公开(公告)号：US09376470B2

公开(公告)日：2016-06-28

申请号：US13131796

申请日：2009-11-27

申请人： Takefumi Gemba ,  Hideki Tomioka ,  Ryoko Sata ,  Nao Tamura ,  Akito Maeda ,  Toshihide Kanamori ,  Yoshimi Saito ,  Shintaro Komaba ,  Ryuichi Morishita

发明人： Takefumi Gemba ,  Hideki Tomioka ,  Ryoko Sata ,  Nao Tamura ,  Akito Maeda ,  Toshihide Kanamori ,  Yoshimi Saito ,  Shintaro Komaba ,  Ryuichi Morishita

IPC分类号： C07K7/04 ,  C07K14/00 ,  C07K14/515 ,  A61K38/00

CPC分类号： C07K14/001 ,  A61K38/00 ,  C07K14/515

摘要： Novel polypeptides which have an excellent angiogenesis-inducing activity and an excellent antibacterial activity and medical uses thereof are disclosed. The amino acid sequences of the novel polypeptides are shown in any one of SEQ ID NOs:1 to 6. These polypeptides have angiogenesis-inducing and antibacterial activities. Such polypeptides are useful for the prevention, amelioration or treatment of skin wounds caused by a cut wound, surgical wound, erosion, burn, decubitus, intractable wound, skin ulcer, leg ulcer, diabetic ulcer, occlusive arterial disease or arteriosclerosis obliteran, and for the prevention, amelioration or treatment of bacterial infection in such skin wounds, and the like.

摘要翻译： 公开了具有优异的血管发生诱导活性和优异的抗菌活性的新型多肽及其医疗用途。 新型多肽的氨基酸序列显示在SEQ ID NO：1至6中的任一个中。这些多肽具有血管发生诱导和抗菌活性。 这样的多肽可用于预防，改善或治疗由切口伤口，手术伤口，侵蚀，烧伤，褥疮，难治性伤口，皮肤溃疡，腿部溃疡，糖尿病性溃疡，闭塞性动脉疾病或闭塞性动脉硬化引起的皮肤伤口，以及 预防，改善或治疗这些皮肤伤口中的细菌感染等。

公开(公告)号：US20120172287A1

公开(公告)日：2012-07-05

申请号：US13322424

申请日：2010-05-25

申请人： Takefumi Gemba ,  Hideki Tomioka ,  Nao Tamura ,  Ryoko Sata ,  Akito Maeda ,  Akiko Tenma ,  Toshihide Kanamori ,  Yoshimi Saito ,  Shintaro Komaba ,  Ryuichi Morishita

发明人： Takefumi Gemba ,  Hideki Tomioka ,  Nao Tamura ,  Ryoko Sata ,  Akito Maeda ,  Akiko Tenma ,  Toshihide Kanamori ,  Yoshimi Saito ,  Shintaro Komaba ,  Ryuichi Morishita

IPC分类号： A61P31/10 ,  A61P31/04 ,  A61K38/16 ,  A61K38/10 ,  C07K7/08 ,  C07K14/00 ,  A61P31/00 ,  A61P17/02

CPC分类号： C07K7/08 ,  A61K38/00 ,  A61K38/10

摘要： A novel polypeptide which has an excellent angiogenesis-inducing activity and an excellent antibacterial activity, and a novel angiogenesis-inducing agent which contains the polypeptide as an effective ingredient or a novel agent for treating a wound(s) which contains the polypeptide as an effective ingredient are disclosed. The polypeptide of the present invention is a polypeptide whose amino acid sequence is shown in any one of SEQ ID NOs:1 to 6, 8 and 10. The angiogenesis-inducing agent which contains the polypeptide of the present invention as an effective ingredient is useful for the prevention, amelioration or treatment of a disease such as a burns, decubitus, wound, skin ulcer, leg ulcer, diabetic ulcer, occlusive arterial disease and arteriosclerosis obliteran.

