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1.发明申请System and method for a hydrogel and hydrogel composite for cartilage repair applications 有权用于软骨修复应用的水凝胶和水凝胶复合物的系统和方法公开(公告)号：US20100233234A1
公开(公告)日：2010-09-16
申请号：US12661242
申请日：2010-03-12
申请人： Treena Arinzeh , George Collins , Bruno Mantilla
发明人： Treena Arinzeh , George Collins , Bruno Mantilla
CPC分类号： A61K38/39 , A61K35/28 , A61L27/26 , A61L27/52 , A61L2430/06 , C08L1/02 , D01D5/0007 , D01F2/24 , C08L1/16
摘要： The embodiments and examples provided herein are put forth so as to provide those of ordinary skill in the art with a complete disclosure and description of how to make and use the present invention, and are not intended to limit the present invention relates to compositions and methods of preparing a hydrogel comprising a water soluble cellulose compound, as well as preparing a three-dimensional matrix of micron sized electrospun fibers, wherein the electrospun fibers are formed from a electrospun composite comprising a water soluble cellulose compound. The matrix provides a scaffold supporting and promoting cartilage regeneration and repair.
摘要翻译： 本文提供的实施方案和实施例提供给本领域普通技术人员的全面公开和描述如何制备和使用本发明，并不旨在限制本发明涉及组合物和方法 制备包含水溶性纤维素化合物的水凝胶，以及制备微米尺寸电纺纤维的三维基质，其中电纺纤维由包含水溶性纤维素化合物的电纺复合材料形成。 该基质提供支架和促进软骨再生和修复的支架。
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2.发明授权System and method for a hydrogel and hydrogel composite for cartilage repair applications 有权用于软骨修复应用的水凝胶和水凝胶复合物的系统和方法公开(公告)号：US09192655B2
公开(公告)日：2015-11-24
申请号：US12661242
申请日：2010-03-12
申请人： Treena Arinzeh , George Collins , Bruno Mantilla
发明人： Treena Arinzeh , George Collins , Bruno Mantilla
IPC分类号： A61K38/39 , A61F2/00 , A01N63/00 , A61K35/28 , A61L27/26 , A61L27/52 , C08L1/02 , D01D5/00 , D01F2/24
CPC分类号： A61K38/39 , A61K35/28 , A61L27/26 , A61L27/52 , A61L2430/06 , C08L1/02 , D01D5/0007 , D01F2/24 , C08L1/16
摘要： The embodiments and examples provided herein are put forth so as to provide those of ordinary skill in the art with a complete disclosure and description of how to make and use the present invention, and are not intended to limit the present invention relates to compositions and methods of preparing a hydrogel comprising a water soluble cellulose compound, as well as preparing a three-dimensional matrix of micron sized electrospun fibers, wherein the electrospun fibers are formed from a electrospun composite comprising a water soluble cellulose compound. The matrix provides a scaffold supporting and promoting cartilage regeneration and repair.
