公开(公告)号：US20120215049A1

公开(公告)日：2012-08-23

申请号：US13260865

申请日：2011-02-23

申请人： Toshihiro Otani ,  Takeshi Hagino ,  Koichi Ikuta

发明人： Toshihiro Otani ,  Takeshi Hagino ,  Koichi Ikuta

IPC分类号： A61N5/00

CPC分类号： A61N5/1045 ,  A61N5/1048 ,  A61N2005/1087 ,  A61N2005/1095 ,  G21K1/046

摘要： The objective is to obtain a particle beam therapy system that prevents dispersion of a charged particle beam, reduction of the energy thereof, and upsizing of the system and that can accurately monitor the opening shape of a multileaf collimator so as to perform high-accuracy particle beam therapy. An image-capturing unit that takes an image of an outer end of a respective downstream side face of a leaf plate is provided for each row of leaves in such a way as to be situated at a position that is at an outer side of an irradiation field; and adjusted in such a way that the base of a perpendicular from a viewpoint to the downstream side face, is situated at a position that is at an inner side of the position of the outer end when the leaf plate is maximally driven in the departing direction.

摘要翻译： 目的是获得一种防止带电粒子束分散的粒子束治疗系统，其能量的减少和系统的大型化，并且可以精确地监测多叶准直器的开口形状，从而执行高精度粒子 梁治疗。 为每排叶片提供拍摄叶片的各个下游侧面的外端的图像的图像捕获单元，以便位于位于照射的外侧的位置 领域; 并且以这样的方式进行调节，使得从视点到下游侧面的垂直线的基部位于当沿着离开方向最大程度地驱动叶板时位于外端位置的内侧的位置 。

公开(公告)号：US08536548B2

公开(公告)日：2013-09-17

申请号：US13260865

申请日：2011-02-23

申请人： Toshihiro Otani ,  Takeshi Hagino ,  Koichi Ikuta

发明人： Toshihiro Otani ,  Takeshi Hagino ,  Koichi Ikuta

IPC分类号： G21K5/04

CPC分类号： A61N5/1045 ,  A61N5/1048 ,  A61N2005/1087 ,  A61N2005/1095 ,  G21K1/046

摘要： A particle beam therapy system that prevents dispersion of a charged particle beam, reduction of the energy thereof, and upsizing of the system and can accurately monitor the opening shape of a multileaf collimator so as to perform high-accuracy particle beam therapy. An image-capturing unit that takes an image of an outer end of a respective downstream side face of a leaf plate is provided for each row of leaves in such a way as to be situated at a position that is at an outer side of an irradiation field; and adjusted in such a way that a foot of a perpendicular line from a viewpoint, of the image capturing unit, to the downstream side face of a leaf plate, is situated at a position that is at an inner side of the position of the outer end when the leaf plate is maximally driven in the departing direction.

摘要翻译： 一种粒子束治疗系统，其防止带电粒子束的分散，其能量的降低和系统的大型化，并且可以精确地监测多叶准直器的开口形状，从而进行高精度的粒子束治疗。 为每排叶片提供拍摄叶片的各个下游侧面的外端的图像的图像捕获单元，以便位于位于照射的外侧的位置 领域; 并且以这样的方式进行调节，使得从图像拍摄单元的视点到叶板的下游侧的垂直线的脚位于位于外侧的位置的内侧的位置 当叶板在离开方向上被最大程度地驱动时结束。

公开(公告)号：US20140228615A1

公开(公告)日：2014-08-14

申请号：US14240650

申请日：2011-11-03

申请人： Masahiro Ikeda ,  Hisashi Harada ,  Kazushi Hanakawa ,  Toshihiro Otani ,  Tadashi Katayose ,  Taizo Honda ,  Yukiko Yamada ,  Yuehu Pu

发明人： Masahiro Ikeda ,  Hisashi Harada ,  Kazushi Hanakawa ,  Toshihiro Otani ,  Tadashi Katayose ,  Taizo Honda ,  Yukiko Yamada ,  Yuehu Pu

IPC分类号： A61N5/10

CPC分类号： A61N5/1081 ,  A61N5/1077 ,  A61N2005/1087 ,  A61N2005/1095

摘要： A particle beam irradiation apparatus according to the present invention is provided with a vacuum duct that forms a vacuum region through which the charged particle beam passes, a vacuum window through which the charged particle beam is launched from the vacuum region, a scanning electromagnet that scans the charged particle beam; a monitoring apparatus including a position monitor that detects the passing position of a charged particle beam and the beam size thereof, a low-scattering gas filling chamber including the monitoring apparatus, and an irradiation management apparatus that controls irradiation of the charged particle beam; the particle beam irradiation apparatus is characterized in that the low-scattering gas filling chamber is changeably disposed in such a manner that the beam-axis-direction positional relationship between the monitoring apparatus and the vacuum window is a desired one and in that the low-scattering gas filling chamber is filled with a low-scattering gas.

