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    INTRA-BEAT BIOMARKER FOR ACCURATE BLOOD PRESSURE ESTIMATIONS
    1.
    发明公开
    INTRA-BEAT BIOMARKER FOR ACCURATE BLOOD PRESSURE ESTIMATIONS 审中-公开

    公开(公告)号：US20230320598A1

    公开(公告)日：2023-10-12

    申请号：US18296637

    申请日：2023-04-06

    申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

    发明人： Michelle Khine ,  Arash Abiri

    IPC分类号： A61B5/021 ,  A61B5/00

    CPC分类号： A61B5/02125 ,  A61B5/7278 ,  A61B2560/0223

    摘要： A method comprising receiving a blood pressure waveform from a sensor and deriving initial values. The method may further comprise deriving a diastolic transit time (DTT) value and a plurality of additional properties from the waveform. The method may further comprise calculating a calibration factor based on the DTT values and the additional properties. The method may further comprise calculating estimated DBP values based on the calibration factor, the DTT values, and the additional properties. The method may further comprise deriving an offset value based on a difference between the estimated DBP values and the raw DBP values, adjusting the blood pressure waveform based on the offset to generate an adjusted blood pressure waveform, and outputting the adjusted blood pressure waveform.

    SHRINK ELECTRODE
    3.
    发明申请
    SHRINK ELECTRODE 审中-公开

    公开(公告)号：US20180113123A1

    公开(公告)日：2018-04-26

    申请号：US15789833

    申请日：2017-10-20

    申请人： The Regents of the University of California

    发明人： Michelle Khine ,  Jonathan Pegan ,  Jason Heikenfeld ,  Adam Hauke ,  Kevin Plaxco

    IPC分类号： G01N33/543 ,  G01N27/327

    CPC分类号： G01N33/5438 ,  G01N27/3275 ,  G01N27/3277

    摘要： A sensor including a flexible substrate, a conductor disposed on the flexible substrate, and a hydrophilic surface coating disposed on the conductor. The flexible substrate and the conductor form wrinkle as a result of the substrate being shrunk. The hydrophilic surface coating is disposed in, e.g., fills, the wrinkles or covers surface areas of the conductor within invaginations of the wrinkles. Also disclosed are methods of preparing the sensor and methods of detecting an amount of an analyte in an aqueous solution. Methods of detecting an amount of analyte can include contacting the sensor with an aqueous solution, and detecting an electrical signal with the sensor, wherein the electrical signal is indicative of the amount of the analyte.

    PATTERNING SILICA ISLANDS ONTO THERMOPLASTIC SHRINK FILM
    4.
    发明申请
    PATTERNING SILICA ISLANDS ONTO THERMOPLASTIC SHRINK FILM 审中-公开
    将二氧化硅岛映射到热塑性收缩膜上

    公开(公告)号：US20160169877A1

    公开(公告)日：2016-06-16

    申请号：US14967145

    申请日：2015-12-11

    申请人： The Regents of the University of California

    发明人： Sophia Lin ,  Michelle Khine

    IPC分类号： G01N33/543 ,  B05D3/02 ,  B05D3/14

    CPC分类号： G01N33/5436 ,  C23C18/04 ,  C23C18/06 ,  C23C18/1212 ,  C23C18/1233 ,  C23C18/1254 ,  C23C18/127 ,  G01N33/54353 ,  G01N33/552

    摘要： The disclosure relates to methods and devices for measuring samples, such as biological samples, especially those at low abundance, with high sensitivity and at low cost. A sample is disposed on a shrinkable scaffold and the shrinkable scaffold is shrunk, reducing the area where the sample is distributed, so as to effectively concentrate the sample on the surface of the scaffold. In the event that a biological sample is covalently attached to a scaffold having a silica structure, the increase in signal enhancement is also due to optical effects stemming from covalent linkage of the biological sample onto the silica structure of the scaffold. Silica (SiO2) may be deposited onto a surface of a polymer film by functionalizing the surface of the polymer film to bind silica from a sol-gel solution, and coating the film with a sol-gel solution containing silica precursors, wherein solid silica from the sol-gel solution is deposited onto the surface of the polymer film. Also disclosed is an immunoassay platform comprising a silica-encapsulated first detection agent deposited on a polymer substrate.

