公开(公告)号：US07754478B2

公开(公告)日：2010-07-13

申请号：US10583511

申请日：2004-12-15

申请人： Tsutomu Suzuki ,  Hiroshi Inomata ,  Yoshihiro Komori ,  Hiroshi Tachikui ,  Naruo Watanabe ,  Satoshi Ozawa ,  Yuji Oka ,  Minoru Ueda ,  Yasushi Nomura ,  Masako Nomura, legal representative ,  Isao Shindo

发明人： Tsutomu Suzuki ,  Hiroshi Inomata ,  Yoshihiro Komori ,  Hiroshi Tachikui ,  Naruo Watanabe ,  Satoshi Ozawa ,  Yuji Oka ,  Minoru Ueda ,  Yasushi Nomura ,  Isao Shindo

IPC分类号： C12M1/02 ,  C12M1/34

CPC分类号： C12M41/14 ,  C12M23/22 ,  C12M27/10 ,  C12M41/48 ,  Y10S435/809

摘要： A device for cell culture capable of automatically performing operations for cell culture over several days to several months while minimizing the risk of contamination. A new medicine can be supplied to an incubator means by using a medicine supply means or unnecessary wastewater can be discharged from the incubator means by using a wastewater discharge means without taking out the incubator means disposed in heat insulation box means from a heat insulation box, and the state of the cell culture can be observed with the incubator means formed in the heat insulation box means. Accordingly, the outside air does not enter directly into the incubator means during culturing, and the risk of contamination is completely eliminated. As a result, the culturing operations can be automatically performed over a long period.

摘要翻译： 用于细胞培养的装置，其能够在几天至几个月内自动执行细胞培养的操作，同时最小化污染的风险。 可以通过使用药物供给装置向培养箱装置提供新药，或者可以通过使用废水排放装置将不需要的废水从培养箱装置排出，而不从隔热箱取出设置在隔热箱装置中的培养箱装置， 并且可以用在隔热箱装置中形成的培养箱装置来观察细胞培养的状态。 因此，外部空气在培养期间不直接进入培养箱装置，并且完全消除污染的风险。 结果，可以长时间自动进行培养操作。

公开(公告)号：US20070148764A1

公开(公告)日：2007-06-28

申请号：US10583511

申请日：2004-12-15

申请人： Tsutomu Suzuki ,  Hiroshi Inomata ,  Yoshihiro Komori ,  Hiroshi Tachikui ,  Naruo Watanabe ,  Satoshi Ozawa ,  Yuji Oka ,  Minoru Ueda ,  Yasushi Nomura ,  Isao Shindo ,  Masako Nomura

发明人： Tsutomu Suzuki ,  Hiroshi Inomata ,  Yoshihiro Komori ,  Hiroshi Tachikui ,  Naruo Watanabe ,  Satoshi Ozawa ,  Yuji Oka ,  Minoru Ueda ,  Yasushi Nomura ,  Isao Shindo ,  Masako Nomura

IPC分类号： C12M1/34

CPC分类号： C12M41/14 ,  C12M23/22 ,  C12M27/10 ,  C12M41/48 ,  Y10S435/809

摘要： A device for cell culture capable of automatically performing operations for cell culture over several days to several months while minimizing the risk of contamination. A new medicine can be supplied to an incubator means by using a medicine supply means or unnecessary wastewater can be discharged from the incubator means by using a wastewater discharge means without taking out the incubator means disposed in heat insulation box means from a heat insulation box, and the state of the cell culture can be observed with the incubator means formed in the heat insulation box means. Accordingly, the outside air does not enter directly into the incubator means during culturing, and the risk of contamination is completely eliminated. As a result, the culturing operations can be automatically performed over a long period.

摘要翻译： 用于细胞培养的装置，其能够在几天至几个月内自动执行细胞培养的操作，同时最小化污染的风险。 可以通过使用药物供给装置向培养箱装置提供新药，或者可以通过使用废水排放装置将不需要的废水从培养箱装置排出，而不从隔热箱取出设置在隔热箱装置中的培养箱装置， 并且可以用在隔热箱装置中形成的培养箱装置来观察细胞培养的状态。 因此，外部空气在培养期间不直接进入培养箱装置，并且完全消除污染的风险。 结果，可以长时间自动进行培养操作。

