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公开(公告)号：US20180338865A1
公开(公告)日：2018-11-29
申请号：US15534026
申请日：2015-12-04
发明人： Motonori Hochi , Yuki Sekido , Akihiro Saito , Shinji Takeoka , Shinya Ohtsubo , Akinari Hinoki , Manabu Kinoshita
CPC分类号： A61F13/02 , A61L15/24 , A61L15/26 , A61L15/28 , A61L31/042 , A61L31/048 , A61L31/06 , B32B27/00 , B32B27/32 , C08B5/00 , C08L5/08 , C08L67/04
摘要： A laminated film includes a polylactic acid-based resin layer and one or more acetylated hyaluronic acid layers laminated on a side of the polylactic acid-based resin layer, is highly flexible and easy to handle and, when stuck to an adherend with curved surface, the laminated film has excellent followability, adhesiveness and coating properties to the adherend, since the acetylated hyaluronic acid layer(s) can be removed easily with an aqueous solution from the polylactic acid-based resin layer in a thin film shape. The acetylated hyaluronic acid and the polylactic acid-based resin are biodegradable and, therefore, the laminated film is highly compatible with skin and organs such as visceral organs. The laminated film is optimally usable as a dermal material for external application such as a wound coating material, an adhesion inhibitor and skin care articles.
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公开(公告)号：US10563025B2
公开(公告)日：2020-02-18
申请号：US15572210
申请日：2016-05-11
发明人： Motonori Hochi , Yuki Sekido , Ichiro Itagaki , Toru Arakane , Shinya Ohtsubo , Shinji Takeoka , Atsushi Murata , Mao Fujii , Yuya Ishizuka , Shuichi Shoji , Jun Mizuno , Takashi Kasahara
IPC分类号： A61K8/04 , A61K8/81 , A61K8/85 , A61K8/86 , A61L15/22 , C08J5/18 , A61L31/00 , A61L15/24 , A61L15/26 , A61L31/04 , A61L31/06 , A61Q19/00 , C08L25/06 , C08L33/12 , C08L67/04
摘要： A polymer film has an average film thickness T0 along a straight line D passing through the center of gravity of a two-dimensional projection such that the area of the polymer film is maximized, satisfies equation (a), the average value L of distances 1 from the center of gravity to edges satisfies equation (b), the Young's modulus E satisfies equation (c), and the thickness deviation Δ defined by equation (d) satisfies equation (e); and a dispersion liquid and an agglomerate using the same. (a) 10 nm≤T0≤1000 nm, (b) 0.1 μm≤L≤500 μm, (c) 0.01 GPa≤E≤4.3 GPa, (d) Δ=1−T1/T2, (e) 0.346E×10−9−1.499
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公开(公告)号：US10531988B2
公开(公告)日：2020-01-14
申请号：US15534026
申请日：2015-12-04
发明人： Motonori Hochi , Yuki Sekido , Akihiro Saito , Shinji Takeoka , Shinya Ohtsubo , Akinari Hinoki , Manabu Kinoshita
IPC分类号： A61F13/02 , B32B27/00 , A61L15/28 , A61L15/24 , A61L15/26 , B32B27/32 , A61L31/06 , A61L31/04 , C08B5/00
摘要： A laminated film includes a polylactic acid-based resin layer and one or more acetylated hyaluronic acid layers laminated on a side of the polylactic acid-based resin layer, is highly flexible and easy to handle and, when stuck to an adherend with curved surface, the laminated film has excellent followability, adhesiveness and coating properties to the adherend, since the acetylated hyaluronic acid layer(s) can be removed easily with an aqueous solution from the polylactic acid-based resin layer in a thin film shape. The acetylated hyaluronic acid and the polylactic acid-based resin are biodegradable and, therefore, the laminated film is highly compatible with skin and organs such as visceral organs. The laminated film is optimally usable as a dermal material for external application such as a wound coating material, an adhesion inhibitor and skin care articles.
