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    METHOD FOR ACTIVATING THE LIPID CATABOLIC METABOLISM IN ENTERIC EPITHELIUM AND IMPROVING THE LIPID METABOLISM IN ENTERIC EPITHELIUM
    3.
    发明申请
    METHOD FOR ACTIVATING THE LIPID CATABOLIC METABOLISM IN ENTERIC EPITHELIUM AND IMPROVING THE LIPID METABOLISM IN ENTERIC EPITHELIUM 审中-公开
    用于激活肠上皮细胞中脂质代谢物的方法，并改善肠系膜上皮脂肪代谢

    公开(公告)号：US20080249171A1

    公开(公告)日：2008-10-09

    申请号：US12125795

    申请日：2008-05-22

    申请人： Tadashi Hase ,  Takatoshi Murase ,  Hiroyuki Watanabe ,  Hidehiko Kondo

    发明人： Tadashi Hase ,  Takatoshi Murase ,  Hiroyuki Watanabe ,  Hidehiko Kondo

    IPC分类号： A61K31/225 ,  A61P3/00

    CPC分类号： A61K31/231

    摘要： Disclosed are a method for activating lipid metabolism in the small intestine epithelium and also a method for promoting accumulation of fatty acids into the small intestine epithelium, each of which features administering an effective amount of a diacylglycerol. Also disclosed are methods for improving various symptoms in diabetes, which have ingesting a diacylglycerol. Ingestion of the diacylglycerol leads to accumulation of the fatty acids in the small intestine. The fatty acids so accumulated promote induction of β-oxidation, thereby not only activating lipid catabolism but also making it difficult to allow lipids to accumulate as triacylglycerols. This series of actions eventually results in development of lowering action for blood remnant-like lipoprotein level and also lowering action for blood leptin level, and hence, lipid metabolism is improved. Further, energy consumption is enhanced by promoting the induction of β-oxidation and activating lipid catabolism.

    摘要翻译： 公开了一种在小肠上皮中激活脂质代谢的方法，还有一种促进脂肪酸向小肠上皮中积累的方法，其特征在于施用有效量的二酰基甘油。 还公开了改善摄取二酰基甘油的糖尿病各种症状的方法。 二酰基甘油的摄入导致脂肪酸在小肠中的积累。 如此积累的脂肪酸促进β-氧化的诱导，从而不仅激活脂质分解代谢，而且使得难以使脂质作为三酰基甘油积累。 这一系列动作最终导致降低血液残留样脂蛋白水平的作用，降低血液瘦素水平的作用，从而改善脂质代谢。 此外，通过促进β-氧化的诱导和激活脂质分解代谢来增加能量消耗。

    Oil composition
    4.
    发明授权
    Oil composition 有权
    油组成

    公开(公告)号：US07182971B2

    公开(公告)日：2007-02-27

    申请号：US10488251

    申请日：2002-09-12

    申请人： Hideto Takase ,  Shin Koike ,  Hideaki Sakai ,  Tsutomu Nishide ,  Tadashi Hase ,  Takatoshi Murase

    发明人： Hideto Takase ,  Shin Koike ,  Hideaki Sakai ,  Tsutomu Nishide ,  Tadashi Hase ,  Takatoshi Murase

    IPC分类号： A23D7/005

    CPC分类号： A23K20/158 ,  A21D2/16 ,  A23D7/0053 ,  A23D7/0056 ,  A23D9/007 ,  A23L27/60 ,  A23L33/105 ,  A23L33/11 ,  A23L33/12

    摘要： Disclosed herein is an oil composition comprising the following components (A) and (B):(A) 15 to 70% by weight of diglycerides in which less than 15% by weight of the constitutive fatty acids are (3 type unsaturated fatty acids; and (B) 30 to 85% by weight of a triglyceride in which at least 15% by weight of the constitutive fatty acids are (3 type unsaturated fatty acids. The oil composition is good in flavor, hard to be colored, excellent in hydrolytic stability and resistance to oxidation, good in emulsion stability and excellent in intake balance among fatty acids even under severe conditions that heating is performed at a high temperature for a long period of time, can be widely developed to medicinal preparations and foods and moreover exhibit an excellent inhibitory effect on accumulation of body fat by ingestion of a small amount of diglycerides.

