-
公开(公告)号：US5808112A
公开(公告)日：1998-09-15
申请号：US877364
申请日：1997-06-17
IPC分类号： C07D333/32 , C07B41/02 , C07B53/00 , C07C35/06 , C07C41/26 , C07C43/196 , C07C309/66 , C07D307/20 , C07D309/12 , C07F7/08 , C07F7/18 , C12P7/02 , C12P41/00 , C07D315/00
CPC分类号： C07C41/26 , C07B53/00 , C07D309/12 , C07F7/1892 , C12P41/004 , C12P7/02 , C07C2101/10
摘要： The present invention relates to a novel process for preparing cis-4-O-protected-substituted-2-cyclopentenol derivatives comprising, a) dissolving a 4-O-protected-2-cyclopentenone in a suitable organic solvent; and b) treating the solution with a suitable Lewis acid and a suitable reducing agent at a temperature of from about -100.degree. C. to about 20.degree. C. The cis-4-O-protected-substituted-2-cyclopentenol derivatives are useful intermediates in the preparation of various cyclopentanyl and cyclopentenyl purine analogs which are useful as immunosuppressants and in the preparation of various prostaglandins.
摘要翻译： 本发明涉及一种制备顺式-4-O-保护取代-2-环戊烯醇衍生物的新方法，包括：a）将4-O-保护的2-环戊烯酮溶于合适的有机溶剂中; 并且b）在约-100℃至约20℃的温度下用合适的路易斯酸和合适的还原剂处理该溶液。顺式-4-O-保护取代的-2-环戊烯醇衍生物是有用的 制备各种环戊基和环戊烯嘌呤类似物的中间体，其可用作免疫抑制剂和制备各种前列腺素。
-
公开(公告)号：US5728899A
公开(公告)日：1998-03-17
申请号：US588584
申请日：1996-02-01
CPC分类号： C07B53/00 , C07C41/26 , C07D309/12 , C07F7/1892 , C12P41/004 , C12P7/02 , C07C2101/20
摘要： The present invention relates to a novel process for preparing cis-4-O-protected-substituted-2-cyclopentenol derivatives comprising, a) dissolving a 4-O-protected-2-cyclopentenone in a suitable organic solvent; and b) treating the solution with a suitable Lewis acid and a suitable reducing agent at a temperature of from about -100.degree. C. to about 20.degree. C. The cis-4-O-protected-substituted-2-cyclopentenol derivatives are useful intermediates in the preparation of various cyclopentanyl and cyclopentenyl purine analogs which are useful as immunosuppressants and in the preparation of various prostaglandins.
-
公开(公告)号：US10302619B2
公开(公告)日：2019-05-28
申请号：US15731024
申请日：2017-04-07
申请人： Jonathan C. Evans , Theodore W. Selby , Marta Manning , Derrick D. Hilliker , Michael A. Habitz
发明人： Jonathan C. Evans , Theodore W. Selby , Marta Manning , Derrick D. Hilliker , Michael A. Habitz
IPC分类号： G01N33/28 , C10M117/02 , C10M121/04 , C10M113/06 , C10M105/32 , C10M105/00
摘要： Grease wear test device includes a body in a form of a collar having an outer surface, a first side and an opposing second side, which are open to form a hollow, open channel through the body, which has a center axis, into which opposing vee blocks can be inserted; and perpendicular to the center axis, a pair of opposing holes through and open to the outer surface of the body and the cylindrical inside wall, through which a cylindrical test journal (falex pin) can be inserted for contact in general with opposing vee-shaped channels of the inserted, opposing vee blocks, and for rotation during testing. The device can be used to modify a falex pin and vee block device, to receive and contain a small sample of grease or another organic paste product for testing such as a modified version of an ASTM D2670 test method for measuring wear properties of fluid lubricants (falex pin and vee block method).
-
公开(公告)号：US20180326385A1
公开(公告)日：2018-11-15
申请号：US15932658
申请日：2018-04-03
CPC分类号： B01J19/0013 , B01J19/02 , B01J2219/00011 , B01J2219/00132 , G01N31/00 , G01N2035/00099
摘要： An active pharmaceutical ingredients (API) or related substance (RS) can be tested for stability by placing the API or RS in an instrument containing a pressure-controllable atmosphere, controlling the pressure of the atmosphere in the instrument for a predetermined time, and evaluating the API or RS for stability. Testing can be carried out also at predetermined temperature(s) and/or under the influence of gaseous trigger(s) and so forth. For instance, an API sample can be placed in a bomb test instrument/reactor, oxygen as a gaseous trigger can be introduced to contact the API sample under constant and/or ramped temperature(s) and elevated pressure(s) for predetermined time(s), and the API sample can be evaluated for stability. An insert carousel may hold a sample of API(s) and/or RS(s) and/or aliquot(s) of sample(s) of API(s) and/or RS(s) for insertion into the bomb test instrument/reactor.
-
公开(公告)号：US10823656B1
公开(公告)日：2020-11-03
申请号：US16350085
申请日：2018-09-21
申请人： Sarah R. Nuss-Warren , Douglas J. Wirsing , Derrick D. Hilliker , Theodore W. Selby , Jonathan C. Evans , Michael T. Kelly , Robert Culver , Fernando Moreira Mendes
发明人： Sarah R. Nuss-Warren , Douglas J. Wirsing , Derrick D. Hilliker , Theodore W. Selby , Jonathan C. Evans , Michael T. Kelly , Robert Culver , Fernando Moreira Mendes
摘要： Instrumentation embraces an at least partially automated rotational tapered bearing simulator viscometer having electronic control and/or monitoring that includes task unit electronics, which includes a task unit electronics interface. With or without such electronics, the instrumentation may include a particular component configuration and/or employ at least one particular material. Further feature(s) may be extant.