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公开(公告)号：US20180118905A1
公开(公告)日：2018-05-03
申请号：US15572210
申请日：2016-05-11
发明人： Motonori Hochi , Yuki Sekido , Ichiro Itagaki , Toru Arakane , Shinya Ohtsubo , Shinji Takeoka , Atsushi Murata , Mao Fujii , Yuya Ishizuka , Shuichi Shoji , Jun Mizuno , Takashi Kasahara
IPC分类号： C08J5/18 , A61Q19/00 , A61K8/04 , A61K8/81 , A61K8/85 , A61K8/86 , C08L25/06 , C08L67/04 , C08L33/12 , A61L15/22 , A61L15/26 , A61L15/24 , A61L31/04 , A61L31/06
CPC分类号： C08J5/18 , A61K8/04 , A61K8/8117 , A61K8/8152 , A61K8/8176 , A61K8/85 , A61K8/86 , A61L15/22 , A61L15/225 , A61L15/24 , A61L15/26 , A61L31/00 , A61L31/041 , A61L31/048 , A61L31/06 , A61Q19/00 , C08J2325/06 , C08J2333/12 , C08J2367/04 , C08J2467/04 , C08L25/06 , C08L33/12 , C08L67/04
摘要： A polymer film has an average film thickness T0 along a straight line D passing through the center of gravity of a two-dimensional projection such that the area of the polymer film is maximized, satisfies equation (a), the average value L of distances 1 from the center of gravity to edges satisfies equation (b), the Young's modulus E satisfies equation (c), and the thickness deviation Δ defined by equation (d) satisfies equation (e); and a dispersion liquid and an agglomerate using the same. (a) 10 nm≤T0≤1000 nm, (b) 0.1 μm≤L≤500 μm, (c) 0.01 GPa≤E≤4.3 GPa, (d) Δ=1−T1/T2, (e) 0.346E×10−9−1.499
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公开(公告)号：US20170043062A1
公开(公告)日：2017-02-16
申请号：US15305460
申请日：2015-04-20
发明人： Yosuke Okamura , Yu Nagase , Takuya Komachi , Motonori Hochi , Yuki Sekido , Toru Arakane
CPC分类号： A61L31/00 , A61L15/16 , A61L15/24 , A61L15/26 , A61L15/28 , A61L15/64 , A61L31/042 , A61L31/048 , A61L31/06 , A61L31/148 , A61L2400/12 , B32B7/05 , B32B9/02 , B32B9/04 , B32B9/045 , B32B27/08 , B32B27/306 , B32B27/36 , B32B2250/05 , B32B2250/24 , B32B2250/44 , B32B2307/7163 , B32B2307/73 , B32B2535/00 , C08L67/04 , C08L5/04 , C08L29/04
摘要： A polymer laminate has 2-100 layers each containing a biodegradable resin and having a thickness of 10 nm-400 nm that are laminated, the thickness of at least one of the outermost layers is 10 nm-180 nm, and the outermost layers are joined to each other. A polymer laminate excellent in biocompatibility and mechanical strength and suitable to medical applications such as wound dressings and antiadhesive materials can be obtained.
摘要翻译： 聚合物层叠体具有层叠了厚度为10nm〜400nm的生物降解性树脂的2〜100层，最外层的至少一层的厚度为10nm〜180nm，最外层接合 对彼此。 可以获得生物相容性和机械强度优异且适用于医疗用途如伤口敷料和防粘附材料的聚合物层压体。
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公开(公告)号：US11046061B2
公开(公告)日：2021-06-29
申请号：US16087423
申请日：2017-03-23
发明人： Yuki Sekido , Motonori Hochi , Mao Fujii
IPC分类号： B32B27/12 , B32B5/02 , B32B7/12 , B32B27/30 , B32B27/36 , B32B27/40 , B32B9/04 , B32B23/10 , B32B27/28 , B32B9/02 , B32B23/08 , B32B23/04 , B32B27/08 , A61L15/58 , A61L15/24 , A61L15/26 , A61L15/28 , A61L31/12 , A61L31/04 , A61L31/06 , A61L31/14
摘要： A laminate has better handling properties achieved when it is attached to an adherend and which allows the solubility irregularity of the water-soluble material layer to be suppressed. The laminate includes: a 10 to 500 nm thick biodegradable material layer containing an aliphatic polyester and a water-soluble material layer disposed on at least one side of the biodegradable material layer, in which the water-soluble material layer is constituted of a 1 to 20 μm thick first layer containing a water-soluble polymer (a), a 10 μm to 10 mm thick fabric structure containing a water-soluble polymer (b), and a 1 to 20 μm thick second layer containing a water-soluble polymer (c), which are layered in this order from the biodegradable material layer side.