摘要翻译： 具有优异的血管发生诱导活性和优异的抗菌活性的新型多肽和含有多肽作为有效成分的新型血管生成诱导剂或用于治疗伤口的新型药剂，其含有多肽作为有效成分 成分被公开。 本发明的多肽是其氨基酸序列示于SEQ ID NO：1-6,8,10中的任一个中的多肽。含有本发明多肽作为有效成分的血管生成诱导剂是有用的 用于预防，改善或治疗诸如烧伤，褥疮，伤口，皮肤溃疡，腿部溃疡，糖尿病性溃疡，闭塞性动脉疾病和闭塞性动脉硬化的疾病。

公开(公告)号：US08969311B2

公开(公告)日：2015-03-03

申请号：US13322424

申请日：2010-05-25

申请人： Takefumi Gemba ,  Hideki Tomioka ,  Nao Tamura ,  Ryoko Sata ,  Akito Maeda ,  Akiko Tenma ,  Toshihide Kanamori ,  Yoshimi Saito ,  Shintaro Komaba ,  Ryuichi Morishita

发明人： Takefumi Gemba ,  Hideki Tomioka ,  Nao Tamura ,  Ryoko Sata ,  Akito Maeda ,  Akiko Tenma ,  Toshihide Kanamori ,  Yoshimi Saito ,  Shintaro Komaba ,  Ryuichi Morishita

IPC分类号： A61K38/10 ,  A61K38/16 ,  A61P35/00 ,  C07K14/515 ,  A61K38/00 ,  A61K38/04 ,  C07K5/00 ,  C07K7/00 ,  C07K16/00 ,  C07K17/00 ,  C07K7/08

CPC分类号： C07K7/08 ,  A61K38/00 ,  A61K38/10

摘要： A novel polypeptide which has an excellent angiogenesis-inducing activity and an excellent antibacterial activity, and a novel angiogenesis-inducing agent which contains the polypeptide as an effective ingredient or a novel agent for treating a wound(s) which contains the polypeptide as an effective ingredient are disclosed. The polypeptide of the present invention is a polypeptide whose amino acid sequence is shown in any one of SEQ ID NOs:1 to 6, 8 and 10. The angiogenesis-inducing agent which contains the polypeptide of the present invention as an effective ingredient is useful for the prevention, amelioration or treatment of a disease such as a burns, decubitus, wound, skin ulcer, leg ulcer, diabetic ulcer, occlusive arterial disease and arteriosclerosis obliteran.

摘要翻译： 具有优异的血管发生诱导活性和优异的抗菌活性的新型多肽和含有多肽作为有效成分的新型血管生成诱导剂或用于治疗伤口的新型药剂，其含有多肽作为有效成分 成分被公开。 本发明的多肽是其氨基酸序列示于SEQ ID NO：1-6,8,10中的任一个中的多肽。含有本发明多肽作为有效成分的血管生成诱导剂是有用的 用于预防，改善或治疗诸如烧伤，褥疮，伤口，皮肤溃疡，腿部溃疡，糖尿病性溃疡，闭塞性动脉疾病和闭塞性动脉硬化的疾病。

公开(公告)号：US20120122766A1

公开(公告)日：2012-05-17

申请号：US13131796

申请日：2009-11-27

申请人： Takefumi Gemba ,  Hideki Tomioka ,  Ryoko Sata ,  Nao Tamura ,  Akito Maeda ,  Toshihide Kanamori ,  Yoshimi Saito ,  Shintaro Komaba ,  Ryuichi Morishita

发明人： Takefumi Gemba ,  Hideki Tomioka ,  Ryoko Sata ,  Nao Tamura ,  Akito Maeda ,  Toshihide Kanamori ,  Yoshimi Saito ,  Shintaro Komaba ,  Ryuichi Morishita

IPC分类号： A61K38/10 ,  C07K14/00 ,  A61P31/04 ,  A61P9/00 ,  A61P17/02 ,  C07K7/08 ,  A61K38/16

CPC分类号： C07K14/001 ,  A61K38/00 ,  C07K14/515

摘要： Novel polypeptides which have an excellent angiogenesis-inducing activity and an excellent antibacterial activity and medical uses thereof are disclosed. The amino acid sequences of the novel polypeptides are shown in any one of SEQ ID NOs:1 to 6. These polypeptides have angiogenesis-inducing and antibacterial activities. Such polypeptides are useful for the prevention, amelioration or treatment of skin wounds caused by a cut wound, surgical wound, erosion, burn, decubitus, intractable wound, skin ulcer, leg ulcer, diabetic ulcer, occlusive arterial disease or arteriosclerosis obliteran, and for the prevention, amelioration or treatment of bacterial infection in such skin wounds, and the like.

