公开(公告)号：US20180129786A1

公开(公告)日：2018-05-10

申请号：US15803664

申请日：2017-11-03

Applicant: The Regents of the University of California

Inventor： Michelle Khine ,  Jonathan Pegan ,  Eugene Lee ,  Michael Chu ,  Francis Duhay

IPC: G06F19/00 ,  G06N99/00

CPC classification number: G06F19/3418 ,  G06N20/00 ,  G16H10/60 ,  G16H40/63 ,  G16H40/67 ,  G16H50/20

Abstract: A mobile medical device for monitoring a respiratory condition in a subject, the medical device including: a sensor configured to be adhered to the skin of a patient, the sensor configured to yield a resistance signal that is modulated by movements of a chest of a patient during respiration; a sensor attachment module configured to receive the signal from the sensor and to output data to a mobile electronic device an indication of an adverse respiratory event. Also disclosed is a server for integrating data collected from a plurality of the mobile medical devices and a crowd-sourced respiration advisory system including a plurality of the mobile medical devices and a server for integrating data collected by the mobile medical devices.

公开(公告)号：US20170156623A1

公开(公告)日：2017-06-08

申请号：US15373353

申请日：2016-12-08

Applicant: The Regents of the University of California

Inventor： Michael Chu ,  Thao Nguyen ,  Michelle Khine ,  Eugene Lee

IPC: A61B5/0408 ,  A61B5/0478 ,  A61B5/0492 ,  B01L3/00

CPC classification number: A61B5/04087 ,  A61B5/0478 ,  A61B5/0492 ,  A61B2562/028 ,  A61B2562/125 ,  A61B2562/168 ,  B01L3/502707 ,  B01L2200/0689 ,  B01L2300/0816 ,  B01L2300/0887 ,  B01L2300/123 ,  B29C65/48 ,  B29C65/76 ,  B29C66/1122 ,  B29C66/53461 ,  B29C66/71 ,  B29C66/73751 ,  B29C66/73755 ,  B29C66/7465 ,  B29L2031/756 ,  B29K2083/00

Abstract: Methods of forming a microfluidic device include: combining a volume of uncured liquid silicone based polymer with a volume of adhesive polymer to provide a flowable material; applying the flowable material to a mold and curing the flowable material on the mold to form a microfluidic device layer comprising an exposed face with at least one channel or chamber; and contacting the exposed face of the microfluidic device layer to a substrate to adhere the microfluidic device layer to the substrate to enclose the at least one channel or chamber to form a microfluidic device. Other methods include combining a volume of uncured liquid silicone based polymer with a volume of adhesive polymer to provide an intermediary material; applying a layer of the intermediary material to a substrate and curing the layer of the intermediary material on the substrate; obtaining a silicon based polymer that comprises an exposed face that comprises at least one channel or chamber; and contacting the exposed face of the silicon based polymer to the cured layer of the intermediary material, wherein the exposed face of the silicon based polymer adheres to the cured layer of the intermediary material to enclose the at least one channel or chamber to form a microfluidic device. Also disclosed are microfluidic devices and sensors comprising the microfluidic devices.

公开(公告)号：US20220280066A1

公开(公告)日：2022-09-08

申请号：US17760608

申请日：2020-09-16

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA ,  MAKANI SCIENCE INC.

Inventor： Michael Chu ,  William E. Saltzstein ,  Michelle Khine

IPC: A61B5/091 ,  A61B5/08 ,  A61B5/00

Abstract: A wearable strain sensor for measuring respiration volume and respiration rate is described herein. The wearable strain sensor includes a flexible yet not stretchable connector that connects soft electronics to hard electronics. The flexible and non-stretch able connector removes stress/strain from the soft/hard interface, thereby preventing damage to sensor components and maintaining electrical connection.

公开(公告)号：US20220009764A1

公开(公告)日：2022-01-13

申请号：US17369658

申请日：2021-07-07

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Yongxiao Zhou ,  Michael Chu ,  Thao Nguyen ,  Michelle Khine ,  Erik Morgan Werner ,  Elliot En-Yu Hui ,  Eugene Lee ,  Kevin Costa

IPC: B81B3/00 ,  B01L3/00 ,  B81B7/02 ,  B81C3/00

Abstract: The present invention features a stretchable strain sensor for detecting minute amounts of strain or pressure. The stretchable strain sensor may comprise a first soft polymer layer, a wrinkled conductive layer disposed on the first soft polymer layer, and a second soft polymer layer disposed on the wrinkled conductive layer. Strain applied to the sensor may cause the wrinkled conductive layer to stretch and crack and send a signal based on resistance. Pressure applied to the sensor may cause the wrinkled conductive layer to deform and crack and send a signal based on resistance. The stretchable strain sensor may be capable of measuring contractions of a tissue, detecting fluid flowing through a microfluidic channel, and detecting whether a microfluidic valve is closed or not.

公开(公告)号：US11545265B2

公开(公告)日：2023-01-03

申请号：US15803664

申请日：2017-11-03

Applicant: The Regents of the University of California

Inventor： Michelle Khine ,  Jonathan Pegan ,  Eugene Lee ,  Michael Chu ,  Francis Duhay ,  Mark Bachman ,  Joshua Kim ,  Sun-Jun Park

IPC: G16H50/20 ,  G16H10/60 ,  G06N20/00

Abstract: A mobile medical device for monitoring a respiratory condition in a subject, the medical device including: a sensor configured to be adhered to the skin of a patient, the sensor configured to yield a resistance signal that is modulated by movements of a chest of a patient during respiration; a sensor attachment module configured to receive the signal from the sensor and to output data to a mobile electronic device an indication of an adverse respiratory event. Also disclosed is a server for integrating data collected from a plurality of the mobile medical devices and a crowd-sourced respiration advisory system including a plurality of the mobile medical devices and a server for integrating data collected by the mobile medical devices.

公开(公告)号：US20230172482A1

公开(公告)日：2023-06-08

申请号：US17995770

申请日：2021-04-09

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA ,  MAKANI SCIENCE INC.

Inventor： Michael Chu ,  William E. Saltzstein

IPC: A61B5/08 ,  A61B5/113

CPC classification number: A61B5/0816 ,  A61B5/1135 ,  A61B2562/0261 ,  A61B2562/12

Abstract: The present invention is directed to the standardization of prestrain applied to a sensor of an external respiratory measurement device. The method may comprise sandwiching the sensor between two adhesive layers and stretching the sensor by a fixed amount in order to match the length of the device to the length of a support layer. The device may then be covered by the support layer in order to keep the sensor in a state of prestrain, such that the length of the device matches the length of the support layer. The device may then be applied to the surface by the lower adhesive layer, and the support layer may then be removed, thus leaving the sensor in a standardized and optimal state of prestrain.