公开(公告)号：US4918054A

公开(公告)日：1990-04-17

申请号：US379656

申请日：1989-07-11

申请人： Tatsuo Haneishi ,  Takao Okazaki ,  Akio Torikata ,  Mutsuo Nakajima ,  Ryuzo Enokita ,  Toshiaki Katayama ,  Seigo Iwado

发明人： Tatsuo Haneishi ,  Takao Okazaki ,  Akio Torikata ,  Mutsuo Nakajima ,  Ryuzo Enokita ,  Toshiaki Katayama ,  Seigo Iwado

IPC分类号： C12P21/02 ,  A61K35/74 ,  A61K38/00 ,  C07K9/00 ,  C07K14/195 ,  C07K14/41 ,  C12P21/04 ,  C12R1/01

CPC分类号： C12R1/01 ,  C07K9/008 ,  A61K38/00

摘要： Novel compounds, called chloropolysporins B and C, and salts thereof have antibiotic properties and would appear to be members of the class of glycopeptide antibiotics containing chlorine. They may be produced by cultivating a suitable strain of miroorganism of the genus Micropolyspora, especially Micropolyspora sp. SANK 60983 (FERM BP-538). They may be combined with conventional pharmaceutically acceptable carriers or diluents for therapeutic use or incorporated into edible excipients, such as feed or water, for use as a growth-promoting agent, especially for farm animals.

摘要翻译： 称为氯霉素B和C的新化合物及其盐具有抗生素性质，并且似乎是含有氯的糖肽抗生素类的成员。 它们可以通过培养合适的微孢子虫微生物菌株而产生，特别是微孢子虫（Micropolyspora sp。）。 SANK 60983（FERM BP-538）。 它们可以与用于治疗用途的常规药学上可接受的载体或稀释剂组合，或并入可食用赋形剂如饲料或水中，用作生长促进剂，特别是用于农场动物。

公开(公告)号：US4557933A

公开(公告)日：1985-12-10

申请号：US627439

申请日：1984-07-03

申请人： Tatsuo Haneishi ,  Takao Okazaki ,  Akio Torikata ,  Mutsuo Nakajima ,  Ryuzou Enokita ,  Toshiaki Katayama ,  Seigo Iwado

发明人： Tatsuo Haneishi ,  Takao Okazaki ,  Akio Torikata ,  Mutsuo Nakajima ,  Ryuzou Enokita ,  Toshiaki Katayama ,  Seigo Iwado

IPC分类号： C07G11/00 ,  A23K20/195 ,  A61K35/74 ,  A61P31/04 ,  C12P1/06 ,  C12P21/00 ,  C12R1/01

CPC分类号： C12P21/005 ,  A23K20/195 ,  C12P1/06

摘要： A novel compound, called chloropolysporin, has antibiotic properties and would appear to be a member of the class of glycopeptide antibiotics containing chlorine. It may be produced by cultivating a suitable strain of microorganism of the genus Micropolyspora, especially Micropolyspora sp. SANK 60983 (FERM BP-538). It may be combined with conventional pharmaceutically acceptable carriers or diluents for therapeutic use or incorporated into edible excipients, such as feed or water, for use as a growth-promoting agent, especially for farm animals.

摘要翻译： 一种称为氯聚球蛋白的新化合物具有抗生素特性，似乎是含有氯的糖肽类抗生素类的成员。 可以通过培养合适的微孢子虫微生物菌株，特别是微孢子虫（Micropolyspora sp。 SANK 60983（FERM BP-538）。 其可以与用于治疗用途的常规药学上可接受的载体或稀释剂组合，或掺入可食用赋形剂如饲料或水中，用作生长促进剂，特别是用于农场动物。

公开(公告)号：US4897104A

公开(公告)日：1990-01-30

申请号：US184409

申请日：1988-04-21

申请人： Tatsuo Haneishi ,  Mutsuo Nakajima ,  Kiyoshi Koi ,  Kohei Furuya ,  Seigo Iwado ,  Sadao Sato

发明人： Tatsuo Haneishi ,  Mutsuo Nakajima ,  Kiyoshi Koi ,  Kohei Furuya ,  Seigo Iwado ,  Sadao Sato

IPC分类号： A01N63/04 ,  C07D307/93 ,  C12N1/14 ,  C12P7/44 ,  C12P17/04 ,  C12R1/79

CPC分类号： C12R1/645 ,  C07D307/93 ,  C12P17/04 ,  C12P7/44 ,  Y10S435/911

摘要： A novel compound named "cornexistin" has the formula (I): ##STR1## and it and the corresponding ring-opened diacid and salts thereof have herbicidal and growth regulating effects. Cornexistin can be prepared by cultivation of a microorganism of the genus Paecilomyces, e.g. Paecilomyces variotii Bainier SANK 21086.