摘要翻译： 公开了具有优异的血管发生诱导活性和优异的抗菌活性的新型多肽及其医疗用途。 新型多肽的氨基酸序列显示在SEQ ID NO：1至6中的任一个中。这些多肽具有血管发生诱导和抗菌活性。 这样的多肽可用于预防，改善或治疗由切口伤口，手术伤口，侵蚀，烧伤，褥疮，难治性伤口，皮肤溃疡，腿部溃疡，糖尿病性溃疡，闭塞性动脉疾病或闭塞性动脉硬化引起的皮肤伤口，以及 预防，改善或治疗这些皮肤伤口中的细菌感染等。

公开(公告)号：US09458429B2

公开(公告)日：2016-10-04

申请号：US13700844

申请日：2011-03-11

申请人： Keiko Kitamura ,  Yuta Inami ,  Koichi Nakaoji ,  Kazuhiko Hamada ,  Akito Maeda ,  Tadashi Furumoto ,  Yasufumi Kaneda ,  Katsuto Tamai

发明人： Keiko Kitamura ,  Yuta Inami ,  Koichi Nakaoji ,  Kazuhiko Hamada ,  Akito Maeda ,  Tadashi Furumoto ,  Yasufumi Kaneda ,  Katsuto Tamai

IPC分类号： C12N5/071 ,  C12N5/0775 ,  A61K36/47 ,  A61K36/60 ,  A61K36/65 ,  A61K36/736 ,  A61K36/74

CPC分类号： A61K36/60 ,  A61K36/185 ,  A61K36/47 ,  A61K36/65 ,  A61K36/736 ,  A61K36/74 ,  C12N5/0662 ,  C12N5/0663

摘要： The present invention aims to provide a mesenchymal stem cell attractant capable of attracting a mesenchymal stem cell; and others. The present invention provides a mesenchymal stem cell attractant containing at least one selected from the group consisting of an extract of a Bodhi tree, an extract of the root bark of Paeonia suffruticosa Andrews, an extract of Mallotus philippinensis, an extract of Uncaria gambir an extract of Pashanbheda, and an extract of a plant belonging to the genus Prunus.

摘要翻译： 本发明旨在提供能够吸引间充质干细胞的间充质干细胞引诱剂; 和别的。 本发明提供了含有至少一种选自菩提树提取物，芍药提取物，芍药提取物，马齿苋提取物，乌贼属提取物的提取物的间充质干细胞引诱剂 （Pashanbheda），以及属于李属（Prunus）属的植物提取物。

公开(公告)号：US20130071920A1

公开(公告)日：2013-03-21

申请号：US13700844

申请日：2011-03-11

申请人： Keiko Kitamura ,  Yuta Inami ,  Koichi Nakaoji ,  Kazuhiko Hamada ,  Akito Maeda ,  Tadashi Furumoto ,  Yasufumi Kaneda ,  Katsuto Tamai

发明人： Keiko Kitamura ,  Yuta Inami ,  Koichi Nakaoji ,  Kazuhiko Hamada ,  Akito Maeda ,  Tadashi Furumoto ,  Yasufumi Kaneda ,  Katsuto Tamai

IPC分类号： C12N5/071 ,  C12N5/07

CPC分类号： A61K36/60 ,  A61K36/185 ,  A61K36/47 ,  A61K36/65 ,  A61K36/736 ,  A61K36/74 ,  C12N5/0662 ,  C12N5/0663

摘要： The present invention aims to provide a mesenchymal stem cell attractant capable of attracting a mesenchymal stem cell; and others. The present invention provides a mesenchymal stem cell attractant containing at least one selected from the group consisting of an extract of a Bodhi tree, an extract of the root bark of Paeonia suffruticosa Andrews, an extract of Mallotus philippinensis, an extract of Uncaria gambir an extract of Pashanbheda, and an extract of a plant belonging to the genus Prunus.

摘要翻译： 本发明旨在提供能够吸引间充质干细胞的间充质干细胞引诱剂; 和别的。 本发明提供了含有至少一种选自菩提树提取物，芍药提取物，芍药提取物，马齿苋提取物，乌贼属提取物的提取物的间充质干细胞引诱剂 （Pashanbheda），以及属于李属（Prunus）属的植物提取物。