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公开(公告)号：US10292631B1
公开(公告)日：2019-05-21
申请号：US14957840
申请日：2015-12-03
发明人： Andrew Homyk , Jerrod Joseph Schwartz , Alberto Clemente Vitari , Joshua Simon Klein , Mark Audeh
IPC分类号： A61B5/1455 , A61B5/1459 , A61B5/145
摘要： Body-mountable devices are provided to detect the presence or status of a tumor in a body by detecting one or more properties of a probe located in subsurface vasculature of the body. A wearable body-mountable device can be worn for a protracted period of time to detect a probe in the vasculature at low concentrations and/or at low rates. A body-mountable device can detect properties of the probe that are indicative of whether the probe has interacted with a tumor of the body and determine the presence or status of a tumor in the body based on such detected properties. Additionally or alternatively, the probe could be introduced into the body as a probe aggregate and released from if the probe aggregate is absorbed by a tumor. The presence of released probes could be detected to determine a presence or status of a tumor in the body.
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公开(公告)号：US10105080B1
公开(公告)日：2018-10-23
申请号：US14583978
申请日：2014-12-29
发明人： Kimberly Kam , Jerrod Joseph Schwartz , Gary Tong
摘要： Devices are provided that include a plurality of microneedles that penetrate skin and that receive interstitial fluid from the skin tissue. The microneedles are further configured to direct the received interstitial fluid to nanosensors configured to change an optical property based on interaction with an analyte in the received interstitial fluid, allowing optical detection of the analyte. Direction of the received interstitial fluid to the nanosensors can be facilitated by a pump configured to control the flow rate of the interstitial fluid through the microneedles. Such devices could be configured to detect the analyte independently or in combination with a reader device configured to be periodically mounted to the devices and to detect the analyte. Further, such devices can include delivery systems configured to transdermally deliver a drug or other substance into or through the skin in response to a detected concentration, presence, or other property of the analyte.
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公开(公告)号：US10028659B2
公开(公告)日：2018-07-24
申请号：US14669424
申请日：2015-03-26
IPC分类号： A61B5/00 , A61B5/07 , A61B5/145 , A61B5/1459 , A61B5/1473 , A61B5/1455
摘要： A system for measuring and/or monitoring an analyte present in interstitial fluid in skin is provided. The system includes a substrate that may be implanted into the skin and a reader device. The substrate includes a sensor comprising aptamer conjugates and is configured to obtain one or more measurements related to at least one analyte in interstitial fluid. The reader device is configured to detect the analyte in interstitial fluid via interaction with the substrate.
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公开(公告)号：US09874554B1
公开(公告)日：2018-01-23
申请号：US14333161
申请日：2014-07-16
CPC分类号： G01N33/54333 , A61B5/0515 , A61B5/14532 , A61B5/681
摘要： A system for modulating a response signal includes aptamer conjugates, e.g., aptamer-particle conjugates, configured to bind with target analytes, a detector configured to detect an analyte response signal transmitted from the body, a modulation source configured to modulate the analyte response signal, and a processor configured to non-invasively detect the one or more target analytes by differentiating the analyte response signal from a background signal, at least in part, based on the modulation. The analyte response signal is related to the binding interaction of the target analytes with the aptamer-particle conjugates. In some examples, the system may also include magnetic particles and a magnetic field source sufficient to distribute the magnetic particles into a spatial arrangement in the body. The analyte response signal may be differentiated from the background signal, at least in part, based on modulation of the signals due, at least in part, to the spatial arrangement of the magnetic particles.
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公开(公告)号：US09861710B1
公开(公告)日：2018-01-09
申请号：US14599435
申请日：2015-01-16
发明人： Timothy Tordella Ruckh , Kimberly Kam , Jerrod Joseph Schwartz , Vasiliki Demas , Andrew Peter Homyk
CPC分类号： A61K49/0054 , A61B5/05 , A61B5/145 , A61K49/0013 , B29B9/10 , B29L2031/00
摘要： A system is provided which includes the composite nanoparticles configured to bind with a target analyte, the composite nanoparticles including a polymer matrix; nanoparticles at least one type; reporter labels at least one type; and targeting entities at least one type, wherein the nanoparticles at least one type, the reporter labels at least one type and the targeting entities at least one type are encapsulated in the polymer matrix; a body-mountable device mounted on an external surface of a living body and configured to detect a target analyte binding response signal transmitted through the external surface, wherein the target analyte binding response signal is related to binding of the composite nanoparticles with one or more target analytes; and a processor configured to non-invasively detect the one or more target analytes based on the target analyte response signal. Composite nanoparticles and methods for use and for making are also provided.