公开(公告)号：US5556597A

公开(公告)日：1996-09-17

申请号：US433569

申请日：1995-05-03

申请人： Isao Shindo ,  Shigeo Mutou ,  Susumu Kai ,  Tokio Omori

发明人： Isao Shindo ,  Shigeo Mutou ,  Susumu Kai ,  Tokio Omori

IPC分类号： G01N35/04 ,  B65G47/14 ,  G01N35/00

CPC分类号： G01N33/4875 ,  B65G47/1428 ,  G01N35/00029 ,  G01N2035/00039 ,  G01N2035/00118 ,  Y10T436/11 ,  Y10T436/112499

摘要： Test strip supply apparatus includes a rotatable container which has guide part materials for holding a through groove and a weight. Under a supporting table having a take-out hole for the test strip dropped from the through groove of the container, a conveyance stage is provided for receiving the test strip dropped from the through groove and transferring it. The weight facing near both ends of the through groove lets the test strip descend and prevents a surplus number of the test strips from entering the through groove.

摘要翻译： 测试条供给装置包括可旋转的容器，该容器具有用于保持通孔和重物的引导部件材料。 在具有从容器的通孔落下的测试条的取出孔的支撑台下方，设置有输送台，用于接收从通孔落下的测试条并将其传送。 面对靠近通孔的两端的重量使得测试条下降并且防止多余的测试条进入通槽。

公开(公告)号：US5470533A

公开(公告)日：1995-11-28

申请号：US149084

申请日：1993-11-09

申请人： Isao Shindo ,  Shigeo Mutou ,  Takao Terayama ,  Masao Okayama ,  Susumu Kai

发明人： Isao Shindo ,  Shigeo Mutou ,  Takao Terayama ,  Masao Okayama ,  Susumu Kai

IPC分类号： G01N21/01 ,  B65G47/14 ,  G01N21/78 ,  G01N35/00 ,  G01N35/02 ,  G01N35/10

CPC分类号： B65G47/1428 ,  G01N35/00029 ,  G01N2035/00089 ,  G01N2035/00108 ,  G01N2035/00168 ,  G01N2035/00455 ,  Y10T436/110833 ,  Y10T436/112499 ,  Y10T436/114165

摘要： A test strip supply apparatus comprises a cylindrical container having an elongate test strip fitting penetration slot formed in its side wall, a container support having a semicylindrical concave surface formed in its upper portion and a test strip take-out hole formed at the center of the concave surface for allowing a test strip dropped from the penetration slot of the container to pass therethrough, and a test strip transfer stage for receiving the test strip dropped from the penetration slot and transferring it. A test strip reversing function is also provided such that during the transfer of the test strip by the transfer stage, optical means determines whether the test strip is placed facing properly or not and, if the back surface is on the upper side, the test strip is reversed upside down before further transfer.

摘要翻译： 测试条供给装置包括：圆柱形容器，其具有形成在其侧壁中的细长测试条拟合穿透槽;容器支撑件，其上部形成有半圆柱形凹形表面;以及测试条取出孔， 凹形表面，用于允许从容器的穿透槽落下的测试条从其中通过;以及测试条传送台，用于接收从穿透槽落下并传送的测试条。 还提供了测试条反转功能，使得在通过传送台传送测试条期间，光学装置确定测试条是否被正确地放置，并且如果背面位于上侧，则测试条 在进一步转让之前被颠倒倒置。

公开(公告)号：US4176957A

公开(公告)日：1979-12-04

申请号：US760130

申请日：1977-01-17

申请人： Yoshio Maeda ,  Koichi Matsumoto ,  Kenji Fukuda ,  Isao Shindo

发明人： Yoshio Maeda ,  Koichi Matsumoto ,  Kenji Fukuda ,  Isao Shindo

IPC分类号： G01J3/02 ,  G01J3/42

CPC分类号： G01J3/42

摘要： Method for optically analyzing a specimen by using two light beams comprises steps of initiating automatically wavelength scanning operation when a predetermined time has elapsed after the switching-on of a power source, sampling a ratio between a reference light intensity and a specimen light intensity during the wavelength scanning operation when no specimen to be measured is placed in the sample cell, and storing signals derived from the sampling operation in a volatile memory. When the specimen is to be measured or analyzed, the measure signal representative of ratio between the reference light intensity and the specimen transmitting light intensity which are produced or the wavelength scanning operation proceeds is corrected by the corresponding signal read out from the volatile memory in accordance with the wavelength of the measure signal, and the corrected signals are processed as the error-free measure signal.

