摘要:
Non-steroidal compounds which are high affinity, high selectivity modulators for steroid receptors are disclosed. Also disclosed are pharmaceutical compositions incorporating such compounds, methods for employing the disclosed compounds and compositions for treating patients requiring steroid receptor agonist or antagonist therapy, intermediates useful in the preparation of the compounds and processes for the preparation of the steroid receptor modulator compounds.
摘要:
Non-steroidal compounds which are high affinity, high selectivity modulators for steroid receptors are disclosed. Also disclosed are pharmaceutical compositions incorporating such compounds, methods for employing the disclosed compounds and compositions for treating patients requiting steroid receptor agonist or antagonist therapy, intermediates useful in the preparation of the compounds and processes for the preparation of the steroid receptor modulator compounds.
摘要:
Non-steroidal compounds which are high affinity, high selectivity modulators for steroid receptors are disclosed. Also disclosed are pharmaceutical compositions incorporating such compounds, methods for employing the disclosed compounds and compositions for treating patients requiring steroid receptor agonist or antagonist therapy, intermediates useful in the preparation of the compounds and processes for the preparation of the steroid receptor modulator compounds.
摘要:
Non-steroidal compounds which are high affinity, high selectivity modulators for steroid receptors are disclosed. Also disclosed are pharmaceutical compositions incorporating such compounds, methods for employing the disclosed compounds and compositions for treating patients requiring steroid receptor agonist or antagonist therapy, intermediates useful in the preparation of the compounds and processes for the preparation of the steroid receptor modulator compounds.
摘要:
Non-steroidal compounds which are high affinity, high selectivity modulators for steroid receptors are disclosed. Also disclosed are pharmaceutical compositions incorporating such compounds, methods for employing the disclosed compounds and compositions for treating patients requiring steroid receptor agonist or antagonist therapy, intermediates useful in the preparation of the compounds and processes for the preparation of the steroid receptor modulator compounds.
摘要:
Non-steroidal compounds which are high affinity, high specificity ligand antagonists for the androgen receptor are disclosed. Also disclosed are methods for employing the disclosed compounds for modulating processes mediated by the androgen receptor and for treating patients requiring androgen receptor antagonist therapy.
摘要:
A system for holding or transporting engraveable workpieces of different configurations is provided. The system includes a first workpiece carrier that has an internal relief configured to receive a first workpiece having a first configuration. The system also includes a second workpiece carrier that has an internal relief configured to receive a second workpiece having a second configuration. The outer surface of the second workpiece carrier is substantially the same as the outer shape of the first workpiece carrier, to thereby provide a carrier of uniform outer dimensions regardless of the workpiece configuration. The carrier may hold the workpiece within the internal relief through a snap lock and in such a manner as to avoid contact with and possible damage from an adjacently stored workpiece.
摘要:
A seat bound exercise system provides resistive rotational motion of the ankle to combat potentially fatal problems such as lower leg thrombosis. The system comprises an attachment member with upper and lower ends. The lower end is provided with a bore and extends to a ground surface. A support cylinder with a top end, a bottom end, an inner edge and an outer edge is provided. The bottom end has a coaxial bore allowing rotatable coupling with a bore of the attachment members with a pin. A handle bar, including a cylindrical receiving bar and a cylindrical intermediate portion, is provided next. The receiving bar has a lower portion telescoping over and coupled to the top ends of the support cylinders and upper portion. The intermediate bar telescopes over and is coupled to the receiving bar. Also included is a source of resistance force with piston rods. A foot pedal with a foot receiving portion is provided.
摘要:
An automated apparatus and method for engraving a workpiece selected from a plurality of workpiece styles, and dispensing the engraved workpiece along with a related accessory. Upon receipt of workpiece selection and text information supplied by a user, the controller generates drive signal which cause the apparatus to: retrieve the selected workpiece from one of a plurality of workpiece storage columns, move the workpiece to an engraving location, engrave the workpiece using a workpiece-specific engraving tool pressure, and dispense of the accessory from one of a plurality of accessory storage columns.
摘要:
Compounds having utility as antinflammatory agents in general and, more specifically, for the prevention and/or treatment of immunoinflammatory and autoimmune diseases are disclosed. The compounds are pyrimidine- or pyrazine-containing compounds and, in one embodiment, are carboxyamides of the same. Methods are also disclosed for preventing and/or treating inflammatory conditions by administering to an animal in need thereof an effective amount of a compound of this invention, preferably in the form of a pharmaceutical composition.