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    Endoprosthesis with Selective Drug Coatings
    2.
    发明申请
    Endoprosthesis with Selective Drug Coatings 审中-公开
    选择性药物涂层内置假体

    公开(公告)号：US20100274352A1

    公开(公告)日：2010-10-28

    申请号：US12429392

    申请日：2009-04-24

    Applicant: Michael Kuehling ,  Torsten Scheuermann ,  Jan Weber ,  Yixin Xu

    Inventor： Michael Kuehling ,  Torsten Scheuermann ,  Jan Weber ,  Yixin Xu

    IPC: A61F2/06

    CPC classification number: A61L31/10 ,  A61L31/088 ,  A61L31/146 ,  A61L31/16 ,  A61L2300/416 ,  A61L2300/45 ,  A61L2300/61

    Abstract: An endoprosthesis such as a coronary stent includes a luminal surface, at least a portion of which is covered with a first coating including a first drug, and an abluminal surface, at least a portion of which is covered with a second coating including a second drug. The first drug has a first eluting profile based on the first coating, and the second drug has a second eluting profile based on the second coating, the first eluting profile being different from the second eluting profile. Methods of making the same are also provided.

    Abstract translation: 诸如冠状动脉支架的内用假体包括管腔表面，其至少一部分被第一涂层覆盖，第一涂层包括第一药物和腔内表面，其至少一部分被第二涂层覆盖，所述第二涂层包括第二药物 。 第一种药物基于第一种涂层具有第一洗脱分布，而第二种药物基于第二种涂层具有第二种洗脱分布，第一种洗脱分布与第二种洗脱分布不同。 还提供了制备其的方法。

    Medical devices having a coating of inorganic material
    4.
    发明授权
    Medical devices having a coating of inorganic material 有权
    具有无机材料涂层的医疗器械

    公开(公告)号：US08920491B2

    公开(公告)日：2014-12-30

    申请号：US12425791

    申请日：2009-04-17

    Applicant: Aiden Flanagan ,  John Kilcooley ,  Tim O'Connor ,  Barry O'Brien ,  Dominique Seidel ,  Michael Kuehling ,  Torsten Scheuermann ,  Jan Weber

    Inventor： Aiden Flanagan ,  John Kilcooley ,  Tim O'Connor ,  Barry O'Brien ,  Dominique Seidel ,  Michael Kuehling ,  Torsten Scheuermann ,  Jan Weber

    IPC: A61F2/06 ,  A61L29/10 ,  A61L29/16 ,  A61L31/08 ,  A61L31/16

    CPC classification number: A61L29/10 ,  A61L29/16 ,  A61L31/082 ,  A61L31/16 ,  A61L2300/602 ,  A61L2300/61

    Abstract: In one aspect, a medical device has a first configuration and a second configuration, a reservoir containing a therapeutic agent, and a barrier layer disposed over the reservoir, wherein the barrier layer comprises an inorganic material. In another aspect, a medical device has a reservoir containing a therapeutic agent, a barrier layer disposed over the reservoir, wherein the barrier layer comprises an inorganic material, and a swellable material disposed between the barrier layer and a surface of the medical device, wherein the swellable material is a material that swells upon exposure to an aqueous environment. In yet another aspect, a medical device has a multi-layered coating having alternating reservoir layers and barrier layers, and a plurality of excavated regions penetrating through at least a partial thickness of the multi-layered coating. In yet another aspect, a medical device has a polymer layer comprising a block co-polymer, wherein the polymer layer contains a therapeutic agent, and a barrier layer disposed over the polymer layer, wherein the barrier layer comprises an inorganic material, and wherein the barrier layer has a plurality of discontinuities. Methods of forming coatings on medical devices and methods of delivering therapeutic agents to body sites are also disclosed.

    Abstract translation: 在一个方面，医疗装置具有第一构造和第二构造，包含治疗剂的贮存器和设置在贮存器上方的阻挡层，其中阻挡层包括无机材料。 在另一方面，医疗装置具有容纳治疗剂的储存器，设置在贮存器上方的阻挡层，其中所述阻挡层包括无机材料，以及设置在所述阻挡层和所述医疗装置的表面之间的可溶胀材料，其中 可膨胀材料是暴露于含水环境时膨胀的材料。 在另一方面，医疗装置具有多层涂层，其具有交替的储层和阻挡层，以及穿透多层涂层的至少部分厚度的多个挖掘区域。 在另一方面，医疗装置具有包含嵌段共聚物的聚合物层，其中聚合物层含有治疗剂，以及设置在聚合物层上的阻挡层，其中阻挡层包含无机材料，其中， 阻挡层具有多个不连续性。 还公开了在医疗装置上形成涂层的方法和将治疗剂递送到身体部位的方法。

