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公开(公告)号：US20090207412A1
公开(公告)日：2009-08-20
申请号：US10596735
申请日：2004-12-23
CPC分类号： G02B27/145 , A61B5/0059 , G01J3/02 , G01J3/0205 , G01J3/0208 , G01J3/021 , G01J3/0218 , G01J3/0291 , G01J3/10 , G01J3/1895 , G01J3/2823 , G01J3/44 , G01N21/255 , G01N21/359 , G01N21/474 , G01N2021/4742 , G01N2021/4766 , G01N2021/6439 , G02B23/2461 , G02B27/144
摘要： A beam splitter array includes first and second beam splitters and a reflector to reflect part of a beam from the second splitter. The first splitter outputs a first beam having a power spectral density comprising a substantial portion of a white light spectrum from a first output port, and a second beam of optical radiation having a power spectral density comprising a substantial portion of a first non-white spectrum and a substantial portion of a second non-white spectrum from a second output port, from an input beam received at a first angle of incidence. The second splitter receives the second beam at a second incidence angle, and reflects a substantial portion of the second beam having a power spectral density comprising the first non-white light spectrum, and transmits a substantial portion of the second beam having a power spectral density comprising the second non-white light spectrum.
摘要翻译： 分束器阵列包括第一和第二分束器和用于反射来自第二分离器的光束的一部分的反射器。 第一分离器输出具有包括来自第一输出端口的白光光谱的主要部分的功率谱密度的第一光束，以及具有包括第一非白色光谱的实质部分的功率谱密度的第二光束 以及来自第二输入端口的第二非白色光谱的大部分来自以第一入射角接收的输入光束。 第二分束器以第二入射角接收第二光束，并且反射具有包括第一非白光光谱的功率谱密度的第二光束的大部分，并且透射具有功率谱密度的第二光束的大部分 包括第二非白光光谱。
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公开(公告)号：US08486373B2
公开(公告)日：2013-07-16
申请号：US10979755
申请日：2004-11-01
CPC分类号： A61K49/0056 , A61B5/0068 , A61B5/0071 , A61B5/0084 , A61B5/0086 , A61K47/60 , A61K49/0032 , A61K49/0054 , A61K49/0058 , C12Q1/6841 , C12Q1/6883 , C12Q2565/30 , C12Q2565/1015 , C12Q2525/301
摘要： An intramolecularly-quenched, near infrared fluorescence probe that emits substantial fluorescence only after interaction with a target tissue (i.e., activation) is disclosed. The probe includes a polymeric backbone and a plurality of near infrared fluorochromes covalently linked to the backbone at fluorescence-quenching interaction-permissive positions separable by enzymatic cleavage at fluorescence activation sites. The probe optionally includes protective chains or fluorochrome spacers, or both. Also disclosed are methods of using the intramolecularly-quenched, near infrared fluorescence probes for in vivo optical imaging.
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公开(公告)号：US08078265B2
公开(公告)日：2011-12-13
申请号：US11456625
申请日：2006-07-11
申请人： Umar Mahmood , Ralph Weissleder , Rahul A. Sheth , Rabi Upadhyay
发明人： Umar Mahmood , Ralph Weissleder , Rahul A. Sheth , Rabi Upadhyay
IPC分类号： A61B6/00
CPC分类号： A61B1/045 , A61B1/00009 , A61B1/043
摘要： An imaging system divides image pixels intensities by exposure time to generate image data in units of intensity per time. The imaging system divides a fluorescent light image in intensity per time units by an excitation light image in intensity per time units to provide a quantitative corrected fluorescent light image that is generally invariant to position of an imaging instrument relative to a biological tissue being imaged.
