公开(公告)号：US5755953A

公开(公告)日：1998-05-26

申请号：US563728

申请日：1995-12-18

Applicant: Timothy P. Henning ,  Thomas G. Spring

Inventor： Timothy P. Henning ,  Thomas G. Spring

IPC: G01N27/327 ,  C12Q1/00 ,  C12Q1/28 ,  C12Q1/54 ,  G01N27/416 ,  G01N27/26

CPC classification number: C12Q1/002 ,  Y10S435/817

Abstract: Provided are microparticle forms of carbon, carbon catalysts and carbon-containing electrically conductive materials which are covalently linked to peroxidase. The carbon:peroxidase conjugates are suitable for use as substrates in conventional electrodes. Surprisingly, the conjugates display very little sensitivity to known interfering substances and thus are suitable for use as interference free electrodes.

Abstract translation: 提供了与过氧化物酶共价连接的碳，碳催化剂和含碳导电材料的微粒形式。 碳：过氧化物酶缀合物适用于常规电极中的底物。 令人惊奇的是，缀合物对已知的干扰物质的灵敏度非常小，因此适合用作无干扰电极。

公开(公告)号：US06261440B1

公开(公告)日：2001-07-17

申请号：US08928364

申请日：1997-09-12

Applicant: Timothy P. Henning ,  Thomas G. Spring

Inventor： Timothy P. Henning ,  Thomas G. Spring

IPC: G01F164

CPC classification number: C12Q1/005 ,  C12Q1/002 ,  Y10S435/817

Abstract: Provided are microparticle forms of carbon, carbon catalysts and carbon-containing electrically conductive materials which are covalently linked to peroxidase. The carbon:peroxidase conjugates are suitable for use as substrates in conventional electrodes. Surprisingly, the conjugates display very little sensitivity to known interfering substances and thus are suitable for use as interference free electrodes.

Abstract translation: 提供了与过氧化物酶共价连接的碳，碳催化剂和含碳导电材料的微粒形式。 碳：过氧化物酶缀合物适用于常规电极中的底物。 令人惊奇的是，缀合物对已知的干扰物质的灵敏度非常小，因此适合用作无干扰电极。

公开(公告)号：US08795477B2

公开(公告)日：2014-08-05

申请号：US12907345

申请日：2010-10-19

Applicant: Yi Wang ,  Timothy P. Henning ,  Edmund T. Marciniec

Inventor： Yi Wang ,  Timothy P. Henning ,  Edmund T. Marciniec

IPC: C23C14/34

CPC classification number: C23C14/3464 ,  C23C14/0694 ,  C23C14/205 ,  H01M4/8885 ,  Y02E60/50

Abstract: The subject invention provides conductive stripes, suitable for use as electrodes, and methods of making conductive stripes.

Abstract translation: 本发明提供适合用作电极的导电条纹，以及制造导电条纹的方法。

公开(公告)号：US06306104B1

公开(公告)日：2001-10-23

申请号：US09612722

申请日：2000-07-10

Applicant: David D. Cunningham ,  Timothy P. Henning ,  Eric B. Shain ,  Douglas F. Young ,  Andrew J. Muetterties ,  Thomas G. Schapira ,  Geoffrey R. Chambers ,  Graham J. Hughes ,  Jared L. Watkin ,  Gary F. Prokop ,  Joshua P. Goldfarb

Inventor： David D. Cunningham ,  Timothy P. Henning ,  Eric B. Shain ,  Douglas F. Young ,  Andrew J. Muetterties ,  Thomas G. Schapira ,  Geoffrey R. Chambers ,  Graham J. Hughes ,  Jared L. Watkin ,  Gary F. Prokop ,  Joshua P. Goldfarb

IPC: A61B500

CPC classification number: A61B5/15186 ,  A61B5/14532 ,  A61B5/1486 ,  A61B5/150022 ,  A61B5/150068 ,  A61B5/150076 ,  A61B5/150099 ,  A61B5/150221 ,  A61B5/150358 ,  A61B5/150412 ,  A61B5/150503 ,  A61B5/150664 ,  A61B5/15113 ,  A61B5/15125 ,  A61B5/1519 ,  A61B5/15194 ,  A61B5/157 ,  A61B5/411 ,  A61B2562/0295

Abstract: Method and apparatus for obtaining a sample of blood from a patient for subsequent diagnostic tests, e.g., glucose monitoring. In one aspect of the invention, the method comprises the steps of: (a) placing a blood collection device over a region on the surface of the skin from which said sample is to be obtained, (b) forming a seal between said blood collection device and said surface of the skin, (c) creating a vacuum sufficient to result in said surface of the skin becoming stretched and engorged with blood, (d) triggering a lancing assembly and causing a lancet to penetrate said skin, (e) retracting said lancet, (f) withdrawing blood toward and onto a fluid collector, and (g) releasing the vacuum. In another aspect of the invention, an apparatus for carrying out the method described previously is provided. The apparatus comprises: (a) a housing having a sealable chamber located therein and a sealable opening in fluid communication with said sealable chamber, (b) a power source, (c) a vacuum pump operably connected to said power source, said vacuum pump in communication with said sealable chamber, (d) a lancing assembly positioned within said housing, said lancing assembly capable of moving a lancet towards said sealable opening, and (e) a fluid collector positioned in said sealable chamber, said fluid collector in fluid communication with said sealable opening.