摘要翻译： 通过使用两个光束对样本进行光学分析的方法包括以下步骤：在电源接通之后经过预定时间时自动启动波长扫描操作，在该期间对参考光强度和标本光强之间的比率进行采样 波长扫描操作，当不测量样本被放置在采样单元中，并将从取样操作得到的信号存储在易失性存储器中。 当要测量或分析样本时，表示参考光强度和所产生的样品透射光强度之间的比率的测量信号或波长扫描操作的进行是通过根据从易失性存储器读出的对应信号来校正的 与测量信号的波长，并且校正的信号被作为无差错测量信号被处理。

公开(公告)号：US5741461A

公开(公告)日：1998-04-21

申请号：US645075

申请日：1996-05-13

申请人： Kenichi Takahashi ,  Tomonori Mimura ,  Naoto Oki ,  Kyoko Imai ,  Isao Shindo ,  Kahei Shiraishi

发明人： Kenichi Takahashi ,  Tomonori Mimura ,  Naoto Oki ,  Kyoko Imai ,  Isao Shindo ,  Kahei Shiraishi

IPC分类号： G01N35/00 ,  G01N35/02 ,  G01N35/04

CPC分类号： G01N35/00594 ,  G01N35/025 ,  G01N2035/0094 ,  G01N2035/0491 ,  G01N35/00663 ,  Y10T436/113332 ,  Y10T436/114998 ,  Y10T436/115831 ,  Y10T436/2575

摘要： Before analysis, the correspondence between the vessel positions and the reaction vessels held in the vessel positions respectively at the time of completion of all the operations of a turntable upon completion of the last analysis are stored in a computer in advance. When a start switch is turned on, a judgment is made as to whether the correspondences between the vessel positions and the reaction vessels coincide with those stored in the computer or not. In the case of coincidence, reaction vessels in vessel positions are regarded as having been already cleaned, so that these reaction vessels are subjected to blank measurement and sample addition in the case of optical measurement, whereas these reaction vessels are directly subjected to sample addition in the case of ISE measurement.

摘要翻译： 在分析之前，预先在计算机中存储在完成最后分析完成后转盘的完成操作时分别保持在船舶位置的船舶位置与反应容器之间的对应关系。 当启动开关打开时，判断容器位置和反应容器之间的对应关系是否与存储在计算机中的那些对应。 在重合的情况下，容器位置的反应容器被认为已经被清洗，因此在光学测量的情况下对这些反应容器进行空白测量和样品添加，而这些反应容器直接进行加样 ISE测量的情况。

公开(公告)号：US4807984A

公开(公告)日：1989-02-28

申请号：US13799

申请日：1987-02-12

申请人： Masaaki Kurimura ,  Ryohei Yabe ,  Isao Shindo

发明人： Masaaki Kurimura ,  Ryohei Yabe ,  Isao Shindo

IPC分类号： G01N35/00 ,  G02B21/26 ,  G02B21/24

CPC分类号： G01N35/00029 ,  G02B21/26 ,  G01N2035/00039 ,  G01N2035/00059 ,  G01N2035/00089

摘要： A slide specimen extracted from a cassette at a receiving position is carried to a holding position for waiting by a carrier along a carrying pass. While at the holding position, a previously inspected specimen that has been observed through a microscope is placed on the carrying pass at a specimen replacing position. Thereafter the specimen that has been held at the holding position is carried to the replacing position by the carrier, while at the same time the specimen that has just been placed at the replacing position is moved along the carrying pass by the carrier. The specimen then placed in the replacing position is picked up by a pair of holding arms and carried to an observing position of the microscope. The specimen is retained by vacuum adsorption and by specimen retainers which resiliently hold it by means of springs in contact with the vacuum adsorption surface. In the meantime, the specimen that has already been observed and shifted toward the specimen feeder is moved the rest of the way to the specimen feeder and replaced into the original cassette from which it was extracted. After replacing the specimen, a new specimen is extracted and carried to the holding position as the process is repeated until all of the slide specimens have been observed.

摘要翻译： 从接收位置处的盒中提取的载玻片样本被携带到用于通过载体等待的保持位置。 在保持位置，将通过显微镜观察到的先前检查的样品放置在样品置换位置的携带通道上。 此后，被保持在保持位置的样本被载体运送到更换位置，同时刚刚放置在更换位置的样本沿着运送通道移动。 然后将放置在替换位置的样品由一对夹持臂拾取并携带到显微镜的观察位置。 样品通过真空吸附和通过与真空吸附表面接触的弹簧弹性保持的样品保持器保持。 同时，已经观察并向样品供料器移动的样品将其余部分移动到样品进料器，并更换为从中提取的原始盒式样。 在更换样品后，重复一个新的样品并将其运送到保持位置，直到观察到所有的载玻片样品。

