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    Systems and methods for treatment of coronary artery disease
    2.
    发明授权
    Systems and methods for treatment of coronary artery disease 失效
    用于治疗冠状动脉疾病的系统和方法

    公开(公告)号：US07481759B2

    公开(公告)日：2009-01-27

    申请号：US10211463

    申请日：2002-08-02

    申请人： Todd K. Whitehurst ,  James P McGivern ,  Kelly H McClure ,  Mark R. Stultz

    发明人： Todd K. Whitehurst ,  James P McGivern ,  Kelly H McClure ,  Mark R. Stultz

    IPC分类号： A61N1/36

    CPC分类号： A61N1/36114 ,  A61M5/14276 ,  A61M2205/3523 ,  A61M2205/8206 ,  A61M2230/06

    摘要： Methods and systems for treatment of coronary artery disease (CAD) include implantation of the discharge portion(s) of a catheter and, optionally, electrodes on a lead, near the tissue(s) to be stimulated. Stimulation pulses, i.e., drug infusion pulses and optional electrical pulses, are supplied by a stimulator implanted remotely, and through the catheter or lead, which is tunneled subcutaneously between the stimulator and stimulation site. Stimulation sites include the coronary arteries, the aorta, the left ventricle, the left atrium, and/or the pulmonary veins, among other locations. Disclosed treatments include drugs used for acute treatment of CAD, for chronic treatment of CAD, to promote angiogenesis, and/or as AGE Crosslink Breakers, among other drugs. For instance, the systems and methods reduce or eliminate the incidence of CAD and related morbidities, improve symptoms resulting from CAD, and/or improve cardiac blood flow, cardiac function, and patient quality of life.

    摘要翻译： 用于治疗冠状动脉疾病（CAD）的方法和系统包括将导管的放电部分和可选地在导线上的电极植入，以被刺激的组织附近。 刺激脉冲，即药物输注脉冲和可选的电脉冲由远程植入的刺激器，以及通过在刺激器和刺激部位之间皮下隧穿的导管或引线提供。 刺激部位包括冠状动脉，主动脉，左心室，左心房和/或肺静脉等。 公开的治疗包括用于急性治疗CAD，用于慢性CAD治疗，促进血管发生的药物和/或作为AGE交联断裂剂等药物。 例如，系统和方法可减少或消除CAD和相关疾病的发生率，改善由CAD引起的症状和/或改善心脏血流量，心脏功能和患者生活质量。

    TREATMENT OF MOVEMENT DISORDERS BY BRAIN STIMULATION
    3.
    发明申请
    TREATMENT OF MOVEMENT DISORDERS BY BRAIN STIMULATION 有权
    通过脑刺激治疗运动障碍

    公开(公告)号：US20100331807A1

    公开(公告)日：2010-12-30

    申请号：US12873170

    申请日：2010-08-31

    申请人： Todd K. Whitehurst ,  James P. McGivern ,  Kelly H. McClure

    发明人： Todd K. Whitehurst ,  James P. McGivern ,  Kelly H. McClure

    IPC分类号： A61N1/36 ,  A61M37/00

    CPC分类号： A61M5/14276 ,  A61K9/0085 ,  A61M2205/3523 ,  A61M2205/3569 ,  A61M2210/0693 ,  A61N1/0529 ,  A61N1/0534 ,  A61N1/325 ,  A61N1/36082 ,  A61N1/37205

    摘要： Systems for treating a movement disorder include a system control unit configured to be implanted at least partially within a patient and to generate at least one stimulus in accordance with one or more stimulation parameters adjusted to treat the movement disorder. The systems further include a programmable memory unit in communication with the system control unit and programmed to store the one or more stimulation parameters to at least partially define the stimulus such that the stimulus is configured to treat the movement disorder. A means for applying the stimulus to one or more stimulation sites within the patient is operably connected to the system control unit.

