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公开(公告)号：US20130040302A1
公开(公告)日：2013-02-14
申请号：US13546365
申请日：2012-07-11
CPC分类号： C12N5/0696 , C12N15/907 , C12N2501/15 , C12N2501/235 , C12N2501/415 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/605 , C12N2501/606 , C12N2501/608 , C12N2501/727 , C12N2506/1307
摘要： Methods for producing engineered induced pluripotent stem (iPS) cells are provided comprising introducing a first nucleic acid into somatic cells for integration into their genome and reprogramming the cells to produce engineered iPS cells having the nucleic acid integrated into their genome. For example, in certain aspects the cells are reprogrammed by introduction of a genetic element that expresses one or more reprogramming factor and culturing of the cells under conditions sufficient to produce reprogrammed cells.
摘要翻译： 提供了用于产生工程化诱导多能干细胞（iPS）细胞的方法，包括将第一核酸引入体细胞用于整合到其基因组中并重新编程细胞以产生具有整合入其基因组中的核酸的工程化iPS细胞。 例如，在某些方面，通过引入表达一种或多种重编程因子的遗传元件并在足以产生重编程细胞的条件下培养细胞来重新编程细胞。
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公开(公告)号：US08765470B2
公开(公告)日：2014-07-01
申请号：US13197529
申请日：2011-08-03
CPC分类号： C12N5/0696 , C12N15/63 , C12N15/85 , C12N2501/06 , C12N2501/115 , C12N2501/15 , C12N2501/235 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/605 , C12N2501/606 , C12N2501/608 , C12N2501/727 , C12N2506/11 , C12N2510/00 , C12N2510/04 , C12N2710/16243 , C12N2800/108
摘要： Methods and composition for providing induced pluripotent stem (iPS) cells are provided. For example, in certain aspects methods including reprogramming B lymphocytes transformed by episomal vectors such as Epstein-Barr virus-based vectors are described. Furthermore, the invention provides induced pluripotent stem cells essentially free of exogenous elements and having B cell immunoglobin variable region rearrangement.
摘要翻译： 提供了用于提供诱导性多能干（iPS）细胞的方法和组合物。 例如，在某些方面，描述了包括通过附加型载体转化的B淋巴细胞重新编程的方法，例如基于Epstein-Barr病毒的载体。 此外，本发明提供基本上不含外源元件并具有B细胞免疫球蛋白可变区重排的诱导多能干细胞。
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公开(公告)号：US20120058562A1
公开(公告)日：2012-03-08
申请号：US13197529
申请日：2011-08-03
CPC分类号： C12N5/0696 , C12N15/63 , C12N15/85 , C12N2501/06 , C12N2501/115 , C12N2501/15 , C12N2501/235 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/605 , C12N2501/606 , C12N2501/608 , C12N2501/727 , C12N2506/11 , C12N2510/00 , C12N2510/04 , C12N2710/16243 , C12N2800/108
摘要： Methods and composition for providing induced pluripotent stem (iPS) cells are provided. For example, in certain aspects methods including reprogramming B lymphocytes transformed by episomal vectors such as Epstein-Barr virus-based vectors are described. Furthermore, the invention provides induced pluripotent stem cells essentially free of exogenous elements and having B cell immunoglobin variable region rearrangement.
摘要翻译： 提供了用于提供诱导性多能干（iPS）细胞的方法和组合物。 例如，在某些方面，描述了包括通过附加型载体转化的B淋巴细胞重新编程的方法，例如基于Epstein-Barr病毒的载体。 此外，本发明提供基本上不含外源元件并具有B细胞免疫球蛋白可变区重排的诱导多能干细胞。
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公开(公告)号：US20160009696A1
公开(公告)日：2016-01-14
申请号：US14772290
申请日：2014-02-27
申请人： Michael MILLER , Kallol BASU , Duane DEMONG , Jack SCOTT , Wei LI , Joel HARRIS , Andrew STAMFORD , Marc POIRIER , Paul TEMPEST , MERCK SHARP & DOHME CORP.
发明人： Michael Miller , Kallol Basu , Duane DeMong , Jack Scott , Wei Li , Joel Harris , Andrew Stamford , Marc Poirier , Paul Tempest
IPC分类号： C07D403/14 , C07D401/14 , C07D491/107 , C07D417/14 , C07D471/10 , C07D413/14 , C07D498/08
CPC分类号： C07D403/14 , A61K31/505 , A61K31/506 , C07D401/14 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/10 , C07D491/107 , C07D498/08
摘要： The present invention is directed to indazole compounds which are potent inhibitors of LRRK2 kinase and useful in the treatment or prevention of diseases in which the LRRK2 kinase is involved, such as Parkinson's Disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which LRRK-2 kinase is involved.