摘要翻译： 根据本发明的粒子束照射装置设置有真空管道，该真空管道形成带电粒子束通过的真空区域，从真空区域发射带电粒子束的真空窗口，扫描的扫描电磁体 带电粒子束; 监视装置，其包括检测带电粒子束的通过位置的位置监视器及其光束尺寸，包括监视装置的低散射气体填充室以及控制带电粒子束的照射的照射管理装置; 所述粒子束照射装置的特征在于，所述低散射气体充填室可变地设置成使得所述监视装置和所述真空窗口之间的射束轴向位置关系是期望的， 散射气体填充室填充有低散射气体。

公开(公告)号：US20140187847A1

公开(公告)日：2014-07-03

申请号：US14240197

申请日：2011-11-02

申请人： Masahiro Ikeda ,  Hisashi Harada ,  Kazushi Hanakawa ,  Toshihiro Otani ,  Tadashi Katayose ,  Taizo Honda ,  Yukiko Yamada ,  Yuehu Pu

发明人： Masahiro Ikeda ,  Hisashi Harada ,  Kazushi Hanakawa ,  Toshihiro Otani ,  Tadashi Katayose ,  Taizo Honda ,  Yukiko Yamada ,  Yuehu Pu

IPC分类号： A61N5/10

CPC分类号： A61N5/1077 ,  A61N5/1049 ,  A61N5/1069 ,  A61N2005/1087

摘要： A particle beam therapy system comprising a treatment table, a treatment table control unit and an irradiation control unit configured to output an instruction for controlling the treatment table control unit, an accelerator and a scanning electromagnet, wherein after the treatment table control unit controls the treatment table so as for a patient isocenter which is reference position of an affected area of a patient to move to a position of an irradiation isocenter which is set at a position which is closer to an irradiation nozzle than an equipment isocenter which is reference of positional relation of the irradiation nozzle and the treatment table, the irradiation control unit outputs an instruction for irradiating the patient with a particle beam.

摘要翻译： 一种粒子束治疗系统，包括治疗台，治疗台控制单元和照射控制单元，其被配置为输出用于控制治疗台控制单元的指令，加速器和扫描电磁体，其中在治疗台控制单元控制治疗 将患者的中心位置作为患者的受影响区域的基准位置移动到被设定在比作为位置关系的参照的设备等角点更靠近照射喷嘴的位置的照射等角点的位置 的照射喷嘴和处理台，照射控制单元输出用于对粒子束照射患者的指示。

公开(公告)号：US07312918B2

公开(公告)日：2007-12-25

申请号：US11138492

申请日：2005-05-27

申请人： Eiji Ishikawa ,  Toshihiro Otani

发明人： Eiji Ishikawa ,  Toshihiro Otani

IPC分类号： H01S4/00 ,  H04B10/12

CPC分类号： H04B10/2916

摘要： An optical transmission system wherein a main signal light is amplified by Raman amplification, and noise light (ASS light) produced by the Raman amplification can be corrected with a simple configuration and with high accuracy. The optical transmission system includes, in each transmission section: a cutoff section for transmitting/cutting off a main signal light outputted from the optical transmitter on the preceding stage and inputted into the Raman amplification medium on an optical transmission line; a control section for varying the power of the pumping light supplied to the Raman amplification medium and changing the state of the cutoff section depending on the variation of the pumping light power; a monitor section for measuring the power of the pumping light supplied to the Raman amplification medium and the power of the light propagated through the optical transmission line and inputted into an optical transmitter on the succeeding stage; and a processing section for separately detecting the power of the main signal light and the power of the ASS light on the basis of the results of the measurement by the monitor section, and correcting the ASS light.

摘要翻译： 一种光传输系统，其中主信号光通过拉曼放大放大，并且可以以简单的配置和高精度校正由拉曼放大产生的噪声光（ASS光）。 光传输系统包括：在每个传输部分中：切断部分，用于发射/切断在前级上的光发射机输出的主信号光，并输入到光传输线上的拉曼放大介质; 控制部分，用于改变提供给拉曼放大介质的泵浦光的功率，并根据泵浦光功率的变化改变截止部分的状态; 用于测量提供给拉曼放大介质的泵浦光的功率和通过光传输线传播并输入到后级光发射机的光的功率的监视器部分; 以及处理部分，用于根据监视部分的测量结果分别检测主信号光的功率和ASS光的功率，并校正ASS光。

公开(公告)号：US08854048B2

公开(公告)日：2014-10-07

申请号：US13262866

申请日：2011-03-10

申请人： Toshihiro Otani ,  Hisashi Harada ,  Masahiro Ikeda ,  Kazushi Hanakawa ,  Taizo Honda

