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    Methods of combined bioprocessing and related microorganisms, thermophilic and/or acidophilic enzymes, and nucleic acids encoding said enzymes
    3.
    发明授权
    Methods of combined bioprocessing and related microorganisms, thermophilic and/or acidophilic enzymes, and nucleic acids encoding said enzymes 有权
    组合生物处理方法和相关微生物，嗜热和/或嗜酸酶以及编码所述酶的核酸

    公开(公告)号：US08492114B2

    公开(公告)日：2013-07-23

    申请号：US12587229

    申请日：2009-10-02

    申请人： David N. Thompson ,  William A. Apel ,  Vicki S. Thompson ,  Thomas E. Ward

    发明人： David N. Thompson ,  William A. Apel ,  Vicki S. Thompson ,  Thomas E. Ward

    IPC分类号： C12P1/00 ,  C12S3/00 ,  C12N1/00 ,  C12N9/00

    CPC分类号： C12P19/14 ,  C12N15/52 ,  C12P7/065 ,  C12P7/10 ,  C12P7/14 ,  C12P19/02 ,  Y02E50/16 ,  Y02E50/17

    摘要： A genetically modified organism comprising: at least one nucleic acid sequence and/or at least one recombinant nucleic acid isolated from Alicyclobacillus acidocaldarius and encoding a polypeptide involved in at least partially degrading, cleaving, transporting, metabolizing, or removing polysaccharides, cellulose, lignocellulose, hemicellulose, lignin, starch, sugars, sugar oligomers, carbohydrates, complex carbohydrates, chitin, heteroxylans, glycosides, xylan-, glucan-, galactan-, or mannan-decorating groups; and at least one nucleic acid sequence and/or at least one recombinant nucleic acid encoding a polypeptide involved in fermenting sugar molecules to a product. Additionally, enzymatic and/or proteinaceous extracts may be isolated from one or more genetically modified organisms. The extracts are utilized to convert biomass into a product. Further provided are methods of converting biomass into products comprising: placing the genetically modified organism and/or enzymatic extracts thereof in fluid contact with polysaccharides, cellulose, lignocellulose, hemicellulose, lignin, starch, sugars, sugar oligomers, carbohydrates, complex carbohydrates, chitin, heteroxylans, glycosides, and/or xylan-, glucan-, galactan-, or mannan-decorating groups.

    摘要翻译： 一种遗传修饰的生物体，包含：至少一种核酸序列和/或至少一种从酸性脂环酸杆菌分离的重组核酸，并编码参与至少部分降解，切割，转运，代谢或去除多糖，纤维素，木质纤维素， 半纤维素，木质素，淀粉，糖，糖低聚物，碳水化合物，复合碳水化合物，壳多糖，异木聚糖，糖苷，木聚糖，葡聚糖，半乳聚糖或甘露聚糖装饰组; 以及至少一种核酸序列和/或至少一种编码参与将糖分子发酵到产品中的多肽的重组核酸。 此外，酶和/或蛋白质提取物可以从一种或多种遗传修饰的生物体分离。 提取物用于将生物质转化成产物。 还提供了将生物质转化成产物的方法，其包括：将经遗传修饰的生物体和/或其酶提取物与多糖，纤维素，木质纤维素，半纤维素，木质素，淀粉，糖，糖低聚物，碳水化合物，复合碳水化合物，甲壳素， 异构木糖，糖苷和/或木聚糖，葡聚糖，半乳聚糖或甘露聚糖装饰组。

    Antibody profiling sensitivity through increased reporter antibody layering
    5.
    再颁专利
    Antibody profiling sensitivity through increased reporter antibody layering 有权
    通过增加报告抗体分层的抗体谱分析灵敏度

    公开(公告)号：USRE44031E1

    公开(公告)日：2013-02-26

    申请号：US13439400

    申请日：2012-04-04

    申请人： William A. Apel ,  Vicki S. Thompson

    发明人： William A. Apel ,  Vicki S. Thompson

    IPC分类号： G01N33/53 ,  G01N31/00

    CPC分类号： G01N33/543 ,  G01N33/94

    摘要： A method for analyzing a biological sample by antibody profiling for identifying forensic samples or for detecting the presence of an analyte. In an embodiment of the invention, the analyte is a drug, such as marijuana, Cocaine (crystalline tropane alkaloid), methamphetamine, methyltestosterone, or mesterolone. The method comprises attaching antigens to a surface of a solid support in a preselected pattern to form an array wherein locations of the antigens are known; contacting the array with the biological sample such that a portion of antibodies in the sample reacts with and binds to the antigens in the array to form immune complexes; washing away antibodies that do form immune complexes; and detecting the immune complexes, to form an antibody profile. Forensic samples are identified by comparing a sample from an unknown source with a sample from a known source. Further, an assay, such as a test for illegal drug use, can be coupled to a test for identity such that the results of the assay can be positively correlated to the subject's identity.