摘要翻译： 成像系统通过曝光时间来分割图像像素强度，以生成以每个时间强度为单位的图像数据。 成像系统通过每时间单位强度的激发光图像以每时间单位的强度对荧光灯图像进行分割，以提供通常对成像仪器相对于被成像的生物组织的位置不变的定量校正荧光图像。
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公开(公告)号：US20080015446A1
公开(公告)日：2008-01-17
申请号：US11456625
申请日：2006-07-11
申请人： Umar Mahmood , Ralph Weissleder , Rahul A. Sheth , Rabi Upadhyay
发明人： Umar Mahmood , Ralph Weissleder , Rahul A. Sheth , Rabi Upadhyay
IPC分类号： A61B6/00
CPC分类号： A61B1/045 , A61B1/00009 , A61B1/043
摘要： An imaging system divides image pixels intensities by exposure time to generate image data in units of intensity per time. The imaging system divides a fluorescent light image in intensity per time units by an excitation light image in intensity per time units to provide a quantitative corrected fluorescent light image that is generally invariant to position of an imaging instrument relative to a biological tissue being imaged.
摘要翻译： 成像系统通过曝光时间来分割图像像素强度，以生成以每个时间强度为单位的图像数据。 成像系统通过每时间单位强度的激发光图像以每时间单位的强度对荧光灯图像进行分割，以提供通常对成像仪器相对于被成像的生物组织的位置不变的定量校正荧光图像。
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公开(公告)号：US06592847B1
公开(公告)日：2003-07-15
申请号：US09604145
申请日：2000-06-27
IPC分类号： A61B1000
CPC分类号： A61K49/0056 , A61B5/0068 , A61B5/0071 , A61B5/0084 , A61B5/0086 , A61K47/60 , A61K49/0032 , A61K49/0054 , A61K49/0058 , C12Q1/6841 , C12Q1/6883 , C12Q2565/30 , C12Q2565/1015 , C12Q2525/301
摘要： An intramolecularly-quenched, near infrared fluorescence probe that emits substantial fluorescence only after interaction with a target tissue (i.e., activation) is disclosed. The probe includes a polymeric backbone and a plurality of near infrared fluorochromes covalently linked to the backbone at fluorescence-quenching interaction-permissive positions separable by enzymatic cleavage at fluorescence activation sites. The probe optionally includes protective chains or fluorochrome spacers, or both. Also disclosed are methods of using the intramolecularly-quenched, near infrared fluorescence probes for in vivo optical imaging.
摘要翻译： 公开了分子内骤冷的近红外荧光探针，其仅在与靶组织相互作用后发射实质性荧光（即，激活）。 探针包括聚合物主链和多个近红外荧光染料，其在荧光猝灭相互作用下共价连接至主链，允许位置可通过荧光激活位点处的酶切割分离。 探针任选地包括保护链或荧光染料间隔物，或两者。 还公开了使用分子内熄灭的近红外荧光探针进行体内光学成像的方法。
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公开(公告)号：US20110152501A1
公开(公告)日：2011-06-23
申请号：US13006954
申请日：2011-01-14
申请人： Ralph Weissleder , Ching-Hsuan Tung , Umar Mahmood
发明人： Ralph Weissleder , Ching-Hsuan Tung , Umar Mahmood
IPC分类号： C07K14/00
CPC分类号： C12Q1/6816 , C12Q1/6823 , C12Q1/6841 , C12Q2565/107
摘要： The invention relates to activatable imaging probes that include a chromophore attachment moiety and a plurality of chromophores, such as near-infrared chromophores, chemically linked to the chromophore attachment moiety so that upon activation of the imaging probe by interaction with a target molecule the optical properties of the plurality of chromophores are altered. The probe optionally includes protective chains or chromophore spacers, or both. Also disclosed are methods of using the imaging probes for in vivo and in vitro optical imaging.
摘要翻译： 本发明涉及可激活的成像探针，其包括发色团附着部分和多个发色团，例如近红外发色团，其与发色团附着部分化学连接，使得当通过与靶分子相互作用激活成像探针时，光学性质 的多个发色团被改变。 探针任选地包括保护链或发色团间隔物，或两者。 还公开了使用成像探针进行体内和体外光学成像的方法。
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公开(公告)号：US20050169843A1
公开(公告)日：2005-08-04
申请号：US10745336
申请日：2003-12-22
申请人： Ralph Weissleder , Ching-Hsuan Tung , Umar Mahmood
发明人： Ralph Weissleder , Ching-Hsuan Tung , Umar Mahmood
CPC分类号： C12Q1/6816 , C12Q1/6823 , C12Q1/6841 , C12Q2565/107
摘要： The invention relates to activatable imaging probes that includes a chromophore attachment moiety and one or more, e.g., a plurality of, chromophores, such as near-infrared chromophores, chemically linked to the chromophore attachment moiety so that upon activation of the imaging probe the optical properties of the plurality of chromophores are altered. The probe optionally includes protective chains or chromophore spacers, or both. Also disclosed are methods of using the imaging probes for optical imaging.