    摘要翻译： 本文公开了一种油组合物，其包含以下组分（A）和（B）：（A））15至70重量％的甘油二酸酯，其中小于15重量％的组成型脂肪酸为（3型不饱和脂肪酸; 和（B）30-85重量％的甘油三酯，其中至少15重量％的组成型脂肪酸是（3型不饱和脂肪酸），油组合物的味道好，难以着色，水解性优异 稳定性和耐氧化性，乳化稳定性好，即使在长时间在高温下进行加热的苛刻条件下，脂肪酸的摄取量平衡优异，可以广泛地发展成药用制剂和食品， 通过摄取少量甘油二酯对身体脂肪的积累具有优异的抑制作用。

    Method for activating the lipid catabolic metabolism in enteric epithelium and improving the lipid metabolism in enteric epithelium
    6.
    发明申请
    Method for activating the lipid catabolic metabolism in enteric epithelium and improving the lipid metabolism in enteric epithelium 审中-公开
    激活肠上皮中脂质分解代谢和改善肠上皮细胞脂质代谢的方法

    公开(公告)号：US20050148666A1

    公开(公告)日：2005-07-07

    申请号：US11054557

    申请日：2005-02-10

    申请人： Tadashi Hase ,  Takatoshi Murase ,  Hiroyuki Watanabe ,  Hidehiko Kondo

    发明人： Tadashi Hase ,  Takatoshi Murase ,  Hiroyuki Watanabe ,  Hidehiko Kondo

    IPC分类号： A61K31/231 ,  A61K31/225

    CPC分类号： A61K31/575 ,  A61K31/231

    摘要： Disclosed are a method for activating lipid metabolism in the small intestine epithelium and also a method for promoting accumulation of fatty acids into the small intestine epithelium, each of which features administering an effective amount of a diacylglycerol. Also disclosed are methods for improving various symptoms in diabetes, which have ingesting a diacylglycerol. Ingestion of the diacylglycerol leads to accumulation of the fatty acids in the small intestine. The fatty acids so accumulated promote induction of β-oxidation, thereby not only activating lipid catabolism but also making it difficult to allow lipids to accumulate as triacylglycerols. This series of actions eventually results in development of lowering action for blood remnant-like lipoprotein level and also lowering action for blood leptin level, and hence, lipid metabolism is improved. Further, energy consumption is enhanced by promoting the induction of β-oxidation and activating lipid catabolism.

    摘要翻译： 公开了一种在小肠上皮中激活脂质代谢的方法，还有一种促进脂肪酸向小肠上皮中积累的方法，其特征在于施用有效量的二酰基甘油。 还公开了改善摄取二酰基甘油的糖尿病各种症状的方法。 二酰基甘油的摄入导致脂肪酸在小肠中的积累。 如此积累的脂肪酸促进β-氧化的诱导，从而不仅激活脂质分解代谢，而且使得难以使脂质作为三酰基甘油积累。 这一系列动作最终导致降低血液残留样脂蛋白水平的作用，降低血液瘦素水平的作用，从而改善脂质代谢。 此外，通过促进β-氧化的诱导和激活脂质分解代谢来增加能量消耗。

    Method for activating the lipid catabolic metabolism in enteric epithelium and improving the lipid metabolism in enteric epithelium
    8.
    发明申请
    Method for activating the lipid catabolic metabolism in enteric epithelium and improving the lipid metabolism in enteric epithelium 审中-公开
    激活肠上皮中脂质分解代谢和改善肠上皮细胞脂质代谢的方法

    公开(公告)号：US20050256190A1

    公开(公告)日：2005-11-17

    申请号：US11185813

    申请日：2005-07-21

    申请人： Tadashi Hase ,  Takatoshi Murase ,  Hiroyuki Watanabe ,  Hidehiko Kondo

    发明人： Tadashi Hase ,  Takatoshi Murase ,  Hiroyuki Watanabe ,  Hidehiko Kondo

    IPC分类号： A61K31/231 ,  A61K31/225

    CPC分类号： A61K31/575 ,  A61K31/231

    摘要： Disclosed are a method for activating lipid metabolism in the small intestine epithelium and also a method for promoting accumulation of fatty acids into the small intestine epithelium, each of which features administering an effective amount of a diacylglycerol. Also disclosed are methods for improving various symptoms in diabetes, which have ingesting a diacylglycerol. Ingestion of the diacylglycerol leads to α-cumulation of the fatty acids in the small intestine. The fatty acids so accumulated promote induction of β-oxidation, thereby not only activating lipid catabolism but also making it difficult to allow lipids to accumulate as triacylglycerols. This series of actions eventually results in development of lowering action for blood remnant-like lipoprotein level and also lowering action for blood leptin level, and hence, lipid metabolism is improved. Further, energy consumption is enhanced by promoting the induction of β-oxidation and activating lipid catabolism.

    摘要翻译： 公开了一种在小肠上皮中激活脂质代谢的方法，还有一种促进脂肪酸向小肠上皮中积累的方法，其特征在于施用有效量的二酰基甘油。 还公开了改善摄取二酰基甘油的糖尿病各种症状的方法。 二酰基甘油的摄取导致小肠中脂肪酸的α-累积。 如此积累的脂肪酸促进β-氧化的诱导，从而不仅激活脂质分解代谢，而且使得难以使脂质作为三酰基甘油积累。 这一系列动作最终导致降低血液残留样脂蛋白水平的作用，降低血液瘦素水平的作用，从而改善脂质代谢。 此外，通过促进β-氧化的诱导和激活脂质分解代谢来增加能量消耗。