Abstract translation: 用于从患者获得血样的方法和装置用于随后的诊断测试，例如葡萄糖监测。 在本发明的一个方面，所述方法包括以下步骤：（a）将血液收集装置放置在要获得所述样品的皮肤表面上的区域上，（b）在所述血液收集器之间形成密封 装置和皮肤表面，（c）产生足以导致皮肤表面变得伸展和凝结的真空的真空，（d）触发穿刺组件并使刺血针穿透所述皮肤，（e）缩回 所述刺血针，（f）朝向流体收集器排出血液，和（g）释放真空。在本发明的另一方面，提供一种用于执行前述方法的装置。 该设备包括：（a）壳体，其中具有位于其中的可密封腔室和与所述可密封腔室流体连通的可密封开口，（b）动力源，（c）可操作地连接到所述动力源的真空泵，所述真空泵 与所述可密封腔室连通，（d）位于所述壳体内的采血组件，所述穿刺组件能够将刺血针移向所述可密封开口，以及（e）定位在所述可密封腔室中的流体收集器，所述流体收集器处于流体连通 具有所述可密封的开口。

公开(公告)号：US06245060B1

公开(公告)日：2001-06-12

申请号：US09472695

申请日：1999-12-27

Applicant: Neil W. Loomis ,  Peter M. Bojan ,  Timothy P. Henning ,  Mark R. Pope ,  Andrew J. Muetterties

Inventor： Neil W. Loomis ,  Peter M. Bojan ,  Timothy P. Henning ,  Mark R. Pope ,  Andrew J. Muetterties

IPC: A61B1818

CPC classification number: A61B18/20 ,  A61B5/14514 ,  A61B5/150022 ,  A61B5/15136 ,  A61B2017/00765 ,  A61B2018/00636 ,  A61B2018/1807 ,  A61M2037/0007

Abstract: A method for increasing the permeability of the stratum corneum by means of a source of light, preferably a laser, more preferably a pulsed laser. By increasing the permeability of the stratum corneum, access to the interstitial fluid is achieved, thereby enabling measurement of analytes in the interstitial fluid. In one aspect, the method comprises the steps of: (a) providing a source of light having a wavelength of from about 930 nm to about 1040 nm; and (b) exposing a region of the stratum corneum of the patient to said source of light for a period of time sufficient to form an opening in the stratum corneum. Preferably, exposure of the region of the stratum corneum to the source of light is ceased when an amount of interstitial fluid fills the opening in the stratum corneum, which amount is sufficient to cause the scatter intensity of the light reflected from the surface of the interstitial fluid occupying the opening in the stratum corneum to differ from the scatter intensity of the light reflected from a region of the stratum corneum that is substantially free of interstitial fluid. The invention also involves an apparatus for carrying out the foregoing method.

Abstract translation: 通过光源，优选激光，更优选脉冲激光来提高角质层的透过性的方法。 通过增加角质层的渗透性，实现对间质液的接近，从而能够测量间质液中的分析物。 一方面，该方法包括以下步骤：（a）提供波长为约930nm至约1040nm的光源; 和（b）将患者的角质层的区域暴露于所述光源的时间足以在角质层中形成开口。优选地，将角质层的区域暴露于光源是 当一定量的间质液填充角质层中的开口时，该量足以使从占据角质层中的开口的间质液的表面反射的光的散射强度不同于 从基本上不含间质液的角质层区域反射的光。 本发明还涉及一种用于执行上述方法的装置。

公开(公告)号：US5895362A

公开(公告)日：1999-04-20

申请号：US606109

申请日：1996-02-23

Applicant: Tuan A. Elstrom ,  Eric B. Shain ,  Timothy P. Henning

Inventor： Tuan A. Elstrom ,  Eric B. Shain ,  Timothy P. Henning

IPC: A61B5/00 ,  A61M37/00 ,  B65D81/00

CPC classification number: A61B5/14514 ,  A61M37/0092 ,  A61M2037/0007

Abstract: A process for the sampling of extracellular fluid across the skin of an animal involves establishing an ultrasonic standing wave across the skin and collecting fluid transudate. Sampling can be enhanced by combining the use of ultrasound with the application of a partial vacuum to the surface of the skin. An apparatus includes an ultrasonic transducer, a reflector and an absorbent material for collecting transudate. The apparatus can further include a pressure component for reducing hydrostatic pressure on the skin surface.

