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公开(公告)号：US11946030B2
公开(公告)日：2024-04-02
申请号：US17124728
申请日：2020-12-17
摘要： System and methods for the culturing of multiple independent cell types under uniform conditions.
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公开(公告)号：US20210189313A1
公开(公告)日：2021-06-24
申请号：US17124728
申请日：2020-12-17
摘要： System and methods for the culturing of multiple independent cell types under uniform conditions.
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公开(公告)号：US10307514B2
公开(公告)日：2019-06-04
申请号：US15591617
申请日：2017-05-10
IPC分类号： A61L27/56 , A61L27/58 , A61L27/18 , A61L27/38 , A61L27/48 , A61L27/52 , A61L27/54 , A61L27/22
摘要： The present invention provides gradient porous scaffolds for bone regeneration and osteochondral defect repair, methods for making such gradient porous scaffolds, and methods for using the gradient porous scaffolds.
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公开(公告)号：US20170239395A1
公开(公告)日：2017-08-24
申请号：US15591617
申请日：2017-05-10
CPC分类号： A61L27/56 , A61L27/18 , A61L27/22 , A61L27/38 , A61L27/48 , A61L27/52 , A61L27/54 , A61L27/58 , A61L2430/02
摘要： The present invention provides gradient porous scaffolds for bone regeneration and osteochondral defect repair, methods for making such gradient porous scaffolds, and methods for using the gradient porous scaffolds.
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公开(公告)号：US09707322B2
公开(公告)日：2017-07-18
申请号：US14136410
申请日：2013-12-20
CPC分类号： A61L27/56 , A61L27/18 , A61L27/22 , A61L27/38 , A61L27/48 , A61L27/52 , A61L27/54 , A61L27/58 , A61L2430/02
摘要： The present invention provides gradient porous scaffolds for bone regeneration and osteochondral defect repair, methods for making such gradient porous scaffolds, and methods for using the gradient porous scaffolds.
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公开(公告)号：US20200062869A1
公开(公告)日：2020-02-27
申请号：US16552774
申请日：2019-08-27
发明人： Stefanie A. Sydlik , Anne M. Arnold , Brian D. Holt , Cato T. Laurencin , Leila Daneshmandi , Stephen Schmidt
摘要： A compound includes a polysaccharide moiety and one or more chelating agents. The one or more chelating agents are covalently bonded to the polysaccharide moiety. The polysaccharide moiety can include a glycosaminoglycan moiety, such as a hyaluronic acid polymer or a sulfated glycosaminoglycan moiety. The compound can be used to treat or prevent a disease or disorder in a patient with a metal implant. The compound reduces a concentration of metal particulates or metal ions in the subject.
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7.发明申请Bi-phasic 3-Dimenisonal Nanofiber Scaffolds, Two Parallel Beam Collector Device and Methods of Use 审中-公开双相三维纳米纤维支架，两个平行光束收集器装置和使用方法公开(公告)号：US20140364948A1
公开(公告)日：2014-12-11
申请号：US14302336
申请日：2014-06-11
发明人： Cato T. Laurencin , Shaun W. McLaughlin , James Veronick , Yusuf Kahn , Lakshmi S. Nair , David J. Goldhamer
IPC分类号： A61F2/08
CPC分类号： A61F2/08 , A61F2/0077 , A61F2002/0894 , A61F2240/001 , A61L27/50 , A61L2400/12 , A61L2430/30
摘要： A biphasic scaffold and devices and methods for making the scaffold are disclosed. An example scaffold may include (a) a first plurality of randomly-oriented nanofibers defining a first tab region, (b) a second plurality of randomly-oriented nanofibers defining a second tab region, and (c) a plurality of aligned nanofibers coupled to and extending between the first tab region and the second tab region, where the plurality of aligned nanofibers are suspended between the first tab region and the second tab region.
摘要翻译： 公开了双相支架和用于制造支架的装置和方法。 示例性支架可以包括（a）限定第一突片区域的第一多个随机取向的纳米纤维，（b）限定第二突片区域的第二多个随机取向的纳米纤维，以及（c）多个对准的纳米纤维， 并且在所述第一突片区域和所述第二突片区域之间延伸，其中所述多个对准的纳米纤维悬挂在所述第一突片区域和所述第二突片区域之间。
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公开(公告)号：US20240309328A1
公开(公告)日：2024-09-19
申请号：US18270368
申请日：2022-01-04
CPC分类号： C12N5/0658 , C07K14/50 , C12N5/0655 , A61K38/00 , C12N2501/119 , C12N2506/1323 , C12N2506/1384
摘要： Methods for enhancing myogenic and/or chondrogenic lineage commitment of stem cells, inhibiting adipogenic differentiation of stem cells, and for promoting tissue regeneration using fibroblast growth factor 8 (FGF8).
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公开(公告)号：US11479617B2
公开(公告)日：2022-10-25
申请号：US16552774
申请日：2019-08-27
发明人： Stefanie A. Sydlik , Anne M. Arnold , Brian D. Holt , Cato T. Laurencin , Leila Daneshmandi , Stephen Schmidt
摘要： A compound includes a polysaccharide moiety and one or more chelating agents. The one or more chelating agents are covalently bonded to the polysaccharide moiety. The polysaccharide moiety can include a glycosaminoglycan moiety, such as a hyaluronic acid polymer or a sulfated glycosaminoglycan moiety. The compound can be used to treat or prevent a disease or disorder in a patient with a metal implant. The compound reduces a concentration of metal particulates or metal ions in the subject.
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公开(公告)号：US20200069838A1
公开(公告)日：2020-03-05
申请号：US16610814
申请日：2018-05-03
摘要： A method for functionalizing graphene oxide includes reacting graphene oxide with a phosphite compound and a metal salt in the presence of a Lewis acid to produce phosphate functionalized graphene oxide including ions of the metal. An apparatus includes a bone scaffold construct formed of phosphate functionalized graphene oxide including metal ions. A bone scaffold construct includes a graphene oxide material formed in the shape of the bone scaffold construct, the graphene oxide material including graphene oxide, phosphate moieties covalently bound to the graphene oxide, and metal counter ions chemically associated with the phosphate moieties. A method for treating a bone defect includes administering a therapeutically effective amount of phosphate functionalized graphene oxide including metal ions.
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