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    Method of amplifying nucleic acid by electromagnetic induction heating and reaction container and reaction device to be used therein
    1.
    发明申请
    Method of amplifying nucleic acid by electromagnetic induction heating and reaction container and reaction device to be used therein 审中-公开
    通过电磁感应加热和反应容器放大核酸的方法及其中使用的反应装置

    公开(公告)号：US20050158725A1

    公开(公告)日：2005-07-21

    申请号：US10510819

    申请日：2003-09-24

    申请人： Tetsuo Yukimasa ,  Nobuhiko Ozaki ,  Masaya Nakatani ,  Hidenobu Yaku ,  Hiroaki Oka ,  Kimi Fukahi

    发明人： Tetsuo Yukimasa ,  Nobuhiko Ozaki ,  Masaya Nakatani ,  Hidenobu Yaku ,  Hiroaki Oka ,  Kimi Fukahi

    IPC分类号： C07H21/00 ,  C12Q1/68 ,  C12M1/34

    CPC分类号： C07H21/00 ,  C12Q1/6844

    摘要： The present invention provides a reaction container, a reaction device, and a method of amplifying a nucleic acid, which are suitable for locally heating a sample which contains a nucleic acid, enable rapid control of temperature changes in the sample, provide easy fabrication, and are low cost. The invention provides a reaction container used for a nucleic acid amplification reaction, which includes a sample holding portion formed from a cavity in the reaction container; and a heating element for heating a sample which contains a nucleic acid and which is held in the sample holding portion, wherein the heating element is made of a conductive material and arranged at a location where the sample or the sample and the periphery of the cavity is (are) to be locally heated, the conductive material generating heat by electromagnetic induction.

    摘要翻译： 本发明提供一种反应容器，反应装置和扩增核酸的方法，其适用于局部加热含有核酸的样品，能够快速控制样品中的温度变化，提供容易的制造，以及 是低成本的。 本发明提供了用于核酸扩增反应的反应容器，其包括由反应容器中的空腔形成的样品保持部分; 以及加热元件，用于加热含有核酸并被保持在样品保持部分中的样品，其中所述加热元件由导电材料制成并且布置在样品或样品和空腔周边的位置 被局部加热，导电材料通过电磁感应产生热量。

    Blood processing apparatus and blood introducing method
    2.
    发明授权
    Blood processing apparatus and blood introducing method 有权
    血液处理装置及血液导入方法

    公开(公告)号：US07368083B2

    公开(公告)日：2008-05-06

    申请号：US11494749

    申请日：2006-07-28

    申请人： Nobuhiko Ozaki ,  Hiroaki Oka ,  Tetsuo Yukimasa ,  Hidenobu Yaku ,  Maki Yotsuhashi ,  Yukari Hataoka

    发明人： Nobuhiko Ozaki ,  Hiroaki Oka ,  Tetsuo Yukimasa ,  Hidenobu Yaku ,  Maki Yotsuhashi ,  Yukari Hataoka

    IPC分类号： G01N33/00

    CPC分类号： G01N35/00069 ,  Y10T436/111666 ,  Y10T436/2575

    摘要： The present invention provides a blood processing apparatus that can introduce a metered quantity of a blood sample into a chamber and does not require an opening linked to the chamber to be closed after the introduction of the blood sample. An introducing chamber, an injection port, and an air port are formed in a rotatable platform of a blood processing apparatus. The injection port links the introducing chamber with the outside of the rotatable platform. A blood sample is introduced from the injection port into the introducing chamber. A blood coagulant is held on the port wall surface of the air port and/or around a portion of the surface of the rotatable platform where the air port is open.

    摘要翻译： 本发明提供一种血液处理装置，其能够将计量量的血液样品引入腔室中，并且在引入血液样本之后不需要连接到待关闭的腔室的开口。 在血液处理装置的可旋转平台中形成有引入室，注射口和空气口。 注入口将引入室与可旋转平台的外部连接。 血液样品从注射口引入引入室。 血液凝结剂被保持在空气端口的端口壁表面上和/或在空气端口打开的可旋转平台的表面的一部分周围。

    Blood processing apparatus and blood introducing method
    5.
    发明申请
    Blood processing apparatus and blood introducing method 有权
    血液处理装置及血液导入方法

    公开(公告)号：US20060263247A1

    公开(公告)日：2006-11-23

    申请号：US11494749

    申请日：2006-07-28

    申请人： Nobuhiko Ozaki ,  Hiroaki Oka ,  Tetsuo Yukimasa ,  Hidenobu Yaku ,  Maki Yotsuhashi ,  Yukari Hataoka

