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1.发明申请SHEET FOR GUIDING REGENERATION OF MESENCHYMAL TISSUE AND PRODUCTION METHOD THEREOF 有权引导生殖组织再生及其生产方法的论文公开(公告)号：US20100158982A1
公开(公告)日：2010-06-24
申请号：US12709748
申请日：2010-02-22
CPC分类号： A61L27/3804 , A61F2/2846 , A61F2/3094 , A61F2002/30062 , A61F2210/0004 , A61K35/35 , A61K2035/124 , A61L27/3633 , A61L27/3641 , A61L27/3839 , A61L31/005 , C12N5/0663 , C12N2533/40
摘要： To provide a sheet for guiding regeneration of mesenchymal tissue having improved formability, strength, absorbability and efficiency, the sheet is produced by steps of containing a culture medium in a surface of a porous sheet produced by freezing a bioabsorbable polymer material dissolved with an organic solvent and drying it, seeding a mesenchymal cell grown after taking from biotissue, and differentiating the mesenchymal cell to a mesenchymal tissue precursor cell, where the mesenchymal tissue precursor cell and an extracellular substrate are adhered on the surface of the porous sheet containing a culture medium, and the extracellular substrate is secreted in a process of the mesenchymal cell being differentiated to the mesenchymal tissue precursor cell.
摘要翻译： 为了提供一种用于引导具有改善的成形性，强度，吸收性和效率的间充质组织再生的片材，该片材通过以下步骤制备：在通过冷冻溶解有有机溶剂的生物可吸收聚合物材料制成的多孔片材的表面中含有培养基 并将其干燥，接种从生物组织取出后生长的间充质细胞，并将间充质细胞分化为间充质组织前体细胞，其中间充质组织前体细胞和细胞外基质粘附在含有培养基的多孔片材的表面上， 并且细胞外基质在分化成间充质组织前体细胞的间充质细胞的过程中分泌。
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2.发明申请SHEET FOR GUIDING REGENERATION OF MESENCHYMAL TISSUE AND PRODUCTION METHOD THEREOF 审中-公开引导生殖组织再生及其生产方法的论文公开(公告)号：US20080220521A1
公开(公告)日：2008-09-11
申请号：US12123572
申请日：2008-05-20
IPC分类号： C12N5/02
CPC分类号： A61L27/3804 , A61F2/2846 , A61F2/3094 , A61F2002/30062 , A61F2210/0004 , A61K35/35 , A61K2035/124 , A61L27/3633 , A61L27/3641 , A61L27/3839 , A61L31/005 , C12N5/0663 , C12N2533/40
摘要： To provide a sheet for guiding regeneration of mesenchymal tissue having improved formability, strength, absorbability and efficiency, the sheet is produced by steps of containing a culture medium in a surface of a porous sheet produced by freezing a bioabsorbable polymer material dissolved with an organic solvent and drying it, seeding a mesenchymal cell grown after taking from biotissue, and differentiating the mesenchymal cell to a mesenchymal tissue precursor cell, where the mesenchymal tissue precursor cell and an extracellular substrate are adhered on the surface of the porous sheet containing a culture medium, and the extracellular substrate is secreted in a process of the mesenchymal cell being differentiated to the mesenchymal tissue precursor cell.
摘要翻译： 为了提供一种用于引导具有改善的成形性，强度，吸收性和效率的间充质组织再生的片材，该片材通过以下步骤制备：在通过冷冻溶解有有机溶剂的生物可吸收聚合物材料制成的多孔片材的表面中含有培养基 并将其干燥，接种从生物组织取出后生长的间充质细胞，并将间充质细胞分化为间充质组织前体细胞，其中间充质组织前体细胞和细胞外基质粘附在含有培养基的多孔片材的表面上， 并且细胞外基质在分化成间充质组织前体细胞的间充质细胞的过程中分泌。
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3.发明授权Sheet for guiding regeneration of mesenchymal tissue and production method thereof 有权用于引导间充质组织再生的片材及其制造方法公开(公告)号：US08722404B2
公开(公告)日：2014-05-13
申请号：US12709748
申请日：2010-02-22
IPC分类号： C12N5/077 , C12N5/0789 , C12N5/0797 , C12N5/02 , A61F2/00 , A61F2/02
CPC分类号： A61L27/3804 , A61F2/2846 , A61F2/3094 , A61F2002/30062 , A61F2210/0004 , A61K35/35 , A61K2035/124 , A61L27/3633 , A61L27/3641 , A61L27/3839 , A61L31/005 , C12N5/0663 , C12N2533/40
摘要： Method for regeneration of mesenchymal tissue from mesenchymal cells on a porous sheet composed of bioabsorbable polymer material.
