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公开(公告)号：US09850290B2
公开(公告)日：2017-12-26
申请号：US15147772
申请日：2016-05-05
发明人： Karl Deisseroth , Ofer Yizhar , Lief Fenno , Peter Hegemann , Matthias Prigge
IPC分类号： C07K14/705 , C07K19/00 , G01N3/50 , C07K14/405 , G01N33/50 , C12N13/00 , A61N5/06 , A01K67/027 , A61K38/00
CPC分类号： C07K14/405 , A01K67/0275 , A01K2217/052 , A01K2227/105 , A01K2267/0393 , A61K38/00 , A61N5/06 , A61N2005/0663 , C07K19/00 , C07K2319/00 , C07K2319/60 , C12N13/00 , G01N33/5058 , G01N2500/10
摘要： Provided herein are compositions comprising light-activated chimeric proteins expressed on plasma membranes and methods of using the same to selectively depolarize excitatory or inhibitory neurons.
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公开(公告)号：US20130296406A1
公开(公告)日：2013-11-07
申请号：US13854750
申请日：2013-04-01
发明人： Karl Deisseroth , Ofer Yizhar , Lisa Gunaydin , Peter Hegemann , Andre Berndt
CPC分类号： A61K38/16 , A61K36/05 , A61K38/00 , A61K41/0023 , A61N5/0601 , A61N5/062 , A61N5/0622 , A61N2005/0651 , A61N2005/067 , C07K14/405 , C07K14/705 , C12N7/00 , C12N13/00 , C12N15/85 , C12N15/86 , C12N2740/15041
摘要： Stimulation of target cells using light, e.g., in vivo or in vitro, is implemented using a variety of methods and devices. One example involves a vector for delivering a light-activated molecule comprising a nucleic acid sequence that codes for light-activated molecule. The light-activated molecule includes a modification to a location near the all-trans retinal Schiff base, e.g., to extends the duration time of the open state. Other aspects and embodiments are directed to systems, methods, kits, compositions of matter and molecules for ion channels or pumps or for controlling currents in a cell (e.g., in vivo or in vitro environments).
摘要翻译： 使用光，例如体内或体外，使用各种方法和装置来实施靶细胞的刺激。 一个实例涉及用于递送包含编码光激活分子的核酸序列的光激活分子的载体。 光激活分子包括对全反式视网膜席夫碱附近的位置的修饰，例如延长开放状态的持续时间。 其它方面和实施方案涉及用于离子通道或泵的物质和分子的系统，方法，试剂盒，组合物或用于控制细胞中的电流（例如，体内或体外环境）。
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公开(公告)号：US09340589B2
公开(公告)日：2016-05-17
申请号：US14862926
申请日：2015-09-23
发明人： Karl Deisseroth , Ofer Yizhar , Lief Fenno , Peter Hegemann , Matthias Prigge
IPC分类号： C07K14/705 , C07K19/00 , G01N3/50 , C07K14/405 , G01N33/50 , C12N13/00 , A61N5/06
CPC分类号： C07K14/405 , A01K67/0275 , A01K2217/052 , A01K2227/105 , A01K2267/0393 , A61K38/00 , A61N5/06 , A61N2005/0663 , C07K19/00 , C07K2319/00 , C07K2319/60 , C12N13/00 , G01N33/5058 , G01N2500/10
摘要： Provided herein are compositions comprising light-activated chimeric proteins expressed on plasma membranes and methods of using the same to selectively depolarize excitatory or inhibitory neurons.