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公开(公告)号：US10456503B2
公开(公告)日：2019-10-29
申请号：US15305460
申请日：2015-04-20
发明人： Yosuke Okamura , Yu Nagase , Takuya Komachi , Motonori Hochi , Yuki Sekido , Toru Arakane
IPC分类号： B32B27/02 , A61L31/00 , A61L15/16 , B32B27/36 , B32B27/08 , B32B27/30 , A61L31/04 , A61L31/06 , A61L31/14 , A61L15/24 , A61L15/26 , A61L15/28 , A61L15/64 , B32B9/02 , B32B9/04 , B32B7/05
摘要： A polymer laminate has 2-100 layers each containing a biodegradable resin and having a thickness of 10 nm-400 nm that are laminated, the thickness of at least one of the outermost layers is 10 nm-180 nm, and the outermost layers are joined to each other. A polymer laminate excellent in biocompatibility and mechanical strength and suitable to medical applications such as wound dressings and antiadhesive materials can be obtained.
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公开(公告)号：US10786980B2
公开(公告)日：2020-09-29
申请号：US15311314
申请日：2015-06-18
发明人： Yuki Sekido , Motonori Hochi , Toru Arakane , Yoshikazu Yakake , Teruhisa Sato
IPC分类号： B32B27/36 , B32B38/10 , B32B5/26 , B32B15/14 , B32B7/12 , A61L15/28 , A61L15/26 , A61L31/04 , B32B29/02 , A61L31/06 , B32B7/04 , A61L15/24 , A61L15/22 , B32B5/02 , B32B9/04 , B32B27/08 , B32B27/12 , B32B27/30 , B32B37/10 , B32B37/18
摘要： A laminate has at least one polylactic acid resin-containing layer (C) with a thickness of 10-500 nm on at least one surface of a fibrous structure (B) containing a water-soluble resin (A). A production method for the laminate is characterized in that water or an aqueous solution is applied to the joining surface of the fibrous structure (B) and the polylactic acid resin-containing layer (C). The laminate exhibits excellent followability, adherence and coatability relative to flexible, curved adherends, exhibits excellent compatibility to organs such as skin and internal organs, and, because the fibrous structure (B) containing a water-soluble resin (A) can easily be removed from the polylactic acid resin-containing layer (C) by the aqueous solution, is adapted for use in materials for external use on the skin, such as wound-dressing materials, adhesion-preventing materials, and skin care products.
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公开(公告)号：US20190099990A1
公开(公告)日：2019-04-04
申请号：US16087423
申请日：2017-03-23
发明人： Yuki Sekido , Motonori Hochi , Mao Fujii
摘要： A laminate has better handling properties achieved when it is attached to an adherend and which allows the solubility irregularity of the water-soluble material layer to be suppressed. The laminate includes: a 10 to 500 nm thick biodegradable material layer containing an aliphatic polyester and a water-soluble material layer disposed on at least one side of the biodegradable material layer, in which the water-soluble material layer is constituted of a 1 to 20 μm thick first layer containing a water-soluble polymer (a), a 10 μm to 10 mm thick fabric structure containing a water-soluble polymer (b), and a 1 to 20 μm thick second layer containing a water-soluble polymer (c), which are layered in this order from the biodegradable material layer side.
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