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    Particles containing mannitol suitable for tabletting into diagnostic reagents
    3.
    发明授权
    Particles containing mannitol suitable for tabletting into diagnostic reagents 失效
    含有适合压片成诊断试剂的甘露醇的颗粒

    公开(公告)号：US5009994A

    公开(公告)日：1991-04-23

    申请号：US296178

    申请日：1989-01-12

    申请人： John K. McGeehan

    发明人： John K. McGeehan

    IPC分类号： C12Q1/00 ,  G01N33/531 ,  G01N33/548

    CPC分类号： G01N33/548 ,  C12Q1/00 ,  G01N33/531

    摘要： A completely water-soluble, solid, labile biochemical-containing diagnostic reagent is prepared without the need of a lyophilization step, by spraying, preferably by a fluidized bed process, an aqueous solution of labile biochemical, e.g., an enzyme, onto small particles, e.g., lower than 20 mesh, of an inert, completely water-soluble solid bulking agent, e.g., mannitol; drying the resultant labile biochemical-coated bulking agent to the desired dryness; and then forming resultant dried labile biochemical-coated bulking agent into a tablet suitable for a diagnostic test reagent, said tablet having a predetermined rate of dissolution.

    摘要翻译： 制备完全水溶性，固体，不稳定的含生物化学物质的诊断试剂，而不需要冷冻干燥步骤，优选通过流化床方法将不稳定生物化学物质例如酶的水溶液喷雾到小颗粒上， 例如低于20目的惰性完全水溶性固体填充剂，例如甘露糖醇; 将所得不稳定的生物化学涂覆的填充剂干燥至所需的干燥度; 然后将得到的干燥不稳定的生物化学包衣的填充剂形成适用于诊断试剂的片剂，所述片剂具有预定的溶解速率。

    SYSTEMS AND METHODS FOR MICRO-CONTACT STAMPING
    4.
    发明申请
    SYSTEMS AND METHODS FOR MICRO-CONTACT STAMPING 有权
    微接触式压印系统与方法

    公开(公告)号：US20120187082A1

    公开(公告)日：2012-07-26

    申请号：US13011734

    申请日：2011-01-21

    申请人： John K. McGeehan

    发明人： John K. McGeehan

    IPC分类号： C23F1/00 ,  B29C59/02

    CPC分类号： C12M33/02 ,  B82Y10/00 ,  B82Y40/00 ,  G03F7/0002

    摘要： Systems and methods for using stamps to print or mask materials on a substrate service. In one particular embodiment, the systems and methods include a microcontacting stamp that has a plurality of rigid posts each having a resilient pad at its distal end. Each post is fitted within an aperture located in a guide plate such that the post may move longitudinally within the guide plate. The guide plate includes a variety of apertures that typically are aligned with the wells of a microtiter plate. The apertures extend typically through the entire thickness of the guide plate. On one side of the guide plate is a resilient member that extends over one or more of the apertures thereby holding the post in place.

    摘要翻译： 使用邮票打印或掩盖基板服务上的材料的系统和方法。 在一个具体实施例中，系统和方法包括微接触印模，其具有多个刚性柱，每个刚性柱在其远端具有弹性垫。 每个柱安装在位于导向板中的孔内，使得柱可以在导向板内纵向移动。 引导板包括通常与微量滴定板的孔对准的各种孔。 孔通常延伸穿过导板的整个厚度。 在导向板的一侧是弹性构件，该弹性构件在一个或多个孔上延伸，从而将柱保持在适当位置。

    Manufacturing process for sample initiated assay device
    5.
    发明授权
    Manufacturing process for sample initiated assay device 失效
    样品启动测定装置的制造过程

    公开(公告)号：US5411858A

    公开(公告)日：1995-05-02

    申请号：US104934

    申请日：1993-08-12

    申请人： John K. McGeehan ,  Gerhard Ertingshausen ,  Timothy B. Meluch

    发明人： John K. McGeehan ,  Gerhard Ertingshausen ,  Timothy B. Meluch

    IPC分类号： B01L3/00 ,  C12Q1/00 ,  G01N33/53 ,  G01N33/543 ,  G01N33/558 ,  G01N35/00 ,  G01N37/00 ,  G01N33/531

    CPC分类号： B01L3/5023 ,  C12Q1/00 ,  G01N33/5302 ,  G01N33/54366 ,  G01N33/558 ,  B01L2200/12 ,  B01L2300/0825 ,  B01L2300/0887 ,  B01L2400/0406 ,  G01N2035/00168 ,  Y10S435/805 ,  Y10S435/97 ,  Y10S436/80 ,  Y10S436/805 ,  Y10S436/81

