公开(公告)号：US20100053830A1

公开(公告)日：2010-03-04

申请号：US12528248

申请日：2008-02-26

申请人： Ulf Andersson ,  Hans Bjorklund ,  John Daniel ,  David Dickmander

发明人： Ulf Andersson ,  Hans Bjorklund ,  John Daniel ,  David Dickmander

IPC分类号： H02H3/20

CPC分类号： G05F1/00 ,  H02H3/023 ,  H02H7/04

摘要： A method and apparatus for mitigating dynamic overvoltage (DOV) in an AC network. A distribution and power transformer has its primary connected to the high voltage bus of the network and its secondary connected to a switching device. Upon the occurrence of a condition known to cause a DOV and the DOV a control system cause the switching device to change from a nonconductive mode to a conductive mode in less than the time for one cycle of the operating frequency of the AC network. This change in switching device conduction places a short circuit across the transformer secondary.

摘要翻译： 一种用于减轻AC网络中的动态过电压（DOV）的方法和装置。 配电和电力变压器主要连接到网络的高压母线，其二次连接到开关装置。 在发生已知导致DOV和DOV的情况下，控制系统使得开关装置在小于AC网络的工作频率的一个周期的时间内从非导通模式改变为导通模式。 开关器件导通的这种变化在变压器二次侧产生短路。

公开(公告)号：US08411400B2

公开(公告)日：2013-04-02

申请号：US12528248

申请日：2008-02-26

申请人： Ulf Andersson ,  Hans Bjorklund ,  John Daniel ,  David Dickmander

发明人： Ulf Andersson ,  Hans Bjorklund ,  John Daniel ,  David Dickmander

IPC分类号： H02H3/00

CPC分类号： G05F1/00 ,  H02H3/023 ,  H02H7/04

摘要： A distribution and power transformer has its primary connected to the high voltage bus of the network and its secondary connected to a switching device. Upon the occurrence of a condition known to cause a dynamic overvoltage (DOV) and the occurrence of the DOV, a control system causes the switching device to change from a nonconductive mode to a conductive mode in less than the time for one cycle of the operating frequency of the AC network. This change in switching device conduction places a short circuit across the transformer secondary and thus mitigates the DOV.

摘要翻译： 配电和电力变压器主要连接到网络的高压母线，其二次连接到开关装置。 在发生已知导致动态过电压（DOV）和DOV的发生的状况的情况下，控制系统使得开关装置在小于操作的一个周期的时间内使开关装置从非导通模式改变为导通模式 交流网络的频率。 开关器件导通的这种变化在变压器二次侧产生短路，从而减轻了DOV。

公开(公告)号：US20140205646A1

公开(公告)日：2014-07-24

申请号：US13984842

申请日：2012-02-13

申请人： Brenda S. Morse ,  Somaly Sith ,  Randall Spencer ,  John Daniel

发明人： Brenda S. Morse ,  Somaly Sith ,  Randall Spencer ,  John Daniel

IPC分类号： A61L27/38 ,  A61K35/50

CPC分类号： A61L27/3891 ,  A61K35/50 ,  A61L27/3604 ,  A61L27/3687 ,  A61L27/3804 ,  A61L27/3839 ,  A61L27/3878 ,  A61L27/3882 ,  A61L2400/18 ,  A61L2430/12 ,  A61L2430/16 ,  A61L2430/22 ,  A61L2430/32 ,  A61L2430/40

摘要： Described herein are tissue grafts derived from the placenta that possess good adhesion to biological tissues and are useful in would healing applications. In one aspect, the tissue graft includes (1) two or more layers of amnion, wherein at least one layer of amnion is cross-linked, (2) two or more layers of chorion, wherein at least one layer of amnion is cross-linked, or (3) one or more layers of amnion and chorion, wherein at least one layer of amnion and/or chorion is cross-linked. In another aspect, the grafts are composed of amnion and chorion cross-linked with one another. In a further aspect, the grafts have one or more layers sandwiched between the amnion and chorion membranes. The amnion and/or the chorion are treated with a cross-linking agent prior to the formation of the graft. Also described herein are methods for making and using the tissue grafts.

