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公开(公告)号：US10967994B2
公开(公告)日：2021-04-06
申请号：US16431549
申请日：2019-06-04
摘要： Systems and methods for aseptically filling pharmaceutical containers with pharmaceutical fluid are disclosed. In one general aspect, these are based on an aseptically sealable chamber that includes a transfer wall to which pre-sealed pharmaceutical source and receiving containers are mounted aseptically. A robotic arm and a syringe store are disposed within the chamber along with a sterilizing facility for establishing in the chamber an aseptic condition. The robotic arm can grip and operate syringes to inject and/or extract pharmaceutical products from the containers by piercing their closures with the needles of the syringes.
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2.发明申请公开(公告)号：US20180072446A1
公开(公告)日：2018-03-15
申请号：US15264554
申请日：2016-09-13
发明人： Juvenal Naing , Yakov Gofman , Marcin Cichy
CPC分类号： B65B55/027 , B65B3/003 , B65B43/50 , B65B55/06 , B65B55/10
摘要： A system for filling nested pharmaceutical containers with a pharmaceutical fluid is disclosed. In one general aspect, it comprises a sterilizable chamber containing a planar rotary stage with a fiducial locating structure for holding a pharmaceutical container nest. The chamber has a rotatable cover removal station, a rotatable filling station with a dispenser head, and camera guided vacuum pickup facilities for handling container and closure nests. An associated method for filling the containers comprises establishing an aseptic condition within the chamber; removing covers from a container tub and a container closure tub by operating both the rotary stage and the cover removal station. The vacuum pickup facility transfers into the fiducial locating structure a container nest bearing pharmaceutical containers. The fluid is dispensed into the containers by operating both the rotary stage and the filling station. A container closure nest is placed on the container nest in the fiducial locating structure with closures in correspondence with containers. A ram in the chamber forces the closures into the containers.
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公开(公告)号：US11980881B2
公开(公告)日：2024-05-14
申请号：US17887667
申请日：2022-08-15
IPC分类号： B01L1/02 , A61J1/12 , A61J1/14 , A61J1/20 , A61L2/07 , A61L2/16 , A61L2/24 , B01L1/04 , B01L3/02 , B25J21/00 , B65B3/00 , B65B3/04 , B65B55/12 , C12M1/00 , C12M1/12 , G01N35/00 , G01N35/10
CPC分类号： B01L1/025 , A61J1/12 , A61J1/14 , A61J1/20 , A61L2/07 , A61L2/16 , A61L2/24 , B01L1/04 , B01L3/02 , B25J21/00 , B65B3/003 , B65B3/04 , B65B55/12 , C12M29/00 , C12M37/02 , C12M41/14 , G01N35/00029 , G01N35/10 , B01L2200/026 , B01L2200/0689 , B01L2200/141 , B01L2300/0609 , B01L2300/0832 , B01L2400/0487 , G01N2035/00148 , G01N2035/00277 , G01N35/0099
摘要： The present invention involves a fill needle system for aseptically dispensing a pharmaceutical fluid in an aseptic chamber comprises a fill needle tubing in fluid communication with a pharmaceutical fluid source via flexible tubing and extending through a fill needle hub; a fill needle dispensing tip disposed at a dispensing end of the fill needle tubing; a fill needle sheath shaped and arranged to removably mate with and seal aseptically to the fill needle hub to form an aseptically sealed volume enclosing the dispensing tip; and a fluid pressure pulse induction system disposed and configured to compress the flexible tubing in order to dislodge droplets of pharmaceutical fluid retained on the dispensing tip after halting dispensing of the pharmaceutical fluid. An associated method of dispensing pharmaceutical fluid comprises operating the fluid pressure pulse induction system to dislodge the droplets. The system may comprise a controller for automatically controlling the dispensing and droplet dislodging.
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公开(公告)号：US10850873B2
公开(公告)日：2020-12-01
申请号：US15453615
申请日：2017-03-08
摘要： Systems and methods for aseptically filling pharmaceutical containers with pharmaceutical fluid are disclosed. In one general aspect, these are based on an aseptically sealable chamber that includes a transfer wall to which pre-sealed pharmaceutical source and receiving containers are mounted aseptically. A robotic arm and a syringe store are disposed within the chamber along with a sterilizing facility for establishing in the chamber an aseptic condition. The robotic arm can grip and operate syringes to inject and/or extract pharmaceutical products from the containers by piercing their closures with the needles of the syringes.