公开(公告)号：US4990178A

公开(公告)日：1991-02-05

申请号：US435695

申请日：1989-11-13

申请人： Tatsuo Haneishi ,  Mutsuo Nakajima ,  Kiyoshi Koi ,  Kohei Furuya ,  Seigo Iwado ,  Sadao Sata

发明人： Tatsuo Haneishi ,  Mutsuo Nakajima ,  Kiyoshi Koi ,  Kohei Furuya ,  Seigo Iwado ,  Sadao Sata

IPC分类号： A01N63/04 ,  C07D307/93 ,  C12N1/14 ,  C12P7/44 ,  C12P17/04 ,  C12R1/79

CPC分类号： C12R1/645 ,  C07D307/93 ,  C12P17/04 ,  C12P7/44 ,  Y10S435/911

摘要： A novel compound names "cornexistin" has the formula (I): ##STR1## and it and the corresponding ring-opened diacid and salts thereof have herbicidal and growth regulating effects. Cornexistin can be prepared by cultivation of a microorganism of the genus Paecilomyces, e.g. Paecilomyces variotii Bainier SANK 21086.

公开(公告)号：US5153124A

公开(公告)日：1992-10-06

申请号：US393001

申请日：1989-08-11

申请人： Kouhei Furuya ,  Takao Okazaki ,  Yoshio Tsujita ,  Seigo Iwado ,  Kiyoshi Hamano ,  Masao Kuroda ,  Jun Yoshikawa ,  Toshiaki Iwai ,  Kunio Nakano

发明人： Kouhei Furuya ,  Takao Okazaki ,  Yoshio Tsujita ,  Seigo Iwado ,  Kiyoshi Hamano ,  Masao Kuroda ,  Jun Yoshikawa ,  Toshiaki Iwai ,  Kunio Nakano

IPC分类号： A61K31/225 ,  C07C67/31 ,  C07C69/675 ,  C07D309/10 ,  C07D309/30 ,  C12P7/62 ,  C12P17/06

CPC分类号： C12R1/645 ,  C07D309/10 ,  C12P17/06 ,  C12P7/62 ,  C12R1/365

摘要： Derivatives of ML-236B carboxylic acid, its salts and esters and corresponding lactone have a hydroxy group at the 3"-position and optionally also at the 6'-position. These derivatives may be prepared by the enzymatic hydroxylation of a corresponding ML-236B compound employing an enzyme produced by a microorganism of the genus Streptomyces or Amycolata, especially Streptomyces sp. SANK 62285, Streptomyces sp. SANK 62385, Streptomyces sp. SANK 62485, Streptomyces sp. SANK 62585, Amycolata autotrophica SANK 62781, Amycolata autotrophica subsp. canberrica SANK 62882 or Amycolata autotrophica subsp. amethystina SANK 62981. These derivatives have the ability to inhibit cholesterol biosynthesis.

摘要翻译： ML-236B羧酸的衍生物，其盐和酯和相应的内酯在3“位和任选也在6'位具有羟基。 这些衍生物可以通过使用由链霉菌属或Amycolata属的微生物，特别是链霉菌属（Streptomyces sp。）产生的酶的相应的ML-236B化合物的酶促羟基化来制备。 SANK 62285，Streptomyces sp。 SANK 62385，Streptomyces sp。 SANK 62485，Streptomyces sp。 SANK 62585，Amycolata autotrophica SANK 62781，Amycolata autotrophica subsp。 canberrica SANK 62882或Amycolata autotrophica subsp。 紫杉醇SANK 62981.这些衍生物具有抑制胆固醇生物合成的能力。