发明人： Toshihiro Otani ,  Hisashi Harada ,  Masahiro Ikeda ,  Kazushi Hanakawa ,  Taizo Honda

IPC分类号： G01N27/62 ,  A61N5/10

CPC分类号： H01J37/304 ,  A61N5/1048 ,  A61N5/1071 ,  A61N5/1077 ,  A61N2005/1087 ,  H01J47/02

摘要： In a particle beam therapy system which scans a particle beam and irradiates the particle beam to an irradiation position of an irradiation subject and has a dose monitoring device for measuring a dose of the particle beam and an ionization chamber smaller than the dose monitoring device, the ionization chamber measuring a dose of a particle beam passing through the dose monitoring device, the dose of the particle beam irradiated by the dose monitoring device is measured; the dose of the particle beam passing through the dose monitoring device is measured by the small ionization chamber; and a correction coefficient of the dose measured by the dose monitoring device corresponding to the irradiation position is found based on the dose of the particle beam measured by the small ionization chamber.

摘要翻译： 在粒子束治疗系统中，扫描粒子束并将粒子束照射到照射对象的照射位置，并且具有用于测量粒子束的剂量和小于剂量监测装置的电离室的剂量监测装置， 电离室测量通过剂量监测装置的粒子束的剂量，测量由剂量监测装置照射的粒子束的剂量; 通过小电离室测量通过剂量监测装置的粒子束的剂量; 并且基于由小电离室测量的粒子束的剂量，求出由与照射位置对应的剂量监测装置测量的剂量的校正​​系数。

公开(公告)号：US5963357A

公开(公告)日：1999-10-05

申请号：US891785

申请日：1997-07-14

申请人： Yoshinobu Kubota ,  Yasuhiro Omori ,  Toshihiro Otani ,  Tomoyuki Itoh

发明人： Yoshinobu Kubota ,  Yasuhiro Omori ,  Toshihiro Otani ,  Tomoyuki Itoh

IPC分类号： G02F1/03 ,  G02F1/01 ,  G02F1/225 ,  G02F1/035

CPC分类号： G02F1/0123 ,  G02F1/225

摘要： An optical modulator for modulating light emitted from a signal light source has a substrate having electrooptic effect, an optical waveguide of a Mach-Zehnder type formed on the substrate, an electrode formed on the substrate to control light propagated in the optical waveguide, an interference light generating means for making radiation light radiated from the optical waveguide and signal light leaking from the optical waveguide interfere with each other to generate interference light, and emitting the interference light from an end surface of the substrate, a photo-detector for monitoring the interference light of the radiation light and the signal light, and a signal controlling circuit for controlling an operating point of the optical modulator according to a change of the interference light monitored by the photo-detector It is thereby possible to prevent degradation of a distinction ratio due to a shift of the operating point of the optical modulator so as to allow stable optical modulation, while facilitating a design of the mechanism of the optical modulator.

摘要翻译： 用于调制从信号光源发出的光的光调制器具有具有电光效应的基板，形成在基板上的马赫 - 策德尔型光波导，形成在基板上的电极，用于控制在光波导中传播的光，干涉 用于产生从光波导辐射的辐射光的光产生装置和从光波导泄漏的信号光相互干扰以产生干涉光，并从基板的端面发射干涉光，用于监测干涉的光检测器 照射光和信号光的光，以及用于根据光检测器所监视的干涉光的变化来控制光调制器的工作点的信号控制电路，从而可以防止由于 到光调制器的工作点的移动，以便允许稳定的光学 l调制，同时有助于光调制器的机制的设计。

公开(公告)号：US5889912A

公开(公告)日：1999-03-30

申请号：US921014

申请日：1997-08-29

申请人： Toshihiro Otani ,  Tomoyuki Ito ,  Yoshinobu Kubota ,  Yasuhiro Omori

发明人： Toshihiro Otani ,  Tomoyuki Ito ,  Yoshinobu Kubota ,  Yasuhiro Omori

IPC分类号： G02B6/122 ,  G02B6/12 ,  G02F1/035 ,  G02F1/21 ,  G02F1/225 ,  G02B6/10

CPC分类号： G02B6/12 ,  G02B2006/12159 ,  G02F1/0356 ,  G02F1/2255 ,  G02F2001/212

摘要： An optical waveguide device including a package housing having an element mounting surface, an element inserting groove opening to the element mounting surface, and a cutout as a space opening to an inner surface of the element inserting groove; and an optical waveguide element having a dielectric substrate, an optical waveguide formed in a surface of the dielectric substrate, and an electrode formed over the surface of the dielectric substrate, the optical waveguide element being inserted and fixed in the element inserting groove of the package housing by using an adhesive. The cutout opens also to the element mounting surface. In applying the adhesive to the bottom surface of the element inserting groove and inserting the optical waveguide element into the element inserting groove, the adhesive flows into the cutout and is prevented from flowing up to the element mounting surface. Further, a working space for application of the adhesive to the bottom surface of the element inserting groove can be ensured by the cutout.