摘要翻译： 从由生物可吸收聚合物材料组成的多孔片材上的间充质细胞的间充质组织的再生方法。
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4.发明申请Sheet for guiding regeneration of mesenchymal tissue and production method thereof 审中-公开用于引导间充质组织再生的片材及其制造方法公开(公告)号：US20060088569A1
公开(公告)日：2006-04-27
申请号：US11256107
申请日：2005-10-24
IPC分类号： A61F13/00
CPC分类号： A61L27/3804 , A61F2/2846 , A61F2/3094 , A61F2002/30062 , A61F2210/0004 , A61K35/35 , A61K2035/124 , A61L27/3633 , A61L27/3641 , A61L27/3839 , A61L31/005 , C12N5/0663 , C12N2533/40
摘要： To provide a sheet for guiding regeneration of mesenchymal tissue having improved formability, strength, absorbability and efficiency, the sheet is produced by steps of containing a culture medium in a surface of a porous sheet produced by freezing a bioabsorbable polymer material dissolved with an organic solvent and drying it, seeding a mesenchymal cell grown after taking from biotissue, and differentiating the mesenchymal cell to a mesenchymal tissue precursor cell, where the mesenchymal tissue precursor cell and an extracellular substrate are adhered on the surface of the porous sheet containing a culture medium, and the extracellular substrate is secreted in a process of the mesenchymal cell being differentiated to the mesenchymal tissue precursor cell.
摘要翻译： 为了提供一种用于引导具有改善的成形性，强度，吸收性和效率的间充质组织再生的片材，该片材通过以下步骤制备：在通过冷冻溶解有有机溶剂的生物可吸收聚合物材料制成的多孔片材的表面中含有培养基 并将其干燥，接种从生物组织取出后生长的间充质细胞，并将间充质细胞分化为间充质组织前体细胞，其中间充质组织前体细胞和细胞外基质粘附在含有培养基的多孔片材的表面上， 并且细胞外基质在分化成间充质组织前体细胞的间充质细胞的过程中分泌。
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公开(公告)号：US20110076770A1
公开(公告)日：2011-03-31
申请号：US12892223
申请日：2010-09-28
IPC分类号： C12N5/077
CPC分类号： C12N5/0663 , C12N2500/50
摘要： To efficiently select and proliferate the mesenchymal stem cells without necessity of an exclusive separating device and a complicated separating operation, mesenchymal stem cells are cultured by seeding at least one of a bone marrow solution, an umbilical cord blood, a peripheral blood, a synovial membrane and an amniotic membrane in a liquid culture medium which is filled in a vessel, includes water as its main components and having a specific gravity between 1.06 and 1.10 g/ml at 37° C., and making a culture at a temperature 37±2° C. on a ceiling side surface of the vessel, preferably the specific gravity being regulated by use of at least one selected from silica fine powder coated by polyvinyl pyrrolidone, a water soluble copolymer of sucrose and epichlorohydrin, and a water soluble compound including a triiodo aromatic ring.
摘要翻译： 为了有效地选择和增殖间充质干细胞而不需要专门的分离装置和复杂的分离操作，通过种植骨髓溶液，脐带血，外周血，滑膜中的至少一种来培养间充质干细胞 在装在容器中的液体培养基中的羊膜包含水作为主要成分，在37℃下比重为1.06〜1.10g / ml，培养温度为37±2℃ ℃，优选通过使用选自由聚乙烯吡咯烷酮涂覆的二氧化硅细粉末，蔗糖和表氯醇的水溶性共聚物和水溶性化合物中选择的至少一种来调节比重，所述水溶性化合物包括 三碘芳环。
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公开(公告)号：US08039256B2
公开(公告)日：2011-10-18
申请号：US12892223
申请日：2010-09-28
CPC分类号： C12N5/0663 , C12N2500/50
摘要： To efficiently select and proliferate the mesenchymal stem cells without necessity of an exclusive separating device and a complicated separating operation, mesenchymal stem cells are cultured by seeding at least one of a bone marrow solution, an umbilical cord blood, a peripheral blood, a synovial membrane and an amniotic membrane in a liquid culture medium which is filled in a vessel, includes water as its main components and having a specific gravity between 1.06 and 1.10 at 37° C., and making a culture at a temperature 37±2° C. on a ceiling side surface of the vessel, preferably the specific gravity being regulated by use of at least one selected from silica fine powder coated by polyvinyl pyrrolidone, a water soluble copolymer of sucrose and epichlorohydrin, and a water soluble compound including a triiodo aromatic ring.
