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公开(公告)号：US20130040302A1
公开(公告)日：2013-02-14
申请号：US13546365
申请日：2012-07-11
CPC分类号： C12N5/0696 , C12N15/907 , C12N2501/15 , C12N2501/235 , C12N2501/415 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/605 , C12N2501/606 , C12N2501/608 , C12N2501/727 , C12N2506/1307
摘要： Methods for producing engineered induced pluripotent stem (iPS) cells are provided comprising introducing a first nucleic acid into somatic cells for integration into their genome and reprogramming the cells to produce engineered iPS cells having the nucleic acid integrated into their genome. For example, in certain aspects the cells are reprogrammed by introduction of a genetic element that expresses one or more reprogramming factor and culturing of the cells under conditions sufficient to produce reprogrammed cells.
摘要翻译： 提供了用于产生工程化诱导多能干细胞（iPS）细胞的方法，包括将第一核酸引入体细胞用于整合到其基因组中并重新编程细胞以产生具有整合入其基因组中的核酸的工程化iPS细胞。 例如，在某些方面，通过引入表达一种或多种重编程因子的遗传元件并在足以产生重编程细胞的条件下培养细胞来重新编程细胞。
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公开(公告)号：US09732724B1
公开(公告)日：2017-08-15
申请号：US15071704
申请日：2016-03-16
申请人： Thomas J. Burke
发明人： Thomas J. Burke
CPC分类号： F03B17/06 , F03B13/264 , F03D5/06 , F05B2210/16 , F05B2240/91 , F05B2240/931 , Y02E10/28
摘要： A reciprocating fluid-energy device to be used in a flowing fluid, having a foil, an upstream support member, a downstream support member, and a frame, where the frame retains the device in place within the flowing fluid, the support members movably attach the foil to the frame, and the foil moves laterally back and forth across the direction of the flow of the fluid, with changes in direction of the movement of the foil occurring automatically and spontaneously without external intervention other than the force of the flowing fluid.
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公开(公告)号：US08733860B1
公开(公告)日：2014-05-27
申请号：US13385855
申请日：2012-03-12
申请人： Thomas J. Burke , Ross Marrone , John Skurzynski
发明人： Thomas J. Burke , Ross Marrone , John Skurzynski
CPC分类号： B65G1/127 , A47B63/067 , A47F1/00 , A47F3/08 , A47F5/03
摘要： A storage system comprising a plurality of shelf units movable together through a circuit attached to and moved by a flexible drive such as a chain or belt, while being guided and stabilized in orientation by a separate guide track which track followers, retained by each shelf unit, move to maintain a selected orientation of the shelves within a system support or enclosure. Each shelf unit is removable by the user from engagement of the drive and from the system enclosure permitting replacement of the shelves within the storage system without system disassembly.
摘要翻译： 一种存储系统，包括多个搁架单元，所述搁板单元可通过连接到柔性驱动器（例如链条或带）的电路移动在一起，同时通过由每个搁架单元保持的跟踪器的单独的导轨被引导和稳定地定向 移动以在系统支持或机箱内维护货架的选定方位。 每个搁架单元可由用户移除，以免驱动器和系统外壳的接合，从而可以在不进行系统拆卸的情况下更换存储系统内的货架。
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公开(公告)号：US07356966B2
公开(公告)日：2008-04-15
申请号：US10891746
申请日：2004-07-15
申请人： Thomas J. Burke
发明人： Thomas J. Burke
IPC分类号： E01F13/00
摘要： An articulate railroad grade crossing assembly. In a preferred embodiment, the crossing assembly has an adjustable reach so that it can be adjusted to completely or partially close roadways of various sizes. In another preferred embodiment, the assembly includes one or more sensors for detecting the presence of people and/or objects in the crossing area so that the assembly can automatically respond to such presence.