摘要翻译： 本文提供的实施方案和实施例提供给本领域普通技术人员的全面公开和描述如何制备和使用本发明，并不旨在限制本发明涉及组合物和方法 制备包含水溶性纤维素化合物的水凝胶，以及制备微米尺寸电纺纤维的三维基质，其中电纺纤维由包含水溶性纤维素化合物的电纺复合材料形成。 该基质提供支架和促进软骨再生和修复的支架。
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3.发明授权公开(公告)号：US09180166B2
公开(公告)日：2015-11-10
申请号：US13097657
申请日：2011-04-29
申请人： Treena Arinzeh , George Collins , Piyush Modak , Ling-Fang Tseng
发明人： Treena Arinzeh , George Collins , Piyush Modak , Ling-Fang Tseng
IPC分类号： A61F13/00 , C12N5/00 , C12N5/02 , A61K38/18 , A61L27/26 , A61L27/38 , A61L27/52 , C08L1/02 , C08L1/16 , C08L5/08 , C12N5/077 , D01D5/00 , D01F2/24 , D01F9/00 , A61K47/38 , A61K35/28 , A61K9/00 , A61K9/06
CPC分类号： A61K38/1841 , A61K9/0024 , A61K9/06 , A61K35/28 , A61K47/38 , A61L27/26 , A61L27/3834 , A61L27/52 , A61L2430/06 , C08L1/02 , C08L1/16 , C08L5/08 , C12N5/0655 , C12N2533/72 , C12N2533/78 , D01D5/0007 , D01F2/24 , D01F9/00 , A61K2300/00
摘要： The present invention relates to hydrogel or scaffold compositions and methods of use for cell growth and/or regenerative medicine. The hydrogel comprises a water soluble cellulose compound and, in certain aspects, a fibrous or filamentous matrix. The hydrogels as described provide a support or scaffold that promotes, facilitates, and/or enhances progenitor or stem cell growth and/or differentiation. In addition, the hydrogel is useful for tissue, e.g., cartilage, regeneration and repair.
摘要翻译： 本发明涉及水凝胶或支架组合物和用于细胞生长和/或再生药物的方法。 水凝胶包含水溶性纤维素化合物，并且在某些方面包括纤维或丝状基质。 如上所述的水凝胶提供促进，促进和/或增强祖细胞或干细胞生长和/或分化的支持物或支架。 此外，水凝胶可用于组织，例如软骨，再生和修复。
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公开(公告)号：US20140008569A1
公开(公告)日：2014-01-09
申请号：US13552550
申请日：2012-07-18
申请人： Bhavita Joshi , George Collins , Treena Arinzeh
发明人： Bhavita Joshi , George Collins , Treena Arinzeh
IPC分类号： B01J20/26
CPC分类号： B01J20/267 , A61L15/60 , B01J20/24 , B01J20/261 , B01J20/265 , B01J20/28047 , B01J2220/445 , B01J2220/68
摘要： A hydrogel matrix and an osmotically active material immobilized in the matrix can be combined into superabsorbent preparations that are capable of adsorbing large amounts of water. The superabsorbent preparations of the invention have advantages in the use of absorbent materials for physiological fluids, such as diapers, incontinence products, wound dressings and the like, as well as agricultural and environmental applications. In addition, biodegradable superabsorbents of the invention can be prepared.
摘要翻译： 固定在基质中的水凝胶基质和渗透活性物质可以组合成能够吸附大量水的超吸收制剂。 本发明的超吸收剂制剂在使用吸收材料用于生理流体，例如尿布，失禁产品，伤口敷料等以及农业和环境应用中具有优点。 此外，可以制备本发明的可生物降解的超吸收剂。
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公开(公告)号：US09504987B2
公开(公告)日：2016-11-29
申请号：US13552550
申请日：2012-07-18
申请人： Bhavita Joshi , George Collins , Treena Arinzeh
发明人： Bhavita Joshi , George Collins , Treena Arinzeh
CPC分类号： B01J20/267 , A61L15/60 , B01J20/24 , B01J20/261 , B01J20/265 , B01J20/28047 , B01J2220/445 , B01J2220/68
摘要： A hydrogel matrix and an osmotically active material immobilized in the matrix can be combined into superabsorbent preparations that are capable of adsorbing large amounts of water. The superabsorbent preparations of the invention have advantages in the use of absorbent materials for physiological fluids, such as diapers, incontinence products, wound dressings and the like, as well as agricultural and environmental applications. In addition, biodegradable superabsorbents of the invention can be prepared.