    摘要翻译： 本公开涉及用于测量样品的方法和装置，例如生物样品，特别是低丰度的样品，具有高灵敏度和低成本。 将样品放置在可收缩的支架上，并且收缩的支架被收缩，减少了样品分布的面积，以便有效地将样品集中在脚手架的表面上。 在生物样品共价连接到具有二氧化硅结构的支架的情况下，信号增强的增加也是由于生物样品共价连接到支架的二氧化硅结构上的光学效应。 通过使聚合物膜的表面官能化从而将二氧化硅（SiO 2）沉积到聚合物膜的表面上，以结合来自溶胶 - 凝胶溶液的二氧化硅，并用含有二氧化硅前体的溶胶 - 凝胶溶液涂覆该膜，其中固体二氧化硅 将溶胶 - 凝胶溶液沉积在聚合物膜的表面上。 还公开了包含沉积在聚合物基底上的二氧化硅包封的第一检测剂的免疫测定平台。

    Predictive respiratory monitor and system
    6.
    发明授权
    Predictive respiratory monitor and system 有权

    公开(公告)号：US11545265B2

    公开(公告)日：2023-01-03

    申请号：US15803664

    申请日：2017-11-03

    申请人： The Regents of the University of California

    发明人： Michelle Khine ,  Jonathan Pegan ,  Eugene Lee ,  Michael Chu ,  Francis Duhay ,  Mark Bachman ,  Joshua Kim ,  Sun-Jun Park

    IPC分类号： G16H50/20 ,  G16H10/60 ,  G06N20/00

    摘要： A mobile medical device for monitoring a respiratory condition in a subject, the medical device including: a sensor configured to be adhered to the skin of a patient, the sensor configured to yield a resistance signal that is modulated by movements of a chest of a patient during respiration; a sensor attachment module configured to receive the signal from the sensor and to output data to a mobile electronic device an indication of an adverse respiratory event. Also disclosed is a server for integrating data collected from a plurality of the mobile medical devices and a crowd-sourced respiration advisory system including a plurality of the mobile medical devices and a server for integrating data collected by the mobile medical devices.

    EVAPORATION ON SUPERHYDROPHOBIC SURFACES FOR DETECTION OF ANALYTES IN BODILY FLUIDS
    10.
    发明申请
    EVAPORATION ON SUPERHYDROPHOBIC SURFACES FOR DETECTION OF ANALYTES IN BODILY FLUIDS 审中-公开
    用于检测人体液中分析物的超级表面蒸发

    公开(公告)号：US20160169867A1

    公开(公告)日：2016-06-16

    申请号：US14591825

    申请日：2015-01-07

    申请人： The Regents of the University of California

    发明人： Michelle Khine ,  Jolie McLane ,  Chun Wu

    IPC分类号： G01N33/493 ,  B01L3/00 ,  G01N21/25 ,  G01N33/68

    CPC分类号： G01N33/493 ,  B01L3/502707 ,  B01L3/502792 ,  B01L3/5088 ,  B01L2200/12 ,  B01L2300/163 ,  B01L2300/166 ,  B01L2400/0406 ,  B01L2400/088 ,  G01N21/05 ,  G01N21/251 ,  G01N33/68 ,  G01N2021/0325 ,  G01N2021/035

    摘要： This disclosure provides a diagnostic system including a detection zone adapted to receive a volume of biological fluid. The detection zone includes a plurality of micro-scale and nano-scale features that render the detection zone superhydrophobic. Analytes (e.g., proteins and/or other molecules) are concentrated when the volume of biological fluid is allowed to evaporate on the detection zone. Concentrating the analytes in the detection zone by evaporation can advantageously increase the sensitivity of detection of the analyte. In various implementations, microfluidic channels can be integrated with the diagnostic system to convey the volume of biological fluid to the detection zone. In various implementations, the microfluidic channels can have a lower hydrophobic characteristic than the surrounding to realize self-driven microfluidic channels that convey the biological fluid to the detection zone without using any external devices.

    摘要翻译： 本公开提供了一种诊断系统，其包括适于接收一定体积的生物流体的检测区域。 检测区域包括使检测区超疏水的多个微尺度和纳米尺度特征。 当允许生物流体的体积在检测区域上蒸发时，浓缩分析物（例如蛋白质和/或其它分子）。 通过蒸发将分析物浓缩在检测区域可以有利地增加检测分析物的灵敏度。 在各种实施方案中，微流体通道可以与诊断系统集成以将生物流体的体积传送到检测区域。 在各种实施方案中，微流体通道可以具有比周围更低的疏水特性，以实现将生物流体传送到检测区而不使用任何外部装置的自驱动微流体通道。