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5.发明授权Substituted cyclopropyl compounds, compositions containing such compounds, and methods of treatment 有权取代的环丙基化合物，含有这些化合物的组合物和治疗方法公开(公告)号：US09006228B2
公开(公告)日：2015-04-14
申请号：US14126685
申请日：2012-06-11
申请人： Michael Miller , Andrew Stamford , Kallol Basu , Harold B. Wood , Duane DeMong , Wanying Sun , Joie Garfunkle , Christopher Moyes , Zhiyong Hu , Ping Liu , Scott D. Edmondson , Xing Dai , Byron Gabriel DuBois
发明人： Michael Miller , Andrew Stamford , Kallol Basu , Harold B. Wood , Duane DeMong , Wanying Sun , Joie Garfunkle , Christopher Moyes , Zhiyong Hu , Ping Liu , Scott D. Edmondson , Xing Dai , Byron Gabriel DuBois
IPC分类号： C07D417/14 , C07D211/24 , C07D401/04 , C07D401/14 , C07D405/14 , C07D413/04 , C07D413/14 , C07D211/22
CPC分类号： C07D211/24 , C07D211/22 , C07D401/04 , C07D401/14 , C07D405/14 , C07D413/04 , C07D413/14 , C07D417/14
摘要： Substituted cyclopropyl compounds of the formula I: and pharmaceutically acceptable salts thereof are disclosed as useful for treating or preventing type 2 diabetes and similar conditions. The compounds are useful as agonists of the G-protein coupled receptor GPR-119. Pharmaceutical compositions and methods of treatment are also included.
摘要翻译： 公开了取代的式I的环丙基化合物及其药学上可接受的盐可用于治疗或预防2型糖尿病和类似病症。 该化合物可用作G蛋白偶联受体GPR-119的激动剂。 还包括药物组合物和治疗方法。
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公开(公告)号：US08791781B2
公开(公告)日：2014-07-29
申请号：US13781019
申请日：2013-02-28
申请人： Michael Miller
发明人： Michael Miller
IPC分类号： H01F7/02
CPC分类号： H01F7/02 , F01K25/10 , F01K27/00 , H01F7/0221
摘要： A spherical magnet is formed as a hollow sphere having a fluid tight outer surface of a first magnetic pole and an inner surface having a second magnetic pole that is magnetically opposite the first pole. A plurality of individual thin flexible rectangular plate magnets are arranged as a continuous outer layer of the spherical magnet. Each individual plate magnet has four sides, an inner magnetic portion and an outer non-magnetic portion that extends around all four sides of the magnetic portion. Each inner magnetic portion includes a first face disposed on the outer surface and having the first pole and a second face opposite the first face, disposed on the inner surface and having the second pole.
摘要翻译： 形成具有第一磁极的流体密封外表面的空心球体和具有与第一极磁性相对的第二磁极的内表面的球形磁体。 多个单独的薄柔性矩形板磁体被布置为球形磁体的连续外层。 每个单独的板状磁体具有四个侧面，内部磁性部分和外部非磁性部分，其围绕磁性部分的所有四个侧面延伸。 每个内磁性部分包括设置在外表面上并且具有第一极和与第一面相对的第二面的第一面，设置在内表面上并具有第二极。
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公开(公告)号：US20130289629A1
公开(公告)日：2013-10-31
申请号：US13458622
申请日：2012-04-27
申请人： Michael Miller
发明人： Michael Miller
IPC分类号： A61B17/84
CPC分类号： A61B17/68 , A61B17/685 , A61B17/846
摘要： A bone dowel is disclosed that may be used for connecting two or more bone components. The bone dowel may have three dowel sections positioned between a base and a tip with a conical upper section. Each bone dowel section may be positioned in axial alignment adjacent at least one other bone dowel section wherein the diameters decrease over the length of the bone dowel from the base to the tip.