摘要翻译： 为了有效地选择和增殖间充质干细胞而不需要专门的分离装置和复杂的分离操作，通过种植骨髓溶液，脐带血，外周血，滑膜中的至少一种来培养间充质干细胞 和填充在容器中的液体培养基中的羊膜包含水作为主要成分，在37℃下的比重为1.06〜1.10，培养温度为37±2℃。 在容器的顶棚侧表面上，优选使用选自由聚乙烯吡咯烷酮涂覆的二氧化硅细粉末，蔗糖和表氯醇的水溶性共聚物和包含三碘芳环的水溶性化合物中的至少一种来调节比重 。
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公开(公告)号：US20090221076A1
公开(公告)日：2009-09-03
申请号：US11817437
申请日：2006-02-28
申请人： Yukio Kato , Koichiro Tsuji , Katsuyuki Yamanaka
发明人： Yukio Kato , Koichiro Tsuji , Katsuyuki Yamanaka
IPC分类号： C12N5/02
CPC分类号： A61L27/18 , A61L27/3817 , A61L27/3852 , A61L27/56 , A61L2430/06 , C12N5/0655 , C12N2501/15 , C12N2501/39 , C12N2533/40 , C08L67/04
摘要： An objective of the present invention is to provide a production method of a sheet for regenerating a cartilage tissue, which uses a conventional sheet-shaped porous body comprising a biological absorbency synthetic high polymer, such as polylactic acid, polyglycolic acid and a copolymer of lactic acid and glycolic acid. The sheet for regenerating the cartilage tissue can differentiate chondrocytes or stem cells without culturing the cells by pressurizing such as a pressurizing culture like the conventional method, and can accumulate the cells in a supporting carrier with high efficiency. The sheet for regenerating the cartilage tissue is produced by the steps of; seeding chondrocytes or stem cells differentiating to the chondrocytes on a sheet-shaped porous body comprising a biological absorbency synthetic high polymer; taking the porous body into a culture liquid; applying acceleration of 100 to 1000 G to the porous body for a predetermined time; and culturing the porous body without applying the acceleration.
摘要翻译： 本发明的目的是提供一种用于再生软骨组织的片材的制造方法，其使用包含生物吸收性合成高分子如聚乳酸，聚乙醇酸和乳酸共聚物的常规片状多孔体 酸和乙醇酸。 用于再生软骨组织的片材可以分化软骨细胞或干细胞，而不用像常规方法那样通过加压培养细胞而不培养细胞，并且可以将细胞以高效率积累在支持载体中。 用于再生软骨组织的片材通过以下步骤制备： 在包含生物吸收性合成高分子的片状多孔体上接种与软骨细胞分化的软骨细胞或干细胞; 将多孔体吸入培养液中; 对多孔体施加100〜1000G的加速度一定时间; 并且在不施加加速度的情况下培养多孔体。
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公开(公告)号：US5505606A
公开(公告)日：1996-04-09
申请号：US190120
申请日：1994-02-03
申请人： Susumu Ito , Katsuyuki Yamanaka , Akira Kouketsu , Kazunari Ijima
发明人： Susumu Ito , Katsuyuki Yamanaka , Akira Kouketsu , Kazunari Ijima
CPC分类号： B29C45/1755 , B29C45/232
摘要： A nozzle hole sealing device for an injection nozzle capable of blocking a hole at the tip of a nozzle by using a robot in purging an injection molding machine. The nozzle hole sealing device includes a tool changer for connecting the nozzle hole sealing device to a wrist of the robot and a nozzle sealing body for sealing a nozzle hole by contacting the nozzle tip of the injection molding machine, thereby composing a nozzle sealing robot tool as a whole. A chuck mechanism for keeping a nozzle tip in contact with the nozzle sealing body, a heat reserving heater for a nozzle tip contact portion, and a resin passage ranging from the nozzle tip contact portion to a purged resin discharge surface including a constant pressure open value disposed in the middle of the passage may be further included.