Abstract translation: 跨越动物皮肤取样细胞外液的过程包括在皮肤上建立超声波驻波并收集流体渗出物。 可以通过将超声波与部分真空的应用组合到皮肤表面来增强采样。 一种装置包括超声换能器，反射器和用于收集渗出物的吸收材料。 该装置还可以包括用于降低皮肤表面上的静水压力的压力分量。

公开(公告)号：US06679841B2

公开(公告)日：2004-01-20

申请号：US09880948

申请日：2001-06-15

Applicant: Peter M. Bojan ,  Timothy P. Henning ,  Neil W. Loomis ,  Mark R. Pope ,  Jonathan A. Eppstein

Inventor： Peter M. Bojan ,  Timothy P. Henning ,  Neil W. Loomis ,  Mark R. Pope ,  Jonathan A. Eppstein

IPC: A61B500

CPC classification number: A61B5/14865 ,  A61B5/14514 ,  A61B5/1486 ,  A61B5/150022 ,  A61B5/150343 ,  A61B5/150358 ,  A61B5/150755 ,  A61B5/157 ,  A61B5/441 ,  A61B10/0045 ,  A61B18/20 ,  A61B2010/008 ,  A61B2017/00765 ,  A61B2018/1807 ,  A61B2562/0295 ,  Y10T436/2575

Abstract: An article capable of both collecting interstitial fluid and detecting an analyte in that fluid and a method for use of that article. Preferably, the article is also capable of measuring the amount of analyte in the interstitial fluid. The article can be used in conjunction with a meter that contains an appropriate detection element for determining the amount of analyte in the interstitial fluid. In one preferred embodiment, the article is a multiple-layer element comprising: (1) a layer that is capable of being placed in contact with the skin of a patient; (2) a layer that is coated over the skin-contacting layer; (3) a layer, substantially coplanar with the overcoat layer, that is capable of transporting interstitial fluid by means of chemically aided wicking; (4) a layer, overlying the interstitial fluid transporting layer, that is capable of being placed in contact with a meter, said layer having an opening therein through which light can be transmitted; (5) a layer, disposed on the surface of the meter-contacting layer that faces the skin-contyacting layer, that is capable of detecting the presence of analyte or measuring the amount of analyte in the fluid. In order to use the multiple-layer element, light from a source of light is transmitted through the opening in the multiple-layer material to be absorbed at a light-absorbing target on the skin-contacting layer. This light transfers energy to the target, and this transferred energy causes an opening to form in the skin-contacting layer and an opening to form in the stratum corneum. Interstitial fluid exudes from the opening in the stratum corneum and contacts the interstitial fluid transporting layer. The interstitial fluid then moves along or through the interstitial fluid transporting layer to the detecting layer.

Abstract translation: 能够收集间质液并检测该液体中的分析物的物品以及该物品的使用方法。 优选地，制品还能够测量间质液中的分析物的量。 该制品可以与包含用于确定间质液中分析物的量的适当检测元件的仪表结合使用。 在一个优选实施例中，制品是多层元件，包括：（1）能够与患者皮肤接触的层;（2）涂覆在皮肤接触层上的层; （3）与外涂层基本上共面的层，其能够通过化学辅助芯吸输送组织液;（4）层叠在间质流体输送层上的层，其能够被置于与 所述层具有开口，通过所述开口可以传输光;（5）设置在所述仪表接触层的面向所述皮肤对接层的表面上的层，其能够检测分析物的存在或测量 流体中的分析物的量。为了使用多层元件，来自光源的光透过多层材料中的开口，以在皮肤接触层上的吸光目标处被吸收 。 这种光将能量转移到目标物上，并且这种转移的能量导致在皮肤接触层中形成开口并在角质层中形成开口。 间质液从角质层中的开口渗出并与组织液输送层接触。 间隙液然后沿着或穿过间隙液输送层移动到检测层。

公开(公告)号：US06071249A

公开(公告)日：2000-06-06

申请号：US982324

申请日：1997-12-02

Applicant: David D. Cunningham ,  Timothy P. Henning ,  Eric B. Shain ,  Douglas F. Young ,  Michael G. Lowery ,  Hugh W. Graham

Inventor： David D. Cunningham ,  Timothy P. Henning ,  Eric B. Shain ,  Douglas F. Young ,  Michael G. Lowery ,  Hugh W. Graham

IPC: A61B5/151 ,  A61B5/00 ,  A61B5/145 ,  A61B5/1459 ,  A61B5/1473 ,  A61B5/15 ,  A61B5/154 ,  A61B5/157 ,  G01N33/48 ,  G01N33/66