摘要翻译： 一个清晰的铁路等级交叉装配。 在优选实施例中，交叉组件具有可调节的距离，使得其可以被调节成完全或部分地关闭各种尺寸的道路。 在另一个优选实施例中，组件包括用于检测交叉区域中的人和/或物体的存在的一个或多个传感器，使得组件可以自动地响应于这种存在。
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公开(公告)号：US06348090B1
公开(公告)日：2002-02-19
申请号：US09661655
申请日：2000-09-14
申请人： Susan M. Grillo , Brian Korchok , Bruce Kinsey , Stuart C. Porter , George Reyes , Thomas J. Burke , Charles Cunningham
发明人： Susan M. Grillo , Brian Korchok , Bruce Kinsey , Stuart C. Porter , George Reyes , Thomas J. Burke , Charles Cunningham
IPC分类号： C09D10302
摘要： A dry film coating composition for forming a coating suspension for film coating nutritional supplements, pharmaceutical tablets, and the like, including tapica dextrin and a detackifier.
摘要翻译： 一种干膜涂料组合物，用于形成用于薄膜包衣的营养补充剂，药物片剂等的包衣悬浮液，包括tapica糊精和防粘剂。
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公开(公告)号：US5483654A
公开(公告)日：1996-01-09
申请号：US122861
申请日：1993-09-15
IPC分类号： G06F9/44
CPC分类号： G06F9/4443
摘要： A "navigation protocol" is implemented via a computer program to provide communication and invocation capability among object-oriented application programs and precompiled library routines, collectively referred to as `programs`. Each application program is "registered" with the operating environment during its installation; registration entails updating a registration-table data structure with information about 1) a program identifier; 2) an object-type identifier identifying a class of objects; and 3) an action identifier, e.g., a menu entry, identifying an action which the program can perform on objects of the class specified by the object-type identifier. A user can manipulate an object by selecting the object and requesting that a list of all actions performable on the object be displayed, then selecting one of the displayed possible actions. The displayed actions are actually performed by programs as specified in the registration table; the user need not be concerned with knowing which program to invoke. Programs from a variety of different vendors can interact without any one program needing to know about any other program. This modularity uncouples the development process of the user's system from that of the organizations providing the individual development tools and allows the user to upgrade individual programs as desired.
摘要翻译： 通过计算机程序实现“导航协议”，以便在面向对象的应用程序和预编译库例程之间提供通信和调用能力，统称为“程序”。 每个应用程序在安装过程中都具有操作环境“注册” 注册需要更新具有关于1）节目标识符的信息的注册表数据结构; 2）识别对象类的对象类型标识符; 以及3）动作标识符，例如菜单条目，标识程序可以对由对象类型标识符指定的类的对象执行的动作。 用户可以通过选择对象并请求显示对象上可执行的所有操作的列表，然后选择所显示的可能动作之一来操纵对象。 显示的动作实际上由注册表中指定的程序执行; 用户不需要关心知道要调用哪个程序。 来自各种不同供应商的程序可以进行交互，而无需任何程序需要知道任何其他程序。 该模块化将用户系统的开发过程与提供各个开发工具的组织的开发流程相结合，并允许用户根据需要升级单个程序。
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公开(公告)号：US09707134B1
公开(公告)日：2017-07-18
申请号：US13728267
申请日：2012-12-27
申请人： Thomas J. Burke , Jack V. Fullman
发明人： Thomas J. Burke , Jack V. Fullman
IPC分类号： A61F13/471 , A61F13/512 , A61F13/491
CPC分类号： A61F13/471 , A61F13/4915 , A61F13/512 , A61F13/5121
摘要： An easily applied and replaced flexible container pouch applied to the penis end and including a restricted opening collar to grasp the penis shaft. The container pouch comprises a plurality of walls having a fluid absorbent layer between at least 2 walls, the inner wall (proximal to the penis) include apertures allowing the fluid emitted by the penis to be received into the absorbent layer(s). In one embodiment, the inner layer(s) comprise fluid barriers (e.g. fluid impermeable or a thick member providing a mechanical spacing) between the fluid-filled absorbent layer(s) and the penis. The resulting device provides comfort and protection from unnecessary fluid immersion and ease of use, application and replacement.