    摘要： A quantitative test device is manufactured using a feedback loop which allows one to modify continuously the dimensions of a reading scale printed on the device. The quantitative test device is manufactured by attaching the critical component of a two-component dye system to minute particles such as microcrystalline cellulose, silica, or latex, which particles are suspended in a solution of a polymeric binder. Additional non-immobilized components of the reaction system of the test device are optionally added to the polymer solution. The suspension of dyed particles in polymer solution is applied to a fabric as a coating, using conventional coating machines, to obtain a homogeneous distribution of immobilized dye throughout the fabric.The device includes a measurement zone which is made from a film support made of a material having a lower melting point than the filter cloth fabric used in the measurement zone was used. By using a lower melting point material for the support film, impulse heat sealing is controlled to a degree such that the lower melting point support is made to melt and extrude through the mesh of the fabric on either side of a channel, forming a seal along the sides of the channel.

    摘要翻译： 使用反馈回路制造定量测试装置，其允许连续修改印刷在装置上的读数标尺的尺寸。 定量测试装置通过将双组分染料体系的关键组分连接到微晶纤维素，二氧化硅或胶乳等微粒上而制成，该颗粒悬浮在聚合物粘合剂的溶液中。 任选地将该测试装置的反应体系的其它非固定化组分加入聚合物溶液中。 使用常规涂布机将染色颗粒在聚合物溶液中的悬浮液作为涂层施加到织物上，以获得固定的染料在整个织物中的均匀分布。 该装置包括由使用由具有比在测量区域中使用的滤布织物的熔点低的材料制成的薄膜支撑件制成的测量区域。 通过使用用于支撑膜的较低熔点的材料，脉冲热密封被控制到一定程度，使得较低熔点的支撑件通过织物的通道的两侧的网状物熔化和挤出，形成密封 渠道的两边。

    Method of preparing particles suitable for tabletting into diagnostic reagents
    6.
    发明授权
    Method of preparing particles suitable for tabletting into diagnostic reagents 失效
    制备适于压片成诊断试剂的颗粒的方法

    公开(公告)号：US4820627A

    公开(公告)日：1989-04-11

    申请号：US842968

    申请日：1986-03-24

    申请人： John K. McGeehan

    发明人： John K. McGeehan

    IPC分类号： C12Q1/00 ,  G01N33/48 ,  G01N33/531 ,  G01N33/548

    CPC分类号： C12Q1/00 ,  G01N33/531 ,  G01N33/548 ,  Y10T436/10 ,  Y10T436/25

    摘要： A completely water-soluble, solid, labile biochemical-containing diagnostic reagent is prepared without the need of a lyophilization step, by spraying, preferably by a fluidized bed process, an aqueous solution of labile biochemical, e.g., an enzyme, onto small particles, e.g., lower than 20 mesh, of an inert, completely water-soluble solid bulking agent, e.g., mannitol; drying the resultant labile biochemical-coated bulking agent to the desired dryness; and then forming resultant dried labile biochemical-coated bulking agent into a tablet suitable for a diagnostic test reagent, said tablet having a predetermined rate of dissolution.

    摘要翻译： 制备完全水溶性，固体，不稳定的含生物化学物质的诊断试剂，而不需要冷冻干燥步骤，优选通过流化床方法将不稳定生物化学物质例如酶的水溶液喷雾到小颗粒上， 例如低于20目的惰性完全水溶性固体填充剂，例如甘露糖醇; 将所得不稳定的生物化学涂覆的填充剂干燥至所需的干燥度; 然后将得到的干燥不稳定的生物化学包衣的填充剂形成适用于诊断试剂的片剂，所述片剂具有预定的溶解速率。

    Systems and methods for micro-contact stamping
    7.
    发明授权
    Systems and methods for micro-contact stamping 有权
    微接触冲压系统和方法

    公开(公告)号：US08449285B2

    公开(公告)日：2013-05-28

    申请号：US13011734

    申请日：2011-01-21

    申请人： John K. McGeehan

    发明人： John K. McGeehan

    IPC分类号： C23F1/00 ,  B29C59/02

    CPC分类号： C12M33/02 ,  B82Y10/00 ,  B82Y40/00 ,  G03F7/0002

    摘要： Systems and methods for using stamps to print or mask materials on a substrate service. In one particular embodiment, the systems and methods include a microcontacting stamp that has a plurality of rigid posts each having a resilient pad at its distal end. Each post is fitted within an aperture located in a guide plate such that the post may move longitudinally within the guide plate. The guide plate includes a variety of apertures that typically are aligned with the wells of a microtiter plate. The apertures extend typically through the entire thickness of the guide plate. On one side of the guide plate is a resilient member that extends over one or more of the apertures thereby holding the post in place.