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公开(公告)号：US10674949B1
公开(公告)日：2020-06-09
申请号：US15946416
申请日：2018-04-05
IPC分类号： A61B5/00 , A61B5/1455 , A61B5/05 , A61B5/0205 , A61B5/145
摘要： A light source emits light into a first portion of a living body. Functionalized particles within the body are configured to specifically bind to a target analyte, and upon receiving the emitted light, undergo a reaction that separates a detectable label from the functionalized particle. A sensor device is configured to detect a response signal from a second portion of the living body that is indicative of an abundance of the detectable label in the second portion. A control system uses the sensor device to obtain sensor data indicative of the response signal from the second portion of the living body detected by the sensor device during a measurement interval, and determines a presence or absence of the target analyte within the first portion of the living body based in part on the obtained data.
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公开(公告)号：US10386300B2
公开(公告)日：2019-08-20
申请号：US15384918
申请日：2016-12-20
IPC分类号： G01N21/64 , G06T7/90 , G02B21/16 , G02B21/36 , G02B26/08 , G02F1/29 , G01J3/02 , G01J3/08 , G01J3/14 , G01J3/18 , G01J3/28 , G01J3/32 , G01J3/44 , G02B5/18 , G01J3/12
摘要： Methods are provided to identify spatially and spectrally multiplexed probes in a biological environment. Such probes are identified by the ordering and color of fluorophores of the probes. The devices and methods provided facilitate determination of the locations and colors of such fluorophores, such that a probe can be identified. In some embodiments, probes are identified by applying light from a target environment to a spatial light modulator that can be used to control the direction and magnitude of chromatic dispersion of the detected light; multiple images of the target, corresponding to multiple different spatial light modulator settings, can be deconvolved and used to determine the colors and locations of fluorophores. In some embodiments, light from a region of the target can be simultaneously imaged spatially and spectrally. Correlations between the spatial and spectral images over time can be used to determine the color of fluorophores in the target.
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公开(公告)号：US09968688B2
公开(公告)日：2018-05-15
申请号：US14539415
申请日：2014-11-12
发明人： Alberto Clemente Vitari , Joshua Simon Klein , Jerrod Joseph Schwartz , Andrew Homyk , Marija Pavlovic
IPC分类号： A61B5/05 , A61K47/48 , A61K49/00 , A61K47/30 , A61M5/00 , A61B5/00 , G01R33/56 , A61B5/145 , A61K49/18 , A61K51/12 , A61B8/08 , A61B6/00
CPC分类号： A61K47/6921 , A61B5/0071 , A61B5/0515 , A61B5/14546 , A61B5/681 , A61B6/481 , A61B8/481 , A61K47/30 , A61K47/61 , A61K47/62 , A61K47/6849 , A61K47/6851 , A61K47/6923 , A61K47/6929 , A61K49/0002 , A61K49/0004 , A61K49/1824 , A61K51/1244 , A61M5/007 , G01R33/5601
摘要： A system is provided which includes nanoparticle conjugates configured to bind with a tumor cell, the nanoparticle conjugate comprising a nanoparticle, at least one targeting entity bound to the nanoparticle, and at least one shielding entity that shields at the at least one targeting entity, the nanoparticle, or both; a body-mountable device mounted on an external surface of a living body and configured to detect a tumor cell binding response signal transmitted through the external surface, wherein the tumor cell binding response signal is related to binding of the nanoparticle conjugates with one or more tumor cells; and a processor configured to non-invasively detect the one or more tumor cells based on the tumor cell response signal. Nanoparticle conjugates and methods for use for treating or imaging tumor cells are also provided.
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公开(公告)号：US09936908B1
公开(公告)日：2018-04-10
申请号：US14558389
申请日：2014-12-02
IPC分类号： A61B5/00 , A61B5/1455 , A61B5/05 , A61B5/0205 , A61B5/145
CPC分类号： A61B5/14556 , A61B5/0022 , A61B5/02055 , A61B5/0515 , A61B5/14546 , A61B5/4839 , A61B5/681 , A61B5/742 , A61B5/746
摘要： A light source emits light into a first portion of a living body. Functionalized particles within the body are configured to specifically bind to a target analyte, and upon receiving the emitted light, undergo a reaction that separates a detectable label from the functionalized particle. A sensor device is configured to detect a response signal from a second portion of the living body that is indicative of an abundance of the detectable label in the second portion. A control system uses the sensor device to obtain sensor data indicative of the response signal from the second portion of the living body detected by the sensor device during a measurement interval, and determines a presence or absence of the target analyte within the first portion of the living body based in part on the obtained data.
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公开(公告)号：US10034625B1
公开(公告)日：2018-07-31
申请号：US14492255
申请日：2014-09-22
IPC分类号： A61B5/1455 , A61B5/145 , A61B5/00
CPC分类号： A61B5/14517 , A61B5/0071 , A61B5/1451 , A61B5/1468 , A61B5/681 , A61B5/6833 , A61B2560/0214
摘要： A system for measuring and/or monitoring an analyte present on the skin is provided. The system includes a substrate that may be attached to an external skin surface and a reader device. The substrate includes a sensor comprising aptamer conjugates and is configured to obtain one or more measurements related to at least one analyte in the perspiration or interstitial fluid. The reader device is configured to detect the analyte in the least one of perspiration or interstitial fluid via interaction with the substrate.
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