    摘要翻译： 用于通过抗体分析分析生物样品以鉴定法医样品或用于检测分析物的存在的方法。 在本发明的一个实施方案中，分析物是药物，例如大麻，可卡因（结晶托烷生物碱），甲基苯丙胺，甲基睾酮或甲酯。 该方法包括将抗原以预先选择的图案附着在固体支持物的表面上以形成阵列，其中抗原的位置是已知的; 使阵列与生物样品接触，使得样品中的一部分抗体与阵列中的抗原反应并结合以形成免疫复合物; 洗掉形成免疫复合物的抗体; 并检测免疫复合物，形成抗体谱。 通过将来自未知来源的样品与来自已知来源的样品进行比较来鉴定法医样品。 此外，诸如用于非法药物使用的测试的测定可以与身份的测试相结合，使得测定的结果可以与受试者的身份正相关。

    Methods of combined bioprocessing and related microorganisms, thermophilic and/or acidophilic enzymes, and nucleic acids encoding said enzymes
    10.
    发明申请
    Methods of combined bioprocessing and related microorganisms, thermophilic and/or acidophilic enzymes, and nucleic acids encoding said enzymes 有权
    组合生物处理方法和相关微生物，嗜热和/或嗜酸酶以及编码所述酶的核酸

    公开(公告)号：US20110081683A1

    公开(公告)日：2011-04-07

    申请号：US12587229

    申请日：2009-10-02

    申请人： David N. Thompson ,  William A. Apel ,  Vicki S. Thompson ,  Thomas E. Ward

    发明人： David N. Thompson ,  William A. Apel ,  Vicki S. Thompson ,  Thomas E. Ward

    IPC分类号： C12P19/00 ,  C12N1/21 ,  C07K14/195

    CPC分类号： C12P19/14 ,  C12N15/52 ,  C12P7/065 ,  C12P7/10 ,  C12P7/14 ,  C12P19/02 ,  Y02E50/16 ,  Y02E50/17

    摘要： A genetically modified organism comprising: at least one nucleic acid sequence and/or at least one recombinant nucleic acid isolated from Alicyclobacillus acidocaldarius and encoding a polypeptide involved in at least partially degrading, cleaving, transporting, metabolizing, or removing polysaccharides, cellulose, lignocellulose, hemicellulose, lignin, starch, sugars, sugar oligomers, carbohydrates, complex carbohydrates, chitin, heteroxylans, glycosides, xylan-, glucan-, galactan, or mannan-decorating groups; and at least one nucleic acid sequence and/or at least one recombinant nucleic acid encoding a polypeptide involved in fermenting sugar molecules to a product. Additionally, enzymatic and/or proteinaceous extracts may be isolated from one or more genetically modified organisms. The extracts are utilized to convert biomass into a product. Further provided are methods of converting biomass into products comprising: placing the genetically modified organism and/or enzymatic extracts thereof in fluid contact with polysaccharides, cellulose, lignocellulose, hemicellulose, lignin, starch, sugars, sugar oligomers, carbohydrates, complex carbohydrates, chitin, heteroxylans, glycosides, and/or xylan-, glucan-, galactan, or mannan-decorating groups.

    摘要翻译： 一种经遗传修饰的生物体，其包含：至少一种核酸序列和/或至少一种从酸性脂环酸杆菌分离的重组核酸，并编码涉及至少部分降解，切割，转运，代谢或去除多糖，纤维素，木质纤维素， 半纤维素，木质素，淀粉，糖，糖低聚物，碳水化合物，复合碳水化合物，壳多糖，异木糖，糖苷，木聚糖，葡聚糖，半乳聚糖或甘露聚糖装饰组; 以及至少一种核酸序列和/或至少一种编码参与将糖分子发酵到产品中的多肽的重组核酸。 此外，酶和/或蛋白质提取物可以从一种或多种遗传修饰的生物体分离。 提取物用于将生物质转化成产物。 还提供了将生物质转化成产物的方法，其包括：将经遗传修饰的生物体和/或其酶促提取物与多糖，纤维素，木质纤维素，半纤维素，木质素，淀粉，糖，糖低聚物，碳水化合物，复合碳水化合物，甲壳素， 异构木糖，糖苷和/或木聚糖，葡聚糖，半乳聚糖或甘露聚糖装饰组。