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    Rapid classification of biological components
    1.
    发明授权
    Rapid classification of biological components 失效
    快速分类生物成分

    公开(公告)号：US07682798B2

    公开(公告)日：2010-03-23

    申请号：US11101254

    申请日：2005-04-06

    申请人： Vicki S. Thompson ,  Karen B. Barrett ,  Diane E. Key

    发明人： Vicki S. Thompson ,  Karen B. Barrett ,  Diane E. Key

    IPC分类号： G01N33/00 ,  G01N33/543

    CPC分类号： G01N33/543 ,  G01N33/94 ,  Y10S435/971 ,  Y10S435/973 ,  Y10S435/975

    摘要： A method is disclosed for analyzing a biological sample by antibody profiling for identifying forensic samples or for detecting the presence of an analyte. In an illustrative embodiment of the invention, the analyte is a drug, such as marijuana, Cocaine (crystalline tropane alkaloid), methamphetamine, methyltestosterone, or mesterolone. The method involves attaching antigens of the surface of a solid support in a preselected pattern to form an array wherein the locations of the antigens are known; contacting the array with the biological sample such that a portion of antibodies in the sample reacts with and binds to antigens in the array, thereby forming immune complexes; washing away antibodies that do not form immune complexes; and detecting the immune complexes, thereby forming an antibody profile. Forensic samples are identified by comparing a sample from an unknown source with a sample from a known source. Further, an assay, such as a test for illegal drug use, can be coupled to a test for identity such that the results of the assay can be positively correlated to a subject's identity.

    摘要翻译： 公开了一种用于通过抗体分析来分析生物样品以识别法医样品或用于检测分析物的存在的方法。 在本发明的说明性实施方案中，分析物是药物，例如大麻，可卡因（结晶托烷生物碱），甲基苯丙胺，甲基睾酮或甲酯。 该方法包括以预选图案附着固体支持物表面的抗原以形成阵列，其中抗原的位置是已知的; 使阵列与生物样品接触，使得样品中的一部分抗体与阵列中的抗原反应并结合抗原，从而形成免疫复合物; 洗掉不形成免疫复合物的抗体; 并检测免疫复合物，从而形成抗体谱。 通过将来自未知来源的样品与来自已知来源的样品进行比较来鉴定法医样品。 此外，诸如用于非法药物使用的试验的测定可以与身份的测试相结合，使得测定的结果可以与受试者的身份正相关。

    Rapid classification of biological components
    2.
    发明授权
    Rapid classification of biological components 失效

    公开(公告)号：US06989276B2

    公开(公告)日：2006-01-24

    申请号：US10017577

    申请日：2001-12-14

    申请人： Vicki S. Thompson ,  Karen B. Barrett ,  Diane E. Key

    发明人： Vicki S. Thompson ,  Karen B. Barrett ,  Diane E. Key

    IPC分类号： G01N33/543

    CPC分类号： G01N33/543 ,  G01N33/94 ,  Y10S435/971 ,  Y10S435/973 ,  Y10S435/975

    摘要： A method is disclosed for analyzing a biological sample by antibody profiling for identifying forensic samples or for detecting the presence of an analyte. In an illustrative embodiment of the invention, the analyte is a drug, such as marijuana, cocaine, methamphetamine, methyltestosterone, or mesterolone. The method involves attaching antigens to the surface of a solid support in a preselected pattern to form an array wherein the locations of the antigens are known; contacting the array with the biological sample such that a portion of antibodies in the sample reacts with and binds to antigens in the array, thereby forming immune complexes; washing away antibodies that do form immune complexes; and detecting the immune complexes, thereby forming an antibody profile. Forensic samples are identified by comparing a sample from an unknown source with a sample from a known source. Further, an assay, such as a test for illegal drug use, can be coupled to a test for identity such that the results of the assay can be positively correlated to the subject's identity.