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4.发明申请DEVICES, SYSTEMS AND METHODS FOR OPTOGENETIC MODULATION OF ACTION POTENTIALS IN TARGET CELLS 审中-公开靶向细胞中动作电位调节的装置，系统和方法公开(公告)号：US20160045599A1
公开(公告)日：2016-02-18
申请号：US14782201
申请日：2014-04-29
申请人： The Board of Trustees of The Leland Stanford Junior University , HUMBOLDT-UNIVERSITAT ZU BERLIN
CPC分类号： A61K41/0057 , A01K67/0275 , A01K2207/05 , A01K2227/105 , A01K2267/0393 , A61N5/0613 , A61N2005/0662 , C07K14/00 , C07K14/705 , C07K2319/33 , C12N15/85 , C12N2750/14143 , C12N2830/002 , C12N2830/15
摘要： Aspects of the disclosure include devices, systems and methods for optogenetic modulation of action potentials in target cells. The subject devices include light-generating devices, control devices, and delivery devices for delivering vectors to target cells. The subject systems include light-activated proteins, response proteins, nucleic acids comprising nucleotide sequences encoding these proteins, as well as expression systems that facilitate expression of these proteins in target cells. Also provided are methods of using the subject devices and systems to optogenetically inhibit and intercept action potentials in target cells, e.g., to treat a neurological or psychiatric condition in a human or non-human animal subject.
摘要翻译： 本公开的方面包括用于靶细胞中动作电位的光遗传调节的装置，系统和方法。 本发明装置包括用于将载体递送到靶细胞的光产生装置，控制装置和递送装置。 受试系统包括光活化蛋白，反应蛋白，包含编码这些蛋白的核苷酸序列的核酸，以及促进这些蛋白质在靶细胞中表达的表达系统。 还提供了使用本发明装置和系统光学抑制和拦截靶细胞中的动作电位的方法，例如治疗人或非人动物受试者的神经或精神病状况。
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公开(公告)号：US20190038705A1
公开(公告)日：2019-02-07
申请号：US16052482
申请日：2018-08-01
发明人： Karl Deisseroth , Ofer Yizhar , Lisa Gunaydin , Peter Hegemann , Andre Berndt
摘要： Stimulation of target cells using light, e.g., in vivo or in vitro, is implemented using a variety of methods and devices. One example involves a vector for delivering a light-activated molecule comprising a nucleic acid sequence that codes for light-activated molecule. The light-activated molecule includes a modification to a location near the all- trans retinal Schiff base, e.g., to extends the duration time of the open state. Other aspects and embodiments are directed to systems, methods, kits, compositions of matter and molecules for ion channels or pumps or for controlling currents in a cell (e.g., in in vivo and in vitro environments).
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公开(公告)号：US20140235826A1
公开(公告)日：2014-08-21
申请号：US14184149
申请日：2014-02-19
发明人： Karl Deisseroth , Ofer Yizhar , Lisa Gunaydin , Peter Hegemann , Andre Berndt
IPC分类号： C07K14/405
CPC分类号： A61K38/16 , A61K36/05 , A61K38/00 , A61K41/0023 , A61N5/0601 , A61N5/062 , A61N5/0622 , A61N2005/0651 , A61N2005/067 , C07K14/405 , C07K14/705 , C12N7/00 , C12N13/00 , C12N15/85 , C12N15/86 , C12N2740/15041
摘要： Stimulation of target cells using light, e.g., in vivo or in vitro, is implemented using a variety of methods and devices. One example involves a vector for delivering a light-activated molecule comprising a nucleic acid sequence that codes for light-activated molecule. The light-activated molecule includes a modification to a location near the all-trans retinal Schiff base, e.g., to extends the duration time of the open state. Other aspects and embodiments are directed to systems, methods, kits, compositions of matter and molecules for ion channels or pumps or for controlling currents in a cell (e.g., in in vivo and in vitro environments).
摘要翻译： 使用光，例如体内或体外，使用各种方法和装置来实施靶细胞的刺激。 一个实例涉及用于递送包含编码光激活分子的核酸序列的光激活分子的载体。 光激活分子包括对全反式视网膜席夫碱附近的位置的修饰，例如延长开放状态的持续时间。 其它方面和实施方案涉及用于离子通道或泵的系统，方法，试剂盒，物质和分子组合物或用于控制细胞中的电流（例如，在体内和体外环境中）。
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公开(公告)号：US20130224821A1
公开(公告)日：2013-08-29
申请号：US13875966
申请日：2013-05-02
发明人： Karl Deisseroth , Ofer Yizhar , Lief Fenno , Peter Hegemann , Matthias Prigge
CPC分类号： C07K14/405 , A01K67/0275 , A01K2217/052 , A01K2227/105 , A01K2267/0393 , A61K38/00 , A61N5/06 , A61N2005/0663 , C07K19/00 , C07K2319/00 , C07K2319/60 , C12N13/00 , G01N33/5058 , G01N2500/10
摘要： Provided herein are compositions comprising light-activated chimeric proteins expressed on plasma membranes and methods of using the same to selectively depolarize excitatory or inhibitory neurons.
