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    METHODS OF TREATING PROLIFERATIVE DISORDERS WITH MALATE OR DERIVATIVES THEREOF
    8.
    发明申请
    METHODS OF TREATING PROLIFERATIVE DISORDERS WITH MALATE OR DERIVATIVES THEREOF 有权
    用恶心或衍生物治疗增殖性疾病的方法

    公开(公告)号：US20150056215A1

    公开(公告)日：2015-02-26

    申请号：US14390155

    申请日：2013-04-04

    Applicant: Vikas P. Sukhatme ,  Jian-Guo Ren

    Inventor： Vikas P. Sukhatme ,  Jian-Guo Ren

    IPC: A61K31/225 ,  A61K33/24 ,  G01N33/50 ,  C12N15/113

    CPC classification number: A61K31/225 ,  A61K33/24 ,  A61K45/06 ,  C12N15/1137 ,  C12N2310/14 ,  C12N2320/31 ,  G01N33/5008 ,  G01N2500/04 ,  G01N2800/7023 ,  A61K2300/00

    Abstract: The present invention relates to methods, compositions, and diagnostic tests for treating and diagnosing proliferative disorders, such as cancel-, that result in dysregulation of malic enzyme 2. In particular, the methods and compositions include monotherapy with malate, or a derivative thereof, as well as combination therapy, such as malate, or a derivative thereof, combined with another therapeutic agent, such as a malic enzyme 2 inhibitor, an antineoplastic agent, a glycolysis inhibitor, an antiangiogenic agent, an immunomodulatory agent, an antibody, or a cytokine.

    Abstract translation: 本发明涉及用于治疗和诊断导致苹果酸酶2失调的增殖性疾病（例如止痛药）的方法，组合物和诊断测试。特别地，所述方法和组合物包括用苹果酸盐或其衍生物进行单一治疗， 以及联合治疗，例如苹果酸盐或其衍生物，与另一种治疗剂如苹果酸酶2抑制剂，抗肿瘤剂，糖酵解抑制剂，抗血管生成剂，免疫调节剂，抗体或抗体 细胞因子。

    Constitutive gene expression in conjunction with ionizing radiation
    9.
    发明授权
    Constitutive gene expression in conjunction with ionizing radiation 有权
    与电离辐射结合的组成型基因表达

    公开(公告)号：US07919310B2

    公开(公告)日：2011-04-05

    申请号：US12019428

    申请日：2008-01-24

    Applicant: Ralph R. Weichselbaum ,  Dennis E. Hallahan ,  Donald W. Kufe ,  Vikas P. Sukhatme

    Inventor： Ralph R. Weichselbaum ,  Dennis E. Hallahan ,  Donald W. Kufe ,  Vikas P. Sukhatme

    IPC: C12N15/74

    CPC classification number: A61K48/005 ,  C12N2799/022

    Abstract: The present disclosure demonstrates the successful use of constitutive promoters operatively linked to genes encoding radiosensitizing or radioprotecting factors, administered to cells, tissues, or patients in conjunction with radiation exposure. Also disclosed are pharmacological preparations to be used to increase the levels of radiosensitizing compounds such as TNF-α, or radioprotective compounds such as MnSOD, in specified tissues or tumors of a subject.

    Abstract translation: 本公开内容显示了与辐射照射联合施用于细胞，组织或患者的与编码放射增敏剂或放射防护因子的基因有效连接的组成型启动子的成功应用。 还公开了用于在受试者的特定组织或肿瘤中增加放射增敏化合物如TNF-α或放射防护化合物如MnSOD的药理学制剂。

    Methods and compositions for the treatment and diagnosis of vascular inflammatory disorders or endothelial cell disorders
    10.
    发明申请
    Methods and compositions for the treatment and diagnosis of vascular inflammatory disorders or endothelial cell disorders 审中-公开
    用于治疗和诊断血管炎症性疾病或内皮细胞病症的方法和组合物

    公开(公告)号：US20100136001A1

    公开(公告)日：2010-06-03

    申请号：US12592034

    申请日：2009-11-18

    Applicant: Vikas P. Sukhatme ,  Chunkong Barden Chan

    Inventor： Vikas P. Sukhatme ,  Chunkong Barden Chan

    IPC: A61K39/395 ,  A61K38/02 ,  A61K31/7008 ,  C12N9/12 ,  A61P29/00

    CPC classification number: A61K39/3955 ,  A61K31/7105 ,  A61K31/711 ,  A61K38/45 ,  C07K14/71 ,  G01N33/6893 ,  G01N2800/328 ,  G01N2800/50

    Abstract: Disclosed herein are methods for treating a vascular inflammatory disorder or endothelial cell disorder using inhibitor compounds that inhibit the expression or biological activity of Tie-1, Tie-1 endodomain, thrombin, VEGFR2, VEGFR2 endodomain, EphA2, and any of the cytokines or kinases that are upregulated by activation of Tie-1 or thrombin, as provided herein. Also disclosed are the use of combinations of inhibitor compounds or the use of an eNOS activator compound in combination with any one or more of the inhibitor compounds. Also disclosed are methods for inhibiting the pro-coagulant activity of thrombin using a Tie-1 or Tie-1 endodomain inhibitor compound or an EphA2 inhibitor compound. Methods for diagnosing and monitoring vascular inflammatory disorders or endothelial cell disorders that include the measurement of any of the polypeptides or nucleic acid molecules of the invention are also disclosed.

    Abstract translation: 本文公开了使用抑制Tie-1，Tie-1结构域，凝血酶，VEGFR2，VEGFR2结构域，EphA2和任何细胞因子或激酶的表达或生物活性的抑制剂化合物治疗血管炎症性疾病或内皮细胞病症的方法 其通过Tie-1或凝血酶的活化而上调，如本文所提供的。 还公开了使用抑制剂化合物的组合或使用eNOS活化剂化合物与任何一种或多种抑制剂化合物的组合。 还公开了使用Tie-1或Tie-1 endodomain抑制剂化合物或EphA2抑制剂化合物抑制凝血酶的促凝血活性的方法。 还公开了诊断和监测包括测量本发明的任何多肽或核酸分子的血管炎症性疾病或内皮细胞病症的方法。

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