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公开(公告)号：US20170043062A1
公开(公告)日：2017-02-16
申请号：US15305460
申请日：2015-04-20
发明人： Yosuke Okamura , Yu Nagase , Takuya Komachi , Motonori Hochi , Yuki Sekido , Toru Arakane
CPC分类号： A61L31/00 , A61L15/16 , A61L15/24 , A61L15/26 , A61L15/28 , A61L15/64 , A61L31/042 , A61L31/048 , A61L31/06 , A61L31/148 , A61L2400/12 , B32B7/05 , B32B9/02 , B32B9/04 , B32B9/045 , B32B27/08 , B32B27/306 , B32B27/36 , B32B2250/05 , B32B2250/24 , B32B2250/44 , B32B2307/7163 , B32B2307/73 , B32B2535/00 , C08L67/04 , C08L5/04 , C08L29/04
摘要： A polymer laminate has 2-100 layers each containing a biodegradable resin and having a thickness of 10 nm-400 nm that are laminated, the thickness of at least one of the outermost layers is 10 nm-180 nm, and the outermost layers are joined to each other. A polymer laminate excellent in biocompatibility and mechanical strength and suitable to medical applications such as wound dressings and antiadhesive materials can be obtained.
摘要翻译： 聚合物层叠体具有层叠了厚度为10nm〜400nm的生物降解性树脂的2〜100层，最外层的至少一层的厚度为10nm〜180nm，最外层接合 对彼此。 可以获得生物相容性和机械强度优异且适用于医疗用途如伤口敷料和防粘附材料的聚合物层压体。
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公开(公告)号：US10456503B2
公开(公告)日：2019-10-29
申请号：US15305460
申请日：2015-04-20
发明人： Yosuke Okamura , Yu Nagase , Takuya Komachi , Motonori Hochi , Yuki Sekido , Toru Arakane
IPC分类号： B32B27/02 , A61L31/00 , A61L15/16 , B32B27/36 , B32B27/08 , B32B27/30 , A61L31/04 , A61L31/06 , A61L31/14 , A61L15/24 , A61L15/26 , A61L15/28 , A61L15/64 , B32B9/02 , B32B9/04 , B32B7/05
摘要： A polymer laminate has 2-100 layers each containing a biodegradable resin and having a thickness of 10 nm-400 nm that are laminated, the thickness of at least one of the outermost layers is 10 nm-180 nm, and the outermost layers are joined to each other. A polymer laminate excellent in biocompatibility and mechanical strength and suitable to medical applications such as wound dressings and antiadhesive materials can be obtained.
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公开(公告)号：US20190216971A1
公开(公告)日：2019-07-18
申请号：US16335082
申请日：2017-09-29
发明人： Akihiro Saito , Megumi Nakanishi , Kazuhiro Tanahashi , Toru Arakane , Motonori Hochi , Ai Suzuki , Koji Okabayashi , Shinji Takeoka , Toshinori Fujie , Yuya Ishizuka , Shinya Ohtsubo
CPC分类号： A61L15/26 , A61L15/28 , A61L15/64 , A61L31/06 , A61L31/12 , A61L31/125 , A61L31/14 , A61L31/145 , A61L31/148 , A61P41/00 , C08G65/2615 , C08L5/08
摘要： A material for adhesion prevention can be adhered to biological tissue with certainty and has improved tissue adhesiveness and biodegradability. Such material for adhesion prevention is composed of: a 1- to 1,000-μm-thick water-soluble support layer comprising a water-soluble polymer; and a 1- to 1,000-μm-thick adhesion prevention layer comprising a biodegradable polymer. The biodegradable polymer has a structure in which a branched polyalkylene glycol comprising 3 to 8 terminal hydroxyl groups per molecule is bound to a polyhydroxy alkanoic acid, and a mass ratio of the branched polyalkylene glycol relative to the total mass is 1% to 30%.