    发明人： Nobuhiko Ozaki ,  Hiroaki Oka ,  Tetsuo Yukimasa ,  Hidenobu Yaku ,  Maki Yotsuhashi ,  Yukari Hataoka

    IPC分类号： G01N33/00

    CPC分类号： G01N35/00069 ,  Y10T436/111666 ,  Y10T436/2575

    摘要： The present invention provides a blood processing apparatus that can introduce a metered quantity of a blood sample into a chamber and does not require an opening linked to the chamber to be closed after the introduction of the blood sample. An introducing chamber, an injection port, and an air port are formed in a rotatable platform of a blood processing apparatus. The injection port links the introducing chamber with the outside of the rotatable platform. A blood sample is introduced from the injection port into the introducing chamber. A blood coagulant is held on the port wall surface of the air port and/or around a portion of the surface of the rotatable platform where the air port is open.

    摘要翻译： 本发明提供一种血液处理装置，其能够将计量量的血液样品引入腔室中，并且在引入血液样本之后不需要连接到待关闭的腔室的开口。 在血液处理装置的可旋转平台中形成有引入室，注射口和空气口。 注入口将引入室与可旋转平台的外部连接。 血液样品从注射口引入引入室。 血液凝结剂被保持在空气端口的端口壁表面上和/或在空气端口打开的可旋转平台的表面的一部分周围。

    Extracellular potential sensing element, device for measuring extracellular potential, apparatus for measuring extracellular potential and method of measuring extracellular potential by using the same
    6.
    发明授权
    Extracellular potential sensing element, device for measuring extracellular potential, apparatus for measuring extracellular potential and method of measuring extracellular potential by using the same 有权
    细胞外电位感测元件，用于测量细胞外电位的装置，用于测量细胞外电位的装置和使用该细胞外电位测量细胞外电位的方法

    公开(公告)号：US08247218B2

    公开(公告)日：2012-08-21

    申请号：US12133452

    申请日：2008-06-05

    申请人： Masaya Nakatani ,  Nobuhiko Ozaki ,  Hiroaki Oka

    发明人： Masaya Nakatani ,  Nobuhiko Ozaki ,  Hiroaki Oka

    IPC分类号： C12M1/34

    CPC分类号： G01N33/48728

    摘要： A sensing element for measuring extracellular potential including a substrate, a well provided in a substrate, a guide section provided on the wall of the well, and a detective electrode formed at a lower surface of the substrate. The guide section is for guiding drug. The well is provided at the bottom with a depression, and a first throughhole penetrating through the depression and the lower surface of the substrate. The well is for mixing a subject cell, a culture solution and the drug together. The above-configured sensing element accurately measures a change generated by a subject cell.

    摘要翻译： 用于测量细胞外电位的感测元件，包括衬底，设置在衬底中的阱，设置在阱的壁上的引导部分和形成在衬底的下表面处的检测电极。 指导部分是指导药物。 井在底部设置有凹陷，并且第一通孔穿过基底的凹陷和下表面。 该井用于将主体细胞，培养液和药物混合在一起。 上述构成的感测元件精确地测量由被摄体单元产生的变化。

    Probe for measuring electric potential of cell
    7.
    发明授权
    Probe for measuring electric potential of cell 失效
    用于测量电池电位的探头

    公开(公告)号：US07736477B2

    公开(公告)日：2010-06-15

    申请号：US10595275

    申请日：2005-07-14

    申请人： Masaya Nakatani ,  Nobuhiko Ozaki ,  Hiroaki Oka

    发明人： Masaya Nakatani ,  Nobuhiko Ozaki ,  Hiroaki Oka

    IPC分类号： G01N33/487

    CPC分类号： G01N33/48728

    摘要： A probe for measuring an electric potential of a cell includes a plate having a surface having a first cavity provided therein, and a sensor element provided in the first cavity. A second cavity is provided in the bottomsurface of the first cavity. The first flow passage having first and second openings is provided in the plate. The first and second openings of the first flow passage open to the second cavity and outside the plate, respectively. The sensor element includes a thin plate, and a supporting substrate provided around the thin plate and in the first cavity of the plate. The thin plate has a through-hole therein having a first opening and a second opening communicating with the second cavity of the plate. The first flow passage allows fluid to flow therein. A sucking device is coupled with the second opening of the first flow passage as to suck the fluid flowing in the first flow passage. This probe can measure an electric potential of a cell floating in solution as it is in this environment.