摘要翻译： 本文提供了包含在质膜上表达的光激活嵌合蛋白质的组合物以及使用其来选择性去极化兴奋性或抑制性神经元的方法。
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公开(公告)号：US20190241627A1
公开(公告)日：2019-08-08
申请号：US16211083
申请日：2018-12-05
发明人： Karl Deisseroth , Ofer Yizhar , Lief Fenno , Peter Hegemann , Matthias Prigge
IPC分类号： C07K14/405 , A61N5/06 , C07K19/00 , C12N13/00 , G01N33/50 , A01K67/027
CPC分类号： C07K14/405 , A01K67/0275 , A01K2217/052 , A01K2227/105 , A01K2267/0393 , A61K38/00 , A61N5/06 , A61N2005/0663 , C07K19/00 , C07K2319/00 , C07K2319/60 , C12N13/00 , G01N33/5058 , G01N2500/10
摘要： Provided herein are compositions comprising light-activated chimeric proteins expressed on plasma membranes and methods of using the same to selectively depolarize excitatory or inhibitory neurons.
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公开(公告)号：US10071132B2
公开(公告)日：2018-09-11
申请号：US15095519
申请日：2016-04-11
发明人： Karl Deisseroth , Ofer Yizhar , Lisa Gunaydin , Peter Hegemann , Andre Berndt
IPC分类号： C07H21/02 , A01N63/00 , C12N15/63 , A61K38/16 , C07K14/705 , A61N5/06 , C12N15/85 , C07K14/405 , A61K36/05 , A61K41/00 , C12N13/00 , C12N7/00 , C12N15/86 , A01K67/00 , A61K38/00 , A61N5/067
CPC分类号： A61K38/16 , A61K36/05 , A61K38/00 , A61K41/0023 , A61N5/0601 , A61N5/062 , A61N5/0622 , A61N2005/0651 , A61N2005/067 , C07K14/405 , C07K14/705 , C12N7/00 , C12N13/00 , C12N15/85 , C12N15/86 , C12N2740/15041
摘要： Stimulation of target cells using light, e.g., in vivo or in vitro, is implemented using a variety of methods and devices. One example involves a vector for delivering a light-activated molecule comprising a nucleic acid sequence that codes for light-activated molecule. The light-activated molecule includes a modification to a location near the all-trans retinal Schiff base, e.g., to extends the duration time of the open state. Other aspects and embodiments are directed to systems, methods, kits, compositions of matter and molecules for ion channels or pumps or for controlling currents in a cell (e.g., in in vivo and in vitro environments).
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公开(公告)号：US20180051058A1
公开(公告)日：2018-02-22
申请号：US15803472
申请日：2017-11-03
发明人： Karl Deisseroth , Ofer Yizhar , Lief Fenno , Peter Hegemann , Matthias Prigge
IPC分类号： C07K14/405 , A01K67/027 , C07K19/00 , C12N13/00 , G01N33/50 , A61N5/06 , A61K38/00
CPC分类号： C07K14/405 , A01K67/0275 , A01K2217/052 , A01K2227/105 , A01K2267/0393 , A61K38/00 , A61N5/06 , A61N2005/0663 , C07K19/00 , C07K2319/00 , C07K2319/60 , C12N13/00 , G01N33/5058 , G01N2500/10
摘要： Provided herein are compositions comprising light-activated chimeric proteins expressed on plasma membranes and methods of using the same to selectively depolarize excitatory or inhibitory neurons.
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