    摘要翻译： 用于治疗运动障碍的系统包括系统控制单元，该系统控制单元被配置为至少部分地植入患者体内，并根据被调整以治疗运动障碍的一个或多个刺激参数产生至少一个刺激。 系统还包括与系统控制单元通信的可编程存储器单元，并被编程为存储一个或多个刺激参数以至少部分地限定刺激，使得刺激被配置为治疗运动障碍。 将刺激施加到患者体内的一个或多个刺激部位的手段可操作地连接到系统控制单元。

    Monitoring, preventing, and treating rejection of transplanted organs
    4.
    发明授权
    Monitoring, preventing, and treating rejection of transplanted organs 失效
    监测，预防和治疗移植器官的排斥

    公开(公告)号：US06970741B1

    公开(公告)日：2005-11-29

    申请号：US10246554

    申请日：2002-09-17

    申请人： Todd K. Whitehurst ,  James P. McGivern ,  Kelly H. McClure ,  Goran N. Marnfeldt ,  James R. Thacker

    发明人： Todd K. Whitehurst ,  James P. McGivern ,  Kelly H. McClure ,  Goran N. Marnfeldt ,  James R. Thacker

    IPC分类号： A61M5/00 ,  A61M5/142 ,  A61M5/172 ,  A61N1/00 ,  A61N1/30 ,  A61N1/32

    CPC分类号： A61B5/413 ,  A61B5/053 ,  A61B5/0538 ,  A61B5/41 ,  A61B5/415 ,  A61B5/416 ,  A61B5/418 ,  A61B5/4244 ,  A61B2560/0219 ,  A61M5/14276 ,  A61M5/1723 ,  A61N1/30 ,  A61N1/32

    摘要： An implantable system control unit (SCU) includes means for measuring tissue impedance or other condition to determine allograft health, in order to predict or detect allograft rejection. The SCU also includes at least two electrodes coupled to means for delivering electrical stimulation to a patient within whom the device is implanted, and may also include a reservoir for holding one or more drugs and a driver means for delivering the drug(s) to the patient. In certain embodiments, the system is capable of open- and closed-loop operation. In closed-loop operation, at least one SCU includes a sensor, and the sensed condition is used to adjust stimulation parameters. Alternatively, this sensory “SCU” sounds an alarm, communicates an alarm to an external device, and/or is responsive to queries regarding sensed information, such as tissue impedance.

    摘要翻译： 可植入系统控制单元（SCU）包括用于测量组织阻抗或其他条件以确定同种异体移植物健康的装置，以便预测或检测同种异体移植排斥。 SCU还包括至少两个电极，其耦合到用于将电刺激递送到其中植入该装置的患者的装置，并且还可以包括用于容纳一种或多种药物的储存器和用于将药物递送至 患者。 在某些实施例中，系统能够进行开环和闭环操作。 在闭环操作中，至少一个SCU包括传感器，并且使用感测到的条件来调整刺激参数。 或者，该感官“SCU”发出警报，向外部设备通报警报，和/或响应关于感测信息（例如组织阻抗）的查询。

    Treatment of movement disorders by brain stimulation
    5.
    发明授权
    Treatment of movement disorders by brain stimulation 有权
    通过脑刺激治疗运动障碍

    公开(公告)号：US08401634B2

    公开(公告)日：2013-03-19

    申请号：US12873170

    申请日：2010-08-31

    申请人： Todd K. Whitehurst ,  James P. McGivern ,  Kelly H. McClure

    发明人： Todd K. Whitehurst ,  James P. McGivern ,  Kelly H. McClure

    IPC分类号： A61N1/00

    CPC分类号： A61M5/14276 ,  A61K9/0085 ,  A61M2205/3523 ,  A61M2205/3569 ,  A61M2210/0693 ,  A61N1/0529 ,  A61N1/0534 ,  A61N1/325 ,  A61N1/36082 ,  A61N1/37205

    摘要： Systems for treating a movement disorder include a system control unit configured to be implanted at least partially within a patient and to generate at least one stimulus in accordance with one or more stimulation parameters adjusted to treat the movement disorder. The systems further include a programmable memory unit in communication with the system control unit and programmed to store the one or more stimulation parameters to at least partially define the stimulus such that the stimulus is configured to treat the movement disorder. A means for applying the stimulus to one or more stimulation sites within the patient is operably connected to the system control unit.