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公开(公告)号：US10918334B2
公开(公告)日：2021-02-16
申请号：US15578862
申请日：2016-07-08
发明人： Shingo Tsukada , Nahoko Kasai , Koji Sumitomo , Hiroshi Nakashima , Masanobu Sato , Toru Arakane , Yuri Hamano , Keiji Takeda , Noriko Nagai , Takashi Teshigawara
IPC分类号： A61B5/00 , A61B5/0408
摘要： A wearable electrode includes: a garment including an outer member and a backing member configured to cover at least a part of an inner surface of the outer member; and an electrode unit configured to come into contact with a living body clothed in the garment to acquire a biological signal emitted by the living body and attached to an opposite side of the backing member from the outer member. The outer member and the backing member are connected to each other in a part other than a part of the backing member, to which the electrode unit is attached.
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公开(公告)号：US10786980B2
公开(公告)日：2020-09-29
申请号：US15311314
申请日：2015-06-18
发明人： Yuki Sekido , Motonori Hochi , Toru Arakane , Yoshikazu Yakake , Teruhisa Sato
IPC分类号： B32B27/36 , B32B38/10 , B32B5/26 , B32B15/14 , B32B7/12 , A61L15/28 , A61L15/26 , A61L31/04 , B32B29/02 , A61L31/06 , B32B7/04 , A61L15/24 , A61L15/22 , B32B5/02 , B32B9/04 , B32B27/08 , B32B27/12 , B32B27/30 , B32B37/10 , B32B37/18
摘要： A laminate has at least one polylactic acid resin-containing layer (C) with a thickness of 10-500 nm on at least one surface of a fibrous structure (B) containing a water-soluble resin (A). A production method for the laminate is characterized in that water or an aqueous solution is applied to the joining surface of the fibrous structure (B) and the polylactic acid resin-containing layer (C). The laminate exhibits excellent followability, adherence and coatability relative to flexible, curved adherends, exhibits excellent compatibility to organs such as skin and internal organs, and, because the fibrous structure (B) containing a water-soluble resin (A) can easily be removed from the polylactic acid resin-containing layer (C) by the aqueous solution, is adapted for use in materials for external use on the skin, such as wound-dressing materials, adhesion-preventing materials, and skin care products.
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公开(公告)号：US10563025B2
公开(公告)日：2020-02-18
申请号：US15572210
申请日：2016-05-11
发明人： Motonori Hochi , Yuki Sekido , Ichiro Itagaki , Toru Arakane , Shinya Ohtsubo , Shinji Takeoka , Atsushi Murata , Mao Fujii , Yuya Ishizuka , Shuichi Shoji , Jun Mizuno , Takashi Kasahara
IPC分类号： A61K8/04 , A61K8/81 , A61K8/85 , A61K8/86 , A61L15/22 , C08J5/18 , A61L31/00 , A61L15/24 , A61L15/26 , A61L31/04 , A61L31/06 , A61Q19/00 , C08L25/06 , C08L33/12 , C08L67/04
摘要： A polymer film has an average film thickness T0 along a straight line D passing through the center of gravity of a two-dimensional projection such that the area of the polymer film is maximized, satisfies equation (a), the average value L of distances 1 from the center of gravity to edges satisfies equation (b), the Young's modulus E satisfies equation (c), and the thickness deviation Δ defined by equation (d) satisfies equation (e); and a dispersion liquid and an agglomerate using the same. (a) 10 nm≤T0≤1000 nm, (b) 0.1 μm≤L≤500 μm, (c) 0.01 GPa≤E≤4.3 GPa, (d) Δ=1−T1/T2, (e) 0.346E×10−9−1.499
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公开(公告)号：US20220096707A1
公开(公告)日：2022-03-31
申请号：US17286181
申请日：2019-10-17
发明人： Shinji Takeoka , Keiko Nakahara , Mamoru Nishiura , Shinya Otsubo , Hajimu Kurumatani , Toru Arakane , Masanobu Takeda , Makoto Nakahara , Kumi Oyama
摘要： A hemostatic material includes a lipid that can accelerate adhesion or aggregation of platelets even if the lipid does not carry a protein or a peptide involved in adhesion or aggregation of platelets such as GPIb and H12 and, to achieve the object, provides a hemostatic material including a water-insoluble base and a lipid supported on a surface of the base, wherein the lipid includes one or two or more anionic lipids.
