Cosmetic Compositions
    3.
    发明申请
    Cosmetic Compositions 审中-公开
    化妆品组合物

    公开(公告)号:US20090298783A1

    公开(公告)日:2009-12-03

    申请号:US12442023

    申请日:2007-09-08

    摘要: Disclosed is a method for preventing and/or soothing dry or sensitive skin against external stresses, comprising contacting the skin with a composition including an agent that decreases the release of granulocyte-macrophage colony-stimulating factor (GMCSF) from keratinocytes in the skin, wherein under conditions of external stress, dry or sensitive skin is soothed and/or prevented. Agents that decrease the release of GMCSF include silybin, piperine, tetrahydropiperine, nortrachelogenine, rhapontin, arctiin, artigenin and mixtures thereof. Also disclosed is a method of identifying an agent that decreases the level of GMCSF released from keratinocytes.

    摘要翻译: 公开了一种用于防止和/或舒缓干性或敏感性皮肤抵抗外部应力的方法,包括使皮肤与包含降低粒细胞 - 巨噬细胞集落刺激因子(GMCSF)从皮肤角质形成细胞的释放的药剂组合物接触,其中 在外部应激条件下,缓解和/或预防干性或敏感性皮肤。 减少GMCSF释放的试剂包括水飞蓟宾,胡椒碱,四氢哌嗪,北美胆碱,大蟾蜍,阿司匹林,芹菜素及其混合物。 还公开了鉴定降低角质形成细胞释放的GMCSF水平的试剂的方法。

    Cosmetic preparations containing PTH fragments
    4.
    发明授权
    Cosmetic preparations containing PTH fragments 有权
    包含PTH片段的化妆品

    公开(公告)号:US09387235B2

    公开(公告)日:2016-07-12

    申请号:US11570614

    申请日:2005-06-06

    摘要: A cosmetic or pharmaceutical composition includes a peptide parathyroid hormone fragment, derivatives thereof, salts thereof, and combinations thereof, where the peptide fragment conforms to the structure R1-NH-AA-R2 where R1 is selected from the group consisting of —H, a linear or branched, saturated or unsaturated acyl group having from 1 to 24 carbon atoms optionally functionalized with an —OH, —SH, —COOH or —CONH2 group, or a sterol group which is bonded by a functional group with the peptide; where R2 is —OH, —OH functionalized by a linear or branched, saturated or unsaturated alkyl group having from 1 to 24 carbon atoms, or a sterol group; and where AA corresponds completely or partially to the sequence of amino acids according to SEQ ID No. 1 corresponding to the PTH (28 to 34) region.

    摘要翻译: 化妆品或药物组合物包括肽甲状旁腺激素片段,其衍生物,其盐及其组合,其中肽片段符合结构R1-NH-AA-R2,其中R1选自-H,a 任选被-OH,-SH,-COOH或-CONH 2基官能化的具有1至24个碳原子的直链或支链,饱和或不饱和的酰基,或通过官能团与该肽键合的固醇基团; 其中R2是-OH,由具有1至24个碳原子的直链或支链,饱和或不饱和的烷基或甾醇基官能化的-OH; 并且其中AA对应于根据对应于PTH(28至34)区域的SEQ ID No.1的氨基酸序列的完全或部分对应。