    摘要翻译： 用于治疗运动障碍的系统包括系统控制单元，该系统控制单元被配置为至少部分地植入患者体内，并根据被调整以治疗运动障碍的一个或多个刺激参数产生至少一个刺激。 系统还包括与系统控制单元通信的可编程存储器单元，并被编程为存储一个或多个刺激参数以至少部分地限定刺激，使得刺激被配置为治疗运动障碍。 将刺激施加到患者体内的一个或多个刺激部位的手段可操作地连接到系统控制单元。

    Lead assembly for implantable microstimulator
    7.
    发明授权
    Lead assembly for implantable microstimulator 有权
    可植入微型激励器的导线组件

    公开(公告)号：US08364278B2

    公开(公告)日：2013-01-29

    申请号：US10503281

    申请日：2003-01-29

    申请人： Anne M. Pianca ,  Todd K. Whitehurst ,  James P. McGivern

    发明人： Anne M. Pianca ,  Todd K. Whitehurst ,  James P. McGivern

    IPC分类号： A61N1/05

    CPC分类号： H01R43/16 ,  A61N1/05 ,  H01R13/5224 ,  Y10T29/49204

    摘要： A lead assembly for a small implantable medical device connects a remote electrode to a microdevice and inhibits fluid ingress into the connection. Microdevices may provide either or both tissue stimulation and sensing. Known microdevices include spaced apart electrodes on the outer surface of the microdevice. The lead assembly includes an insulated lead including a proximal end and a distal end, with at least one conductor therebetween; at least one electrode at the distal end of the lead and electrically connected to the at least one conductor, and a connector attached to the proximal end of the lead and adapted to be removably connectable to the microdevice. The connector includes at least one contact to electrically connect at least one device electrode on the microdevice to the at least one conductor. The lead assembly is configured to inhibit fluid ingress into the connector.

    摘要翻译： 用于小型可植入医疗装置的引导组件将远程电极连接到微型装置并且阻止流体进入连接。 微器件可以提供组织刺激和感测之一或两者。 已知的微器件在微器件的外表面上包括间隔开的电极。 引线组件包括绝缘引线，其包括近端和远端，其间具有至少一个导体; 在所述引线的远端处的至少一个电极并且电连接到所述至少一个导体，以及连接到所述引线的近端并适于可移除地连接到所述微器件的连接器。 所述连接器包括至少一个接触件，以将所述微器件上的至少一个器件电极电连接到所述至少一个导体。 引线组件被配置为抑制流体进入连接器。

    Fully implantable neurostimulator for cavernous nerve stimulation as a therapy for erectile dysfunction and other sexual dysfunction
    9.
    发明授权
    Fully implantable neurostimulator for cavernous nerve stimulation as a therapy for erectile dysfunction and other sexual dysfunction 有权
    用于海绵神经刺激的完全植入式神经刺激器作为勃起功能障碍和其他性功能障碍的治疗方法

    公开(公告)号：US06650943B1

    公开(公告)日：2003-11-18

    申请号：US09799988

    申请日：2001-03-06

    申请人： Todd K. Whitehurst ,  James P. McGivern

    发明人： Todd K. Whitehurst ,  James P. McGivern

    IPC分类号： A61N136

    CPC分类号： A61N1/372 ,  A61N1/36007 ,  A61N1/37205

    摘要： An implantable stimulator(s) with at least two electrodes, which is small enough to have the electrodes located adjacent to a cavernous nerve(s) or other nerve(s) innervating the reproductive organs, uses a power source/storage device, such as a rechargeable battery. Periodic recharging of such a battery is accomplished, for example, by inductive coupling with an external appliance. The small stimulator provides means of stimulating a nerve(s) when desired, without the need for external appliances during the stimulation session. When necessary, external appliances are used for the transmission of data to and/or from the stimulator(s) and for the transmission of power. In a preferred embodiment, the system is capable of open-and closed-loop operation. In closed-loop operation, at least one implant includes a sensor, and the sensed condition is used to adjust stimulation parameters.

    摘要翻译： 具有至少两个电极的可植入刺激器，其足够小以使电极位于邻近海绵状神经或支配生殖器官的其他神经，使用电源/存储装置，例如 可充电电池 这种电池的定期再充电例如通过与外部电器的感应耦合来实现。 小刺激器提供在需要时刺激神经的手段，而不需要在刺激期间的外部器具。 必要时，外部设备用于传送和/或从刺激器传输数据和传输电力。 在优选实施例中，系统能够进行开环和闭环操作。 在闭环操作中，至少一个植入物包括传感器，并且所使用的感测条件用于调节刺激参数。