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公开(公告)号：US09931434B2
公开(公告)日：2018-04-03
申请号：US14357443
申请日：2012-11-09
申请人： Trustees of Tufts College , University of Pittsburgh—of the Commonwealth System of Higher Education , Wake Forest University Health Sciences
发明人： Evangelia Bellas , Kacey Marra , J. Peter Rubin , David L. Kaplan , James J. Yoo
CPC分类号： A61L27/227 , A61L27/3604 , A61L27/3834 , A61L27/48 , A61L27/54 , A61L27/56 , A61L27/58 , A61L2400/06 , A61L2430/34 , Y10T428/2982 , C08L89/00
摘要： The inventions provided herein relate to compositions, methods, delivery devices and kits for repairing or augmenting a tissue in a subject. The compositions described herein are injectable such that they can be placed in a tissue to be treated with a minimally-invasive procedure (e.g., by injection) and/or be molded flexibly into a tissue void of any shape and/or size. In some embodiments, the composition described herein comprises a plurality of silk fibroin particles, which can retain their original volume within the tissue for a period of time. The compositions can be used as a filler to replace a tissue void, e.g., for tissue repair and/or augmentation, or as a scaffold to support tissue regeneration and/or reconstruction. In some embodiments, the compositions described herein can be used for soft tissue repair or augmentation.
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公开(公告)号：US20180339084A1
公开(公告)日：2018-11-29
申请号：US15899463
申请日：2018-02-20
申请人： Trustees of Tufts College , University of Pittsburgh - of the Commonwealth System of Higher Education , Wake Forest University Health Sciences
发明人： Evangelia Bellas , Kacey Marra , J. Peter Rubin , David L. Kaplan , James J. Yoo
IPC分类号： A61L27/22 , A61L27/56 , A61L27/54 , A61L27/58 , A61L27/48 , A61L27/38 , A61L27/36 , C08L89/00
摘要： The inventions provided herein relate to compositions, methods, delivery devices and kits for repairing or augmenting a tissue in a subject. The compositions described herein are injectable such that they can be placed in a tissue to be treated with a minimally-invasive procedure (e.g., by injection) and/or be molded flexibly into a tissue void of any shape and/or size. In some embodiments, the composition described herein comprises a plurality of silk fibroin particles, which can retain their original volume within the tissue for a period of time. The compositions can be used as a filler to replace a tissue void, e.g., for tissue repair and/or augmentation, or as a scaffold to support tissue regeneration and/or reconstruction. In some embodiments, the compositions described herein can be used for soft tissue repair or augmentation.
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公开(公告)号：US20210244850A1
公开(公告)日：2021-08-12
申请号：US17091835
申请日：2020-11-06
申请人： TRUSTEES OF TUFTS COLLEGE , University of Pittsburgh - of the Commonwealth System of Higher Education , Wake Forest University Health Sciences
发明人： Evangelia Bellas , Kacey Marra , J. Peter Rubin , David L. Kaplan , James J. Yoo
摘要： The inventions provided herein relate to compositions, methods, delivery devices and kits for repairing or augmenting a tissue in a subject. The compositions described herein are injectable such that they can be placed in a tissue to be treated with a minimally-invasive procedure (e.g., by injection) and/or be molded flexibly into a tissue void of any shape and/or size. In some embodiments, the composition described herein comprises a plurality of silk fibroin particles, which can retain their original volume within the tissue for a period of time. The compositions can be used as a filler to replace a tissue void, e.g., for tissue repair and/or augmentation, or as a scaffold to support tissue regeneration and/or reconstruction. In some embodiments, the compositions described herein can be used for soft tissue repair or augmentation.
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公开(公告)号：US20160279299A1
公开(公告)日：2016-09-29
申请号：US15036910
申请日：2014-11-21
申请人： TRUSTEES OF TUFTS COLLEGE , UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
CPC分类号： A61L29/048 , A61L29/005 , A61L29/049 , A61L29/146 , A61L29/148 , A61L29/16 , A61L31/047 , A61L2300/222 , A61L2300/252 , A61L2300/412 , A61L2300/416 , A61L2300/43 , A61L2300/64 , A61L2400/08 , A61L2430/00 , A61M25/0009
摘要： The present invention is directed to systems and/or biopolymer devices and methods of using the same. The systems and/or biopolymer devices described herein can be used for delivery of a fluid and/or molecules such as therapeutic agent(s), and/or for recruitment or collection of body fluids, e.g., for medical diagnosis. Methods of making and using the systems and/or biopolymer devices are also provided herein. In some embodiments, the systems and/or biopolymer devices can be used for continuous delivery of a therapeutic agent to repair or regenerate a tissue in a subject. In some embodiments, the biopolymer devices can be adapted for use as a catheter for fluid delivery to a target site.