摘要翻译： PCT No.PCT / JP93 / 00757 Sec。 371日期：1994年2月3日 102（e）日期1994年2月3日PCT提交1993年6月4日PCT公布。 公开号WO93 / 25369 日本特愿1993年12月23日。一种用于注射喷嘴的喷嘴孔密封装置，其能够通过使用机器人在吹扫注射成型机中阻塞喷嘴尖端的孔。 喷嘴孔密封装置包括用于将喷嘴孔密封装置连接到机器人手腕的工具更换器和用于通过与注塑机的喷嘴头接触来密封喷嘴孔的喷嘴密封体，从而组成喷嘴密封机器人工具 作为一个整体。 用于保持喷嘴头与喷嘴密封体接触的卡盘机构，用于喷嘴头接触部分的储热加热器和从喷嘴头接触部分到包括恒压开启值的清洗树脂排出表面的树脂通道 可以进一步包括设置在通道的中间。
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公开(公告)号：US07134863B2
公开(公告)日：2006-11-14
申请号：US11098473
申请日：2005-04-05
IPC分类号： B29C45/64
CPC分类号： B29C45/1761 , B29C45/661 , B29C2045/1788
摘要： Jack-up bolts are provided at two places along the rear platen movement direction on both sides of a lower part of a rear platen of an injection molding machine. The jack-up bolt engages threadedly with a bolt hole formed in the rear platen, and a lower end face of the jack-up bolt abuts on the upper surface of a slide plate to support the rear platen. A fixing bolt is inserted in a through hole formed in the jack-up bolt, and is threadedly engaged with a tap hole provided in the slide plate, by which the rear platen and the slide plate are integrated. The rear platen moves while being supported by the slide plate. When the tilt of the rear platen is corrected, the fixing bolt is loosened and the jack-up bolt is turned, by which a distance between the rear platen and the slide plate is adjusted.
摘要翻译： 在注射成型机的后台板的下部的两侧，沿着后板移动方向的两个位置设置有夹头螺栓。 起升螺栓与形成在后压板中的螺栓孔螺纹接合，并且起升螺栓的下端面抵靠滑板的上表面以支撑后压板。 将固定螺栓插入形成在自升式螺栓中的通孔中，并且与设置在滑板中的抽头孔螺纹接合，后压板和滑板通过该通孔被一体化。 后台板在被滑板支撑的同时移动。 当后台板的倾斜被校正时，固定螺栓松动并且自升式螺栓被转动，由此调整后压板和滑板之间的距离。
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公开(公告)号：US5792395A
公开(公告)日：1998-08-11
申请号：US406868
申请日：1995-03-23
申请人： Susumu Ito , Katsuyuki Yamanaka
发明人： Susumu Ito , Katsuyuki Yamanaka
CPC分类号： B29C45/76 , B29C45/7666 , B29C45/768
摘要： A plasticization control method for an injection molding machine in which the plasticized state of resin in an injection cylinder is controlled in measuring based on the detected rotating force of a screw. A reference screw rotating force C or F required for desired measuring operation is determined. Using the reference screw rotating force C or F as a reference, upper and lower limits D and E of an allowable screw rotating force range, in which measuring can be performed normally, are set for each of screw positions, and then stored as an allowable value file. The rotating force V acting on the screw during measuring operation is successively detected. If the rotating force V is not between the upper and lower limits D and E of the allowable range relating to the current position of the screw, it is judged that plasticization is abnormal and an abnormality alarm is outputted. Thus, insufficient heating of the injection cylinder, intrusion of foreign matter in the molding material, insufficient supply of resin, etc. can surely be detected.
摘要翻译： PCT No.PCT / JP94 / 01151 Sec。 371日期：1995年3月23日 102（e）1995年3月23日PCT PCT 1994年7月13日PCT公布。 公开号WO95 / 03161 日期1995年2月2日一种注射成型机的增塑控制方法，其中根据检测到的螺杆的旋转力来测量注射缸中树脂的塑化状态。 确定所需测量操作所需的参考螺杆旋转力C或F. 使用参考螺杆旋转力C或F作为参考，对于每个螺丝位置设定能够正常进行测量的允许的螺杆旋转力范围的上限和下限D和E，然后作为允许 值文件。 连续地检测在测量操作期间作用在螺钉上的旋转力V. 如果旋转力V不在与螺杆的当前位置有关的允许范围的上限D和下限E之间，则判断塑化异常并且输出异常警报。 因此，可以确实地检测注射缸的加热不足，异物在成型材料中的侵入，树脂等的供给不足。
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