摘要翻译： 本文描述了衍生自胎盘的组织移植物，其具有对生物组织的良好粘附性并且可用于治愈应用。 在一个方面，组织移植物包括（1）两层或更多层羊膜，其中至少一层羊膜交联，（2）两层或多层绒毛膜，其中至少一层羊膜是交叉的， 连接或（3）一层或多层羊膜和绒毛膜，其中至少一层羊膜和/或绒毛膜交联。 另一方面，移植物由彼此交联的羊膜和绒毛膜组成。 在另一方面，移植物具有夹在羊膜和绒毛膜之间的一层或多层。 羊膜和/或绒毛膜在形成移植物之前用交联剂处理。 本文还描述了用于制造和使用组织移植物的方法。

公开(公告)号：US08597687B2

公开(公告)日：2013-12-03

申请号：US13569095

申请日：2012-08-07

申请人： John Daniel

发明人： John Daniel

IPC分类号： A61K35/50

CPC分类号： A61K35/50 ,  A61F2/02 ,  A61J1/00 ,  A61L27/3604 ,  A61L27/3683 ,  A61L27/3687 ,  A61L27/3691 ,  A61L27/3695 ,  A61L27/40 ,  A61L27/50 ,  A61L27/54 ,  A61L27/58 ,  A61L2300/412 ,  A61L2300/60 ,  A61L2300/64 ,  A61L2430/40 ,  B65D25/205 ,  B65D81/18 ,  B65D85/70

摘要： A method for preparing placenta membrane tissue grafts for medical use, includes obtaining a placenta from a subject, cleaning the placenta, separating the chorion tissue from the amniotic membrane, mounting a selected layer of either the chorion tissue or the amniotic membrane onto a drying fixture, dehydrating the selected layer on the drying fixture, and cutting the selected layer into a plurality of tissue grafts. Preferably, the drying fixture includes grooves or raised edges that define the outer contours of each desired tissue graft, after they are cut, and further includes raised or indented logos that emboss the middle area of the tissue grafts during dehydration and that enables an end user to distinguish the top from the bottom side of the graft. The grafts are comprised of single layers of amnion or chorion, multiple layers of amnion or chorion, or multiple layers of a combination of amnion and chorion.

摘要翻译： 一种用于制备用于医疗用途的胎盘膜组织移植物的方法，包括从受试者获得胎盘，清洁胎盘，将绒毛膜组织与羊膜分离，将选定的绒毛膜组织或羊膜安装在干燥装置上 使干燥夹具上的所选层脱水，将所选择的层切割成多个组织移植物。 优选地，干燥夹具包括凹槽或凸起边缘，其限定每个期望的组织移植物在其切割之后的外部轮廓，并且还包括在脱水期间压印组织移植物的中间区域的凸起或凹入的标识，并且使最终使用者 以区分顶部与移植物的底侧。 移植物由单层羊膜或绒毛膜，多层羊膜或绒毛膜组成，或多层羊膜和绒毛膜组合。

公开(公告)号：US20130224159A1

公开(公告)日：2013-08-29

申请号：US13861305

申请日：2013-04-11

申请人： John Daniel ,  Randall Spencer

发明人： John Daniel ,  Randall Spencer

IPC分类号： A61K35/12

CPC分类号： A61K35/28 ,  A61F2/02 ,  A61F2210/00 ,  A61F2230/00 ,  A61K9/7007 ,  A61K35/19 ,  A61K35/33 ,  A61K35/50 ,  A61L27/3604 ,  A61L27/3683 ,  A61L27/3834 ,  A61L27/56 ,  A61L2430/34 ,  A61L2430/40 ,  Y10T156/10 ,  Y10T156/1039

摘要： Described herein are tissue grafts derived from the placenta. The grafts are composed of at least one layer of amnion tissue where the epithelium layer has been substantially removed in order to expose the basement layer to host cells. By removing the epithelium layer, cells from the host can more readily interact with the cell-adhesion bio-active factors located onto top and within of the basement membrane. Also described herein are methods for making and using the tissue grafts. The laminin structure of amnion tissue is nearly identical to that of native human tissue such as, for example, oral mucosa tissue. This includes high level of laminin-5, a cell adhesion bio-active factor show to bind gingival epithelia-cells, found throughout upper portions of the basement membrane.

摘要翻译： 这里描述的是来自胎盘的组织移植物。 移植物由至少一层羊膜组织组成，其中已经基本上去除了上皮层，以便将基底层暴露于宿主细胞。 通过去除上皮层，来自宿主的细胞可以更容易地与位于基底膜顶部和内部的细胞粘附生物活性因子相互作用。 本文还描述了用于制造和使用组织移植物的方法。 羊膜组织的层粘连蛋白结构与天然人体组织例如口腔粘膜组织几乎相同。 这包括高水平的层粘连蛋白-5，细胞粘附生物活性因子显示结合牙龈上皮细胞，遍及基底膜的上部。

公开(公告)号：US08460716B2

公开(公告)日：2013-06-11

申请号：US13569131

申请日：2012-08-07

申请人： John Daniel

发明人： John Daniel

IPC分类号： A61K35/50

CPC分类号： A61K35/50 ,  A61F2/02 ,  A61J1/00 ,  A61L27/3604 ,  A61L27/3683 ,  A61L27/3687 ,  A61L27/3691 ,  A61L27/3695 ,  A61L27/40 ,  A61L27/50 ,  A61L27/54 ,  A61L27/58 ,  A61L2300/412 ,  A61L2300/60 ,  A61L2300/64 ,  A61L2430/40 ,  B65D25/205 ,  B65D81/18 ,  B65D85/70