摘要翻译： 一种光波导装置，包括具有元件安装表面的封装壳体，通向元件安装表面的元件插入槽以及通向元件插入槽内表面的开口的切口; 以及具有电介质基板的光波导元件，形成在电介质基板的表面的光波导，以及在电介质基板的表面上形成的电极，光波导元件被插入并固定在封装的元件插入槽内 通过使用粘合剂进行住房。 切口也打开到元件安装表面。 在将粘合剂施加到元件插入槽的底表面并将光波导元件插入元件插入槽中时，粘合剂流入切口并防止其向元件安装表面流动。 此外，可以通过切口来确保用于将粘合剂施加到元件插入槽的底面的工作空间。

公开(公告)号：US5215714A

公开(公告)日：1993-06-01

申请号：US709062

申请日：1991-05-30

申请人： Satoru Okada ,  Yoshiteru Mizuno ,  Takayoshi Izumi ,  Toshihiro Otani

发明人： Satoru Okada ,  Yoshiteru Mizuno ,  Takayoshi Izumi ,  Toshihiro Otani

IPC分类号： G01N35/10

CPC分类号： G01N35/1009 ,  G01N2035/1025 ,  G01N2035/1086 ,  G01N35/1004

摘要： A buffer solution is sampled from a buffer solution vessel and is dispensed into a reaction vessel on a reaction table by first sampling/dispensing means, and a specimen containing an antigen or antibody to be measured is sampled from a specimen vessel and is dispensed into the reaction vessel by second sampling/dispensing means. A reagent containing insoluble carriers to which is bonded an antibody or antigen that specifically reacts with the antigen or antibody in the specimen is sampled from a reagent vessel and dispensed into the reaction vessel by third sampling/dispensing means. The entire reaction table is shaken continuously during mixing of the buffer solution, reagent and specimen, and the reaction vessel is maintained in an isothermal state. A stable antigen-antibody reaction in the resulting reaction solution is thus promoted to form an agglutinate of the insoluble carriers. The reaction solution is sampled from the reaction vessel and dispensed into a sample chamber by fourth sampling/dispensing means. The dispensed reaction solution is transferred to a detector through which the insoluble carriers are passed and in which a signal is generated based upon a difference in terms of electrical or optical characteristics. The degree of agglutination of the insoluble carriers is obtained as a numerical value, thus making it possible to quantify the antigen or antibody of interest contained in the specimen.

摘要翻译： 缓冲溶液从缓冲溶液容器中取样，并通过第一取样/分配装置分配到反应台上的反应容器中，并从样品容器中取出含有待测量的抗原或抗体的样品，并将其分配到 反应容器通过第二采样/分配装置。 从试剂容器中取出含有与试样中的抗原或抗体特异性反应的抗体或抗原结合的不溶性载体的试剂，并通过第三取样/分注装置分配到反应容器中。 在缓冲溶液，试剂和试样的混合过程中，整个反应台连续摇动，反应容器保持在等温状态。 因此促进所得反应溶液中的稳定的抗原 - 抗体反应形成不溶性载体的凝集物。 反应溶液从反应容器中取样并通过第四取样/分配装置分配到样品室中。 分配的反应溶液转移到不可溶载体通过的检测器，并且基于电或光学特性的差异产生信号。 获得不溶性载体的凝集度作为数值，从而可以定量试样中包含的感兴趣的抗原或抗体。

公开(公告)号：US08350234B2

公开(公告)日：2013-01-08

申请号：US13127112

申请日：2008-12-24

申请人： Yuehu Pu ,  Toshihiro Otani

发明人： Yuehu Pu ,  Toshihiro Otani

IPC分类号： A61N5/10

CPC分类号： A61N5/1048 ,  A61N2005/1056 ,  A61N2005/1087

摘要： Light from a light source is made to be reflected by a light source mirror and to pass through a variable collimator, an irradiation field shape shaped by the variable collimator is projected on a photographing screen by the light passed through the variable collimator, a projection portion of the photographing screen is photographed by a photographic device, and an image photographed by the photographic device is analyzed by an image processor.

摘要翻译： 使来自光源的光由光源反射镜反射并穿过可变准直器，通过可变准直仪形成的照射场形状，通过可变准直器的光投射在拍摄屏幕上，突出部 通过摄影装置拍摄拍摄画面，并且通过图像处理器分析由照相装置拍摄的图像。