Modified carbon, silicon, & germanium surfaces
    7.
    发明授权
    Modified carbon, silicon, & germanium surfaces 有权
    改性碳,硅和锗表面

    公开(公告)号:US06569979B1

    公开(公告)日:2003-05-27

    申请号:US09659442

    申请日:2000-09-08

    IPC分类号: C08G7700

    摘要: Chemically-modified surfaces on unoxidized carbon, silicon, and germanium substrates are disclosed. Ultraviolet radiation mediates the reaction of protected &ohgr;-modified, &agr;-unsaturated aminoalkenes (preferred) with hydrogen-terminated carbon, silicon, or germanium surfaces. Removal of the protecting group yields an aminoalkane-modified silicon surface. These amino groups can be coupled to terminal-modified oligonucleotides using a bifunctional crosslinker, thereby permitting the preparation of modified surfaces and arrays. Methods for controlling the surface density of molecules attached to the substrate are also disclosed.

    摘要翻译: 公开了未氧化的碳,硅和锗衬底上的化学修饰的表面。 紫外线辐射介导受保护的ω-改性的α-不饱和氨基烯烃(优选)与氢封端的碳,硅或锗表面的反应。 去除保护基产生氨基烷烃改性的硅表面。 这些氨基可以使用双功能交联剂与末端修饰的寡核苷酸偶联,从而允许制备改性的表面和阵列。 还公开了用于控制附着于基底的分子的表面密度的方法。

    Ordered organic monolayers and methods of preparation thereof
    8.
    发明授权
    Ordered organic monolayers and methods of preparation thereof 失效
    有序有机单层及其制备方法

    公开(公告)号:US5908692A

    公开(公告)日:1999-06-01

    申请号:US786873

    申请日:1997-01-23

    摘要: Systems and methods for fabricating ordered anisotropic organic monolayers are described. An apparatus includes a substrate including a surface; and an ordered organic monolayer chemically bonded to the surface, the ordered organic monolayer including a plurality of cyclic organic molecules, each of the plurality of cyclic organic molecules being obtained from an unsaturated cyclic organic reactant that is chemically bonded to the surface through an addition reaction. The systems and methods provide advantages in that translational and rotational order from the substrate is extended into the monolayer.

    摘要翻译: 描述了制备有序各向异性有机单层的系统和方法。 一种装置,包括:包括表面的基板; 化学键合到表面的有序有机单层,有序的有机单层包括多个环状有机分子,多个环状有机分子中的每一个均由不饱和的环状有机反应物获得,所述不饱和环状有机反应物通过加成反应与表面化学键合 。 这些系统和方法提供了优点,即从底物的平移和旋转顺序延伸到单层中。

    SURFACE PLASMON RESONANCE COMPATIBLE CARBON THIN FILMS
    9.
    发明申请
    SURFACE PLASMON RESONANCE COMPATIBLE CARBON THIN FILMS 有权
    表面等离子体共混碳薄膜

    公开(公告)号:US20090141376A1

    公开(公告)日:2009-06-04

    申请号:US12037332

    申请日:2008-02-26

    CPC分类号: G01N21/553 G02B5/04

    摘要: SPR-compatible substrates for high density microarray fabrication and analyses are provided. Novel carbon-on-metal thin film substrate architecture permits the integration of surface plasmon resonance detection with photolithographically fabricated biomolecule arrays for the analysis of biomolecular interactions. The utility of the technology is shown in the analysis of specific DNA-DNA, DNA-RNA and DNA-protein binding interactions. These new substrates may be used to determine the secondary structure of RNA molecules, to probe the sequence-specific binding kinetics and affinity of proteins and small molecules, and as substrates for small-molecule combinatorial chemistry platforms for drug discovery applications.

    摘要翻译: 提供了用于高密度微阵列制造和分析的SPR兼容基板。 新的碳 - 金属薄膜基板架构允许将表面等离子体共振检测与光刻制造的生物分子阵列整合以用于生物分子相互作用的分析。 该技术的实用性在特异性DNA-DNA,DNA-RNA和DNA-蛋白结合相互作用的分析中显示。 这些新的底物可用于确定RNA分子的二级结构,以探测序列特异性结合动力学和蛋白质和小分子的亲和力,以及作为用于药物发现应用的小分子组合化学平台的底物。

    Halogen-modified silicon, surfaces
    10.
    发明授权
    Halogen-modified silicon, surfaces 有权
    卤素改性硅,表面

    公开(公告)号:US06689858B2

    公开(公告)日:2004-02-10

    申请号:US09770885

    申请日:2001-01-26

    IPC分类号: C08G7700

    摘要: Chemically-modified surfaces on unoxidized, bromine- or iodine-terminated carbon, silicon, and germanium substrates are disclosed. Visible light mediates the reaction of protected &ohgr;-modified, &agr;-unsaturated aminoalkenes (preferred) with bromine- or iodine-terminated carbon, silicon, or germanium surfaces. Removal of the protecting group yields an aminoalkane-modified silicon surface. These amino groups can be coupled to terminal-modified oligonucleotides using a bifunctional crosslinker, thereby permitting the preparation of modified surfaces and arrays. Methods for controlling the surface density of molecules attached to the substrate are also disclosed.

    摘要翻译: 公开了未氧化,溴或碘封端的碳,硅和锗衬底上的化学修饰的表面。 可见光介导受保护的ω-改性的α-不饱和氨基烯烃(优选)与溴或碘封端的碳,硅或锗表面的反应。 去除保护基产生氨基烷烃改性的硅表面。 这些氨基可以使用双功能交联剂与末端修饰的寡核苷酸偶联,从而允许制备改性的表面和阵列。 还公开了用于控制附着于基底的分子的表面密度的方法。