    摘要翻译： 用于测量电池的电位的探针包括具有设置在其中的具有第一腔的表面的板和设置在第一腔中的传感器元件。 在第一腔的底面设有第二腔。 具有第一和第二开口的第一流动通道设置在板中。 第一流动通道的第一和第二开口分别向第二腔室和板外开口。 传感器元件包括薄板，以及设置在薄板周围和板的第一腔中的支撑基板。 薄板的通孔中具有第一开口和与板的第二腔连通的第二开口。 第一流道允许流体流入其中。 抽吸装置与第一流动通道的第二开口联接以吸收在第一流动通道中流动的流体。 该探头可以在这种环境中测量浮动在溶液中的电池的电位。

    Apparatus for measuring extracellular potential
    8.
    发明授权
    Apparatus for measuring extracellular potential 有权
    用于测量细胞外电位的装置

    公开(公告)号：US08030059B2

    公开(公告)日：2011-10-04

    申请号：US12133461

    申请日：2008-06-05

    申请人： Masaya Nakatani ,  Nobuhiko Ozaki ,  Hiroaki Oka

    发明人： Masaya Nakatani ,  Nobuhiko Ozaki ,  Hiroaki Oka

    IPC分类号： C12M1/34

    CPC分类号： G01N33/48728

    摘要： A sensing element for measuring extracellular potential including a substrate, a well provided in a substrate, a guide section provided on the wall of the well, and a detective electrode formed at a lower surface of the substrate. The guide section is for guiding drug. The well is provided at the bottom with a depression, and a first throughhole penetrating through the depression and the lower surface of the substrate. The well is for mixing a subject cell, a culture solution and the drug together. The above-configured sensing element accurately measures a change generated by a subject cell.

    摘要翻译： 用于测量细胞外电位的感测元件，包括衬底，设置在衬底中的阱，设置在阱的壁上的引导部分和形成在衬底的下表面处的检测电极。 指导部分是指导药物。 井在底部设置有凹陷，并且第一通孔穿过基底的凹陷和下表面。 该井用于将主体细胞，培养液和药物混合在一起。 上述构成的感测元件精确地测量由被摄体单元产生的变化。

    PROBE FOR MEASURING ELECTRIC POTENTIAL OF CELL
    9.
    发明申请
    PROBE FOR MEASURING ELECTRIC POTENTIAL OF CELL 审中-公开
    用于测量细胞电位的探针

    公开(公告)号：US20100147682A1

    公开(公告)日：2010-06-17

    申请号：US12712370

    申请日：2010-02-25

    申请人： Masaya Nakatani ,  Nobuhiko Ozaki ,  Hiroaki Oka

    发明人： Masaya Nakatani ,  Nobuhiko Ozaki ,  Hiroaki Oka

    IPC分类号： G01N27/26

    CPC分类号： G01N33/48728

    摘要： A probe for measuring an electric potential of a cell includes a plate having a surface having a first cavity provided therein, and a sensor element provided in the first cavity. A second cavity is provided in the bottom surface of the first cavity. The first flow passage having first and second openings is provided in the plate. The first and second openings of the first flow passage open to the second cavity and outside the plate, respectively. The sensor element includes a thin plate, and a supporting substrate provided around the thin plate and in the first cavity of the plate. The thin plate has a through-hole therein having a first opening and a second opening communicating with the second cavity of the plate. The first flow passage allows fluid to flow therein. A sucking device is coupled with the second opening of the first flow passage as to suck the fluid flowing in the first flow passage. This probe can measure an electric potential of a cell floating in solution as it is in this environment.

    摘要翻译： 用于测量电池的电位的探针包括具有设置在其中的具有第一腔的表面的板和设置在第一腔中的传感器元件。 在第一腔的底表面中设置第二腔。 具有第一和第二开口的第一流动通道设置在板中。 第一流动通道的第一和第二开口分别向第二腔室和板外开口。 传感器元件包括薄板，以及设置在薄板周围和板的第一腔中的支撑基板。 薄板的通孔中具有第一开口和与板的第二腔连通的第二开口。 第一流道允许流体流入其中。 抽吸装置与第一流动通道的第二开口联接以吸收在第一流动通道中流动的流体。 该探头可以在这种环境中测量浮动在溶液中的电池的电位。