公开(公告)号：US08746168B2

公开(公告)日：2014-06-10

申请号：US12892783

申请日：2010-09-28

Applicant: Hamed Abbasian ,  Pamela Chan ,  Valerio Ditizio ,  Vyacheslav Dudnyk ,  Zhaopeng Li ,  Said Loloie ,  Natali Yakeemovich ,  Frank DiCosmo

Inventor： Hamed Abbasian ,  Pamela Chan ,  Valerio Ditizio ,  Vyacheslav Dudnyk ,  Zhaopeng Li ,  Said Loloie ,  Natali Yakeemovich ,  Frank DiCosmo

IPC: B05C3/02 ,  C09D4/00 ,  A61L27/34 ,  A61L29/08 ,  C09D133/08 ,  C08F2/48 ,  A61L31/10 ,  C08J7/18 ,  C08L33/08

CPC classification number: C08F2/48 ,  A61L27/34 ,  A61L29/085 ,  A61L31/10 ,  A61L2400/10 ,  A61L2420/02 ,  C08J7/18 ,  C08L33/08 ,  C09D4/00 ,  C09D133/08

Abstract: A system and method for photo-grafting a coating polymer onto the surface of a medical device are provided. The system comprises a plurality of stations including a novel grafting station. The system and method of the invention are both time- and resource-efficient. The system includes several stations, each station including a dipping tank. The system allows for the automated, semi-automated, or manual dipping of medical devices into the dipping tanks in a specified order, as desired, wherein at least one of the stations is a grafting station for photo-grafting the coating polymer onto the surface of the medical device. The system is modular, which allows for modification of the process as required, depending on the needs of the user. The system may comprise stations for incorporating an antimicrobial agent into the coating, and/or for rendering the coating lubricious.

Abstract translation: 提供了一种用于将涂层聚合物光刻接到医疗器械表面上的系统和方法。 该系统包括多个站，包括一个新颖的移植站。 本发明的系统和方法既时间又资源有效。 该系统包括几个站，每个站包括一个浸渍槽。 该系统允许根据需要以特定的顺序将医疗装置自动化，半自动化或手动地浸入浸渍罐中，其中至少一个站是用于将涂层聚合物光刻接合到表面上的接枝站 的医疗器械。 该系统是模块化的，这允许根据需要修改过程，具体取决于用户的需求。 该系统可以包括用于将抗微生物剂并入涂层中的站和/或用于使涂层润滑的站。

公开(公告)号：US20110212152A1

公开(公告)日：2011-09-01

申请号：US12982178

申请日：2010-12-30

Applicant: Valerio Ditizio ,  Frank DiCosmo

Inventor： Valerio Ditizio ,  Frank DiCosmo

IPC: A61K9/00 ,  A61K47/48 ,  A61P31/00 ,  B05D3/06 ,  C25D5/48

CPC classification number: A61L27/34 ,  A61L27/54 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/104 ,  A61L2300/404 ,  A61L2300/452 ,  A61L2400/18

Abstract: Methods for making modified surfaces and in particular, surfaces that may be lubricious and may be further treated to be anti-microbial are disclosed. Devices comprising modified surfaces prepared by the methods are also disclosed. An exemplary method comprises incubating a photo-initiator-coated substrate in an aqueous monomer solution that is capable of free radical polymerization, exposing the incubating substrate to ultraviolet (UV) light creating a modified surface on the substrate. An anti-microbial agent may be added to the modified surface.

Abstract translation: 公开了制备改性表面，特别是可能是光滑的并可进一步处理为抗微生物的表面的方法。 还公开了包含通过该方法制备的改性表面的装置。 一种示例性方法包括将能够进行自由基聚合的单体水溶液中的光引发剂涂布的基材孵育，将培养基材暴露于紫外线（UV）光，从而在基材上产生改性表面。 可以将抗菌剂添加到改性表面。

公开(公告)号：US08920886B2

公开(公告)日：2014-12-30

申请号：US12892770

申请日：2010-09-28

Applicant: Hamed Abbasian ,  Pamela Chan ,  Valerio Ditizio ,  Vyacheslav Dudnyk ,  Zhaopeng Li ,  Said Loloie ,  Natali Yakeemovich ,  Frank DiCosmo

Inventor： Hamed Abbasian ,  Pamela Chan ,  Valerio Ditizio ,  Vyacheslav Dudnyk ,  Zhaopeng Li ,  Said Loloie ,  Natali Yakeemovich ,  Frank DiCosmo

IPC: C08J7/18 ,  A61L31/10 ,  C08F2/48 ,  C09D133/08 ,  A61L29/08 ,  C09D4/00 ,  A61L27/34 ,  C08L33/08

CPC classification number: C08F2/48 ,  A61L27/34 ,  A61L29/085 ,  A61L31/10 ,  A61L2400/10 ,  A61L2420/02 ,  C08J7/18 ,  C08L33/08 ,  C09D4/00 ,  C09D133/08

Abstract: One aspect of the present disclosure can include a method for grafting a coating polymer onto a surface of a device. The method can include the following steps: a) submerging the device into a photoinitiator solution; b) without first drying the device, submerging the device into a polymerizable solution; c) bubbling an oxygen-scavenging gas through the polymerizable solution; d) applying a UV light to the device to activate the photoinitiator, thereby grafting the coating polymer onto the device; and e) drying the device.