-
公开(公告)号：US20170284994A1
公开(公告)日：2017-10-05
申请号：US15731004
申请日：2017-04-05
IPC分类号： G01N33/28 , C10M113/06 , C10M169/02 , C10M109/00 , C10M121/04
CPC分类号： G01N33/2805 , C10M109/00 , C10M113/06 , C10M121/04 , C10M169/02 , C10N2240/10 , G01N21/35 , G01N33/2888 , G01N2021/3595
摘要： Effects of Oxygen on grease or another organic paste product can be evaluated with a modified version of the ASTM D942 test methodology for oxidation stability of lubricating greases or other organic paste products by employment of an oxidation pressure vessel, in which at least one of (A) a very small sample of the grease or other organic paste product is deployed for testing within the oxidation pressure vessel such that the sample has an enhanced surface area to mass ratio, and (B) a temperature other than about 99° C. is employed during the testing. In general, the testing is carried out under oxidation pressure conditions. The sample may be evaluated with respect to Oxygen uptake. Additional technique(s) directed to oxidation and/or other properties of the sample may be carried out before to after any Oxygen uptake evaluation, for example, FTIR analysis and/or ATR-FTIR analysis.
-
公开(公告)号：US09175906B2
公开(公告)日：2015-11-03
申请号：US10639361
申请日：2003-08-12
CPC分类号： A61K9/1688 , A61K6/0008 , A61K9/14 , A61K9/145 , A61K9/1694 , A61K9/19 , A61K9/5089 , A61K31/192 , A61K31/38 , A61K31/4412 , A61K31/496 , A61K31/55 , A61K31/573 , A61K31/58 , A61K38/13 , F26B5/065 , F26B17/284
摘要： The present invention is a method for preparing micron-sized or submicron-sized drug particles comprising contacting a solution comprising a poorly water soluble drug substance and at least one freezable organic solvent with a cold surface so as to freeze the solution; and removing the organic solvent. The resulting particles are also disclosed, as are several embodiments of an apparatus that can be used in performing the method of the present invention.
摘要翻译： 本发明是一种制备微米级或亚微米尺寸药物颗粒的方法，其包括将包含难溶于水的药物物质和至少一种可冷冻有机溶剂的溶液与冷表面接触以冷冻该溶液; 并除去有机溶剂。 还可以公开所得到的颗粒，以及可以用于执行本发明的方法的装置的几个实施方案。
-
公开(公告)号：US10914719B2
公开(公告)日：2021-02-09
申请号：US14121952
申请日：2014-11-06
申请人： Theodore W. Selby , Jonathan C. Evans , Gregory C. Miiller , Calvin David Hugo , Sarah Nuss-Warren , Douglas J. Wirsing
发明人： Theodore W. Selby , Jonathan C. Evans , Gregory C. Miiller , Calvin David Hugo , Sarah Nuss-Warren , Douglas J. Wirsing
摘要： A significantly improved version of the ASTM D942 Test Method, with apparatus employable to effect the same, is provided. This is useful in measurement of grease oxidation.
-
![Processes for the preparation of (R)-&agr;-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol](/abs-image/US/2004/03/30/US06713627B2/abs.jpg.150x150.jpg)
9.发明授权Processes for the preparation of (R)-&agr;-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol 失效制备（R）-α-（2,3-二甲氧基苯基）-1- [2-（4-氟苯基）乙基] -4-哌啶甲醇的方法公开(公告)号：US06713627B2
公开(公告)日：2004-03-30
申请号：US10043498
申请日：2002-01-11
申请人： Edward D. Daugs , Jonathan C. Evans , Hans-Wolfram Flemming , Thomas Heinz Eduard Hilpert , Johannes Nicolaas Koek , Frederick M. Laskovics , Sandra K. Stolz-Dunn , Ian A. Tomlinson
发明人： Edward D. Daugs , Jonathan C. Evans , Hans-Wolfram Flemming , Thomas Heinz Eduard Hilpert , Johannes Nicolaas Koek , Frederick M. Laskovics , Sandra K. Stolz-Dunn , Ian A. Tomlinson
IPC分类号： C07D21122
CPC分类号： C07D211/32 , C07D211/22
摘要： The present invention provides various processes for the preparation of (R)-&agr;-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol. These processes may be characterized by the following scheme:
摘要翻译： 本发明提供制备（R）-α-（2,3-二甲氧基苯基）-1- [2-（4-氟苯基）乙基] -4-哌啶甲醇的各种方法。 这些过程可以通过以下方案来表征：
-
公开(公告)号：US5599986A
公开(公告)日：1997-02-04
申请号：US513501
申请日：1995-08-31
IPC分类号： A61K31/135 , A61P43/00 , C07C20060101 , C07C17/16 , C07C25/24 , C07C29/147 , C07C29/149 , C07C33/48 , C07C69/65 , C07C209/62 , C07C211/29 , C07C231/08 , C07C231/24 , C07C233/13 , C07C233/90 , C07C233/00
CPC分类号： C07C17/16 , C07C211/29 , C07C233/13 , C07C25/24 , C07C29/147 , C07C33/483 , C07C69/65
摘要： The present invention relates to a novel process for preparing alkali metal salts of diformylamide and a novel crystalline form of sodium diformylamide.
摘要翻译： 本发明涉及一种制备二酰胺的碱金属盐的新方法和二甲酰胺钠的新结晶形式。
-
-
-
-
-
-
-
-
-
搜索结果
22 条记录 (耗时 0.025 秒)