    Rapid classification of biological components
    3.
    发明授权
    Rapid classification of biological components 失效
    快速分类生物成分

    公开(公告)号：US07682797B2

    公开(公告)日：2010-03-23

    申请号：US11101216

    申请日：2005-04-06

    申请人： Vicki S. Thompson ,  Karen B. Barrett ,  Diane E. Key

    发明人： Vicki S. Thompson ,  Karen B. Barrett ,  Diane E. Key

    IPC分类号： G01N33/00 ,  G01N33/543

    CPC分类号： G01N33/543 ,  G01N33/94 ,  Y10S435/971 ,  Y10S435/973 ,  Y10S435/975

    摘要： A method is disclosed for analyzing a biological sample by antibody profiling for identifying forensic samples or for detecting the presence of an analyte. In an illustrative embodiment of the invention, the analyte is a drug, such as marijuana, cocaine (crystalline tropane alkaloid), methamphetamine, methyltestosterone, or mesterolone. The method involves attaching antigens to a surface of a solid support in a preselected pattern to form an array wherein the locations of the antigens are known; contacting the array with the biological sample such that a portion of antibodies in the sample reacts with and binds to antigens in the array, thereby forming immune complexes; washing away antibodies that do not form immune complexes; and detecting the immune complexes, thereby forming an antibody profile. Forensic samples are identified by comparing a sample from an unknown source with a sample from a known source. Further, an assay, such as a test for illegal drug use, can be coupled to a test for identity such that the results of the assay can be positively correlated to a subject's identity.

    摘要翻译： 公开了一种用于通过抗体分析来分析生物样品以识别法医样品或用于检测分析物的存在的方法。 在本发明的说明性实施方案中，分析物是药物，例如大麻，可卡因（结晶托烷生物碱），甲基苯丙胺，甲基睾酮或甲酯。 该方法包括将抗原以预选图案附着在固体支持物的表面上以形成阵列，其中抗原的位置是已知的; 使阵列与生物样品接触，使得样品中的一部分抗体与阵列中的抗原反应并结合抗原，从而形成免疫复合物; 洗掉不形成免疫复合物的抗体; 并检测免疫复合物，从而形成抗体谱。 通过将来自未知来源的样品与来自已知来源的样品进行比较来鉴定法医样品。 此外，诸如用于非法药物使用的试验的测定可以与身份的测试相结合，使得测定的结果可以与受试者的身份正相关。

    Rapid classification of biological components
    4.
    再颁专利
    Rapid classification of biological components 失效
    快速分类生物成分

    公开(公告)号：USRE44539E1

    公开(公告)日：2013-10-15

    申请号：US13425181

    申请日：2012-03-20

    申请人： Vicki S. Thompson ,  Karen B. Barrett ,  Diane E. Key

    发明人： Vicki S. Thompson ,  Karen B. Barrett ,  Diane E. Key

    IPC分类号： G01N31/00 ,  G01N33/53

    CPC分类号： G01N33/543 ,  G01N33/94 ,  Y10S435/971 ,  Y10S435/973 ,  Y10S435/975

    摘要： A method is disclosed for analyzing a biological sample by antibody profiling for identifying forensic samples or for detecting the presence of an analyte. In an illustrative embodiment of the invention, the analyte is a drug, such as marijuana, cocaine (crystalline tropane alkaloid), methamphetamine, methyltestosterone, or mesterolone. The method involves attaching antigens to a surface of a solid support in a preselected pattern to form an array wherein the locations of the antigens are known; contacting the array with the biological sample such that a portion of antibodies in the sample reacts with and binds to antigens in the array, thereby forming immune complexes; washing away antibodies that do not form immune complexes; and detecting the immune complexes, thereby forming an antibody profile. Forensic samples are identified by comparing a sample from an unknown source with a sample from a known source. Further, an assay, such as a test for illegal drug use, can be coupled to a test for identity such that the results of the assay can be positively correlated to a subject's identity.

    摘要翻译： 公开了一种用于通过抗体分析来分析生物样品以识别法医样品或用于检测分析物的存在的方法。 在本发明的说明性实施方案中，分析物是药物，例如大麻，可卡因（结晶托烷生物碱），甲基苯丙胺，甲基睾酮或甲酯。 该方法包括将抗原以预选图案附着在固体支持物的表面上以形成阵列，其中抗原的位置是已知的; 使阵列与生物样品接触，使得样品中的一部分抗体与阵列中的抗原反应并结合抗原，从而形成免疫复合物; 洗掉不形成免疫复合物的抗体; 并检测免疫复合物，从而形成抗体谱。 通过将来自未知来源的样品与来自已知来源的样品进行比较来鉴定法医样品。 此外，诸如用于非法药物使用的试验的测定可以与身份的测试相结合，使得测定的结果可以与受试者的身份正相关。