    Medical devices having inorganic particle layers
    6.
    发明授权
    Medical devices having inorganic particle layers 有权
    具有无机颗粒层的医疗装置

    公开(公告)号：US08932346B2

    公开(公告)日：2015-01-13

    申请号：US12428775

    申请日：2009-04-23

    Applicant: Michael Kuehling ,  Dominique Seidel ,  Torsten Scheuermann ,  Jan Weber

    Inventor： Michael Kuehling ,  Dominique Seidel ,  Torsten Scheuermann ,  Jan Weber

    IPC: A61F2/82 ,  A61L31/08 ,  A61L31/16

    CPC classification number: A61L31/16 ,  A61L31/08 ,  A61L2300/61 ,  A61L2300/62 ,  A61L2420/02

    Abstract: An expandable medical device having a particle layer disposed over a reservoir containing a therapeutic agent. The particle layer has a first porosity when the medical device is in the unexpanded configuration and a second porosity when the medical device is in the expanded configuration. The particle layer comprises a plurality of micron-sized or nano-sized particles. In certain embodiments, the particles are not connected to each other, and as such, the different porosities are provided by changes in the spacing between the particles as the medical device is expanded/unexpanded. Also disclosed are medical devices having a particle layer, wherein the particle layer comprises a plurality of encapsulated particles, and methods of coating medical devices with particles.

    Abstract translation: 一种可膨胀医疗装置，其具有设置在含有治疗剂的贮器上的颗粒层。 当医疗装置处于未膨胀构型时，颗粒层具有第一孔隙度，并且当医疗装置处于膨胀构型时具有第二孔隙率。 颗粒层包含多个微米级或纳米尺寸的颗粒。 在某些实施方案中，颗粒彼此不连接，因此，当医疗装置膨胀/未膨胀时，由颗粒之间的间隔的变化提供不同的孔隙度。 还公开了具有颗粒层的医疗装置，其中所述颗粒层包含多个包封的颗粒，以及用颗粒涂覆医疗装置的方法。

    Medical devices having inorganic barrier coatings
    7.
    发明授权
    Medical devices having inorganic barrier coatings 有权
    具有无机屏障涂层的医疗器械

    公开(公告)号：US09220818B2

    公开(公告)日：2015-12-29

    申请号：US12501671

    申请日：2009-07-13

    Applicant: Torsten Scheuermann ,  Michael Kuehling ,  Jan Weber ,  Dominique Seidel

    Inventor： Torsten Scheuermann ,  Michael Kuehling ,  Jan Weber ,  Dominique Seidel

    IPC: A61F2/82 ,  A61K9/22 ,  A61L27/34 ,  A61L31/16 ,  A61L31/08 ,  A61L31/14

    CPC classification number: A61L31/16 ,  A61L31/082 ,  A61L31/146 ,  A61L2300/608 ,  A61L2420/08

    Abstract: Medical devices having a barrier layer comprising an inorganic material. The medical device has a reservoir containing a therapeutic agent and the barrier layer is disposed over the reservoir. In one aspect, the barrier layer has one permeability to the therapeutic agent at one portion of the medical device and a different permeability at another portion of the medical device. In another aspect, the dosage amount of the therapeutic agent in the reservoir at one portion of the medical device is different from the dosage amount of the therapeutic agent in the reservoir at another portion of the medical device. In another aspect, a bioresorbable layer is disposed over the barrier layer at one or more portions of the medical device, wherein the bioresorbable layer comprises a bioresorbable material. Also, methods of coating a medical device are disclosed, in which a barrier layer over a medical device is formed using a lithographic etching process where a plurality of particles serve as an etch mask.

    Abstract translation: 具有包含无机材料的阻挡层的医疗装置。 医疗装置具有含有治疗剂的储液器，并且阻挡层设置在贮存器的上方。 在一个方面，阻挡层在医疗装置的一部分处具有对治疗剂的一种渗透性，并且在医疗装置的另一部分具有不同的渗透性。 另一方面，医疗器械的一部分处的储存器中的治疗剂的剂量与医疗器械的另一部分处的储存器中的治疗剂的剂量不同。 在另一方面，生物可再吸收层设置在医疗装置的一个或多个部分的阻挡层之上，其中生物可再吸收层包括生物可再吸收材料。 此外，公开了涂覆医疗装置的方法，其中使用光刻蚀刻工艺形成医疗装置上的阻挡层，其中多个颗粒用作蚀刻掩模。

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