摘要翻译： 公开了可用于连接两个或更多个骨组件的骨榫。 骨榫可以具有定位在基部和具有锥形上部的尖端之间的三个定位销部分。 每个骨榫部分可以邻近至少一个另外的骨榫部分定位成轴向对准，其中直径从骨榫的长度减小到从基部到尖端。
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公开(公告)号：US20130253563A1
公开(公告)日：2013-09-26
申请号：US13428901
申请日：2012-03-23
申请人： Mark Eberhardt , Hiroyoshi Ise , George Stern , Michael Miller , Yasutake Yamada , Husexin Fertac Bilge
发明人： Mark Eberhardt , Hiroyoshi Ise , George Stern , Michael Miller , Yasutake Yamada , Husexin Fertac Bilge
IPC分类号： A61M29/00
CPC分类号： A61M25/0097 , A61M25/01 , A61M29/00 , A61M39/22
摘要： The present technology is directed to a dilator centering device and assemblies and methods using same. In particular, a dilator centering device in accordance with the disclosed technology can be used with a sheath hub assembly. In one embodiment, a dilator centering device includes a lumen capable of receiving a dilator shaft and centering a dilator shaft with respect to the sheath hub as the dilator shaft enters the sheath hub. In one embodiment, the dilator centering device can be attached to the sheath hub during manufacturing or it can be attached at the use site. In one embodiment, the dilator centering device can be integrated with and non-removable from the sheath hub. The embodiments disclosed herein are illustrative and do not limit the scope and spirit of the disclosed technology.
摘要翻译： 本技术涉及一种扩张器定中心装置及使用其的装配和方法。 特别地，根据所公开的技术的扩张器定心装置可以与护套轮毂组件一起使用。 在一个实施例中，扩张器定心装置包括能够接收扩张器轴并且当扩张器轴进入护套中心时使扩张器轴相对于护套毂居中的内腔。 在一个实施例中，扩张器定心装置可以在制造期间附接到护套，或者可以在使用场所附接。 在一个实施例中，扩张器定心装置可以与鞘毂集成在一起并且不可移除。 本文公开的实施例是说明性的，并不限制所公开技术的范围和精神。
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公开(公告)号：US08420478B2
公开(公告)日：2013-04-16
申请号：US12610131
申请日：2009-10-30
申请人： Tony Chiang , Prashant Phatak , Michael Miller
发明人： Tony Chiang , Prashant Phatak , Michael Miller
IPC分类号： H01L21/8234
CPC分类号： H01L45/122 , G11C13/0007 , G11C2213/32 , G11C2213/55 , G11C2213/56 , H01L21/265 , H01L21/322 , H01L27/2463 , H01L45/08 , H01L45/10 , H01L45/12 , H01L45/1233 , H01L45/1246 , H01L45/146 , H01L45/1616 , H01L45/1625 , H01L45/1641 , H01L45/165 , H01L45/1658 , H01L45/1675
摘要： Controlled localized defect paths for resistive memories are described, including a method for forming controlled localized defect paths including forming a first electrode forming a metal oxide layer on the first electrode, masking the metal oxide to create exposed regions and concealed regions of a surface of the metal oxide, and altering the exposed regions of the metal oxide to create localized defect paths beneath the exposed regions.
摘要翻译： 描述了用于电阻存储器的受控局部缺陷路径，包括用于形成受控局部缺陷路径的方法，包括形成在第一电极上形成金属氧化物层的第一电极，掩蔽金属氧化物以产生暴露区域和隐藏区域 金属氧化物，并且改变金属氧化物的暴露区域以在暴露区域下方产生局部缺陷路径。
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公开(公告)号：US20120312899A1
公开(公告)日：2012-12-13
申请号：US13154902
申请日：2011-06-07
申请人： Michael Miller , James Wu , Alex Wu , Cewen Yang
发明人： Michael Miller , James Wu , Alex Wu , Cewen Yang
IPC分类号： B05B1/32
CPC分类号： B05B1/18 , B05B1/1636
摘要： A shower head includes a push-button operated rotatable valve having a plurality of positions including; a first position in which the shower head allows water to flow to a first function, a second position radially offset from the first position in which the shower head allows water to flow to a second function, a third position radially offset from the first position and the second position and to the first position, in which the shower head allows water to flow trickle through the shower head.
摘要翻译： 淋浴头包括具有多个位置的按钮操作的可旋转阀，包括： 第一位置，其中淋浴喷头允许水流动到第一功能;第二位置，从第一位置径向偏移，淋浴头允许水流动到第二功能，第三位置径向偏离第一位置， 第二位置和第一位置，其中淋浴头允许水流过淋浴头。
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