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公开(公告)号：US12037150B2
公开(公告)日：2024-07-16
申请号：US17588610
申请日：2022-01-31
发明人： Juvenal Naing , Yakov Gofman , Marcin Cichy , John Senger , Craig Rathe , Carlos Alberto Diaz Guerrero
CPC分类号： B65B3/003 , A61L2/20 , B65B43/60 , B65B55/18 , A61L2202/122 , A61L2202/14
摘要： The system of the invention involves a gloveless aseptic processing system. The automated system is for filling nested pharmaceutical containers with a pharmaceutical fluid substance. A closed sterilizable gloveless isolator chamber is capable of maintaining an aseptic condition, having a sterilization system. The container filling system has a dispensing head for filling the containers, and a container closing system disposed within the gloveless isolator chamber with rams for pushing closures into openings of the nested containers. The container manipulation mechanism is disposed within the gloveless isolator chamber and is capable of positioning the nested pharmaceutical containers within the gloveless isolator chamber including operably disposing the nested pharmaceutical containers with the container filling system and the container closing system. Container tubs sealed by removable covers and contain a container nest bearing a plurality of pre-sterilized pharmaceutical containers.
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公开(公告)号：US11554886B2
公开(公告)日：2023-01-17
申请号：US17008458
申请日：2020-08-31
摘要： Systems and methods for aseptically filling pharmaceutical containers with pharmaceutical fluid are disclosed. In one general aspect, these are based on an aseptically sealable chamber that includes a transfer wall to which pre-sealed pharmaceutical source and receiving containers are mounted aseptically. A robotic arm and a syringe store are disposed within the chamber along with a sterilizing facility for establishing in the chamber an aseptic condition. The robotic arm can grip and operate syringes to inject and/or extract pharmaceutical products from the containers by piercing their closures with the needles of the syringes.
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公开(公告)号：US11439999B2
公开(公告)日：2022-09-13
申请号：US16858599
申请日：2020-04-25
IPC分类号： B01L1/02 , A61L2/07 , C12M1/00 , A61L2/16 , A61L2/24 , B25J21/00 , C12M1/12 , A61J1/12 , A61J1/14 , A61J1/20 , B01L1/04 , B01L3/02 , B65B3/00 , B65B3/04 , B65B55/12 , G01N35/00 , G01N35/10
摘要： The present invention involves a fill needle system for aseptically dispensing a pharmaceutical fluid in an aseptic chamber comprises a fill needle tubing in fluid communication with a pharmaceutical fluid source via flexible tubing and extending through a fill needle hub; a fill needle dispensing tip disposed at a dispensing end of the fill needle tubing; a fill needle sheath shaped and arranged to removably mate with and seal aseptically to the fill needle hub to form an aseptically sealed volume enclosing the dispensing tip; and a fluid pressure pulse induction system disposed and configured to compress the flexible tubing in order to dislodge droplets of pharmaceutical fluid retained on the dispensing tip after halting dispensing of the pharmaceutical fluid. An associated method of dispensing pharmaceutical fluid comprises operating the fluid pressure pulse induction system to dislodge the droplets. The system may comprise a controller for automatically controlling the dispensing and droplet dislodging.
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公开(公告)号：US11103866B2
公开(公告)日：2021-08-31
申请号：US16185035
申请日：2018-11-09
IPC分类号： B01L1/02 , A61L2/07 , A61L2/16 , A61L2/24 , B25J21/00 , C12M1/00 , C12M1/12 , A61J1/12 , A61J1/14 , A61J1/20 , B01L1/04 , B01L3/02 , B65B3/00 , B65B3/04 , B65B55/12 , G01N35/00 , G01N35/10
摘要： The present invention involves a fill needle system for aseptically dispensing a pharmaceutical fluid in an aseptic chamber comprises a fill needle tubing in fluid communication with a pharmaceutical fluid source via flexible tubing and extending through a fill needle hub; a fill needle dispensing tip disposed at a dispensing end of the fill needle tubing; a fill needle sheath shaped and arranged to removably mate with and seal aseptically to the fill needle hub to form an aseptically sealed volume enclosing the dispensing tip; and a fluid pressure pulse induction system disposed and configured to compress the flexible tubing in order to dislodge droplets of pharmaceutical fluid retained on the dispensing tip after halting dispensing of the pharmaceutical fluid. An associated method of dispensing pharmaceutical fluid comprises operating the fluid pressure pulse induction system to dislodge the droplets. The system may comprise a controller for automatically controlling the dispensing and droplet dislodging.
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