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公开(公告)号：US20210387943A1
公开(公告)日：2021-12-16
申请号：US17286448
申请日：2019-10-17
发明人： Shinji Takeoka , Keiko Nakahara , Mamoru Nishiura , Shinya Otsubo , Hajimu Kurumatani , Toru Arakane
IPC分类号： C07C233/47 , A61K47/54 , A61K47/64
摘要： A carboxylic acid-type lipid can accelerate adhesion or aggregation of platelets even if the carboxylic acid-type lipid does not carry a protein involved in adhesion or aggregation of platelets or a peptide corresponding to an active site of the protein; a lipid particle and a lipid membrane each include the carboxylic acid-type lipid; and a platelet aggregation accelerating agent, a platelet adhesion accelerating agent, a hemostatic agent and a platelet substitute each include the carboxylic acid-type lipid, the lipid particle or the lipid membrane. A carboxylic acid-type lipid is selected from carboxylic acid-type lipids represented by formulas (I) to (VI), a lipid particle includes the carboxylic acid-type lipid, a lipid membrane includes the carboxylic acid-type lipid, and a platelet aggregation accelerating agent, a platelet adhesion accelerating agent, a hemostatic agent and a platelet substitute each include the carboxylic acid-type lipid, the lipid particle or the lipid membrane.
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公开(公告)号：US10940229B2
公开(公告)日：2021-03-09
申请号：US16335082
申请日：2017-09-29
发明人： Akihiro Saito , Megumi Nakanishi , Kazuhiro Tanahashi , Toru Arakane , Motonori Hochi , Ai Suzuki , Koji Okabayashi , Shinji Takeoka , Toshinori Fujie , Yuya Ishiduka , Shinya Ohtsubo
IPC分类号： A61L15/26 , A61L31/14 , A61L31/12 , A61L31/06 , A61L15/64 , A61L15/28 , A61P41/00 , C08G65/26 , C08L5/08
摘要： A material for adhesion prevention can be adhered to biological tissue with certainty and has improved tissue adhesiveness and biodegradability. Such material for adhesion prevention is composed of: a 1- to 1,000-μm-thick water-soluble support layer comprising a water-soluble polymer; and a 1- to 1,000-μm-thick adhesion prevention layer comprising a biodegradable polymer. The biodegradable polymer has a structure in which a branched polyalkylene glycol comprising 3 to 8 terminal hydroxyl groups per molecule is bound to a polyhydroxy alkanoic acid, and a mass ratio of the branched polyalkylene glycol relative to the total mass is 1% to 30%.
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公开(公告)号：US10213530B2
公开(公告)日：2019-02-26
申请号：US15534188
申请日：2016-06-17
发明人： Akihiro Saito , Toru Arakane , Kazuhiro Tanahashi , Koji Okabayashi , Shinji Takeoka , Toshinori Fujie , Shoichiro Suzuki , Atsushi Murata , Shinya Otsubo
IPC分类号： C08G81/02 , C08G63/06 , C08G63/664 , C08J5/18 , C08L53/00 , A61L31/04 , A61L27/00 , A61L31/00 , A61L15/00 , C08G81/00 , C08G65/332 , A61L15/50 , C08G65/331
摘要： A polymer film can be adjusted to movement or a fine uneven surface of a living body and has excellent ability to adhere to a biological tissue. The polymer film includes a block copolymer having a structure in which branched polyalkylene glycol and polyhydroxyalkanoic acid are bound to each other, wherein the polymer film has a film thickness of 10 to 1000 nm. The branched polyalkylene glycol has at least three terminal hydroxyl groups per molecule, the mass percentage of the branched polyalkylene glycol relative to the total mass of the block copolymer is 1% to 30%, and a value obtained by dividing the average molecular weight of polyhydroxyalkanoic acid in the block copolymer by X that is the number of terminal hydroxyl groups present per a single molecule of the branched polyalkylene glycol is 10000 to 30000.
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