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公开(公告)号：US08149138B1
公开(公告)日：2012-04-03
申请号：US12070691
申请日：2008-02-21
申请人： Thomas J. Burke , John Dinunzi
发明人： Thomas J. Burke , John Dinunzi
IPC分类号： G08G1/095
CPC分类号： E01F13/06
摘要： A manually operated traffic barrier gate which may economically installed and maintained, and easily operated by a single individual during emergency or other critical situations. One embodiment comprises a permanently mounted barrier gate movable from a retracted, upright position to lowered position extended to bridge a preselected traffic path, wherein the gate is counterbalanced to stay in the upright position until deployed, and to be balanced to stay in the deployed state when extended. The barrier gate are operable by one person and includes locking devices to maintain their stored upright or deployed lowered position. A further embodiment of the present invention provides a dual mobile gate which may be towed singly or in a chain (dual gate one behind the other), in a retracted length to the desired location, and thereafter be disconnected from the towing vehicle and left at the site to be deployed in an extended manner or retracted and moved as needed.
摘要翻译： 手动操作的交通障碍门，可以经济地安装和维护，并且在紧急情况或其他危急情况下由单个人轻松操作。 一个实施例包括永久安装的阻挡门，其可从缩回的直立位置移动到延伸以桥接预选交通路径的降低位置，其中门平衡以保持在直立位置直到展开，并且被平衡以保持在展开状态 延长时 障碍门可由一个人操作，并且包括锁定装置以保持其存储的直立或展开的降低位置。 本发明的另一个实施例提供一种双移动门，其可以以缩回的长度单独拖到链条中（双门一个在另一个之后）到所需位置，然后与牵引车辆分离并保持在 该站点将以扩展方式进行部署，或根据需要进行撤回和移动。
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公开(公告)号：US20110287973A1
公开(公告)日：2011-11-24
申请号：US13204089
申请日：2011-08-05
CPC分类号： G01N33/543 , C40B30/04 , G01N33/6845
摘要： The present invention relates to novel methods for the quantitative detection of molecules in an array. In particular, the present invention relates to methods and apparatuses for producing a frameless array. In another embodiment, the present invention relates to a composition comprising nitrocellulose that is useful of producing a frameless array. In another embodiment, the present invention relates to a method for detecting a molecular interaction. In yet another embodiment, the present invention relates to kits useful for practicing the methods and apparatuses of the present invention. The present invention provides improved methods and apparatuses for the high throughput analysis of molecular interactions and quantitative detection.
摘要翻译： 本发明涉及用于定量检测阵列中分子的新方法。 特别地，本发明涉及无框架阵列的制造方法和装置。 在另一个实施方案中，本发明涉及可用于生产无框架阵列的包含硝酸纤维素的组合物。 在另一个实施方案中，本发明涉及用于检测分子相互作用的方法。 在另一个实施方案中，本发明涉及可用于实施本发明的方法和装置的试剂盒。 本发明提供了用于分子相互作用和定量检测的高通量分析的改进的方法和装置。
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公开(公告)号：US07533494B2
公开(公告)日：2009-05-19
申请号：US10623792
申请日：2003-07-21
申请人： Thomas J. Burke
发明人： Thomas J. Burke
IPC分类号： E01F13/00
摘要： A railroad grade crossing assembly including a programmable controller. In a preferred embodiment, the crossing assembly includes at least one camera for the purpose of visually monitoring the crossing assembly and/or the area around the assembly. In another preferred embodiment, the crossing assembly includes a communication link for remotely monitoring and/or controlling the assembly.
摘要翻译： 包括可编程控制器的铁路等级交叉组件。 在优选实施例中，交叉组件包括至少一个照相机，用于视觉监测交叉组件和/或组件周围的区域。 在另一优选实施例中，交叉组件包括用于远程监视和/或控制组件的通信链路。
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