2012-04-19
申请号：US13234273
申请日：2011-09-16
申请人： Takuro Yamamoto , Takayoshi Mamine , Toru Takumi , Makoto Akashi
发明人： Takuro Yamamoto , Takayoshi Mamine , Toru Takumi , Makoto Akashi
IPC分类号： A61K39/395 , A61P25/24 , A61P25/20 , A61P35/00 , A61P25/00
CPC分类号： A61K31/7105 , A61K31/7088 , C07K14/4702 , C07K14/70567 , G01N33/743 , G01N2333/70567 , G01N2500/00
摘要： An object of the present invention is to clarify unelucidated aspects in the control mechanism of circadian rhythms. The present inventors have newly found that RORα (retinoic acid binding-receptor alpha; the same shall apply hereinafter) stimulates an induction of Bmal1 expression and also that the induction of Bmal1 expression is promoted under hypoxia. These findings strongly suggest the existence of a control mechanism of circadian rhythms that, when RORα expression is promoted under hypoxia or the like, an induction of Bmal1 expression is stimulated and, when the induction of Bmal1 expression is stimulated, binding between BMAL1 and CLOCK is stimulated and an induction of Per gene or Cry gene expression is stimulated. The present invention, therefore, has applicability as jet-lag regulating agents and anticancer agents.
摘要翻译： 本发明的目的是澄清昼夜节律控制机制中的未消化方面。 本发明人新发现RORα（视黄酸结合受体α，以下同样适用）刺激Bmal1表达的诱导，并且在缺氧下促进Bmal1表达的诱导。 这些发现强烈地表明存在昼夜节律的控制机制，当在缺氧等下促进RORα表达时，刺激Bmal1表达的诱导，并且当刺激Bmal1表达的诱导时，BMAL1和CLOCK之间的结合是 刺激并诱导Per基因或Cry基因表达。 因此，本发明具有作为喷射滞后调节剂和抗癌剂的适用性。
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公开(公告)号：US08623597B2
公开(公告)日：2014-01-07
申请号：US10484134
申请日：2003-05-21
申请人： Takayoshi Mamine , Takuro Yamamoto
发明人： Takayoshi Mamine , Takuro Yamamoto
CPC分类号： G01N33/543 , B01J2219/0036 , B01J2219/00362 , B01J2219/00378 , B01J2219/00527 , B01J2219/00536 , B01J2219/00576 , B01J2219/00585 , B01J2219/00596 , B01J2219/00653 , B01J2219/00659 , B01J2219/00677 , B01J2219/00722 , B01J2219/00725 , C40B40/06 , C40B40/10 , C40B60/14 , G01N33/54366 , G01N33/54373 , G01N33/54393
摘要： Disclosed is a bioassay method in which, by controlling the electric field formation in the reaction region where an interaction between substances, such as a hybridization, is performed, the efficiency of the interaction can be improved. Also disclosed is a bioassay apparatus in which the method can be favorably carried out. The method includes at least a step of turning on/off the electric field formation by the electric field-forming means E at a predetermined timing.
摘要翻译： 公开了一种生物测定方法，其中通过控制在进行诸如杂交的物质之间的相互作用的反应区域中的电场形成，可以提高相互作用的效率。 还公开了可以有利地进行该方法的生物测定装置。 该方法至少包括在预定定时通过电场形成装置E接通/断开电场形成的步骤。
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公开(公告)号：US20090292111A1
公开(公告)日：2009-11-26
申请号：US11909058
申请日：2006-03-27
申请人： Takuro Yamamoto , Takayoshi Mamine , Toru Takumi , Makoto Akashi
发明人： Takuro Yamamoto , Takayoshi Mamine , Toru Takumi , Makoto Akashi
CPC分类号： A61K31/7105 , A61K31/7088 , C07K14/4702 , C07K14/70567 , G01N33/743 , G01N2333/70567 , G01N2500/00
摘要： An object of the present invention is to clarify unelucidated aspects in the control mechanism of circadian rhythms. The present inventors have newly found that RORα (retinoic acid binding-receptor alpha; the same shall apply hereinafter) stimulates an induction of Bmal1 expression and also that the induction of Bmal1 expression is promoted under hypoxia. These findings strongly suggest the existence of a control mechanism of circadian rhythms that, when RORα expression is promoted under hypoxia or the like, an induction of Bmal1 expression is stimulated and, when the induction of Bmal1 expression is stimulated, binding between BMAL1 and CLOCK is stimulated and an induction of Per gene or Cry gene expression is stimulated. The present invention, therefore, has applicability as jet-lag regulating agents and anticancer agents.