公开(公告)号：US5008191A

公开(公告)日：1991-04-16

申请号：US131413

申请日：1987-12-10

申请人： Takao Okazaki ,  Shuji Takahashi ,  Seigo Iwado ,  Keiji Tanaka ,  Toshiaki Yanai ,  Hisaki Kajino

发明人： Takao Okazaki ,  Shuji Takahashi ,  Seigo Iwado ,  Keiji Tanaka ,  Toshiaki Yanai ,  Hisaki Kajino

IPC分类号： C07D493/22 ,  A01N43/90 ,  A01N49/00 ,  A01P7/02 ,  A01P7/04 ,  C07D307/00 ,  C07D309/00 ,  C07H19/01 ,  C12P17/18 ,  C12P19/54

CPC分类号： C07H19/01 ,  A01N49/00 ,  C12P17/181 ,  Y02P20/55 ,  Y10S435/898

摘要： Compounds with acaricidal, insecticidal and anthelmintic activities have the formula: ##STR1## wherein: --X--Y-- is selected from the group consisting of --CH.sub.2 --CH.sub.2 --, --CH.sub.2 --CHOH--, --CH.dbd.CH--, and --CH.sub.2 --C(.dbd.O)--;R.sup.1 is selected from the group consisting of a methyl group, an ethyl group, an isopropyl group, a sec-butyl group and groups of formula --C(CH.sub.3).dbd.CHR.sup.5 in which R.sup.5 is selected from the group consisting of a methyl group, an ethyl group and an isopropyl group;R.sup.2 represents a group of formula --(CH.sub.2).sub.n --C(R.sup.6).dbd.C(R.sup.7)(R.sup.8) in which n is 0, 1 or 2, R.sup.6 and R.sup.7 each is selected from the group consisting of a hydrogen atom and a methyl group and R.sup.8 is selected from the group consisting of a hydrogen atom, a C.sub.1-4 alkyl group, a phenyl group and a phenyl group substituted with at least one substituent selected from the group consisting of halogen, methyl and nitro substitutents;R.sup.3 is selected from the group consisting of a hydrogen atom, a methyl group, a hydroxy-protecting group, an ester-forming carboxylic acid residue, and an ester-forming carbonic acid residue; andR.sup.4 is selected from the group consisting of a hydrogen atom and an .alpha.-L-oleandrosyl-.alpha.-L-oleandrosyloxy group, with the proviso that R.sup.4 represents a hydrogen atom when the group R.sup.1 is selected from the group consisting of a methyl group, an ethyl group, and groups of formula --C(CH.sub.3).dbd.CHR.sup.5 in which R.sup.5 is selected from the group consisting of a methyl group, an ethyl group and an isopropyl group.

公开(公告)号：US5272174A

公开(公告)日：1993-12-21

申请号：US919154

申请日：1992-07-23

申请人： Kouhei Furuya ,  Takao Okazaki ,  Yoshio Tsujita ,  Seigo Iwado ,  Kiyoshi Hamano ,  Masao Kuroda ,  Jun Yoshikawa ,  Toshiaki Iwai ,  Kunio Nakano

发明人： Kouhei Furuya ,  Takao Okazaki ,  Yoshio Tsujita ,  Seigo Iwado ,  Kiyoshi Hamano ,  Masao Kuroda ,  Jun Yoshikawa ,  Toshiaki Iwai ,  Kunio Nakano

IPC分类号： C07D309/10 ,  C12P7/62 ,  C12P17/06 ,  A61K31/365 ,  A61K31/215

CPC分类号： C12R1/645 ,  C07D309/10 ,  C12P17/06 ,  C12P7/62 ,  C12R1/365 ,  Y10S514/824

摘要： Derivatives of ML-236B carboxylic acid, its salts and esters and corresponding lactone have a hydroxy group at the 3"-position and optionally also at the 6'-position. These derivatives may be prepared by the enzymatic hydroxylation of a corresponding ML-236B compound employing an enzyme produced by a microorganism of the genus Streptomyces or Amycolata, especially Streptomyces sp. SANK 62285, Streptomyces sp. SANK 62385, Streptomyces sp. SANK 62485, Streptomyces sp. SANK 62585, Amycolata autotrophica SANK 62781. Amycolata autotrophica subsp. canberrica SANK 62882 or Amycolata autotrophica subsp. amethystina SANK 62981. These derivatives have the ability to inhibit cholesterol biosynthesis.