摘要： A method for preparing placenta membrane tissue grafts for medical use, includes obtaining a placenta from a subject, cleaning the placenta, separating the chorion tissue from the amniotic membrane, mounting a selected layer of either the chorion tissue or the amniotic membrane onto a drying fixture, dehydrating the selected layer on the drying fixture, and cutting the selected layer into a plurality of tissue grafts. Preferably, the drying fixture includes grooves or raised edges that define the outer contours of each desired tissue graft, after they are cut, and further includes raised or indented logos that emboss the middle area of the tissue grafts during dehydration and that enables an end user to distinguish the top from the bottom side of the graft. The grafts are comprised of single layers of amnion or chorion, multiple layers of amnion or chorion, or multiple layers of a combination of amnion and chorion.

摘要翻译： 一种用于制备用于医疗用途的胎盘膜组织移植物的方法，包括从受试者获得胎盘，清洁胎盘，将绒毛膜组织与羊膜分离，将选定的绒毛膜组织或羊膜安装在干燥装置上 使干燥夹具上的所选层脱水，将所选择的层切割成多个组织移植物。 优选地，干燥夹具包括凹槽或凸起边缘，其限定每个期望的组织移植物在其切割之后的外部轮廓，并且还包括在脱水期间压印组织移植物的中间区域的凸起或凹入的标识，并且使最终使用者 以区分顶部与移植物的底侧。 移植物由单层羊膜或绒毛膜，多层羊膜或绒毛膜组成，或多层羊膜和绒毛膜组合。

公开(公告)号：US08323701B2

公开(公告)日：2012-12-04

申请号：US12428908

申请日：2009-04-23

申请人： John Daniel ,  Robert Tofe ,  Randall Spencer ,  John Russo

发明人： John Daniel ,  Robert Tofe ,  Randall Spencer ,  John Russo

IPC分类号： A61K35/50

CPC分类号： A61K35/28 ,  A61F2/02 ,  A61F2210/00 ,  A61F2230/00 ,  A61K9/7007 ,  A61K35/19 ,  A61K35/33 ,  A61K35/50 ,  A61L27/3604 ,  A61L27/3683 ,  A61L27/3834 ,  A61L27/56 ,  A61L2430/34 ,  A61L2430/40 ,  Y10T156/10 ,  Y10T156/1039

摘要： Described herein are tissue grafts derived from the placenta. The grafts are composed of at least one layer of amnion tissue where the epithelium layer has been substantially removed in order to expose the basement layer to host cells. By removing the epithelium layer, cells from the host can more readily interact with the cell-adhesion bio-active factors located onto top and within of the basement membrane. Also described herein are methods for making and using the tissue grafts. The laminin structure of amnion tissue is nearly identical to that of native human tissue such as, for example, oral mucosa tissue. This includes high level of laminin-5, a cell adhesion bio-active factor show to bind gingival epithelia-cells, found throughout upper portions of the basement membrane.

摘要翻译： 这里描述的是来自胎盘的组织移植物。 移植物由至少一层羊膜组织组成，其中已经基本上去除了上皮层，以便将基底层暴露于宿主细胞。 通过去除上皮层，来自宿主的细胞可以更容易地与位于基底膜顶部和内部的细胞粘附生物活性因子相互作用。 本文还描述了用于制造和使用组织移植物的方法。 羊膜组织的层粘连蛋白结构与天然人体组织例如口腔粘膜组织几乎相同。 这包括高水平的层粘连蛋白-5，表现为结合牙龈上皮细胞的细胞粘附生物活性因子，其遍及基底膜的上部。

公开(公告)号：US20120294810A1

公开(公告)日：2012-11-22

申请号：US13569095

申请日：2012-08-07

申请人： John Daniel

发明人： John Daniel

IPC分类号： A61K35/12

CPC分类号： A61K35/50 ,  A61F2/02 ,  A61J1/00 ,  A61L27/3604 ,  A61L27/3683 ,  A61L27/3687 ,  A61L27/3691 ,  A61L27/3695 ,  A61L27/40 ,  A61L27/50 ,  A61L27/54 ,  A61L27/58 ,  A61L2300/412 ,  A61L2300/60 ,  A61L2300/64 ,  A61L2430/40 ,  B65D25/205 ,  B65D81/18 ,  B65D85/70

摘要： A method for preparing placenta membrane tissue grafts for medical use, includes obtaining a placenta from a subject, cleaning the placenta, separating the chorion tissue from the amniotic membrane, mounting a selected layer of either the chorion tissue or the amniotic membrane onto a drying fixture, dehydrating the selected layer on the drying fixture, and cutting the selected layer into a plurality of tissue grafts. Preferably, the drying fixture includes grooves or raised edges that define the outer contours of each desired tissue graft, after they are cut, and further includes raised or indented logos that emboss the middle area of the tissue grafts during dehydration and that enables an end user to distinguish the top from the bottom side of the graft. The grafts are comprised of single layers of amnion or chorion, multiple layers of amnion or chorion, or multiple layers of a combination of amnion and chorion.