摘要翻译： 本发明的目的是澄清昼夜节律控制机制中的未消化方面。 本发明人新发现，RORalpha（视黄酸结合受体α，以下相同）将刺激Bmal1表达的诱导，并且在缺氧下促进Bmal1表达的诱导。 这些发现强烈地表明存在昼夜节律的控制机制，当在缺氧等下促进RORalpha表达时，刺激Bmal1表达的诱导，并且当刺激Bmal1表达的诱导时，BMAL1和CLOCK之间的结合是 刺激并诱导Per基因或Cry基因表达。 因此，本发明作为喷射滞后调节剂和抗癌剂具有适用性。
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公开(公告)号：US20060127904A1
公开(公告)日：2006-06-15
申请号：US10525714
申请日：2003-08-20
CPC分类号： B01J19/0046 , B01J2219/00436 , B01J2219/00529 , B01J2219/00576 , B01J2219/00596 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/0063 , B01J2219/00653 , B01J2219/00713 , B01J2219/00722 , B01L3/502761 , B01L2200/0663 , B01L2300/0819 , B01L2400/0424 , B03C5/005 , B03C5/026 , G01N33/54373
摘要： The present invention provides a hybridization detector (1a) and the like that are improved in the hybridization efficiency by arraying nucleotide probes in a stretched form, a sensor chip including the hybridization detector (1a) or the like, and a method of hybridization using these detectors or the chip. The hybridization detector (la) and the like include a reaction region (R) for hybridization between the nucleotide probes (X) and target nucleotide sequences (Y) having a base sequence complementary to the nucleotide probes (X). The reaction region (R) has a configuration for stretching the nucleotide probes (X) by an electric field and immobilizing the nucleotide probes (X) on ends (E) of scanning electrodes (C) by dielectrophoresis.
摘要翻译： 本发明提供了通过以拉伸形式排列核苷酸探针而提高杂交效率的杂交检测器（1a）等，包括杂交检测器（1a）的传感器芯片等，以及杂交方法 使用这些探测器或芯片。 杂交检测器（1a）等包括核苷酸探针（X）和碱基序列与核苷酸探针（X）互补的靶核苷酸序列（Y）之间进行杂交的反应区域（R）。 反应区域（R）具有通过电场拉伸核苷酸探针（X）的构造，并且通过介电电泳将扫描电极（C）的端部（E）固定在核苷酸探针（X）上。
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公开(公告)号：US20050069880A1
公开(公告)日：2005-03-31
申请号：US10484134
申请日：2003-05-21
申请人： Takayoshi Mamine , Takuro Yamamoto
发明人： Takayoshi Mamine , Takuro Yamamoto
IPC分类号： C12Q1/68 , C40B40/06 , C40B40/10 , C40B60/14 , G01N33/543
CPC分类号： G01N33/543 , B01J2219/0036 , B01J2219/00362 , B01J2219/00378 , B01J2219/00527 , B01J2219/00536 , B01J2219/00576 , B01J2219/00585 , B01J2219/00596 , B01J2219/00653 , B01J2219/00659 , B01J2219/00677 , B01J2219/00722 , B01J2219/00725 , C40B40/06 , C40B40/10 , C40B60/14 , G01N33/54366 , G01N33/54373 , G01N33/54393
摘要： Disclosed is a bioassay method in which, by controlling the electric field formation in the reaction region where an interaction between substances, such as a hybridization, is performed, the efficiency of the interaction can be improved. Also disclosed is a bioassay apparatus in which the method can be favorably carried out. In the method, an interaction between substances is detected by a detecting element 1 (10), the detecting element including at least a detection surface S (S′) which is surface-treated for immobilizing a detecting substance D, a reaction region R (R′) which provides a field for interaction between the detecting substance D immobilized on the detection surface S (S′) and a target substance T, and an electric field-forming means E which forms an electric field in the reaction region R (R′) by applying a potential difference in the reaction region R (R′), and the method includes at least a step of turning on/off the electric field formation by the electric field-forming means E at a predetermined timing.