摘要翻译： 固定在基质中的水凝胶基质和渗透活性物质可以组合成能够吸附大量水的超吸收制剂。 本发明的超吸收剂制剂在使用吸收材料用于生理流体，例如尿布，失禁产品，伤口敷料等以及农业和环境应用中具有优点。 此外，可以制备本发明的可生物降解的超吸收剂。
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公开(公告)号：US09334476B2
公开(公告)日：2016-05-10
申请号：US12661264
申请日：2010-03-12
申请人： Treena Arinzeh , George Collins , Yee-Shuan Lee
发明人： Treena Arinzeh , George Collins , Yee-Shuan Lee
CPC分类号： C12N5/0618 , A61L27/16 , A61L27/54 , A61L2300/414 , A61L2400/12 , C12M25/14 , C12N5/0068 , C12N2533/30 , C08L27/16
摘要： Provided is an electroactive structure for growing isolated differentiable cells comprising a three dimensional matrix of fibers formed of a biocompatible synthetic piezoelectric polymeric material, wherein the matrix of fibers is seeded with the isolated differentiable cells and forms a supporting scaffold for growing the isolated differentiable cells, and wherein the matrix of fibers stimulates differentiation of the isolated differentiable cells into a mature cell phenotype on the structure.
摘要翻译： 提供一种用于生长分离的可分化细胞的电活性结构，其包含由生物相容性合成压电聚合材料形成的纤维的三维矩阵，其中纤维基质用分离的可分化细胞接种，并形成用于生长分离的可分化细胞的支持性支架， 并且其中纤维基质刺激分离的可分化细胞在结构上成熟细胞表型的分化。
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7.发明申请公开(公告)号：US20110274742A1
公开(公告)日：2011-11-10
申请号：US13097657
申请日：2011-04-29
申请人： Treena Arinzeh , George Collins , Piyush Modak , Ling-Fang Tseng
发明人： Treena Arinzeh , George Collins , Piyush Modak , Ling-Fang Tseng
CPC分类号： A61K38/1841 , A61K9/0024 , A61K9/06 , A61K35/28 , A61K47/38 , A61L27/26 , A61L27/3834 , A61L27/52 , A61L2430/06 , C08L1/02 , C08L1/16 , C08L5/08 , C12N5/0655 , C12N2533/72 , C12N2533/78 , D01D5/0007 , D01F2/24 , D01F9/00 , A61K2300/00
摘要： The present invention relates to hydrogel or scaffold compositions and methods of use for cell growth and/or regenerative medicine. The hydrogel comprises a water soluble cellulose compound and, in certain aspects, a fibrous or filamentous matrix. The hydrogels as described provide a support or scaffold that promotes, facilitates, and/or enhances progenitor or stem cell growth and/or differentiation. In addition, the hydrogel is useful for tissue, e.g., cartilage, regeneration and repair.
摘要翻译： 本发明涉及水凝胶或支架组合物和用于细胞生长和/或再生药物的方法。 水凝胶包含水溶性纤维素化合物，并且在某些方面包括纤维或丝状基质。 如上所述的水凝胶提供促进，促进和/或增强祖细胞或干细胞生长和/或分化的支持物或支架。 此外，水凝胶可用于组织，例如软骨，再生和修复。
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8.发明申请公开(公告)号：US20100324697A1
公开(公告)日：2010-12-23
申请号：US12661264
申请日：2010-03-12
申请人： Treena Arinzeh , George Collins , Yee-Shuan Lee
发明人： Treena Arinzeh , George Collins , Yee-Shuan Lee
IPC分类号： A61F2/02 , C12N5/0797 , B29C47/30
CPC分类号： C12N5/0618 , A61L27/16 , A61L27/54 , A61L2300/414 , A61L2400/12 , C12M25/14 , C12N5/0068 , C12N2533/30 , C08L27/16
摘要： Provided is an electroactive structure for growing isolated differentiable cells comprising a three dimensional matrix of fibers formed of a biocompatible synthetic piezoelectric polymeric material, wherein the matrix of fibers is seeded with the isolated differentiable cells and forms a supporting scaffold for growing the isolated differentiable cells, and wherein the matrix of fibers stimulates differentiation of the isolated differentiable cells into a mature cell phenotype on the structure.