摘要翻译： 一种用于制备用于医疗用途的胎盘膜组织移植物的方法，包括从受试者获得胎盘，清洁胎盘，将绒毛膜组织与羊膜分离，将选定的绒毛膜组织或羊膜安装在干燥装置上 使干燥夹具上的所选层脱水，将所选择的层切割成多个组织移植物。 优选地，干燥夹具包括凹槽或凸起边缘，其限定每个期望的组织移植物在其切割之后的外部轮廓，并且还包括在脱水期间压印组织移植物的中间区域的凸起或凹入的标识，并且使最终使用者 以区分顶部与移植物的底侧。 移植物由单层羊膜或绒毛膜，多层羊膜或绒毛膜组成，或多层羊膜和绒毛膜组合。

公开(公告)号：US20060167130A1

公开(公告)日：2006-07-27

申请号：US10526006

申请日：2003-08-27

申请人： Ivan Ong ,  John Daniel

发明人： Ivan Ong ,  John Daniel

IPC分类号： C09D5/16 ,  C08K5/13

CPC分类号： C08K5/136 ,  A01N31/08 ,  A01N31/16 ,  C08K5/0058 ,  C08K5/06 ,  C08K5/13 ,  C08L33/06 ,  C08L33/12 ,  C09D5/14 ,  A01N25/10 ,  A01N25/34 ,  A01N2300/00

摘要： An antimicrobial additive composition is provided which economically and efficiently imparts antimicrobial characteristics to acrylic polymers, and particularly thermoformable acrylic sheets made from such polymers. The antimicrobial composition contains 2,4,4′-trichloro-2′-hydroxydiphenyl ether, also known as triclosan, and orthophenyl phenol also known as OPP.

摘要翻译： 提供了抗菌添加剂组合物，其经济有效地赋予丙烯酸聚合物抗微生物特性，特别是由这种聚合物制成的可热成形丙烯酸片材。 抗微生物组合物含有2,4,4'-三氯-2'-羟基二苯醚，也称为三氯生，邻苯基苯酚也称为OPP。

公开(公告)号：US06512349B1

公开(公告)日：2003-01-28

申请号：US09928488

申请日：2001-08-14

申请人： Bilal Gerhard ,  John Daniel ,  Madhav Manjrekar

发明人： Bilal Gerhard ,  John Daniel ,  Madhav Manjrekar

IPC分类号： H02J700

CPC分类号： H02J3/1814 ,  Y02E40/18

摘要： A method is specified for operating a charger (1) for a voltage-maintaining device (2), in which a rectifier (5), connected to phase inputs (PA, PB; PC) via a transformer (3) with an electric AC voltage supply system (4), of the charger (1) is driven by means of a drive signal (S) formed from reference charging voltages (ULA, ref; ULB, ref; ULC, ref). Furthermore, a charging voltage (ULA; ULB; ULC) for the corresponding phase (A; B; C) is generated at each phase input (PA; PB; PC) a substantially constant DC voltage (UDC) being generated-on the DC voltage side of the rectifier (5). Each charging voltage (ULA; ULB; ULC) is generated in such a way that in the corresponding phase (A; B; C) a charging current (ILA; ILB; ILC) is injected in a fashion substantially proportional to a phase system voltage (UNA; UNB; UNC) of the corresponding phase (A; B; C) of the electric AC voltage supply system (3). An apparatus for carrying out the method is also disclosed.

摘要翻译： 一种用于操作电压维持装置（2）的充电器（1）的方法，其中经由具有电AC的变压器（3）连接到相位输入（PA，PB; PC）的整流器（5） 通过由参考充电电压（ULA，ref; ULB，ref; ULC，ref）形成的驱动信号（S）驱动充电器（1）的电压供应系统（4）。 此外，在每个相位输入（PA; PB; PC）上产生在DC上产生的基本上恒定的DC电压（UDC）的相应相位（A; B; C）的充电电压（ULA; ULB; ULC） 整流器（5）的电压侧。 每个充电电压（ULA; ULB; ULC）以这样一种方式产生，使得在相应的相位（A; B; C）中，充电电流（ILA; ILB; ILC）以与相位系统电压 （UNA; UNB; UNC）的交流电压供应系统（3）的相应相位（A; B; C）。 还公开了一种用于执行该方法的装置。