摘要翻译： 公开了一种生物测定方法，其中通过控制在进行诸如杂交的物质之间的相互作用的反应区域中的电场形成，可以提高相互作用的效率。 还公开了可以有利地进行该方法的生物测定装置。 在该方法中，通过检测元件1（10）检测物质之间的相互作用，检测元件至少包括用于固定检测物质D进行表面处理的检测表面S（S'），反应区域R（ R'），其提供固定在检测表面S（S'）上的检测物质D与目标物质T之间的相互作用的场和在反应区域R（R）中形成电场的电场形成装置E '）通过在反应区域R（R'）中施加电位差，并且该方法至少包括在预定的时刻由电场形成装置E接通/关闭电场形成的步骤。
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9.发明授权Imaging apparatus, an imaging system, and a driving method of an imaging apparatus using correction data applied to pixels of same color 有权成像装置，成像系统和使用校正数据应用于相同像素的成像装置的驱动方法公开(公告)号：US09001246B2
公开(公告)日：2015-04-07
申请号：US13359366
申请日：2012-01-26
申请人： Koichiro Iwata , Tomoyuki Noda , Takeshi Akiyama , Kazumichi Morita , Kazuhiro Sonoda , Takuro Yamamoto
发明人： Koichiro Iwata , Tomoyuki Noda , Takeshi Akiyama , Kazumichi Morita , Kazuhiro Sonoda , Takuro Yamamoto
IPC分类号： H04N5/335 , H04N5/357 , H04N5/3745 , H04N5/378
CPC分类号： H04N5/3575 , H04N5/37457 , H04N5/378
摘要： An imaging apparatus includes a pixel unit, an amplifying transistor, and a control unit. The pixel unit includes a first photoelectric conversion unit generating a first charge based on incident light of a first color, a second photoelectric conversion unit generating a second charge based on incident light of the first color, and a third photoelectric conversion unit generating a third charge based on incident light of a second color. The amplifying transistor is provided in common to the first to third photoelectric conversion units, and outputs a signal based on the first, second, and third charges generated by the first, second, and third photoelectric conversion units, respectively. The control unit sets the pixel unit to a selected state or a non-selected state according to an electric potential of a control terminal of the amplifying transistor.
摘要翻译： 成像装置包括像素单元，放大晶体管和控制单元。 像素单元包括基于第一颜色的入射光产生第一电荷的第一光电转换单元，基于第一颜色的入射光产生第二电荷的第二光电转换单元和产生第三电荷的第三光电转换单元 基于第二种颜色的入射光。 放大晶体管与第一至第三光电转换单元共同设置，并分别输出基于由第一，第二和第三光电转换单元产生的第一，第二和第三电荷的信号。 控制单元根据放大晶体管的控制端子的电位将像素单元设定为选择状态或非选择状态。
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公开(公告)号：US08538251B2
公开(公告)日：2013-09-17
申请号：US13565125
申请日：2012-08-02
IPC分类号： G03B3/10
CPC分类号： H04N5/23212 , H04N5/3696
摘要： A focus detecting apparatus, comprising a first pair of sensor blocks each including a sensor unit and a detection unit, and a power supply unit configured to supply power to the detection unit, wherein when one of the first pair of sensor blocks operates in a first mode, the other operates in a second mode, the detection unit of the sensor block operating in the first mode detects an output of the sensor unit, the sensor unit of the sensor block operating in the second mode accumulates charges and terminates the charge accumulation operation in response to the detection operation, and the power supply unit shuts off power supply to the detection unit of the sensor block operating in the second mode for at least part of the period of time during the operation in the second mode.
摘要翻译： 一种焦点检测装置，包括：第一对传感器块，每个传感器块包括传感器单元和检测单元;以及电源单元，被配置为向所述检测单元供电，其中当所述第一对传感器块中的一个以第一对 模式，另一方式在第二模式下工作，则以第一模式操作的传感器块的检测单元检测传感器单元的输出，以第二模式操作的传感器块的传感器单元累积电荷并终止电荷累积操作 响应于所述检测操作，并且所述电源单元在所述第二模式中的操作期间的至少一部分时间内关闭在所述第二模式中操作的所述传感器块的检测单元的电力供应。
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