Abstract translation: 本公开的一个方面可以包括将涂覆聚合物接枝到设备的表面上的方法。 该方法可以包括以下步骤：a）将装置浸入光引发剂溶液中; b）没有首先干燥装置，将装置浸入可聚合溶液中; c）将氧气清除气体鼓泡通过可聚合溶液; d）向该装置施加UV光以激活光引发剂，从而将涂覆聚合物接枝到该装置上; 和e）干燥该装置。

公开(公告)号：US20110097402A1

公开(公告)日：2011-04-28

申请号：US11664184

申请日：2005-06-15

Applicant: Valerio Ditizio ,  Frank Dicosmo ,  Yuehua Xiao

Inventor： Valerio Ditizio ,  Frank Dicosmo ,  Yuehua Xiao

IPC: A61K9/00 ,  A61K33/38 ,  A61K33/34 ,  A61K33/24 ,  A61K31/164 ,  A61K31/4355

CPC classification number: A61K47/42 ,  A61K9/7007 ,  A61K47/10 ,  A61K47/36 ,  A61L15/225 ,  A61L15/325 ,  A61L15/425 ,  A61L31/041 ,  A61L31/045 ,  A61L31/146 ,  C08L5/00 ,  C08L5/04 ,  C08L5/08 ,  C08L71/00 ,  C08L89/00 ,  C08L89/06 ,  C08L2205/02 ,  C08L2666/26 ,  C08L2666/14 ,  C08L2666/02

Abstract: The present invention is a substantially non-adhesive elastic gelatin matrix. The matrix is both non-adhesive to wounds, tissues and organs and is also elastic such that it is flexible. The matrix is a lyophilized mixture of protein(s), polymer(s), cross-linking agent(s) and optional plasticizer(s). The invention also provides methods for making the non-adhesive elastic gelatin matrix.

Abstract translation: 本发明是基本上不粘的弹性明胶基体。 基质既不与伤口，组织和器官粘合，也具有弹性，使其柔韧。 基质是蛋白质，聚合物，交联剂和任选的增塑剂的冻干混合物。 本发明还提供了制造非粘性弹性明胶基质的方法。

公开(公告)号：US08354123B2

公开(公告)日：2013-01-15

申请号：US13166433

申请日：2011-06-22

Applicant: Valerio Ditizio ,  Frank Dicosmo ,  Yuehua Xiao

Inventor： Valerio Ditizio ,  Frank Dicosmo ,  Yuehua Xiao

IPC: A61K9/70

CPC classification number: A61K47/42 ,  A61K9/7007 ,  A61K47/10 ,  A61K47/36 ,  A61L15/225 ,  A61L15/325 ,  A61L15/425 ,  A61L31/041 ,  A61L31/045 ,  A61L31/146 ,  C08L5/00 ,  C08L5/04 ,  C08L5/08 ,  C08L71/00 ,  C08L89/00 ,  C08L89/06 ,  C08L2205/02 ,  C08L2666/26 ,  C08L2666/14 ,  C08L2666/02

Abstract: The present invention is a substantially non-adhesive elastic gelatin matrix. The matrix is both non-adhesive to wounds, tissues and organs and is also elastic such that it is flexible. The matrix is a lyophilized mixture of protein(s), polymer(s), cross-linking agent(s) and optional plasticizer(s). The invention also provides methods for making the non-adhesive elastic gelatin matrix.

Abstract translation: 本发明是基本上不粘的弹性明胶基体。 基质既不与伤口，组织和器官粘合，也具有弹性，使其柔韧。 基质是蛋白质，聚合物，交联剂和任选的增塑剂的冻干混合物。 本发明还提供了制造非粘性弹性明胶基质的方法。

公开(公告)号：US20110104390A1

公开(公告)日：2011-05-05

申请号：US12892770

申请日：2010-09-28

Applicant: Hamed Abbasian ,  Pamela Chan ,  Valerio Ditizio ,  Vyacheslav Dudnyk ,  Zhaopeng Li ,  Said Loloie ,  Natali Yakeemovich ,  Frank Dicosmo

Inventor： Hamed Abbasian ,  Pamela Chan ,  Valerio Ditizio ,  Vyacheslav Dudnyk ,  Zhaopeng Li ,  Said Loloie ,  Natali Yakeemovich ,  Frank Dicosmo

IPC: C08J7/18

CPC classification number: C08F2/48 ,  A61L27/34 ,  A61L29/085 ,  A61L31/10 ,  A61L2400/10 ,  A61L2420/02 ,  C08J7/18 ,  C08L33/08 ,  C09D4/00 ,  C09D133/08

Abstract: A system and method for photo-grafting a coating polymer onto the surface of a medical device are provided. The system comprises a plurality of stations including a novel grafting station. The system and method of the invention are both time- and resource-efficient. The system includes several stations, each station including a dipping tank. The system allows for the automated, semi-automated, or manual dipping of medical devices into the dipping tanks in a specified order, as desired, wherein at least one of the stations is a grafting station for photo-grafting the coating polymer onto the surface of the medical device. The system is modular, which allows for modification of the process as required, depending on the needs of the user. The system may comprise stations for incorporating an antimicrobial agent into the coating, and/or for rendering the coating lubricious.