CPC classification number: A61B5/15186 ,  A61B5/14532 ,  A61B5/1486 ,  A61B5/150022 ,  A61B5/150068 ,  A61B5/150076 ,  A61B5/150099 ,  A61B5/150221 ,  A61B5/150412 ,  A61B5/150503 ,  A61B5/150664 ,  A61B5/15113 ,  A61B5/15125 ,  A61B5/1519 ,  A61B5/15194 ,  A61B5/157 ,  A61B5/411 ,  A61B2562/0295 ,  A61B5/150358

Abstract: Method and apparatus for obtaining a sample of blood from a patient for subsequent diagnostic tests, e.g., glucose monitoring. In one aspect of the invention, the method comprises the steps of:(a) forming an unobstructed opening in the area of the skin from which the sample of blood is to be extracted; and(b) extracting the sample of blood from the unobstructed opening in the skin, with the aid of a vacuum and a stretching of the skin.In another aspect of the invention, an apparatus for carrying out the method described previously is provided. The apparatus comprises:(a) a device for forming an unobstructed opening in an area of skin from which said sample is to be extracted, preferably a lancing assembly; and(b) a vacuum pump.Preferably, the apparatus also includes a housing.It has also been discovered that an improved design and construction of the nosepiece can provide enhanced collection of blood from the unobstructed opening in the skin. It has been discovered that by controlling the construction of the interior cavity of the nosepiece, collection of blood can be improved.

Abstract translation: 用于从患者获得血样的方法和装置用于随后的诊断测试，例如葡萄糖监测。 在本发明的一个方面，所述方法包括以下步骤：（a）在要从其中提取血液样本的皮肤区域中形成无障碍的开口; 和（b）借助于真空和皮肤拉伸从皮肤中的无阻塞的开口提取血液样品。 在本发明的另一方面，提供一种用于执行前述方法的装置。 该装置包括：（a）用于在皮肤区域形成无障碍的开口的装置，所述皮肤区域将从所述皮肤区域中提取所述样品，优选为采血组件; 和（b）真空泵。 优选地，该装置还包括壳体。 还已经发现，鼻梁的改进的设计和结构可以提供来自皮肤中无障碍开口的血液的增强的收集。 已经发现，通过控制鼻梁的内腔的构造，可以提高血液的收集。

公开(公告)号：US6032059A

公开(公告)日：2000-02-29

申请号：US898209

申请日：1997-07-22

Applicant: Timothy P. Henning ,  Eric B. Shain ,  Gamal Khalil ,  Tuan A. Elstrom

Inventor： Timothy P. Henning ,  Eric B. Shain ,  Gamal Khalil ,  Tuan A. Elstrom

IPC: G01N27/28 ,  A61B5/00 ,  A61B5/145 ,  A61B5/1459 ,  A61B5/1473 ,  A61B5/1495 ,  A61B5/15 ,  A61B5/157 ,  A61B10/00 ,  G01N21/35 ,  A61B5/05

CPC classification number: A61B5/14865 ,  A61B5/14532 ,  A61B5/6848

Abstract: The present invention relates to a device for the sampling of blood or other body fluids which includes means for the direct measurement of the analyte of interest within the fluid. Also disclosed is a `closed-loop` device and method wherein the analyte is measured and the required amount of drug is determined and injected, without removal of the device from the patient's body.

Abstract translation: 本发明涉及一种用于血液或其他体液取样的装置，其包括用于直接测量流体内感兴趣分析物的装置。 还公开了一种“闭环”装置和方法，其中测量分析物并确定和注射所需量的药物，而不需要从患者身体移除装置。

公开(公告)号：US6014577A

公开(公告)日：2000-01-11

申请号：US974797

申请日：1997-11-20

Applicant: Timothy P. Henning ,  Eric B. Shain ,  Gamal Khalil ,  Tuan A. Elstrom

Inventor： Timothy P. Henning ,  Eric B. Shain ,  Gamal Khalil ,  Tuan A. Elstrom

IPC: G01N27/28 ,  A61B5/00 ,  A61B5/145 ,  A61B5/1459 ,  A61B5/1473 ,  A61B5/1495 ,  A61B5/15 ,  A61B5/157 ,  A61B10/00 ,  G01N21/35 ,  A61B5/05

CPC classification number: A61B5/14865 ,  A61B5/14532 ,  A61B5/6848

Abstract: The present invention relates to a device for the sampling of blood or other body fluids which includes means for the direct measurement of the analyte of interest within the fluid. Also disclosed is a `closed-loop` device and method wherein the analyte is measured and the required amount of drug is determined and injected, without removal of the device from the patient's body.