公开(公告)号：US06440369B1

公开(公告)日：2002-08-27

申请号：US09029655

申请日：1998-02-27

申请人： Mitsuru Oonuma ,  Atsushi Katayama ,  Isamu Takekoshi ,  Isao Shindo ,  Kahei Shiraishi ,  Hiromichi Sato

发明人： Mitsuru Oonuma ,  Atsushi Katayama ,  Isamu Takekoshi ,  Isao Shindo ,  Kahei Shiraishi ,  Hiromichi Sato

IPC分类号： G01N3510

CPC分类号： G01N35/00594 ,  G01N35/00623 ,  G01N35/00712 ,  G01N35/025 ,  G01N2035/00306 ,  G01N2035/009 ,  G01N2035/0091 ,  G01N2035/0443 ,  G01N2035/0444 ,  G01N2035/0446 ,  G01N2035/0453 ,  Y10T436/11 ,  Y10T436/113332

摘要： A small automatic analyzer in which a specimen disc 12 and a reagent disc 22 are disposed at different positions in a depth direction in a this-side area of an upper surface of an analyzer housing 40, a reaction disc 3 is disposed backward from the specimen disc 12 between the specimen disc 12 and the reagent disc 22, a specimen extracting and injecting unit 14 is disposed between the reaction disc 3 and the specimen disc 12, a reagent extracting and injecting unit 24 is disposed between the reaction disc 3 and the reagent disc 22, the specimen and reagent extracting and injecting units 14 and 24 are arranged at different positions in an oblique direction, the reaction disc 3, specimen disc 12 and reaction disc 22 each have a separate cover therefor, and the specimen extracting and injecting unit 14 and the specimen extracting and injecting unit 24 have a common cover therefor.

摘要翻译： 在分析器壳体40的上表面的该侧区域中，将样本盘12和试剂盘22配置在深度方向的不同位置的小型自动分析装置，将反作用盘3从试样 样品盘12和试剂盘22之间的盘12，试样提取和注射单元14设置在反应盘3和样品盘12之间，试剂提取和注射单元24设置在反应盘3和试剂 盘22中，样本和试剂提取和注入单元14和24沿倾斜方向布置在不同的位置，反应盘3，样本盘12和反作用盘22各自具有单独的盖，并且样本提取和注射单元 14并且样本提取和注射单元24具有共同的盖。

公开(公告)号：USD380551S

公开(公告)日：1997-07-01

申请号：US41933

申请日：1995-07-27

申请人： Mitsuru Ohnuma ,  Atsushi Katayama ,  Isamu Takekoshi ,  Isao Shindo ,  Kahei Shiraishi ,  Hiromichi Sato

设计人： Mitsuru Ohnuma ,  Atsushi Katayama ,  Isamu Takekoshi ,  Isao Shindo ,  Kahei Shiraishi ,  Hiromichi Sato

公开(公告)号：US5580526A

公开(公告)日：1996-12-03

申请号：US226984

申请日：1994-04-13

申请人： Masao Okayama ,  Takao Terayama ,  Kazuo Honma ,  Hiroshi Ohki ,  Isao Shindo ,  Susumu Kai ,  Shigeo Mutou

发明人： Masao Okayama ,  Takao Terayama ,  Kazuo Honma ,  Hiroshi Ohki ,  Isao Shindo ,  Susumu Kai ,  Shigeo Mutou

IPC分类号： G01N33/493 ,  G01N33/52 ,  G01N35/00 ,  G01N35/02 ,  G01N35/04 ,  G01N35/10 ,  B65H3/00

CPC分类号： G01N35/00029 ,  G01N2035/00039 ,  G01N2035/00118 ,  G01N2035/00455 ,  G01N2035/1025

摘要： An analytic test sheet feeder comprises a cylindrical container 11 having an elongated through hole 15 formed in a side wall thereof for receiving a test sheet, a container support 18 which comprises an upper portion having a semi-cylindrical concave surface and a hole 20 formed in a central portion of the concave surface to permit a test sheet descending from the through hole of the container 11 to be taken out therethrough 20, and a test sheet delivering stage 31 which receives and delivers the test sheet descending from the through hole 15.

摘要翻译： 分析试纸输送机包括圆柱形容器11，其具有形成在其侧壁中的用于容纳测试片的细长通孔15，容器支架18，其包括具有半圆柱形凹面的上部和形成在其中的孔20 凹面的中心部分，允许从容器11的通孔下降的测试片从其中取出;以及测试片输送台31，其接收并输送从通孔15下降的测试片。