摘要翻译： 提供一种用于生长分离的可分化细胞的电活性结构，其包含由生物相容性合成压电聚合材料形成的纤维的三维矩阵，其中纤维基质用分离的可分化细胞接种，并形成用于生长分离的可分化细胞的支持性支架， 并且其中纤维基质刺激分离的可分化细胞在结构上成熟细胞表型的分化。
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公开(公告)号：US20100233807A1
公开(公告)日：2010-09-16
申请号：US12763755
申请日：2010-04-20
IPC分类号： C12N5/071
CPC分类号： H03L7/093 , A61K2035/124 , A61L27/18 , A61L27/3633 , A61L27/3821 , A61L27/3852 , A61L27/3895 , A61L27/56 , C12M25/14 , C12N5/0654 , C12N5/0655 , C12N5/0663 , C12N2506/1346 , C12N2533/40 , D01D5/0038 , C08L67/04
摘要： The invention described herein provides a structure for growing isolated differentiable human mesenchymal cells, which includes a three-dimensional matrix of fibers. The matrix serves as an implantable scaffolding for delivery of differentiable human mesenchymal cells in tissue engineering. The invention further provides compositions that contain the three-dimensional matrix of fibers seeded with isolated differentiable human mesenchymal cells, wherein the matrix forms a supporting scaffold for growing the isolated differentiable human mesenchymal cells, and wherein the differentiable human mesenchymal cells differentiate into a mature cell phenotype. The invention further provides methods of preparing the implantable nanofiber matrix scaffolding seeded with differentiable human mesenchymal cells for use in tissue engineering.
摘要翻译： 本文描述的本发明提供了用于生长分离的可分化人间充质细胞的结构，其包括三维纤维基质。 该基质用作在组织工程中递送可微分的人类间充质细胞的可植入脚手架。 本发明还提供了含有分离的可分化人间充质细胞的纤维的三维基质的组合物，其中所述基质形成用于生长分离的可分化人间充质细胞的支持性支架，并且其中所述可分化的人间充质细胞分化成成熟细胞 表型。 本发明还提供了制备用于组织工程的可分化的人间充质细胞接种的可植入纳米纤维基质支架的方法。
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公开(公告)号：US20060128012A1
公开(公告)日：2006-06-15
申请号：US11291701
申请日：2005-12-01
CPC分类号： H03L7/093 , A61K2035/124 , A61L27/18 , A61L27/3633 , A61L27/3821 , A61L27/3852 , A61L27/3895 , A61L27/56 , C12M25/14 , C12N5/0654 , C12N5/0655 , C12N5/0663 , C12N2506/1346 , C12N2533/40 , D01D5/0038 , C08L67/04
摘要： The invention described herein provides a structure for growing isolated differentiable human mesenchymal cells, which includes a three-dimensional matrix of fibers. The matrix serves as an implantable scaffolding for delivery of differentiable human mesenchymal cells in tissue engineering. The invention further provides compositions that contain the three-dimensional matrix of fibers seeded with isolated differentiable human mesenchymal cells, wherein the matrix forms a supporting scaffold for growing the isolated differentiable human mesenchymal cells, and wherein the differentiable human mesenchymal cells differentiate into a mature cell phenotype. The invention further provides methods of preparing the implantable nanofiber matrix scaffolding seeded with differentiable human mesenchymal cells for use in tissue engineering.
摘要翻译： 本文描述的本发明提供了用于生长分离的可分化人间充质细胞的结构，其包括三维纤维基质。 该基质用作在组织工程中递送可微分的人类间充质细胞的可植入脚手架。 本发明还提供了含有分离的可分化人间充质细胞的纤维的三维基质的组合物，其中所述基质形成用于生长分离的可分化人间充质细胞的支持性支架，并且其中所述可分化的人间充质细胞分化成成熟细胞 表型。 本发明还提供了制备用于组织工程的可分化的人间充质细胞接种的可植入纳米纤维基质支架的方法。
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