    摘要翻译： 使用邮票打印或掩盖基板服务上的材料的系统和方法。 在一个具体实施例中，系统和方法包括微接触印模，其具有多个刚性柱，每个刚性柱在其远端具有弹性垫。 每个柱安装在位于导向板中的孔内，使得柱可以在导向板内纵向移动。 引导板包括通常与微量滴定板的孔对准的各种孔。 孔通常延伸穿过导板的整个厚度。 在导向板的一侧是弹性构件，该弹性构件在一个或多个孔上延伸，从而将柱保持在适当位置。

    Apparatus for red blood cell separation
    9.
    发明授权
    Apparatus for red blood cell separation 失效
    红细胞分离装置

    公开(公告)号：US5766552A

    公开(公告)日：1998-06-16

    申请号：US596828

    申请日：1996-02-05

    申请人： Sonal R. Doshi ,  John K. McGeehan ,  Wai Tak Law

    发明人： Sonal R. Doshi ,  John K. McGeehan ,  Wai Tak Law

    IPC分类号： B01L3/00 ,  G01N33/49 ,  G01N33/50 ,  G01N1/28 ,  B01L11/00

    CPC分类号： G01N33/491 ,  B01L3/5023 ,  G01N33/5002 ,  B01L2300/0681 ,  B01L2300/0825 ,  B01L2400/0406 ,  G01N33/92 ,  Y10S436/827

    摘要： Red blood cells are removed from whole blood or a fraction thereof by agglutinating whole blood with a mixture of a free agglutinating agent and nucleating particles having agglutinating agent intimately associated therewith to form clusters of red blood cells. High molecular weight polyethylene glycol may be added further to enhance agglutination. The clusters of red blood cells are much larger than the size of individual red blood cells, so that the clusters can easily be filtered through a porous medium. The plasma, which is substantially free of red blood cells, is further passed through a filter that optionally contains an additional agglutinating agent. Flow-delay additives may be provided to retain the fluid sample in contact with a reagent for a predetermined time.

    摘要翻译： 通过与自由凝集剂的混合物和具有与其紧密结合的凝集剂的成核颗粒的混合物凝集全血，从全血或其部分除去红细胞，形成红细胞簇。 可以进一步加入高分子量聚乙二醇以增强凝集。 红细胞簇比单个红细胞的大小大得多，从而可以容易地通过多孔介质过滤簇。 基本上不含红细胞的血浆进一步通过可选地含有另外的凝集剂的过滤器。 可以提供流动延迟添加剂以保持流体样品与试剂接触预定时间。

    Apparatus for red blood cell separation
    10.
    发明授权
    Apparatus for red blood cell separation 失效
    红细胞分离装置

    公开(公告)号：US5660798A

    公开(公告)日：1997-08-26

    申请号：US482853

    申请日：1995-06-07

    申请人： Sonal R. Doshi ,  John K. McGeehan ,  Wai Tak Law

    发明人： Sonal R. Doshi ,  John K. McGeehan ,  Wai Tak Law

    IPC分类号： B01L3/00 ,  G01N33/49 ,  G01N33/50 ,  B01L11/00

    CPC分类号： B01L3/5023 ,  G01N33/491 ,  G01N33/5002 ,  B01L2300/0681 ,  B01L2300/0825 ,  B01L2400/0406 ,  Y10S436/827

    摘要： Red blood cells are removed from whole blood or a fraction thereof by contacting whole blood with a combination of an agglutinating agent and nucleating particles to form clusters of red blood cells. High molecular weight polyethylene glycol may be added further to enhance agglutination. The clusters of red blood cells are much larger than the size of individual red blood cells, so that the clusters can easily be filtered through a porous medium. The plasma which is substantially free of red blood cells is further passed through a filter that optionally contains an additional agglutinating agent. Flow-delay means may be provided to return the fluid sample in contact with a regard for a predetermined time.

    摘要翻译： 通过使全血与凝集剂和成核颗粒的组合接触以形成红细胞簇，从全血或其部分除去红细胞。 可以进一步加入高分子量聚乙二醇以增强凝集。 红细胞簇比单个红细胞的大小大得多，从而可以容易地通过多孔介质过滤簇。 基本上不含红细胞的血浆进一步通过任选含有另外的凝集剂的过滤器。 可以提供流动延迟装置以使流体样品在预定时间内相接触。