摘要翻译： ML-236B羧酸的衍生物，其盐和酯和相应的内酯在3“位和任选也在6'位具有羟基。 这些衍生物可以通过使用由链霉菌属或Amycolata属的微生物，特别是链霉菌属（Streptomyces sp。）产生的酶的相应的ML-236B化合物的酶促羟基化来制备。 SANK 62285，Streptomyces sp。 SANK 62385，Streptomyces sp。 SANK 62485，Streptomyces sp。 SANK 62585，Amycolata autotrophica SANK 62781. Amycolata autotrophica subsp。 canberrica SANK 62882或Amycolata autotrophica subsp。 紫杉醇SANK 62981.这些衍生物具有抑制胆固醇生物合成的能力。

公开(公告)号：US5212322A

公开(公告)日：1993-05-18

申请号：US644100

申请日：1991-01-22

申请人： Takao Okazaki ,  Shuji Takahashi ,  Seigo Iwado ,  Keiji Tanaka ,  Toshiaki Yanai ,  Hisaki Kajino

发明人： Takao Okazaki ,  Shuji Takahashi ,  Seigo Iwado ,  Keiji Tanaka ,  Toshiaki Yanai ,  Hisaki Kajino

IPC分类号： A01N49/00 ,  C07H19/01 ,  C12P17/18

CPC分类号： C07H19/01 ,  A01N49/00 ,  C12P17/181 ,  Y02P20/55 ,  Y10S424/08

摘要： Compounds with acaricidal, insecticidal and anthelmintic activities have the formula: ##STR1## wherein: --X--Y-- is selected from the group consisting of --CH.sub.2 --CH.sub.2 --, --CH.sub.2 --CHOH--, --CH.dbd.CH--, and --CH.sub.2 --C(.dbd.O)--;R.sup.1 is selected from the group consisting of a methyl group, an ethyl group, an isopropyl group, a sec-butyl group and groups of formula --C(CH.sub.3).dbd.CHR.sup.5 in which R.sup.5 is selected from the group consisting of a methyl group, an ethyl group and an isopropyl group;R.sup.2 represents a group of formula --(CH.sub.2).sub.n --C(R.sup.6).dbd.C(R.sup.7)(R.sup.8) in which n is 0, 1 or 2, R.sup.6 and R.sup.7 each is selected from the group consisting of a hydrogen atom and a methyl group and R.sup.8 is selected from the group consisting of a hydrogen atom, a C.sub.1-4 alkyl group, a phenyl group and a phenyl group substituted with at least one substituent selected from the group consisting of halogen, methyl and nitro substituents;R.sup.3 is selected from the group consisting of a hydrogen atom, a methyl group, a hydroxy-protecting group, an ester-forming carboxylic acid residue, and an ester-forming carbonic acid residue; andR.sup.4 is selected from the group consisting of a hydrogen atom and an .alpha.-L-oleandrosyl-.alpha.-L-oleandrosyloxy group, with the proviso that R.sup.4 represents a hydrogen atom when the group R.sup.1 is selected from the group consisting of a methyl group, an ethyl group, and groups of formula --C(CH.sub.3).dbd.CHR.sup.5 in which R.sup.5 is selected from the group consisting of a methyl group, an ethyl group and an isopropyl group.

摘要翻译： 具有杀螨，杀虫和驱虫活性的化合物具有下式：其中：-XY-选自-CH 2 -CH 2 - ， - CH 2 -CHOH - ， - CH = CH-和 - CH2-C（= O） - ; R 1选自甲基，乙基，异丙基，仲丁基和式-C（CH 3）= CHR 5的基团，其中R 5选自甲基， 乙基和异丙基; R 2表示式 - （CH 2）n C（R 6）= C（R 7）（R 8）的基团，其中n为0,1或2，R 6和R 7各自为氢原子和甲基 并且R 8选自氢原子，C 1-4烷基，苯基和被至少一个选自卤素，甲基和硝基取代基的取代基取代的苯基; R3选自氢原子，甲基，羟基保护基，成酯羧酸残基和形成酯的碳酸残基; 并且R 4选自氢原子和α-L-甘氨酰基-α-L-胆碱基氧基，条件是当R 1选自甲基时，R 4表示氢原子 ，乙基和式-C（CH 3）= CHR 5基团，其中R 5选自甲基，乙基和异丙基。