摘要翻译： 本发明涉及系统和/或生物聚合物装置及其使用方法。 本文所述的系统和/或生物聚合物装置可用于输送流体和/或分子例如治疗剂，和/或用于募集或收集体液，例如用于医学诊断。 本文还提供制备和使用系统和/或生物聚合物装置的方法。 在一些实施方案中，系统和/或生物聚合物装置可用于连续递送治疗剂以修复或再生受试者的组织。 在一些实施方案中，生物聚合物装置可以适于用作用于流体输送到靶位点的导管。
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5.发明公开公开(公告)号：US20240132836A1
公开(公告)日：2024-04-25
申请号：US18352366
申请日：2023-07-14
IPC分类号： C12N5/00
CPC分类号： C12N5/0068 , C12N2533/50 , C12N2537/10
摘要： Saccharide-substituted silk fibroin compositions as well as methods for making and using the same are provided. The compositions can include at least one saccharide coupled to silk fibroin. The coupling can be via various residues on the silk fibroin.
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公开(公告)号：US11576862B2
公开(公告)日：2023-02-14
申请号：US15646601
申请日：2017-07-11
发明人： David L. Kaplan , Tuna Yucel , Xiaoqin Wang , Michael Lovett
摘要： Provided herein relates to methods and compositions for preparing a silk microsphere and the resulting silk microsphere. In some embodiments, the methods and compositions described herein are all aqueous, which can be used for encapsulating an active agent in a silk microsphere, while maintaining activity of the active agent during processing. In some embodiments, the resulting silk microsphere can be used for sustained delivery of an active agent encapsulated therein.
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7.发明申请公开(公告)号：US20220299494A1
公开(公告)日：2022-09-22
申请号：US17753312
申请日：2020-08-28
发明人： David L. Kaplan , Qiaobing Xu
摘要： The present disclosure provides a method for screening drug delivery vehicles for use in delivering cargo via oral delivery. The method includes introducing a drug delivery vehicle comprising an imaging agent into a lumen of an artificial intestine system composed of a scaffold matrix material. The scaffold matrix material includes an interconnected network of pores, intestinal epithelial cells positioned on an inner surface of the lumen, and human-based cells positioned within the pores and surrounding the intestinal epithelial cells. The method includes maintaining the artificial intestine system in physiologically relevant conditions for a predetermined length of time, and detecting a color change induced by the imaging agent within at least a portion of the human-based cells.
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公开(公告)号：US11266339B2
公开(公告)日：2022-03-08
申请号：US16408122
申请日：2019-05-09
发明人： David L. Kaplan , Lee W. Tien , Gary G. Leisk , Tim Jia-Ching Lo , Cinzia Metallo , Fiorenzo Omenetto
IPC分类号： A61L31/10 , A61B5/291 , A61B5/00 , A61L27/22 , A61L27/36 , A61L31/04 , A61L31/14 , A61N1/05 , A61L31/16
摘要： Provided herein relates to implantable devices and systems with dynamic silk coatings. In some embodiments, the dynamic silk coatings can be formed in situ or in vivo.
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公开(公告)号：US20210333178A1
公开(公告)日：2021-10-28
申请号：US17302069
申请日：2021-04-22
发明人： David L. Kaplan , Rachael N. Parker
IPC分类号： G01N1/30
摘要： Compositions and methods for improved histological analysis of organoids are disclosed. The compositions and methods include silk-elastin-like polymers have temperature-induced shape change properties.
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公开(公告)号：US20200282106A1
公开(公告)日：2020-09-10
申请号：US16406538
申请日：2019-05-08
发明人： David L. Kaplan , Ung-Jin Kim , Jaehyung Park , Hyoung-Joon Jin
IPC分类号： A61L27/22 , A61L27/36 , A61L27/38 , A61L27/52 , A61L27/56 , C07K14/435 , C08J3/07 , C08J3/075 , C08J5/18 , C08J9/00 , C08J9/26 , C08J9/28 , C08L89/00 , D01D5/00 , D01F4/02 , B29C39/00 , B29C39/20 , B29C55/00 , B29D7/01
摘要： The present invention provides for concentrated aqueous silk fibroin solutions and an all-aqueous mode for preparation of concentrated aqueous fibroin solutions that avoids the use of organic solvents, direct additives, or harsh chemicals. The invention further provides for the use of these solutions in production of materials, e.g., fibers, films, foams, meshes, scaffolds and hydrogels.
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