Pseudoporous surface of implantable materials and methods of making the same

    公开(公告)号:US10293153B2

    公开(公告)日:2019-05-21

    申请号:US14727774

    申请日:2015-06-01

    IPC分类号: A61N1/05

    摘要: An implantable medical device can include an electrode substrate electrically connected to at least one electrode. The device can have a pseudoporous surface across the electrode substrate and electrode. This surface can result in a real surface area (RSA) greater than the geometric surface area (GSA) of the device. The pseudoporous surface can be a macroporous surface enabling a charge injection capacity greater than 1 mC/cm2 while minimizing rejection of the device by surrounding tissue in chronic implant applications. The electrode can be a thin layer of conductive material, such as platinum or another metal, conformally deposited on the pseudoporous surface of the electrode substrate. A method of making the implantable device can include forming the device having an electrode substrate and at least one electrode electrically coupled to the electrode substrate, and forming a pseudoporous surface on the electrode substrate and electrode.

    MULTI-SITE ELECTRODE ARRAYS AND METHODS OF MAKING THE SAME
    2.
    发明申请
    MULTI-SITE ELECTRODE ARRAYS AND METHODS OF MAKING THE SAME 审中-公开
    多点电极阵列及其制作方法

    公开(公告)号:US20170007813A1

    公开(公告)日:2017-01-12

    申请号:US15271062

    申请日:2016-09-20

    摘要: A multi-site electrode array (100) can include a microneedle array and a set of electrically active sites (115). The microneedle array includes a plurality of microneedles (105) supported on a base substrate (110). The set of electrically active sites (115) can be arranged at and/or near the tip of each microneedle (105), and in many cases along a shaft of the microneedles. Further, at least a portion of the active sites (115) can be independently electrically addressable such that a remaining portion of the active sites (115) are optionally electrically shunted together. In some cases all of the active sites (115) are independently electrically addressable

    摘要翻译: 多位点电极阵列(100)可以包括微针阵列和一组电活性位点(115)。 微针阵列包括支撑在基底基板(110)上的多个微针(105)。 电活性部位(115)可以布置在每个微针(105)的尖端处和/或附近,并且在许多情况下沿着微针的轴布置。 此外,活性位点(115)的至少一部分可以独立地电寻址,使得活性位点(115)的剩余部分可选地电分流在一起。 在一些情况下,所有活动位点(115)都是独立电可寻址的

    NEURAL INTERFACE
    3.
    发明申请
    NEURAL INTERFACE 审中-公开
    神经界面

    公开(公告)号:US20150305643A1

    公开(公告)日:2015-10-29

    申请号:US14667154

    申请日:2015-03-24

    IPC分类号: A61B5/0478 A61B5/04

    摘要: Technology for a neural interface is described. The neural interface can include an intracranial electrode grid operable to detect neural activity. The neural interface can include a subcutaneous microelectronic signal processing unit operable to process the neural activity in order to obtain digital neural activity information. The neural interface can include a cable connecting the intracranial electrode grid and the subcutaneous microelectronic signal processing unit. The neural interface can include a wired connector attached to the subcutaneous microelectronic signal processing unit that is operable to transmit the digital neural activity information from the subcutaneous microelectronic signal processing unit to an external signal processing device.

    摘要翻译: 描述了神经接口技术。 神经界面可以包括可操作以检测神经活动的颅内电极网格。 神经接口可以包括皮下微电子信号处理单元,其可操作以处理神经活动以获得数字神经活动信息。 神经接口可以包括连接颅内电极网格和皮下微电子信号处理单元的电缆。 神经接口可以包括附接到皮下微电子信号处理单元的有线连接器,其可操作以将数字神经活动信息从皮下微电子信号处理单元传送到外部信号处理装置。

    PSEUDOPOROUS SURFACE OF IMPLANTABLE MATERIALS AND METHODS OF MAKING THE SAME
    6.
    发明申请
    PSEUDOPOROUS SURFACE OF IMPLANTABLE MATERIALS AND METHODS OF MAKING THE SAME 审中-公开
    可植入材料的光滑表面及其制造方法

    公开(公告)号:US20150343204A1

    公开(公告)日:2015-12-03

    申请号:US14727774

    申请日:2015-06-01

    IPC分类号: A61N1/05

    CPC分类号: A61N1/0551 A61N1/0529

    摘要: An implantable medical device can include an electrode substrate electrically connected to at least one electrode. The device can have a pseudoporous surface across the electrode substrate and electrode. This surface can result in a real surface area (RSA) greater than the geometric surface area (GSA) of the device. The pseudoporous surface can be a macroporous surface enabling a charge injection capacity greater than 1 mC/cm2 while minimizing rejection of the device by surrounding tissue in chronic implant applications. The electrode can be a thin layer of conductive material, such as platinum or another metal, conformally deposited on the pseudoporous surface of the electrode substrate. A method of making the implantable device can include forming the device having an electrode substrate and at least one electrode electrically coupled to the electrode substrate, and forming a pseudoporous surface on the electrode substrate and electrode.

    摘要翻译: 可植入医疗装置可以包括电连接到至少一个电极的电极基底。 器件可以在电极基底和电极上具有伪孔表面。 该表面可以导致大于装置的几何表面积(GSA)的实际表面积(RSA)。 伪孔表面可以是大孔表面,使得电荷注入能力大于1mC / cm 2,同时通过在慢性植入物应用中的周围组织最小化装置的排斥。 电极可以是保形地沉积在电极基板的伪孔表面上的导电材料的诸如铂或另一种金属的薄层。 制造可植入装置的方法可以包括形成具有电极基板的装置和与电极基板电耦合的至少一个电极,以及在电极基板和电极上形成伪孔表面。

    Neural interface
    9.
    发明授权

    公开(公告)号:US10058263B2

    公开(公告)日:2018-08-28

    申请号:US14667154

    申请日:2015-03-24

    IPC分类号: A61B5/0478 A61B5/04 A61B5/00

    摘要: Technology for a neural interface is described. The neural interface can include an intracranial electrode grid operable to detect neural activity. The neural interface can include a subcutaneous microelectronic signal processing unit operable to process the neural activity in order to obtain digital neural activity information. The neural interface can include a cable connecting the intracranial electrode grid and the subcutaneous microelectronic signal processing unit. The neural interface can include a wired connector attached to the subcutaneous microelectronic signal processing unit that is operable to transmit the digital neural activity information from the subcutaneous microelectronic signal processing unit to an external signal processing device.