摘要翻译： 本发明涉及可激活的成像探针，其包括发色团附着部分和一个或多个，例如多个发色团，例如近红外发色团，其与发色团附着部分化学连接，使得在激活成像探针时，光学 改变多个发色团的性质。 探针任选地包括保护链或发色团间隔物，或两者。 还公开了使用成像探针进行光学成像的方法。
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公开(公告)号：US08423127B2
公开(公告)日：2013-04-16
申请号：US13274781
申请日：2011-10-17
申请人： Umar Mahmood , Ralph Weissleder , Rahul A. Sheth , Rabi Upadhyay
发明人： Umar Mahmood , Ralph Weissleder , Rahul A. Sheth , Rabi Upadhyay
IPC分类号： A61B6/00
CPC分类号： A61B1/045 , A61B1/00009 , A61B1/043
摘要： An imaging system divides image pixels intensities by exposure time to generate image data in units of intensity per time. The imaging system divides a fluorescent light image in intensity per time units by an excitation light image in intensity per time units to provide a quantitative corrected fluorescent light image that is generally invariant to position of an imaging instrument relative to a biological tissue being imaged.
摘要翻译： 成像系统通过曝光时间来分割图像像素强度，以生成以每个时间强度为单位的图像数据。 成像系统通过每时间单位强度的激发光图像以每时间单位的强度对荧光灯图像进行分割，以提供通常对成像仪器相对于被成像的生物组织的位置不变的定量校正荧光图像。
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公开(公告)号：US20060275775A1
公开(公告)日：2006-12-07
申请号：US10979755
申请日：2004-11-01
CPC分类号： A61K49/0056 , A61B5/0068 , A61B5/0071 , A61B5/0084 , A61B5/0086 , A61K47/60 , A61K49/0032 , A61K49/0054 , A61K49/0058 , C12Q1/6841 , C12Q1/6883 , C12Q2565/30 , C12Q2565/1015 , C12Q2525/301
摘要： An intramolecularly-quenched, near infrared fluorescence probe that emits substantial fluorescence only after interaction with a target tissue (i.e., activation) is disclosed. The probe includes a polymeric backbone and a plurality of near infrared fluorochromes covalently linked to the backbone at fluorescence-quenching interaction-permissive positions separable by enzymatic cleavage at fluorescence activation sites. The probe optionally includes protective chains or fluorochrome spacers, or both. Also disclosed are methods of using the intramolecularly-quenched, near infrared fluorescence probes for in vivo optical imaging.
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公开(公告)号：US20120150043A1
公开(公告)日：2012-06-14
申请号：US13274781
申请日：2011-10-17
申请人： Umar Mahmood , Ralph Weissleder , Rahul A. Sheth , Rabi Upadhyay
发明人： Umar Mahmood , Ralph Weissleder , Rahul A. Sheth , Rabi Upadhyay
CPC分类号： A61B1/045 , A61B1/00009 , A61B1/043
摘要： An imaging system divides image pixels intensities by exposure time to generate image data in units of intensity per time. The imaging system divides a fluorescent light image in intensity per time units by an excitation light image in intensity per time units to provide a quantitative corrected fluorescent light image that is generally invariant to position of an imaging instrument relative to a biological tissue being imaged.
摘要翻译： 成像系统通过曝光时间来分割图像像素强度，以生成以每个时间强度为单位的图像数据。 成像系统通过每时间单位强度的激发光图像以每时间单位的强度对荧光灯图像进行分割，以提供通常对成像仪器相对于被成像的生物组织的位置不变的定量校正荧光图像。
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