公开(公告)号：US4460765A

公开(公告)日：1984-07-17

申请号：US377435

申请日：1982-05-12

申请人： Atsushi Naito ,  Fumio Nakagawa ,  Takao Okazaki ,  Akira Terahara ,  Seigo Iwado ,  Mitsuo Yamazaki

发明人： Atsushi Naito ,  Fumio Nakagawa ,  Takao Okazaki ,  Akira Terahara ,  Seigo Iwado ,  Mitsuo Yamazaki

IPC分类号： A61K35/74 ,  A61K38/55 ,  A61P9/00 ,  A61P21/02 ,  A61P29/00 ,  A61P35/00 ,  C07G99/00 ,  C07H19/16 ,  C12N9/99 ,  C12P1/06 ,  C12P19/40 ,  C12R1/465 ,  C07H17/02 ,  C12P17/18

CPC分类号： A61K31/70 ,  A61K35/742 ,  C07H19/16 ,  C12N9/99 ,  C12P1/06 ,  C12P19/40 ,  C12R1/465 ,  Y10S435/886

摘要： A new compound, named "Griseolic acid", and its salts and can be prepared by the cultivation of Streptomyces griseoaurantiacus SANK 63479 (FERM-P 5223). Griseolic acid and its salts inhibit the activity of the enzyme cyclic adenosine monophosphate phosphodiesterase and, as a result of this, have variety of physiological activities and uses.

摘要翻译： 一种名为“Griseolic acid”的新化合物及其盐，可以通过培养Griseotoreiacus SANK 63479（FERM-P 5223）来制备。 绿藻酸及其盐抑制环状腺苷磷酸二酯酶的活性，其结果是具有多种生理活性和用途。

公开(公告)号：US4323648A

公开(公告)日：1982-04-06

申请号：US137821

申请日：1980-04-04

申请人： Kazuhiko Tanzawa ,  Seigo Iwado ,  Yoshio Tsujita ,  Masao Kuroda ,  Kouhei Furuya

发明人： Kazuhiko Tanzawa ,  Seigo Iwado ,  Yoshio Tsujita ,  Masao Kuroda ,  Kouhei Furuya

IPC分类号： A61K36/06 ,  A61K31/35 ,  A61P3/06 ,  C07D233/64 ,  C07D309/30 ,  C12P1/02 ,  C12P7/62 ,  C12P17/02 ,  C12P17/06 ,  C12R1/645

CPC分类号： C12P17/06 ,  C07D309/30 ,  Y10S435/911

摘要： Monacolin K, which is an antihypercholesteraemic agent of molecular formula C.sub.24 H.sub.36 O.sub.5, is prepared by cultivating one or more of the microorganisms Monascus anka SANK 10171 (IFO 6540), Monascus purpureus SANK 10271 (IFO 4513), Monascus ruber SANK 10671 (FERM 4958), Monascus vitreus SANK 10960 (FERM 4960), Monascus paxii SANK 11172 (IFO 8201), Monascus ruber SANK 13778 (FERM 4959), Monascus ruber SANK 15177 (FERM 4956) or Monascus ruber SANK 18174 (FERM 4957) in a suitable culture medium and then isolating the Monacolin K from the resulting culture broth.

摘要翻译： 作为分子式C24H36O5的抗高胆固醇血症药的莫纳可林K是通过培养一种或多种微生物Monkaus又名SANK 10171（IFO 6540），红曲霉SANK 10271（IFO 4513），红曲霉SANK 10671（FERM 4958）， 红曲霉玻璃体SANK 10960（FERM 4960），红曲霉SANK 11172（IFO 8201），红曲霉SANK 13778（FERM 4959），红曲霉SANK 15177（FERM 4956）或红曲霉SANK 18174（FERM 4957）在合适的培养基中， 然后从所得培养液中分离出莫纳可林K。